Detailed information for compound 950773

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 433.521 | Formula: C25H28FN5O
  • H donors: 3 H acceptors: 3 LogP: 4.44 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)[C@@H]1CC[C@H](CC1)CNc1nc(NCc2ccc(cc2)F)cc(n1)c1ccccc1
  • InChi: 1S/C25H28FN5O/c26-21-12-8-18(9-13-21)15-28-23-14-22(19-4-2-1-3-5-19)30-25(31-23)29-16-17-6-10-20(11-7-17)24(27)32/h1-5,8-9,12-14,17,20H,6-7,10-11,15-16H2,(H2,27,32)(H2,28,29,30,31)/t17-,20-
  • InChiKey: LKHKBJHWEMTQCY-IRJFHVNHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens valosin containing protein Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126926 All targets in OG5_126926
Trypanosoma congolense Valosin-containing protein, putative Get druggable targets OG5_126926 All targets in OG5_126926
Plasmodium berghei cell division cycle protein 48 homologue, putative Get druggable targets OG5_126926 All targets in OG5_126926
Mycobacterium ulcerans ATPase Get druggable targets OG5_126926 All targets in OG5_126926
Cryptosporidium parvum CDC48 like AAA ATPase ortholog Get druggable targets OG5_126926 All targets in OG5_126926
Trypanosoma brucei gambiense valosin-containing protein homolog,Transitional endoplasmic reticulum ATPase, putative Get druggable targets OG5_126926 All targets in OG5_126926
Plasmodium vivax cell division cycle protein 48 homologue, putative Get druggable targets OG5_126926 All targets in OG5_126926
Entamoeba histolytica cdc48-like protein, putative Get druggable targets OG5_126926 All targets in OG5_126926
Plasmodium knowlesi cell division cycle protein 48 homologue, putative Get druggable targets OG5_126926 All targets in OG5_126926
Leishmania braziliensis Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog Get druggable targets OG5_126926 All targets in OG5_126926
Babesia bovis cell division control protein 48, putative Get druggable targets OG5_126926 All targets in OG5_126926
Cryptosporidium hominis cell division cycle protein 48 Get druggable targets OG5_126926 All targets in OG5_126926
Echinococcus multilocularis transitional endoplasmic reticulum atpase Get druggable targets OG5_126926 All targets in OG5_126926
Trypanosoma cruzi Valosin-containing protein, putative Get druggable targets OG5_126926 All targets in OG5_126926
Candida albicans microsomal protein of CDC48 family of ATPases Get druggable targets OG5_126926 All targets in OG5_126926
Schistosoma mansoni cell division control protein 48 aaa family protein Get druggable targets OG5_126926 All targets in OG5_126926
Echinococcus granulosus transitional endoplasmic reticulum atpase Get druggable targets OG5_126926 All targets in OG5_126926
Plasmodium yoelii cell division cycle protein 48 homolog Get druggable targets OG5_126926 All targets in OG5_126926
Leishmania donovani Valosin-containing protein, putative Get druggable targets OG5_126926 All targets in OG5_126926
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog Get druggable targets OG5_126926 All targets in OG5_126926
Schistosoma japonicum ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative Get druggable targets OG5_126926 All targets in OG5_126926
Leishmania mexicana Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog Get druggable targets OG5_126926 All targets in OG5_126926
Candida albicans microsomal protein of CDC48 family of ATPases Get druggable targets OG5_126926 All targets in OG5_126926
Theileria parva cell division cycle protein 48, putative Get druggable targets OG5_126926 All targets in OG5_126926
Trypanosoma brucei Valosin-containing protein Get druggable targets OG5_126926 All targets in OG5_126926
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative Get druggable targets OG5_126926 All targets in OG5_126926
Schistosoma mansoni cell division control protein 48 aaa family protein Get druggable targets OG5_126926 All targets in OG5_126926
Schistosoma japonicum Transitional endoplasmic reticulum ATPase homolog 2, putative Get druggable targets OG5_126926 All targets in OG5_126926
Toxoplasma gondii cell division protein CDC48CY Get druggable targets OG5_126926 All targets in OG5_126926
Plasmodium falciparum cell division cycle protein 48 homologue, putative Get druggable targets OG5_126926 All targets in OG5_126926
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog Get druggable targets OG5_126926 All targets in OG5_126926
Mycobacterium tuberculosis Putative conserved ATPase Get druggable targets OG5_126926 All targets in OG5_126926
Plasmodium vivax cell division cycle ATPase, putative Get druggable targets OG5_126926 All targets in OG5_126926
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative Get druggable targets OG5_126926 All targets in OG5_126926
Neospora caninum hypothetical protein Get druggable targets OG5_126926 All targets in OG5_126926
Trichomonas vaginalis spermatogenesis associated factor, putative Get druggable targets OG5_126926 All targets in OG5_126926
Giardia lamblia AAA family ATPase Get druggable targets OG5_126926 All targets in OG5_126926
Leishmania infantum Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog Get druggable targets OG5_126926 All targets in OG5_126926
Schistosoma mansoni cell division control protein 48 aaa family protein Get druggable targets OG5_126926 All targets in OG5_126926
Toxoplasma gondii cell division protein CDC48AP Get druggable targets OG5_126926 All targets in OG5_126926
Babesia bovis cell division cycle protein ATPase, putative Get druggable targets OG5_126926 All targets in OG5_126926
Loa Loa (eye worm) VCP protein Get druggable targets OG5_126926 All targets in OG5_126926
Theileria parva cell division cycle protein 48, putative Get druggable targets OG5_126926 All targets in OG5_126926
Echinococcus multilocularis transitional endoplasmic reticulum atpase Get druggable targets OG5_126926 All targets in OG5_126926
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative Get druggable targets OG5_126926 All targets in OG5_126926
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Echinococcus granulosus thyroid hormone receptor alpha 0.0053 0.2661 0.2847
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.05 0.3301
Brugia malayi hypothetical protein 0.0053 0.2661 0.2847
Mycobacterium tuberculosis Putative conserved ATPase 0.002 0.0527 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0053 0.2661 0.3575
Loa Loa (eye worm) hypothetical protein 0.0059 0.3077 0.33
Brugia malayi nuclear receptor NHR-88 0.0053 0.2661 0.2847
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.05 0.0477
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0053 0.2661 0.2837
Brugia malayi Nuclear hormone receptor-like 1 0.0113 0.6545 0.7168
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0113 0.6545 0.7168
Brugia malayi ecdysteroid receptor 0.0113 0.6545 0.7168
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.003 0.1151 0.1155
Loa Loa (eye worm) vesicle-fusing ATPase 0.002 0.05 0.0429
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.002 0.05 0.0443
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0113 0.6545 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0113 0.6545 0.7168
Loa Loa (eye worm) hypothetical protein 0.0113 0.6545 0.7164
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.002 0.05 0.3824
Schistosoma mansoni retinoic acid receptor RXR 0.0113 0.6545 0.651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0113 0.6545 0.7164
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.05 0.0443
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.05 0.0402
Loa Loa (eye worm) hypothetical protein 0.0059 0.3077 0.33
Loa Loa (eye worm) hypothetical protein 0.0132 0.7784 0.8544
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0044 0.206 0.2179
Echinococcus granulosus voltage gated potassium channel 0.0044 0.206 0.2179
Schistosoma mansoni nuclear receptor 0.0053 0.2661 0.2585
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.1151 0.1167
Brugia malayi Cyclic-nucleotide gated cation channel 0.003 0.1151 0.1167
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.05 0.3301
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0113 0.6545 0.651
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.002 0.05 0.0429
Loa Loa (eye worm) hypothetical protein 0.0044 0.206 0.2168
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.002 0.05 0.0402
Toxoplasma gondii cell division protein CDC48AP 0.002 0.0527 0.0294
Echinococcus multilocularis cGMP dependent protein kinase 1 0.002 0.05 0.0429
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0113 0.6545 0.651
Loa Loa (eye worm) DR-78 0.0053 0.2661 0.2837
Echinococcus multilocularis thyroid hormone receptor alpha 0.0113 0.6545 0.7164
Brugia malayi nuclear receptor NHR-67 0.0053 0.2661 0.2847
Loa Loa (eye worm) nuclear receptor NHR-67 0.0053 0.2661 0.2837
Loa Loa (eye worm) hypothetical protein 0.0113 0.6545 0.7164
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0113 0.6545 0.7168
Schistosoma mansoni serine/threonine protein kinase 0.002 0.05 0.0402
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0059 0.3077 0.3006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0152 0.9091 1
Mycobacterium leprae Conserved hypothetical protein 0.002 0.05 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0113 0.6545 0.7168
Loa Loa (eye worm) hypothetical protein 0.0113 0.6545 0.7164
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.6545 0.7168
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.1151 0.106
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.2661 0.2837
Echinococcus multilocularis cGMP dependent protein kinase 1 0.002 0.05 0.0429
Echinococcus multilocularis FTZ F1 alpha 0.0113 0.6545 0.7164
Treponema pallidum catabolite gene activator 0.002 0.05 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0113 0.6545 0.651
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.002 0.05 0.3824
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.206 0.2179
Loa Loa (eye worm) hypothetical protein 0.003 0.1151 0.1155
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0113 0.6545 0.7164
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.002 0.05 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0113 0.6545 0.7168
Brugia malayi valosin containing protein 0.002 0.05 0.0443
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.002 0.05 0.0443
Loa Loa (eye worm) steroid hormone receptor 0.0113 0.6545 0.7164
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.2661 0.2837
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0053 0.2661 0.3575
Schistosoma mansoni serine/threonine protein kinase 0.002 0.05 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0113 0.6545 0.7168
Loa Loa (eye worm) hypothetical protein 0.0059 0.3077 0.33
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.1151 0.1258
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.2661 0.2847
Onchocerca volvulus 0.0053 0.2661 0.3575
Echinococcus multilocularis patatin phospholipase domain containing protein 0.002 0.05 0.0429
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.05 0.0402
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0113 0.6545 0.7164
Schistosoma mansoni nuclear hormone receptor 0.0053 0.2661 0.2585
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.002 0.0527 0.0294
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.2661 0.2837
Trypanosoma brucei cAMP binding protein, putative 0.002 0.05 0.3301
Echinococcus multilocularis ecdysone induced protein 78C 0.0113 0.6545 0.7164
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0152 0.9091 1
Schistosoma mansoni RAR-like nuclear receptor 0.0113 0.6545 0.651
Loa Loa (eye worm) hypothetical protein 0.0113 0.6545 0.7164
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0034 0.1422 0.1469
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0753 0.0658
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.05 0.0402
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0053 0.2661 0.2585
Echinococcus multilocularis nuclear receptor nhr 48 0.0053 0.2661 0.2837
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.6545 0.7168
Echinococcus granulosus patatin phospholipase domain containing protein 0.002 0.05 0.0443
Loa Loa (eye worm) hypothetical protein 0.0113 0.6545 0.7164
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0032 0.1307 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0113 0.6545 0.7164
Echinococcus multilocularis voltage gated potassium channel 0.0044 0.206 0.2168
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.002 0.05 0.0429
Brugia malayi nuclear receptor NHR-88 0.0113 0.6545 0.7168
Brugia malayi Nuclear hormone receptor E75 0.0053 0.2661 0.2847
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.6545 0.7168
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.002 0.05 0.0443
Schistosoma mansoni 60S ribosomal protein L21 0.0024 0.0753 0.0658
Schistosoma mansoni nuclear hormone receptor 0.0113 0.6545 0.651
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.05 0.0477
Brugia malayi nuclear receptor RXR 0.0059 0.3077 0.331
Trypanosoma brucei Flagellar Member 6 0.002 0.05 0.3301
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0113 0.6545 0.7168
Brugia malayi Nuclear hormone receptor E75 0.0053 0.2661 0.2847
Trypanosoma brucei Valosin-containing protein 0.0032 0.1307 1
Loa Loa (eye worm) hypothetical protein 0.002 0.05 0.0429
Echinococcus granulosus cGMP dependent protein kinase 0.002 0.05 0.0443
Mycobacterium ulcerans ATPase 0.002 0.0527 1
Schistosoma mansoni coup transcription factor 0.0113 0.6545 0.651
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.1151 0.1258
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.1151 0.106
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0053 0.2661 0.2837
Brugia malayi steroid hormone receptor 0.0113 0.6545 0.7168
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.003 0.1151 0.1155
Brugia malayi photoreceptor-specific nuclear receptor 0.0113 0.6545 0.7168
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0032 0.1307 0.5
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0034 0.1422 0.1526
Loa Loa (eye worm) AGC/PKG protein kinase 0.002 0.05 0.0429
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0113 0.6545 0.7164
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.05 0.0429
Brugia malayi hypothetical protein 0.0053 0.2661 0.2847
Loa Loa (eye worm) hypothetical protein 0.0113 0.6545 0.7164
Loa Loa (eye worm) hypothetical protein 0.002 0.05 0.0429
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.05 0.0429
Loa Loa (eye worm) hypothetical protein 0.002 0.05 0.0429
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.206 0.1979
Loa Loa (eye worm) hypothetical protein 0.0059 0.3077 0.33
Onchocerca volvulus 0.0053 0.2661 0.3575
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Echinococcus granulosus cGMP dependent protein kinase 1 0.002 0.05 0.0443
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.6545 0.7168
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0113 0.6545 0.7168
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.05 0.0402
Loa Loa (eye worm) hypothetical protein 0.0059 0.3077 0.33
Brugia malayi vesicle-fusing ATPase 0.002 0.05 0.0443
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0152 0.9091 1
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.002 0.05 0.0443
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0059 0.3077 0.33
Echinococcus granulosus FTZ F1 alpha 0.0113 0.6545 0.7168
Schistosoma mansoni nuclear hormone receptor 0.0053 0.2661 0.2585
Schistosoma mansoni thyroid hormone receptor 0.0113 0.6545 0.651
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.05 0.0402
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0113 0.6545 0.7164
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0032 0.1307 1
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.002 0.05 0.0402
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0113 0.6545 0.7168
Schistosoma mansoni similar to Protein C20orf152 homolog 0.002 0.05 0.0402
Trypanosoma brucei protein kinase A regulatory subunit 0.002 0.05 0.3301
Echinococcus granulosus ecdysone induced protein 78C 0.0113 0.6545 0.7168
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.206 0.2168
Brugia malayi hypothetical protein 0.0059 0.3077 0.331
Trichomonas vaginalis conserved hypothetical protein 0.002 0.05 0.0477
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.1151 0.106
Onchocerca volvulus Bile acid receptor homolog 0.0113 0.6545 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0113 0.6545 0.7164
Onchocerca volvulus 0.0113 0.6545 1
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.002 0.05 0.0402
Brugia malayi Steroid receptor seven-up type 2 0.0113 0.6545 0.7168
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0142 0.8439 1
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0014 0.0115 0.0013
Loa Loa (eye worm) hypothetical protein 0.0113 0.6545 0.7164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.6545 0.7168
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Toxoplasma gondii cell division protein CDC48CY 0.0034 0.1422 1
Schistosoma mansoni hypothetical protein 0.002 0.05 0.0402
Schistosoma mansoni thyroid hormone receptor 0.0113 0.6545 0.651
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.1151 0.1167
Brugia malayi ecdysone receptor 0.0053 0.2661 0.2847
Brugia malayi orphan nuclear receptor NR2E1 0.0053 0.2661 0.2847
Treponema pallidum catabolite gene activator (Crp) 0.002 0.05 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0059 0.3077 0.33
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0032 0.1307 0.1218
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.05 0.0402
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0113 0.6545 0.7164
Schistosoma mansoni voltage-gated potassium channel 0.003 0.1151 0.106
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Loa Loa (eye worm) nuclear hormone receptor 0.0053 0.2661 0.2837
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0113 0.6545 0.651
Brugia malayi nuclear hormone receptor family member nhr-6 0.0053 0.2661 0.2847
Treponema pallidum cyclic nucleotide binding protein 0.002 0.05 0.5
Brugia malayi N-terminal motif family protein 0.002 0.05 0.0443
Schistosoma mansoni zinc finger protein 0.0053 0.2661 0.2585
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.002 0.05 0.0477
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.1151 0.1167
Schistosoma mansoni nuclear receptor nhr-48 0.0053 0.2661 0.2585
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0113 0.6545 0.7168
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.002 0.05 0.0477
Giardia lamblia AAA family ATPase 0.002 0.0527 1
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.002 0.05 0.0443
Echinococcus granulosus nuclear receptor nhr 48 0.0053 0.2661 0.2847
Schistosoma mansoni voltage-gated potassium channel 0.0165 1 1
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.002 0.05 0.0402
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.1151 0.1155
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.1151 0.1167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.6545 0.7164
Schistosoma mansoni serine/threonine protein kinase 0.002 0.05 0.0402
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.002 0.05 0.0443
Echinococcus granulosus cGMP dependent protein kinase 1 0.002 0.05 0.0443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0113 0.6545 0.7164
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.1151 0.1155
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.2661 0.2847
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0032 0.1307 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0053 0.2661 0.2847
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.002 0.05 0.0429
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.6545 0.7168
Onchocerca volvulus Protein ultraspiracle homolog 0.0113 0.6545 1
Brugia malayi nuclear hormone receptor 0.0053 0.2661 0.2847
Brugia malayi Nuclear hormone receptor-like 1 0.0059 0.3077 0.331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0113 0.6545 0.7164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0113 0.6545 0.7164
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0053 0.2661 0.2585
Trypanosoma brucei cAMP response protein 1, putative 0.002 0.05 0.3301
Loa Loa (eye worm) hypothetical protein 0.0053 0.2661 0.2837
Treponema pallidum cyclic nucleotide binding protein 0.002 0.05 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0113 0.6545 0.651
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0053 0.2661 0.2847
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0053 0.2661 0.2837
Schistosoma mansoni nuclear receptor 0.0053 0.2661 0.2585
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0014 0.0115 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.6545 0.7168
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0059 0.3077 0.331
Brugia malayi hypothetical protein 0.0059 0.3077 0.331
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.1151 0.1155
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0034 0.1422 0.1457
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.1151 0.1155
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.003 0.1151 0.1167
Brugia malayi nuclear hormone receptor 0.0113 0.6545 0.7168
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.003 0.1151 0.1155
Entamoeba histolytica cdc48-like protein, putative 0.0032 0.1307 0.5
Trypanosoma cruzi Valosin-containing protein, putative 0.0032 0.1307 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0152 0.9091 1
Brugia malayi nuclear receptor RXR 0.0053 0.2661 0.2847
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0059 0.3077 0.3006
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0034 0.1422 0.1334
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0113 0.6545 0.7168
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.1151 0.106
Schistosoma mansoni steroid hormone receptor ad4bp 0.0113 0.6545 0.651
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0113 0.6545 0.651
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.206 0.1979
Echinococcus multilocularis expressed conserved protein 0.002 0.05 0.0429
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.6545 0.7164
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0142 0.8439 1
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.002 0.05 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.6545 0.7168
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.1151 0.106
Brugia malayi tailless protein 0.0053 0.2661 0.2847
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0113 0.6545 0.7168
Brugia malayi Egg laying defective protein 4 0.002 0.05 0.0443
Loa Loa (eye worm) hypothetical protein 0.0113 0.6545 0.7164
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.003 0.1151 0.1167
Brugia malayi conserved hypotetical protein 0.0053 0.2661 0.2847
Brugia malayi Nuclear hormone receptor-like 1 0.0059 0.3077 0.331
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0053 0.2661 0.2847
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.2661 0.2847
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0034 0.1422 0.1583
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.002 0.05 0.0402

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.433 uM Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP formation by NADH coupled assay ChEMBL. 25474526

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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