TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.304 | Formula: C17H14N2O4
H donors: 4 H acceptors: 4 LogP: 2.25 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC(=O)c2c(/C/1=C/NCc1ccc(c(c1)O)O)cccc2
InChi: 1S/C17H14N2O4/c20-14-6-5-10(7-15(14)21)8-18-9-13-11-3-1-2-4-12(11)16(22)19-17(13)23/h1-7,9,18,20-21H,8H2,(H,19,22,23)/b13-9-
InChiKey: IZEARPXQOBMDEK-LCYFTJDESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin D1		References
Homo sapiens	cyclin-dependent kinase 3	Starlite/ChEMBL	References
Homo sapiens	cyclin-dependent kinase 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium parvum	Cdc2-like CDK2/CDC28 like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cell division protein kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Theileria parva	cell division control protein 2 related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium hominis	cdc2-like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Neospora caninum	CMGC kinase, CDK family TgPK2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium berghei	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02087 cyclin-dependent kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02090 cyclin-dependent kinase 5, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium knowlesi	Cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium vivax	protein kinase Crk2	Get druggable targets OG5_126712	All targets in OG5_126712
Babesia bovis	cell division control protein 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium falciparum	protein kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium yoelii	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division related protein kinase 2, putative,CDC2-related protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	cyclin-dependent kinase 3	305 aa	303 aa	32.0 %
Trypanosoma brucei	mitogen-activated protein kinase 5	cyclin-dependent kinase 4	303 aa	312 aa	29.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0501	0.0495
Echinococcus multilocularis	smad	0.0179	0.0569	0.1374
Brugia malayi	MH2 domain containing protein	0.0179	0.0569	0.0563
Echinococcus multilocularis	segment polarity protein dishevelled	0.0046	0.0057	0.0124
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0047	0.0061	0.0568
Echinococcus multilocularis	mothers against decapentaplegic 6	0.008	0.0188	0.0444
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0072	0.0159	0.0372
Brugia malayi	RNA binding protein	0.0868	0.322	0.3216
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0047	0.0061	0.0096
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.016	0.0376
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.1098	0.4105	0.4102
Brugia malayi	RNA recognition motif domain containing protein	0.0868	0.322	0.3216
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0072	0.0675
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.024	0.0803	1
Schistosoma mansoni	hypothetical protein	0.0072	0.0159	0.025
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0084	0.0132
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1098	0.4105	0.6462
Echinococcus multilocularis	dna polymerase eta	0.0048	0.0065	0.0143
Onchocerca volvulus		0.0472	0.1696	0.4863
Loa Loa (eye worm)	MH2 domain-containing protein	0.008	0.0188	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0078	0.0072
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0047	0.0061	0.0096
Brugia malayi	isocitrate dehydrogenase	0.024	0.0803	0.0798
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.2461	0.935	0.9349
Trypanosoma cruzi	cdc2-related kinase 3	0.0053	0.0084	0.0972
Echinococcus granulosus	cyclin dependent kinase	0.0053	0.0084	0.0189
Echinococcus multilocularis	regulator of G protein signaling 7	0.0046	0.0057	0.0124
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0053	0.0084	0.0078
Echinococcus multilocularis	cyclin dependent kinase 1	0.0053	0.0084	0.0189
Brugia malayi	MH1 domain containing protein	0.0179	0.0569	0.0563
Brugia malayi	Calcitonin receptor-like protein seb-1	0.2461	0.935	0.9349
Brugia malayi	serine/threonine-protein kinase plk-2	0.01	0.0263	0.0257
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0053	0.0084	0.0931
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0084	0.0799
Echinococcus granulosus	cyclin dependent kinase 1	0.0053	0.0084	0.0189
Echinococcus multilocularis	isocitrate dehydrogenase	0.024	0.0803	0.1945
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0047	0.0061	0.0096
Leishmania major	hypothetical protein, conserved	0.0162	0.0501	0.6194
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0047	0.0061	0.0055
Echinococcus granulosus	tar DNA binding protein	0.0868	0.322	0.7841
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0263	0.2647
Brugia malayi	Latrophilin receptor protein 2	0.0779	0.2876	0.2872
Onchocerca volvulus		0.0046	0.0057	0.0146
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.024	0.0803	0.1945
Schistosoma mansoni	smad1 5 8 and	0.0179	0.0569	0.0896
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.024	0.0803	1
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.024	0.0803	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0046	0.0057	0.0124
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0046	0.0057	0.0146
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.0263	0.3222
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0263	0.2647
Trypanosoma brucei	polo-like protein kinase	0.01	0.0263	0.2683
Schistosoma mansoni	tar DNA-binding protein	0.0868	0.322	0.5069
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0047	0.0061	0.0055
Plasmodium vivax	ataxin-2 like protein, putative	0.0162	0.0501	0.5804
Entamoeba histolytica	cell division protein kinase 2, putative	0.0053	0.0084	0.3017
Loa Loa (eye worm)	nuclear factor I	0.0099	0.0261	0.0255
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.024	0.0803	0.1264
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.024	0.0803	0.1945
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0033	0.0006	0.001
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0046	0.0057	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0061	0.0055
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0047	0.0061	0.0055
Trypanosoma cruzi	cdc2-related kinase 3	0.0053	0.0084	0.0972
Schistosoma mansoni	tar DNA-binding protein	0.0868	0.322	0.5069
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0053	0.0084	0.0931
Brugia malayi	hypothetical protein	0.0104	0.0281	0.0275
Brugia malayi	Protein kinase domain containing protein	0.0053	0.0084	0.0078
Loa Loa (eye worm)	TAR-binding protein	0.0868	0.322	0.3216
Schistosoma mansoni	regulator of G protein signaling	0.0046	0.0057	0.009
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.0263	0.3222
Trypanosoma brucei	cdc2-related kinase 1	0.0053	0.0084	0.0255
Plasmodium falciparum	ataxin-2 like protein, putative	0.0162	0.0501	0.5804
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0047	0.0061	0.0096
Trypanosoma cruzi	DNA polymerase eta, putative	0.0034	0.001	0.0046
Brugia malayi	MH2 domain containing protein	0.008	0.0188	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0061	0.0055
Giardia lamblia	Kinase, PLK	0.01	0.0263	1
Schistosoma mansoni	DNA polymerase eta	0.0048	0.0065	0.0102
Loa Loa (eye worm)	transcription factor SMAD2	0.263	1	1
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0047	0.0061	0.0134
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0047	0.0061	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0936	0.3482	0.3478
Schistosoma mansoni	tar DNA-binding protein	0.0868	0.322	0.5069
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0263	0.0414
Trypanosoma cruzi	PAB1-binding protein , putative	0.0162	0.0501	0.6212
Onchocerca volvulus	Serine\/threonine kinase homolog	0.01	0.0263	0.0739
Schistosoma mansoni	kinase	0.0051	0.0077	0.0121
Brugia malayi	N-terminal motif family protein	0.0936	0.3482	0.3478
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0033	0.0006	0.001
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0061	0.0055
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0047	0.0061	0.0096
Brugia malayi	DIX domain containing protein	0.0046	0.0057	0.0051
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0047	0.0061	0.0096
Echinococcus granulosus	mothers against decapentaplegic 6	0.008	0.0188	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0261	0.0255
Brugia malayi	Smad1	0.0179	0.0569	0.0563
Echinococcus granulosus	cyclin dependent kinase 5	0.0053	0.0084	0.0189
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1098	0.4105	0.6462
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0084	0.0799
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0047	0.0061	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0057	0.0051
Brugia malayi	MH2 domain containing protein	0.0179	0.0569	0.0563
Schistosoma mansoni	hypothetical protein	0.0342	0.1196	0.1882
Echinococcus multilocularis	segment polarity protein dishevelled	0.0046	0.0057	0.0124
Brugia malayi	latrophilin 2 splice variant baaae	0.1682	0.6353	0.6351
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0936	0.3482	1
Onchocerca volvulus		0.0047	0.0061	0.0159
Brugia malayi	hypothetical protein	0.0046	0.0057	0.0051
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0072	0.0159	0.0372
Loa Loa (eye worm)	hypothetical protein	0.008	0.0188	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1696	0.1691
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0047	0.0061	0.0096
Echinococcus granulosus	Smad4	0.0179	0.0569	0.1374
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.016	0.0252
Loa Loa (eye worm)	G protein alpha subunit 3	0.0047	0.0061	0.0055
Mycobacterium ulcerans	glutaminase	0.0285	0.0976	0.5
Loa Loa (eye worm)	hypothetical protein	0.1682	0.6353	0.6351
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.024	0.0803	0.5
Trypanosoma cruzi	cdc2-related kinase 1	0.0053	0.0084	0.0972
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0084	0.0799
Loa Loa (eye worm)	DIX domain-containing protein	0.0046	0.0057	0.0051
Loa Loa (eye worm)	RNA binding protein	0.0868	0.322	0.3216
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0047	0.0061	0.0055
Echinococcus multilocularis	geminin	0.0342	0.1196	0.2903
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0047	0.0061	0.0055
Entamoeba histolytica	serine/threonine protein kinase, putative	0.01	0.0263	1
Echinococcus multilocularis	GPCR, family 2	0.0779	0.2876	0.7001
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0047	0.0061	0.0568
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0868	0.322	0.3216
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.01	0.0263	0.0627
Brugia malayi	hypothetical protein	0.0472	0.1696	0.1691
Echinococcus multilocularis	regulator of G protein signaling 7	0.0046	0.0057	0.0124
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0047	0.0061	0.0055
Schistosoma mansoni	smad	0.0179	0.0569	0.0896
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0047	0.0061	0.0096
Toxoplasma gondii	isocitrate dehydrogenase	0.024	0.0803	1
Echinococcus granulosus	GPCR family 2	0.0779	0.2876	0.7001
Echinococcus granulosus	segment polarity protein dishevelled	0.0046	0.0057	0.0124
Loa Loa (eye worm)	MH1 domain-containing protein	0.0179	0.0569	0.0563
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0179	0.0569	0.1374
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0047	0.0061	0.0568
Loa Loa (eye worm)	hypothetical protein	0.2461	0.935	0.9349
Echinococcus multilocularis	expressed protein	0.0047	0.0061	0.0134
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0047	0.0061	0.0096
Echinococcus granulosus	mothers against decapentaplegic 2	0.008	0.0188	0.0444
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0779	0.2876	0.7001
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0047	0.0061	0.0134
Schistosoma mansoni	hypothetical protein	0.0779	0.2876	0.4527
Schistosoma mansoni	ras GTP exchange factor	0.0033	0.0006	0.001
Brugia malayi	MH1 domain containing protein	0.0179	0.0569	0.0563
Echinococcus granulosus	mothers against decapentaplegic 5	0.0179	0.0569	0.1374
Schistosoma mansoni	Smad4	0.0179	0.0569	0.0896
Entamoeba histolytica	hypothetical protein	0.0073	0.016	0.6006
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0047	0.0061	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0065	0.0059
Entamoeba histolytica	cell division protein kinase 2, putative	0.0053	0.0084	0.3017
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.024	0.0803	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.008	0.0188	0.0182
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0047	0.0061	0.0055
Toxoplasma gondii	hypothetical protein	0.0046	0.0057	0.0595
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0053	0.0084	0.0078
Echinococcus multilocularis	cyclin dependent kinase	0.0053	0.0084	0.0189
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.024	0.0803	1
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0047	0.0061	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0057	0.0051
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0046	0.0057	0.0051
Trypanosoma cruzi	cdc2-related kinase 1	0.0053	0.0084	0.0972
Echinococcus multilocularis	cyclin dependent kinase 5	0.0053	0.0084	0.0189
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0053	0.0084	0.0189
Brugia malayi	TAR-binding protein	0.0868	0.322	0.3216
Schistosoma mansoni	tar DNA-binding protein	0.0868	0.322	0.5069
Brugia malayi	ImpB/MucB/SamB family protein	0.0048	0.0065	0.0059
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0047	0.0061	0.0096
Toxoplasma gondii	LsmAD domain-containing protein	0.0162	0.0501	0.6194
Brugia malayi	mothers against decapentaplegic homolog 3	0.008	0.0188	0.0182
Schistosoma mansoni	hypothetical protein	0.0342	0.1196	0.1882
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0047	0.0061	0.0134
Schistosoma mansoni	smad1 5 8 and	0.0179	0.0569	0.0896
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0047	0.0061	0.0568
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0779	0.2876	0.2872
Echinococcus granulosus	regulator of G protein signaling 7	0.0046	0.0057	0.0124
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0053	0.0084	0.0078
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.1098	0.4105	0.4102
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0046	0.0057	0.009
Schistosoma mansoni	glutaminase	0.0285	0.0976	0.1537
Brugia malayi	hypothetical protein	0.0162	0.0501	0.0495
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.024	0.0803	0.1945
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0047	0.0061	0.0055
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0033	0.0006	0.001
Schistosoma mansoni	hypothetical protein	0.0073	0.016	0.0252
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0047	0.0061	0.0055
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0779	0.2876	0.7001
Leishmania major	DNA polymerase eta, putative	0.0048	0.0065	0.0693
Entamoeba histolytica	hypothetical protein	0.0073	0.016	0.6006
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.1098	0.4105	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.2461	0.935	0.9349
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.1098	0.4105	1
Brugia malayi	hypothetical protein	0.0047	0.0061	0.0055
Brugia malayi	glutaminase DH11.1	0.0285	0.0976	0.0971
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0046	0.0057	0.0051
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.01	0.0263	0.0627
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.008	0.0188	0.0523
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0047	0.0061	0.0568
Schistosoma mansoni	Smad4	0.008	0.0188	0.0296
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.01	0.0263	0.0257
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0072	0.0675
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0047	0.0061	0.0134
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.01	0.0263	0.3191
Brugia malayi	MH1 domain containing protein	0.0099	0.0261	0.0255
Loa Loa (eye worm)	glutaminase	0.0285	0.0976	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0061	0.0055
Echinococcus granulosus	smad	0.0179	0.0569	0.1374
Brugia malayi	Isocitrate dehydrogenase	0.024	0.0803	0.0798
Schistosoma mansoni	dishevelled	0.0046	0.0057	0.009
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0047	0.0061	0.0568
Loa Loa (eye worm)	MH2 domain-containing protein	0.0179	0.0569	0.0563
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0263	0.2647
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0047	0.0061	0.0096
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0779	0.2876	0.7001
Trypanosoma brucei	PAB1-binding protein , putative	0.0162	0.0501	0.5911
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0263	0.2647
Schistosoma mansoni	hypothetical protein	0.0779	0.2876	0.4527
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0047	0.0061	0.0568
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0084	0.0132
Schistosoma mansoni	hypothetical protein	0.0779	0.2876	0.4527
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.016	0.0376
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0047	0.0061	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0057	0.0051
Onchocerca volvulus		0.0047	0.0061	0.0159
Schistosoma mansoni	smad	0.008	0.0188	0.0296
Trypanosoma brucei	cdc2-related kinase 3	0.0053	0.0084	0.0255
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.024	0.0803	0.1945
Loa Loa (eye worm)	hypothetical protein	0.0779	0.2876	0.2872
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.1098	0.4105	1
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0047	0.0061	0.0096
Loa Loa (eye worm)	isocitrate dehydrogenase	0.024	0.0803	0.0798
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0047	0.0061	0.0134
Loa Loa (eye worm)	MH2 domain-containing protein	0.263	1	1
Trichomonas vaginalis	glutaminase, putative	0.0285	0.0976	1
Schistosoma mansoni	smad1 5 8 and	0.0179	0.0569	0.0896
Onchocerca volvulus		0.0047	0.0061	0.0159
Plasmodium falciparum	ataxin-2 like protein, putative	0.0162	0.0501	0.5804
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0263	0.2647
Echinococcus granulosus	segment polarity protein dishevelled	0.0046	0.0057	0.0124
Schistosoma mansoni	tar DNA-binding protein	0.0868	0.322	0.5069
Brugia malayi	MH1 domain containing protein	0.0099	0.0261	0.0255
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1098	0.4105	0.6462
Echinococcus granulosus	dna polymerase eta	0.0048	0.0065	0.0143
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.024	0.0803	1
Schistosoma mansoni	hypothetical protein	0.0779	0.2876	0.4527
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0033	0.0006	0.001
Echinococcus multilocularis	tar DNA binding protein	0.0868	0.322	0.7841
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0047	0.0061	0.0568
Echinococcus granulosus	expressed protein	0.0047	0.0061	0.0134
Schistosoma mansoni	dep domain containing protein	0.0046	0.0057	0.009
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0061	0.0055
Entamoeba histolytica	hypothetical protein	0.0073	0.016	0.6006
Brugia malayi	G-protein alpha subunit	0.0047	0.0061	0.0055
Brugia malayi	hypothetical protein	0.0073	0.016	0.0154
Entamoeba histolytica	hypothetical protein	0.0073	0.016	0.6006
Schistosoma mansoni	hypothetical protein	0.1682	0.6353	1
Echinococcus multilocularis	Smad4	0.0179	0.0569	0.1374
Trypanosoma cruzi	DNA polymerase eta, putative	0.0048	0.0065	0.0736
Brugia malayi	regulator of G-protein signaling egl-10	0.0046	0.0057	0.0051
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0053	0.0084	0.0931
Brugia malayi	hypothetical protein	0.0046	0.0057	0.0051
Echinococcus multilocularis	cyclin dependent kinase 1	0.0053	0.0084	0.0189
Echinococcus multilocularis	mothers against decapentaplegic 2	0.008	0.0188	0.0444
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0047	0.0061	0.0134
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.024	0.0803	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0779	0.2876	0.2872
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.024	0.0803	0.1945
Loa Loa (eye worm)	Smad1	0.0179	0.0569	0.0563
Entamoeba histolytica	G protein alpha subunit, putative	0.0047	0.0061	0.2146
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0047	0.0061	0.0096
Schistosoma mansoni	z-protein (S1r protein)	0.0046	0.0057	0.009
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0046	0.0057	0.0051
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0779	0.2876	0.7001
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.1098	0.4105	1
Toxoplasma gondii	isocitrate dehydrogenase	0.024	0.0803	1
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0046	0.0057	0.0124
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0263	0.2647
Brugia malayi	cell division control protein 2 homolog	0.0053	0.0084	0.0078
Loa Loa (eye worm)	glutaminase 2	0.0285	0.0976	0.0971
Echinococcus granulosus	geminin	0.0342	0.1196	0.2903
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0179	0.0569	0.1374
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0047	0.0061	0.0055
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0263	0.2647
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0179	0.0569	0.1374
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0047	0.0061	0.0134
Schistosoma mansoni	Smad4	0.008	0.0188	0.0296
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0047	0.0061	0.0055
Trypanosoma cruzi	PAB1-binding protein , putative	0.0162	0.0501	0.6212
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0179	0.0569	0.0896
Schistosoma mansoni	dishevelled	0.0046	0.0057	0.009

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.2 uM	Inhibition of CDK4/Cyclin D1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation	ChEMBL.	19317452
IC50 (binding)	= 12.5 uM	Inhibition of CDK2/Cyclin E assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation	ChEMBL.	19317452
IC50 (binding)	= 36.6 uM	Inhibition of CDK1/Cyclin B1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation	ChEMBL.	19317452

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL450383

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 950935