Detailed information for compound 950481

Basic information

Technical information
  • TDR Targets ID: 950481
  • Name: 2-(dimethyl-$l^{4}-sulfanylidene)-1,4-di(phen yl)butane-1,3-dione
  • MW: 298.399 | Formula: C18H18O2S
  • H donors: 0 H acceptors: 2 LogP: 3.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CS(=C(C(=O)c1ccccc1)C(=O)Cc1ccccc1)C
  • InChi: 1S/C18H18O2S/c1-21(2)18(17(20)15-11-7-4-8-12-15)16(19)13-14-9-5-3-6-10-14/h3-12H,13H2,1-2H3
  • InChiKey: VVUXVJJKXZQYHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis guanylate cyclase, putative 0.0048 0.042 1
Mycobacterium ulcerans oxidoreductase 0.0031 0.0158 0.0099
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Schistosoma mansoni aldo-keto reductase 0.0031 0.0158 0.0054
Brugia malayi hypothetical protein 0.0048 0.042 0.0456
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0224 0.4086
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0048 0.042 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0158 0.3767
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0224 0.5335
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.005 0.0444 0.0419
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0188 0.4428
Echinococcus granulosus lipoxygenase domain containing protein 0.0181 0.2389 0.2369
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Schistosoma mansoni hypothetical protein 0.0181 0.2389 0.2308
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Loa Loa (eye worm) oxidoreductase 0.0031 0.0158 0.0088
Onchocerca volvulus 0.0139 0.1771 0.3007
Plasmodium vivax multidomain scavenger receptor, putative 0.0181 0.2389 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0158 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.042 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.1531 0.2071
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0502 0.7146 1
Onchocerca volvulus 0.0181 0.2389 0.4123
Echinococcus granulosus endoplasmin 0.0026 0.0089 0.0063
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0089 0.2111
Onchocerca volvulus 0.0031 0.0158 0.0096
Trypanosoma brucei heat shock protein, putative 0.0033 0.0188 0.4428
Trypanosoma brucei heat shock protein, putative 0.0033 0.0188 0.4428
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0048 0.042 1
Mycobacterium ulcerans isocitrate lyase Icl 0.0502 0.7146 1
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Echinococcus multilocularis aldo keto reductase 0.0031 0.0158 0.0132
Echinococcus granulosus aldo keto reductase 0.0031 0.0158 0.0132
Schistosoma mansoni apoptosis regulator bax 0.0493 0.7019 0.6987
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0158 0.0132
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0158 0.0132
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0188 0.4428
Loa Loa (eye worm) hypothetical protein 0.0027 0.0105 0.0011
Echinococcus granulosus heat shock protein 90 0.0026 0.0089 0.0063
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0158 0.0132
Onchocerca volvulus 0.0031 0.0158 0.0096
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0493 0.7019 0.7011
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0048 0.042 1
Schistosoma mansoni hypothetical protein 0.0493 0.7019 0.6987
Echinococcus multilocularis transcription factor btf3 0.0035 0.0224 0.0198
Echinococcus multilocularis transfer RNA-Lys 0.0138 0.1747 0.1725
Brugia malayi PAS domain containing protein 0.0186 0.2465 0.3413
Leishmania major protein kinase, putative 0.0048 0.042 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0158 0.0077
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0158 0.3767
Schistosoma mansoni loxhd1 0.0181 0.2389 0.2308
Schistosoma mansoni microtubule-associated protein tau 0.0694 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0158 0.0132
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0158 0.0077
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Onchocerca volvulus 0.0181 0.2389 0.4123
Echinococcus granulosus geminin 0.0171 0.2231 0.2211
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.005 0.0444 0.0419
Loa Loa (eye worm) apoptosis regulator protein 0.0493 0.7019 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Trypanosoma brucei heat shock protein, putative 0.0033 0.0188 0.4428
Echinococcus granulosus RUN 0.0181 0.2389 0.2369
Echinococcus multilocularis aldo keto reductase 0.0031 0.0158 0.0132
Loa Loa (eye worm) oxidoreductase 0.0031 0.0158 0.0088
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0089 0.5
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0224 1
Leishmania major basic transcription factor 3a, putative 0.0035 0.0224 0.4086
Loa Loa (eye worm) hypothetical protein 0.0181 0.2389 0.3311
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0158 0.3767
Schistosoma mansoni single-minded 0.0186 0.2465 0.2385
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0224 0.0183
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0048 0.042 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0158 0.3767
Brugia malayi bHLH-PAS transcription factor 0.0138 0.1747 0.2375
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0048 0.042 1
Brugia malayi beta-NAC-like protein 0.0035 0.0224 0.0173
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Echinococcus granulosus aldo keto reductase 0.0031 0.0158 0.0132
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Plasmodium falciparum LCCL domain-containing protein 0.0181 0.2389 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0158 0.0099
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Leishmania major prostaglandin f synthase, putative 0.0031 0.0158 0.2099
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0188 0.2979
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0158 0.0077
Onchocerca volvulus 0.0031 0.0158 0.0096
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0493 0.7019 1
Schistosoma mansoni lipoxygenase 0.0507 0.7224 0.7195
Echinococcus granulosus heat shock protein 90 0.0033 0.0188 0.0162
Echinococcus multilocularis aldo keto reductase 0.0031 0.0158 0.0132
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0502 0.7146 1
Schistosoma mansoni rab6-interacting 0.0181 0.2389 0.2308
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0188 0.4461
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0089 0.2111
Loa Loa (eye worm) doublecortin family protein 0.0181 0.2389 0.3311
Schistosoma mansoni hypothetical protein 0.0493 0.7019 0.6987
Schistosoma mansoni endoplasmin 0.0033 0.0188 0.0083
Echinococcus multilocularis lipoxygenase domain containing protein 0.0181 0.2389 0.2369
Echinococcus granulosus single minded 2 0.0138 0.1747 0.1725
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0188 0.2979
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0158 0.0132
Mycobacterium leprae Possible regulatory protein 0.0048 0.042 0.0553
Schistosoma mansoni rab6-interacting 0.0181 0.2389 0.2308
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0158 0.0132
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0048 0.042 1
Giardia lamblia Aldose reductase 0.0031 0.0158 0.7046
Echinococcus granulosus aryl hydrocarbon receptor 0.0402 0.5668 0.5657
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0158 0.0132
Echinococcus multilocularis lipoxygenase domain containing protein 0.0181 0.2389 0.2369
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0048 0.042 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0158 0.0132
Trypanosoma brucei heat shock protein, putative 0.0033 0.0188 0.4428
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0089 0.2111
Echinococcus multilocularis musashi 0.0027 0.0105 0.0079
Schistosoma mansoni heat shock protein 0.0033 0.0188 0.0083
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0105 0.0011
Loa Loa (eye worm) hypothetical protein 0.0238 0.3231 0.4527
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.0158 0.2099
Onchocerca volvulus 0.0031 0.0158 0.0096
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0055 0.0519 0.5
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0188 0.4428
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0188 0.2979
Echinococcus multilocularis geminin 0.0171 0.2231 0.2211
Echinococcus granulosus lamin 0.0027 0.0105 0.0079
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0188 0.4428
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.3231 0.3213
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Trichomonas vaginalis adenylate cyclase, putative 0.0048 0.042 1
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0158 0.3767
Echinococcus multilocularis Polycystic kidney disease protein 0.0181 0.2389 0.2369
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0158 0.0132
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0048 0.042 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0048 0.042 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0188 0.4428
Echinococcus multilocularis RUN 0.0181 0.2389 0.2369
Schistosoma mansoni hypothetical protein 0.0171 0.2231 0.2149
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0048 0.042 1
Echinococcus multilocularis endoplasmin 0.0026 0.0089 0.0063
Echinococcus granulosus lamin dm0 0.0027 0.0105 0.0079
Schistosoma mansoni survival motor neuron protein 0.0049 0.0422 0.0321
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.042 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0158 0.0132
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0507 0.7224 0.7217
Schistosoma mansoni polycystin 1-related 0.0181 0.2389 0.2308
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0224 0.5335
Loa Loa (eye worm) hypothetical protein 0.0352 0.4927 0.6977
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0105 0.0011
Treponema pallidum heat shock protein 90 0.0026 0.0089 0.5
Echinococcus multilocularis aryl hydrocarbon receptor 0.0402 0.5668 0.5657
Brugia malayi Endoplasmin precursor 0.0033 0.0188 0.0119
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.0158 0.0185
Echinococcus multilocularis lamin dm0 0.0027 0.0105 0.0079
Schistosoma mansoni transcription factor btf3 0.0035 0.0224 0.0121
Brugia malayi hypothetical protein 0.0181 0.2389 0.3303
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0158 0.0132
Echinococcus granulosus Polycystic kidney disease protein 0.0181 0.2389 0.2369
Trypanosoma brucei heat shock protein, putative 0.0033 0.0188 0.4428
Loa Loa (eye worm) oxidoreductase 0.0031 0.0158 0.0088
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0422 0.0459
Brugia malayi hypothetical protein 0.0123 0.1531 0.2062
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0502 0.7146 1
Echinococcus multilocularis aldo keto reductase 0.0031 0.0158 0.0132
Giardia lamblia Aldose reductase 0.0031 0.0158 0.7046
Brugia malayi hypothetical protein 0.0181 0.2389 0.3303
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0493 0.7019 0.7011
Mycobacterium ulcerans isocitrate lyase AceAb 0.0502 0.7146 1
Schistosoma mansoni lipoxygenase 0.0181 0.2389 0.2308
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0089 0.0063
Trypanosoma brucei heat shock protein, putative 0.0033 0.0188 0.4428
Loa Loa (eye worm) hypothetical protein 0.0181 0.2389 0.3311
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0188 0.4428
Onchocerca volvulus 0.0031 0.0158 0.0096
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0188 0.4428
Loa Loa (eye worm) hypothetical protein 0.0493 0.7019 1
Trichomonas vaginalis guanylate cyclase, putative 0.0048 0.042 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Loa Loa (eye worm) oxidoreductase 0.0031 0.0158 0.0088
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0048 0.042 1
Loa Loa (eye worm) oxidoreductase 0.0031 0.0158 0.0088
Schistosoma mansoni heat shock protein 0.0033 0.0188 0.0083
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0493 0.7019 0.7011
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0158 0.0132
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0352 0.4927 0.6974
Echinococcus multilocularis heat shock protein 0.0033 0.0188 0.0162
Entamoeba histolytica hypothetical protein 0.0035 0.0224 1
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0224 0.0167
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.0158 0.2099
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0158 0.0132
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0158 0.0132
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0048 0.042 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0158 0.3767
Leishmania major aldo-keto reductase-like protein 0.0031 0.0158 0.2099
Schistosoma mansoni hypothetical protein 0.0493 0.7019 0.6987
Trypanosoma cruzi aldo-keto reductase 0.0031 0.0158 0.2099
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0158 0.0077
Echinococcus granulosus transcription factor btf3 0.0035 0.0224 0.0198
Echinococcus multilocularis microtubule associated protein 2 0.0694 1 1
Echinococcus granulosus hypothetical protein 0.0031 0.0158 0.0132
Schistosoma mansoni pol-related 0.0031 0.0158 0.0054
Loa Loa (eye worm) hypothetical protein 0.0401 0.5644 0.8014
Echinococcus granulosus intermediate filament protein 0.0027 0.0105 0.0079
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0158 0.0132
Echinococcus multilocularis heat shock protein 90 0.0026 0.0089 0.0063
Brugia malayi hypothetical protein 0.0238 0.3231 0.4522
Echinococcus granulosus heat shock protein 0.0033 0.0188 0.0162
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0224 1
Schistosoma mansoni endoplasmin 0.0033 0.0188 0.0083
Loa Loa (eye worm) hypothetical protein 0.0031 0.0158 0.0088
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0224 0.4086
Onchocerca volvulus Huntingtin homolog 0.0123 0.1531 0.2574
Schistosoma mansoni hypothetical protein 0.0171 0.2231 0.2149
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.005 0.0444 0.0501
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0224 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Mycobacterium leprae Isocitrate lyase 0.0235 0.3192 0.4446
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.3231 0.3213
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0188 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0224 0.5335
Loa Loa (eye worm) hypothetical protein 0.0354 0.495 0.7011
Brugia malayi Doublecortin family protein 0.0181 0.2389 0.3303
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0089 0.0088
Schistosoma mansoni hypothetical protein 0.0049 0.0422 0.0321
Onchocerca volvulus 0.0049 0.0422 0.0573
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0188 1
Schistosoma mansoni aldo-keto reductase 0.0031 0.0158 0.0054
Brugia malayi heat shock protein 90 0.0033 0.0188 0.0119
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0158 0.0132
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0158 0.0132
Echinococcus multilocularis heat shock protein 90 0.0033 0.0188 0.0162
Schistosoma mansoni aryl hydrocarbon receptor 0.054 0.7712 0.7688
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0188 0.2979
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Mycobacterium ulcerans putative regulatory protein 0.0138 0.1747 0.2349
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0188 0.2979
Loa Loa (eye worm) hypothetical protein 0.0048 0.042 0.0466
Onchocerca volvulus 0.0401 0.5644 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0502 0.7146 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0188 0.4428
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0158 0.2099
Onchocerca volvulus Huntingtin homolog 0.0123 0.1531 0.2574
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.2979
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0493 0.7019 0.7011
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0158 0.3767
Echinococcus granulosus lipoxygenase domain containing protein 0.0181 0.2389 0.2369
Onchocerca volvulus 0.0031 0.0158 0.0096
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0507 0.7224 0.7217
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0158 0.0132
Loa Loa (eye worm) hypothetical protein 0.0123 0.1531 0.2071
Loa Loa (eye worm) endoplasmin 0.0033 0.0188 0.013
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0158 0.0132
Echinococcus granulosus aldo keto reductase 0.0031 0.0158 0.0132
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0493 0.7019 0.6987
Leishmania major protein kinase, putative 0.0048 0.042 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.042 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0224 0.0939
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0188 0.4428
Plasmodium falciparum heat shock protein 90 0.0033 0.0188 0.0785
Echinococcus multilocularis lamin 0.0027 0.0105 0.0079

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = -1.2 % Activation of human estrogen receptor alpha expressed in HEK293 cells at 10 uM by beta-galactosidase reporter gene assay relative to 3,17 beta-estradiol ChEMBL. 18517258
Activity (binding) = 5.8 % Activation of human estrogen receptor beta expressed in HEK293 cells at 10 uM beta-galactosidase reporter gene assay relative to 3,17-beta-estradiol ChEMBL. 18517258

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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