Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0038 | 0.0038 |
Onchocerca volvulus | 0.0445 | 0.1639 | 1 | |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.0038 | 1 |
Echinococcus granulosus | neuroligin | 0.0445 | 0.1639 | 0.1639 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0445 | 0.1639 | 0.1639 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0038 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0163 | 0.0561 | 0.0561 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.029 | 0.1047 | 0.1047 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.0258 | 0.0258 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1639 | 0.1639 |
Onchocerca volvulus | 0.0445 | 0.1639 | 1 | |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | acetyltransferase | 0.0163 | 0.0561 | 0.0561 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0048 | 0.0122 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0445 | 0.1639 | 0.1639 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2634 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.0451 | 0.0451 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0038 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0445 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1639 | 0.1639 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0445 | 0.1639 | 0.1639 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0355 | 0.1297 | 0.1297 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.0451 | 0.0451 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0163 | 0.0561 | 0.0561 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0044 | 0.0107 | 0.5 |
Schistosoma mansoni | serine-rich repeat protein | 0.0083 | 0.0258 | 0.0258 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.02 | 0.0705 | 0.3843 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.019 | 0.0666 | 0.3585 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0445 | 0.1639 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0044 | 0.0107 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0048 | 0.0122 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0445 | 0.1639 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.029 | 0.1047 | 0.1047 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0445 | 0.1639 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2634 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0445 | 0.1639 | 0.1639 |
Echinococcus multilocularis | acetylcholinesterase | 0.2634 | 1 | 1 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0078 | 0.0238 | 0.0238 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0445 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.2634 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0038 | 0.0038 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.0164 | 0.0164 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0445 | 0.1639 | 0.1639 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0445 | 0.1639 | 0.1639 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.029 | 0.1047 | 0.6095 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.019 | 0.0666 | 0.3585 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.029 | 0.1047 | 0.6095 |
Schistosoma mansoni | acetylcholinesterase | 0.0445 | 0.1639 | 0.1639 |
Onchocerca volvulus | 0.0445 | 0.1639 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2634 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0445 | 0.1639 | 1 |
Onchocerca volvulus | 0.0445 | 0.1639 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.2634 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0038 | 0.0038 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0162 | 0.0557 | 0.0557 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0445 | 0.1639 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1639 | 0.1639 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0445 | 0.1639 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.029 | 0.1047 | 0.6095 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0158 | 0.0543 | 0.0543 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.029 | 0.1047 | 0.6095 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0162 | 0.0557 | 0.0557 |
Brugia malayi | Carboxylesterase family protein | 0.0445 | 0.1639 | 0.1639 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0445 | 0.1639 | 0.1639 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0155 | 0.0532 | 0.0532 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0038 | 0.0038 |
Onchocerca volvulus | 0.0445 | 0.1639 | 1 | |
Echinococcus granulosus | neuropeptide s receptor | 0.0519 | 0.1922 | 0.1922 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0519 | 0.1922 | 0.1922 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.029 | 0.1047 | 0.6095 |
Brugia malayi | Carboxylesterase family protein | 0.0445 | 0.1639 | 0.1639 |
Schistosoma mansoni | gliotactin | 0.0445 | 0.1639 | 0.1639 |
Trypanosoma brucei | cytochrome P450, putative | 0.0026 | 0.0038 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0048 | 0.0122 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.019 | 0.0666 | 0.3585 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.02 | 0.0705 | 0.3843 |
Echinococcus granulosus | carboxylesterase 5A | 0.2634 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2634 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.019 | 0.0666 | 0.3585 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.019 | 0.0666 | 0.3585 |
Loa Loa (eye worm) | carboxylesterase | 0.0445 | 0.1639 | 0.1639 |
Brugia malayi | Carboxylesterase family protein | 0.0445 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | carboxylesterase | 0.2634 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.019 | 0.0666 | 0.3585 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0445 | 0.1639 | 0.1639 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.0038 | 0.0229 |
Echinococcus multilocularis | acetylcholinesterase | 0.2634 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1639 | 0.1639 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0355 | 0.1297 | 0.1297 |
Loa Loa (eye worm) | hypothetical protein | 0.2634 | 1 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0519 | 0.1922 | 0.1922 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.0451 | 0.0451 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.019 | 0.0666 | 0.3585 |
Brugia malayi | Carboxylesterase family protein | 0.2634 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1639 | 0.1639 |
Brugia malayi | Cache domain containing protein | 0.0072 | 0.0213 | 0.0213 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0445 | 0.1639 | 0.1639 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0445 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.0164 | 0.0164 |
Mycobacterium leprae | putative cytochrome p450 | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.029 | 0.1047 | 0.6095 |
Echinococcus multilocularis | neuroligin | 0.0445 | 0.1639 | 0.1639 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0048 | 0.0122 | 0.0122 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0.0107 | 0.5 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0519 | 0.1922 | 0.1922 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0445 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | carboxylesterase | 0.0445 | 0.1639 | 0.1639 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0163 | 0.0561 | 0.0561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.