Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0119 | 0.1612 | 0.1924 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0151 | 0.1061 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0144 | 0.121 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0121 | 0.165 | 0.1972 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0056 | 0.0613 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0082 | 0.1021 | 0.1009 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.026 | 0.3045 |
Trichomonas vaginalis | set domain proteins, putative | 0.0267 | 0.3967 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0144 | 0.01 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.009 | 0.1156 | 0.1143 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0144 | 0.0914 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0192 | 0.2777 | 0.2767 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0121 | 0.165 | 0.1638 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.036 | 0.7941 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0932 | 0.1757 |
Onchocerca volvulus | 0.0107 | 0.1416 | 0.3117 | |
Schistosoma mansoni | bromodomain containing protein | 0.0213 | 0.3112 | 0.3102 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0192 | 0.2777 | 0.3411 |
Echinococcus granulosus | zinc finger protein | 0.0069 | 0.0817 | 0.0909 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1021 | 0.1929 |
Brugia malayi | Cation transporter family protein | 0.0082 | 0.1021 | 0.2559 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0119 | 0.1612 | 0.1924 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0518 | 0.7935 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0151 | 0.0885 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0192 | 0.2777 | 0.5289 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0068 | 0.0809 | 0.1522 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 0.5238 | 0.5231 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0171 | 0.2445 | 0.2435 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0107 | 0.1416 | 0.1673 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0809 | 0.0796 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0151 | 0.1061 |
Brugia malayi | Pre-SET motif family protein | 0.0235 | 0.3452 | 0.865 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1156 | 0.2186 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.0293 | 0.5 |
Onchocerca volvulus | 0.0267 | 0.3967 | 1 | |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.036 | 0.0657 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.036 | 0.5997 |
Brugia malayi | follicle stimulating hormone receptor | 0.0269 | 0.3991 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0107 | 0.1416 | 0.1404 |
Brugia malayi | Bromodomain containing protein | 0.0131 | 0.18 | 0.451 |
Brugia malayi | mbt repeat family protein | 0.0107 | 0.1416 | 0.3547 |
Schistosoma mansoni | ran | 0.0024 | 0.0106 | 0.0092 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.042 | 0.6386 | 0.8021 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.165 | 0.3131 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.036 | 0.0657 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0107 | 0.1416 | 0.1404 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0075 | 0.0909 | 0.1026 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0144 | 0.01 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.036 | 0.0662 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.009 | 0.1156 | 0.1143 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0192 | 0.2777 | 0.3411 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0033 | 0.0242 | 0.2686 |
Schistosoma mansoni | ran | 0.0024 | 0.0106 | 0.0092 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0192 | 0.2777 | 0.3411 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.036 | 0.5997 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.036 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.174 | 0.3305 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0202 | 0.2924 | 0.36 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0192 | 0.2777 | 0.6957 |
Brugia malayi | RNA, U transporter 1 | 0.0093 | 0.1194 | 0.2992 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.036 | 0.5001 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0242 | 0.0437 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0151 | 0.0262 |
Onchocerca volvulus | 0.0082 | 0.1021 | 0.2053 | |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1021 | 0.1929 |
Schistosoma mansoni | zinc finger protein | 0.0051 | 0.0529 | 0.0516 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0107 | 0.1416 | 0.1673 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0151 | 0.0885 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0269 | 0.3991 | 0.7614 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0056 | 0.0613 | 0.1314 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0106 | 0.0265 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0075 | 0.0909 | 0.0897 |
Echinococcus granulosus | snurportin 1 | 0.0347 | 0.5238 | 0.6555 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0518 | 0.7935 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.042 | 0.6386 | 0.8021 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0347 | 0.5238 | 1 |
Brugia malayi | Inositol-1 | 0.004 | 0.036 | 0.0901 |
Onchocerca volvulus | 0.0082 | 0.1021 | 0.2053 | |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0056 | 0.0621 | 0.0608 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0033 | 0.0242 | 0.0174 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.026 | 0.0652 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.036 | 0.0324 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0202 | 0.2924 | 0.36 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0106 | 0.0176 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.0293 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0192 | 0.2777 | 0.2767 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0151 | 0.1061 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1416 | 0.2684 |
Loa Loa (eye worm) | acetyltransferase | 0.0171 | 0.2445 | 0.4655 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0151 | 0.1405 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0242 | 0.3221 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0171 | 0.2445 | 0.6127 |
Brugia malayi | Bromodomain containing protein | 0.0252 | 0.3727 | 0.9339 |
Brugia malayi | mbt repeat family protein | 0.0107 | 0.1416 | 0.3547 |
Schistosoma mansoni | importin beta-1 | 0.0033 | 0.0242 | 0.0228 |
Plasmodium vivax | importin-beta 2, putative | 0.0033 | 0.0242 | 0.2686 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.036 | 0.0657 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0144 | 0.0914 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.026 | 0.0247 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0056 | 0.0621 | 0.0658 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0159 | 0.2248 | 0.2737 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0107 | 0.1416 | 0.1673 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0107 | 0.1416 | 0.1673 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.036 | 0.0346 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0056 | 0.0613 | 0.0648 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0192 | 0.2777 | 0.2767 |
Trypanosoma cruzi | ISWI complex protein | 0.0051 | 0.0529 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0051 | 0.0529 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0121 | 0.165 | 0.1972 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0121 | 0.165 | 0.1972 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0075 | 0.0909 | 0.1026 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0192 | 0.2777 | 0.3411 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0082 | 0.1021 | 0.1009 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0242 | 0.3221 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0121 | 0.165 | 0.4133 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0107 | 0.1416 | 0.2684 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0044 | 0.0425 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.026 | 0.3045 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0056 | 0.0621 | 0.0658 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0518 | 0.7935 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0069 | 0.0817 | 0.0804 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.009 | 0.1156 | 0.1341 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0044 | 0.0425 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0051 | 0.0529 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0529 | 0.0516 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0056 | 0.0613 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0056 | 0.0613 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0056 | 0.0621 | 0.0608 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.036 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.036 | 0.5997 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0144 | 0.01 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0.0425 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0151 | 0.1061 |
Echinococcus granulosus | neuropeptide s receptor | 0.0518 | 0.7935 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0069 | 0.0817 | 0.0909 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.026 | 0.0247 |
Onchocerca volvulus | 0.0082 | 0.1021 | 0.2053 | |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.2029 | 0.3857 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0151 | 0.1405 |
Brugia malayi | Importin beta-1 subunit | 0.0033 | 0.0242 | 0.0606 |
Loa Loa (eye worm) | MBCTL1 | 0.0121 | 0.165 | 0.3131 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.3439 | 0.6557 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.009 | 0.1156 | 0.1341 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0235 | 0.3452 | 0.6582 |
Brugia malayi | PHD-finger family protein | 0.0086 | 0.1097 | 0.2749 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.0529 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0062 | 0.0717 | 0.1346 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0107 | 0.1416 | 0.3117 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0241 | 0.0172 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0121 | 0.165 | 0.1972 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0171 | 0.2445 | 0.2988 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.036 | 0.5997 |
Echinococcus granulosus | importin subunit beta 1 | 0.0033 | 0.0242 | 0.0174 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0056 | 0.0613 | 0.1314 |
Plasmodium falciparum | importin beta, putative | 0.0033 | 0.0242 | 0.4265 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.036 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.026 | 0.0197 |
Echinococcus multilocularis | snurportin 1 | 0.0347 | 0.5238 | 0.6555 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.036 | 0.0324 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0107 | 0.1416 | 0.1404 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0151 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1928 | 0.3665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.