TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 251.28 | Formula: C16H13NO2
H donors: 1 H acceptors: 1 LogP: 3.23 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Nc1ccc(cc1)c1cc2cc(C)ccc2oc1=O
InChi: 1S/C16H13NO2/c1-10-2-7-15-12(8-10)9-14(16(18)19-15)11-3-5-13(17)6-4-11/h2-9H,17H2,1H3
InChiKey: ZZAMGYGTJZMFKR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	monoamine oxidase B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	Get druggable targets OG5_130722	All targets in OG5_130722
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	Get druggable targets OG5_130722	All targets in OG5_130722
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	Get druggable targets OG5_130722	All targets in OG5_130722

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	amine oxidase, flavin-containing family protein	monoamine oxidase B	520 aa	462 aa	19.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0166	0.0191
Trypanosoma cruzi	6-phosphogluconolactonase, putative	0.0042	0.012	0.0139
Echinococcus multilocularis	serotonin receptor	0.0667	0.4733	0.5458
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0166	0.0166
Giardia lamblia	Glucose-6-phosphate 1-dehydrogenase	0.1019	0.7334	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0477	0.3332	0.3842
Loa Loa (eye worm)	hypothetical protein	0.0382	0.2628	0.2628
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.1019	0.7334	0.7334
Leishmania major	hexokinase, putative	0.12	0.8673	1
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0068	0.0078
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0068	0.0078
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0019	0.0022
Echinococcus multilocularis	caspase 2	0.0053	0.0205	0.0236
Entamoeba histolytica	hypothetical protein	0.0072	0.0344	0.0396
Entamoeba histolytica	hypothetical protein	0.0072	0.0344	0.0396
Echinococcus multilocularis	hexokinase	0.12	0.8673	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0386	0.266	0.3067
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0033	0.0051	0.0059
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0053	0.0205	0.0236
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0124	0.0724	0.0835
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0051	0.0051
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0036	0.0041
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0053	0.0205	0.0205
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.2555	0.2555
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0053	0.0205	0.0205
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0124	0.0724	0.0835
Loa Loa (eye worm)	hexokinase	0.0371	0.2553	0.2553
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0205	0.0205
Echinococcus multilocularis	muscleblind protein	0.018	0.1142	0.1317
Schistosoma mansoni	serine/threonine protein kinase	0.0477	0.3332	0.3332
Echinococcus granulosus	Smad4	0.0033	0.0051	0.0059
Echinococcus multilocularis	6 phosphogluconolactonase	0.0042	0.012	0.0139
Schistosoma mansoni	kinase	0.0242	0.16	0.16
Brugia malayi	MH2 domain containing protein	0.0033	0.0051	0.0051
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0477	0.3332	0.3332
Loa Loa (eye worm)	hypothetical protein	0.018	0.1142	0.1142
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0268	0.0268
Echinococcus multilocularis	glucose 6 phosphate 1 dehydrogenase	0.0977	0.7024	0.81
Treponema pallidum	glucose-6-phosphate 1-dehydrogenase	0.0977	0.7024	0.8073
Loa Loa (eye worm)	MH2 domain-containing protein	0.0477	0.3335	0.3335
Trypanosoma brucei	metacaspase	0.0053	0.0205	0.0236
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0053	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0819	0.5855	0.5855
Loa Loa (eye worm)	glutaminase 2	0.138	1	1
Mycobacterium ulcerans	hypothetical protein	0.0124	0.0724	0.0611
Trypanosoma brucei	metacaspase MCA3	0.0053	0.0205	0.0236
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0053	0.0205	0.0205
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0667	0.4733	0.4733
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0977	0.7024	0.6988
Trypanosoma brucei	polo-like protein kinase	0.0477	0.3332	0.3842
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0036	0.0041
Trypanosoma cruzi	hexokinase, putative	0.12	0.8673	1
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0044	0.0139	0.0139
Entamoeba histolytica	hexokinase 2	0.12	0.8673	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0166	0.0191
Brugia malayi	hypothetical protein	0.003	0.0036	0.0036
Plasmodium falciparum	metacaspase 1	0.0053	0.0205	0.0236
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0166	0.0191
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0068	0.0078
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.0344	0.0396
Echinococcus granulosus	6 phosphogluconolactonase	0.0042	0.012	0.0139
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0124	0.0724	0.0611
Trypanosoma cruzi	hexokinase, putative	0.12	0.8673	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0053	0.0205	0.0205
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0359	0.2458	0.2366
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0199	0.1283	0.148
Schistosoma mansoni	Smad4	0.0033	0.0051	0.0051
Trypanosoma brucei	hexokinase	0.12	0.8673	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0036	0.0036
Loa Loa (eye worm)	Smad1	0.0033	0.0051	0.0051
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0638	0.4522	0.4455
Trypanosoma cruzi	hypothetical protein, conserved	0.1074	0.774	0.8925
Loa Loa (eye worm)	MH1 domain-containing protein	0.0033	0.0051	0.0051
Brugia malayi	hypothetical protein	0.0045	0.0141	0.0141
Echinococcus multilocularis	snurportin 1	0.0372	0.2555	0.2946
Loa Loa (eye worm)	transcription factor SMAD2	0.0477	0.3335	0.3335
Entamoeba histolytica	hypothetical protein	0.0028	0.0019	0.0022
Trichomonas vaginalis	CAMK family protein kinase	0.0477	0.3332	0.3332
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0036	0.0041
Brugia malayi	hypothetical protein	0.0072	0.0344	0.0344
Trichomonas vaginalis	CAMK family protein kinase	0.0236	0.1554	0.1554
Schistosoma mansoni	caspase-7 (C14 family)	0.0053	0.0205	0.0205
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0045	0.0141	0.0141
Onchocerca volvulus		0.0753	0.537	0.6129
Echinococcus granulosus	caspase 8	0.0053	0.0205	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0139	0.0139
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.013	0.0768	1
Echinococcus granulosus	citrate lyase subunit beta protein	0.0124	0.0724	0.0835
Trypanosoma cruzi	metacaspase 5, putative	0.0053	0.0205	0.0236
Leishmania major	hypothetical protein, conserved	0.1074	0.774	0.8925
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0064	0.0282	0.0282
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0166	0.0166
Plasmodium falciparum	importin beta, putative	0.0035	0.0068	0.0078
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.027	0.1806	0.1706
Echinococcus granulosus	caspase	0.0199	0.1283	0.148
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0166	0.0166
Loa Loa (eye worm)	glucose-6-phosphate dehydrogenase	0.0977	0.7024	0.7024
Trypanosoma cruzi	hypothetical protein, conserved	0.1074	0.774	0.8925
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0166	0.0166
Leishmania major	hypothetical protein, conserved	0.003	0.0036	0.0041
Echinococcus granulosus	muscleblind protein	0.018	0.1142	0.1317
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0045	0.0141	0.0141
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0359	0.2458	0.2366
Treponema pallidum	hexokinase (hxk)	0.12	0.8673	1
Brugia malayi	Cell death protein 3 precursor	0.0053	0.0205	0.0205
Trypanosoma brucei	glucose-6-phosphate 1-dehydrogenase	0.0977	0.7024	0.81
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0205	0.0205
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0042	0.012	0.012
Trichomonas vaginalis	CAMK family protein kinase	0.0477	0.3332	0.3332
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0036	0.0041
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.0344	0.0396
Brugia malayi	Importin beta-1 subunit	0.0035	0.0068	0.0068
Schistosoma mansoni	glucosamine-6-phosphate isomerase	0.0042	0.012	0.012
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0268	0.0268
Giardia lamblia	Glucosamine-6-phosphate deaminase	0.0042	0.012	0.0164
Onchocerca volvulus		0.12	0.8673	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0205	0.0205
Trypanosoma brucei	metacaspase 5, putative	0.0053	0.0205	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0205	0.0205
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0036	0.0041
Trypanosoma brucei	metacaspase MCA2	0.0053	0.0205	0.0236
Echinococcus multilocularis	hexokinase	0.12	0.8673	1
Plasmodium falciparum	glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0.1019	0.7334	0.8456
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0053	0.0205	0.0205
Brugia malayi	hypothetical protein	0.0064	0.028	0.028
Schistosoma mansoni	glutaminase	0.138	1	1
Toxoplasma gondii	hexokinase	0.12	0.8673	1
Echinococcus multilocularis	caspase 3	0.0146	0.089	0.1026
Brugia malayi	RNA, U transporter 1	0.0099	0.0542	0.0542
Brugia malayi	Hexokinase family protein	0.0753	0.537	0.537
Schistosoma mansoni	hypothetical protein	0.0041	0.0115	0.0115
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0268	0.0268
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0033	0.0051	0.0059
Loa Loa (eye worm)	hexokinase	0.12	0.8673	0.8673
Echinococcus granulosus	smad	0.0033	0.0051	0.0059
Trichomonas vaginalis	6-phosphogluconolactonase, putative	0.1019	0.7334	0.7334
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.0638	0.4522	0.5214
Echinococcus multilocularis	Smad4	0.0033	0.0051	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0064	0.028	0.028
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0977	0.7024	0.81
Brugia malayi	Hexokinase family protein	0.0371	0.2553	0.2553
Loa Loa (eye worm)	hypothetical protein	0.0667	0.4733	0.4733
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.1019	0.7334	0.7334
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0382	0.2628	0.2628
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0477	0.3332	0.3842
Schistosoma mansoni	6-phosphogluconolactonase	0.0042	0.012	0.012
Brugia malayi	MH2 domain containing protein	0.0477	0.3335	0.3335
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0019	0.0019
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0045	0.0141	0.0141
Loa Loa (eye worm)	glutaminase	0.138	1	1
Trypanosoma cruzi	metacaspase 5, putative	0.0053	0.0205	0.0236
Schistosoma mansoni	glucose-6-phosphate 1-dehydrogenase	0.0977	0.7024	0.7024
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0051	0.0051
Echinococcus granulosus	hexokinase	0.12	0.8673	1
Brugia malayi	Muscleblind-like protein	0.018	0.1142	0.1142
Leishmania major	glucosamine-6-phosphate isomerase, putative	0.0042	0.012	0.0139
Giardia lamblia	Kinase, PLK	0.0477	0.3332	0.4543
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0124	0.0724	0.0611
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0255	0.0255
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0268	0.0268
Echinococcus multilocularis	serotonin receptor	0.0667	0.4733	0.5458
Trypanosoma cruzi	6-phosphogluconolactonase, putative	0.0042	0.012	0.0139
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0268	0.0309
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0033	0.0051	0.0059
Trypanosoma cruzi	metacaspase, putative	0.0053	0.0205	0.0236
Echinococcus granulosus	hexokinase type 2	0.12	0.8673	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0033	0.0051	0.0051
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0386	0.266	0.3067
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.1019	0.7334	0.8456
Trypanosoma brucei	glucosamine-6-phosphate isomerase, putative	0.0042	0.012	0.0139
Mycobacterium ulcerans	hypothetical protein	0.0124	0.0724	0.0611
Trypanosoma brucei	6-phosphogluconolactonase	0.0042	0.012	0.0139
Trypanosoma cruzi	metacaspase, putative	0.0053	0.0205	0.0236
Echinococcus granulosus	snurportin 1	0.0372	0.2555	0.2946
Trichomonas vaginalis	CAMK family protein kinase	0.0477	0.3332	0.3332
Entamoeba histolytica	hypothetical protein	0.0072	0.0344	0.0396
Leishmania major	hexokinase, putative	0.12	0.8673	1
Schistosoma mansoni	hexokinase	0.12	0.8673	0.8673
Leishmania major	glucose-6-phosphate 1-dehydrogenase, putative	0.0977	0.7024	0.81
Schistosoma mansoni	importin beta-1	0.0035	0.0068	0.0068
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0051	0.0051
Brugia malayi	RNA binding protein	0.0062	0.0268	0.0268
Schistosoma mansoni	hypothetical protein	0.0072	0.0344	0.0344
Brugia malayi	glucose-6-phosphate dehydrogenase	0.0977	0.7024	0.7024
Trypanosoma brucei	Metacaspase-4	0.0053	0.0205	0.0236
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0124	0.0724	0.0835
Schistosoma mansoni	hypothetical protein	0.0372	0.2555	0.2555
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0053	0.0205	0.0205
Loa Loa (eye worm)	hexokinase type II	0.12	0.8673	0.8673
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0139	0.0139
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.0344	0.0344
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0068	0.0078
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0477	0.3332	0.3842
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0268	0.0268
Echinococcus granulosus	caspase 2	0.0053	0.0205	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0068	0.0068
Onchocerca volvulus		0.12	0.8673	1
Brugia malayi	TAR-binding protein	0.0062	0.0268	0.0268
Onchocerca volvulus	Cell death protein 3 homolog	0.0053	0.0205	0.0074
Plasmodium vivax	glucose-6-phosphate 1-dehydrogenase, putative	0.1019	0.7334	0.8456
Echinococcus multilocularis	caspase	0.0199	0.1283	0.148
Schistosoma mansoni	6-phosphogluconolactonase	0.0042	0.012	0.012
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0205	0.0205
Chlamydia trachomatis	glucose-6-phosphate 1-dehydrogenase	0.0977	0.7024	1
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0064	0.0282	0.0325
Loa Loa (eye worm)	6-phosphogluconolactonase	0.0042	0.012	0.012
Trichomonas vaginalis	CAMK family protein kinase	0.0477	0.3332	0.3332
Echinococcus multilocularis	hexokinase	0.12	0.8673	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0477	0.3332	0.3842
Trypanosoma cruzi	metacaspase, putative	0.0053	0.0205	0.0236
Plasmodium falciparum	metacaspase-like protein	0.0053	0.0205	0.0236
Loa Loa (eye worm)	hexokinase	0.0753	0.537	0.537
Leishmania major	6-phosphogluconolactonase	0.0042	0.012	0.0139
Entamoeba histolytica	hexokinase 1	0.12	0.8673	1
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0053	0.0205	0.0236
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0053	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0115	0.0115
Trypanosoma cruzi	metacaspase, putative	0.0053	0.0205	0.0236
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0019	0.0022
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0255	0.0255
Echinococcus multilocularis	hexokinase type 2	0.12	0.8673	1
Trichomonas vaginalis	CAMK family protein kinase	0.0236	0.1554	0.1554
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0036	0.0041
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0268	0.0268
Trypanosoma cruzi	glucosamine-6-phosphate isomerase, putative	0.0042	0.012	0.0139
Trypanosoma cruzi	Glucose-6-phosphate dehydrogenase, putative	0.0314	0.2132	0.2458
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0477	0.3332	0.374
Echinococcus granulosus	biogenic amine 5HT receptor	0.0667	0.4733	0.5458
Brugia malayi	Smad1	0.0033	0.0051	0.0051
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0124	0.0724	0.0835
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0053	0.0205	0.0205
Brugia malayi	hexokinase	0.12	0.8673	0.8673
Brugia malayi	MH2 domain containing protein	0.0033	0.0051	0.0051
Onchocerca volvulus		0.12	0.8673	1
Trypanosoma brucei	beta lactamase	0.013	0.0768	0.0886
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0333	0.2271	0.9738
Schistosoma mansoni	caspase-7 (C14 family)	0.0199	0.1283	0.1283
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0033	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0139	0.0139
Entamoeba histolytica	glucosamine-6-phosphate isomerase, putative	0.0042	0.012	0.0139
Echinococcus granulosus	mothers against decapentaplegic 5	0.0033	0.0051	0.0059
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0124	0.0724	0.0611
Brugia malayi	MH1 domain containing protein	0.0033	0.0051	0.0051
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.013	0.0768	0.028
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0053	0.0205	0.0205
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0019	0.0019
Mycobacterium tuberculosis	Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)	0.0339	0.2313	1
Brugia malayi	6-phosphogluconolactonase family protein	0.0042	0.012	0.012
Brugia malayi	Hexokinase family protein	0.12	0.8673	0.8673
Schistosoma mansoni	caspase-3 (C14 family)	0.0199	0.1283	0.1283
Trypanosoma cruzi	glucosamine-6-phosphate isomerase, putative	0.0042	0.012	0.0139
Mycobacterium ulcerans	glutaminase	0.138	1	1
Leishmania major	metacaspase, putative	0.0053	0.0205	0.0236
Brugia malayi	hypothetical protein	0.0044	0.0139	0.0139
Plasmodium vivax	hexokinase, putative	0.12	0.8673	1
Echinococcus granulosus	hexokinase	0.12	0.8673	1
Plasmodium vivax	hypothetical protein, conserved	0.0053	0.0205	0.0236
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0477	0.3332	0.3842
Onchocerca volvulus		0.0064	0.028	0.0162
Echinococcus granulosus	hexokinase	0.12	0.8673	1
Echinococcus granulosus	aryl hydrocarbon receptor	0.0064	0.0282	0.0325
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0166	0.0191
Echinococcus multilocularis	caspase 8	0.0053	0.0205	0.0236
Echinococcus granulosus	glucose 6 phosphate 1 dehydrogenase	0.0977	0.7024	0.81
Plasmodium vivax	metacaspase 1, putative	0.0053	0.0205	0.0236
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0124	0.0724	0.0724
Trypanosoma brucei	hexokinase, putative	0.12	0.8673	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0166	0.0166
Trypanosoma cruzi	polo-like protein kinase, putative	0.0477	0.3332	0.3842
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0019	0.0019
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0053	0.0205	0.0236
Loa Loa (eye worm)	hexokinase	0.12	0.8673	0.8673
Echinococcus multilocularis	smad	0.0033	0.0051	0.0059
Brugia malayi	serine/threonine-protein kinase plk-2	0.0477	0.3332	0.3332
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.027	0.1806	0.6808
Brugia malayi	hexokinase type II	0.0382	0.2628	0.2628
Giardia lamblia	Glucosamine-6-phosphate deaminase	0.0042	0.012	0.0164
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0268	0.0268
Entamoeba histolytica	hypothetical protein	0.0072	0.0344	0.0396
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0068	0.0078
Trichomonas vaginalis	CAMK family protein kinase	0.0477	0.3332	0.3332
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0045	0.0141	0.0141
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0324	0.2201	0.2538
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.018	0.1142	0.1142
Trypanosoma brucei	hexokinase	0.12	0.8673	1
Trypanosoma brucei	hypothetical protein, conserved	0.1074	0.774	0.8925
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0199	0.1283	0.148
Echinococcus granulosus	caspase 3	0.0146	0.089	0.1026
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0036	0.0041
Plasmodium falciparum	hexokinase	0.12	0.8673	1
Trichomonas vaginalis	CAMK family protein kinase	0.0477	0.3332	0.3332
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0068	0.0078
Trichomonas vaginalis	CAMK family protein kinase	0.0477	0.3332	0.3332
Onchocerca volvulus	Hexokinase homolog	0.0753	0.537	0.6129
Echinococcus multilocularis	muscleblind protein 1	0.018	0.1142	0.1317
Schistosoma mansoni	smad	0.0033	0.0051	0.0051
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0255	0.0255
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0053	0.0205	0.0205
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0268	0.0268
Brugia malayi	MH1 domain containing protein	0.0033	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0205	0.0205
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0268	0.0268
Trichomonas vaginalis	glutaminase, putative	0.138	1	1
Mycobacterium ulcerans	lipoprotein LpqF	0.013	0.0768	0.0656
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0268	0.0309
Loa Loa (eye worm)	hypothetical protein	0.006	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0667	0.4733	0.4733
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0386	0.266	0.266

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of human recombinant MAOA expressed in BTI-TN-5B1-4 cells using p-tyramine substrate assessed as reduction in H2O2 production	ChEMBL.	25532905
IC50 (binding)	= 4.1 nM	Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells using p-tyramine substrate assessed as reduction in H2O2 production	ChEMBL.	25532905
Inhibition (binding)		Inhibition of human recombinant MAOA expressed in BTI-TN-5B1-4 cells using p-tyramine substrate assessed as reduction in H2O2 production at 100 uM	ChEMBL.	25532905

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3360735

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 950615