Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | protein kinase C, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3722 | 0.3515 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1629 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2388 | 0.2137 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0019 | 0.0476 | 0.1279 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0994 | 0.0697 |
Brugia malayi | protein kinase C II. | 0.0019 | 0.0476 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2878 | 0.2643 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.2757 | 0.2518 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0476 | 0.1279 |
Schistosoma mansoni | atypical protein kinase C | 0.0018 | 0.0374 | 0.1006 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.032 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1629 | 0.1353 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3722 | 0.3515 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0048 | 0.2388 | 0.6415 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.032 | 0.0859 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.032 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0994 | 0.0697 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2757 | 0.2518 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3722 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0355 | 0.0037 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.2757 | 0.2518 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0067 | 0.3673 | 0.9867 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3722 | 0.3515 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3722 | 0.3515 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0994 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.032 | 0.0859 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1629 | 0.4376 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0994 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0049 | 0.2505 | 0.2257 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3722 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0067 | 0.3673 | 0.9867 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0994 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0018 | 0.0374 | 0.1006 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3722 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0018 | 0.0374 | 0.1006 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.032 | 0.0859 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0994 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.032 | 0.0859 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0994 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.2757 | 0.2518 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0048 | 0.2388 | 0.6415 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3722 | 0.3515 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.032 | 0.0859 |
Brugia malayi | Protein kinase c protein 2 | 0.0057 | 0.2995 | 0.2764 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3722 | 0.3515 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0994 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0019 | 0.0476 | 0.1279 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0994 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.0059 | 0.3183 | 0.8551 |
Onchocerca volvulus | 0.0161 | 1 | 0.5 | |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0048 | 0.2388 | 0.6415 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.032 | 0.0859 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.032 | 0.0859 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3722 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0019 | 0.0476 | 0.0162 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0059 | 0.3183 | 0.8551 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0994 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.032 | 0.0859 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3722 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.3673 | 0.9867 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3722 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.3673 | 0.9867 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3722 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 159.9 nM | Displacement of [3H]PDBu form mouse PKCalpha by scintillation counting | ChEMBL. | 18698758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.