Detailed information for compound 951067

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 540.588 | Formula: C30H29FN6O3
  • H donors: 0 H acceptors: 4 LogP: 4.62 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=CCn1c(nc2c1c(=O)n(c(=O)n2C)Cc1ccc(cc1)F)c1ccc(cc1)OCCN(c1ccccn1)C
  • InChi: 1S/C30H29FN6O3/c1-4-17-36-26-28(35(3)30(39)37(29(26)38)20-21-8-12-23(31)13-9-21)33-27(36)22-10-14-24(15-11-22)40-19-18-34(2)25-7-5-6-16-32-25/h4-16H,1,17-20H2,2-3H3
  • InChiKey: WHANOPQEKPMJSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0109 0.0102
Brugia malayi intermediate filament protein 0.0028 0.0194 0.0287
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0075 0.0015
Schistosoma mansoni hypothetical protein 0.0103 0.1165 0.1891
Brugia malayi beta-lactamase family protein 0.0035 0.0287 0.0448
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0985 0.158
Brugia malayi MBOAT family protein 0.0021 0.0109 0.0142
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3092 0.5219
Echinococcus granulosus geminin 0.0343 0.426 0.7262
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0109 0.0189
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0194 0.0287
Echinococcus granulosus metabotropic glutamate receptor 2 0.0042 0.0368 0.0617
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0075 0.0068
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0109 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0287 1
Brugia malayi beta-lactamase family protein 0.0035 0.0287 0.0448
Brugia malayi hypothetical protein 0.0036 0.0292 0.0455
Schistosoma mansoni hypothetical protein 0.031 0.3826 0.6484
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0136 0.3087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0985 0.0978
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0109 0.0189
Leishmania major glycerol uptake protein, putative 0.0021 0.0109 0.1844
Brugia malayi MBOAT family protein 0.0021 0.0109 0.0142
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0287 0.0479
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.134 0.2325
Echinococcus granulosus lamin dm0 0.0028 0.0194 0.0319
Loa Loa (eye worm) TAR-binding protein 0.0253 0.3092 0.5368
Brugia malayi MBOAT family protein 0.0021 0.0109 0.0142
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0021 0.0109 0.0102
Schistosoma mansoni P2X receptor subunit 0.0067 0.0696 0.1083
Brugia malayi Metabotropic glutamate receptor precursor. 0.005 0.0472 0.0763
Schistosoma mansoni hypothetical protein 0.0343 0.426 0.7233
Entamoeba histolytica hypothetical protein 0.0024 0.0136 0.3026
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0021 0.0109 0.1844
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0449 0.0779
Loa Loa (eye worm) hypothetical protein 0.0029 0.0207 0.0359
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0021 0.0109 0.0174
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0075 0.0015
Echinococcus multilocularis GPCR, family 2 0.0048 0.0449 0.0443
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0108 0.1805
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0468 0.5863 1
Brugia malayi diacylglycerol acyltransferase 0.0021 0.0109 0.0142
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0449 0.0725
Loa Loa (eye worm) hypothetical protein 0.0151 0.1781 0.3091
Schistosoma mansoni P2X receptor subunit 0.0067 0.0696 0.1083
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0292 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0109 0.1844
Trichomonas vaginalis ran, putative 0.0021 0.0108 0.1805
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0287 0.0498
Schistosoma mansoni sterol O-acyltransferase 1 0.0219 0.266 0.4472
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0026 0.0045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0985 0.1669
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0069 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.2612
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0109 0.1844
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.2612
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0194 0.0335
Schistosoma mansoni lamin 0.0028 0.0194 0.0215
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0069 0.0073
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0696 0.0689
Echinococcus multilocularis musashi 0.0028 0.0194 0.0187
Echinococcus granulosus GPCR family 2 0.0048 0.0449 0.0755
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0287 0.0377
Entamoeba histolytica hypothetical protein 0.0036 0.0292 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0449 0.0443
Echinococcus granulosus importin subunit beta 1 0.0029 0.0207 0.0341
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0109 0.1844
Entamoeba histolytica hypothetical protein, conserved 0.0021 0.0109 0.1808
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.1781 0.3006
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0287 1
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0021 0.0109 0.007
Loa Loa (eye worm) hypothetical protein 0.021 0.2546 0.4419
Trypanosoma cruzi GUP1, putative 0.0021 0.0109 0.1844
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0075 0.0084
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0292 0.0385
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0109 0.38
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.2612
Echinococcus multilocularis snurportin 1 0.031 0.3826 0.3821
Leishmania major DNA polymerase kappa, putative 0.0019 0.0075 0.0282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0985 0.0978
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0189
Echinococcus multilocularis geminin 0.0343 0.426 0.4256
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.0559 0.0847
Schistosoma mansoni ran 0.0021 0.0108 0.0068
Loa Loa (eye worm) hhat protein 0.0021 0.0109 0.0189
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0287 0.0538
Toxoplasma gondii hypothetical protein 0.0021 0.0109 0.1844
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0207 0.02
Brugia malayi TAR-binding protein 0.0253 0.3092 0.5254
Brugia malayi RNA binding protein 0.0253 0.3092 0.5254
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0334 0.4133 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0207 0.7204
Loa Loa (eye worm) glutamate receptor 0.005 0.0472 0.0818
Brugia malayi MBOAT family protein 0.0021 0.0109 0.0142
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0287 0.0538
Echinococcus granulosus intermediate filament protein 0.0028 0.0194 0.0319
Trichomonas vaginalis porcupine, putative 0.0021 0.0109 0.1844
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0069 0.0062
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0292 0.0285
Schistosoma mansoni metabotropic glutamate receptor 0.0042 0.0368 0.0517
Mycobacterium tuberculosis Conserved protein 0.0035 0.0287 0.0538
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0075 0.0015
Schistosoma mansoni P2X receptor subunit 0.0067 0.0696 0.1083
Entamoeba histolytica vacuolar protein sorting 26 0.0021 0.0109 0.1808
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0449 0.0755
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0449 0.0755
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0287 0.0538
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.2612
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0287 0.0538
Trichomonas vaginalis esterase, putative 0.0035 0.0287 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2736 0.6563
Echinococcus granulosus dna polymerase kappa 0.0019 0.0075 0.0116
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0108 0.0187
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0498
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0108 0.2855
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.021 0.2546 0.4419
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0287 1
Echinococcus multilocularis sterol O acyltransferase 1 0.0219 0.266 0.2655
Echinococcus multilocularis dna polymerase eta 0.0019 0.0075 0.0068
Schistosoma mansoni hypothetical protein 0.0048 0.0449 0.0657
Schistosoma mansoni hypothetical protein 0.0036 0.0292 0.0385
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0468 0.5863 0.586
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0287 0.0538
Echinococcus multilocularis lamin dm0 0.0028 0.0194 0.0187
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0696 0.1177
Schistosoma mansoni intermediate filament proteins 0.0028 0.0194 0.0215
Loa Loa (eye worm) hypothetical protein 0.0028 0.0194 0.0335
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0021 0.0109 0.0102
Loa Loa (eye worm) hypothetical protein 0.0027 0.0187 0.0324
Echinococcus multilocularis lamin 0.0028 0.0194 0.0187
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0136 0.3087
Echinococcus granulosus dna polymerase eta 0.0019 0.0075 0.0116
Mycobacterium ulcerans beta-lactamase 0.0035 0.0287 0.0538
Loa Loa (eye worm) hypothetical protein 0.021 0.2546 0.4419
Echinococcus granulosus lamin 0.0028 0.0194 0.0319
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0021 0.0109 0.0189
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0109 0.38
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.2612
Echinococcus multilocularis tar DNA binding protein 0.0253 0.3092 0.3088
Leishmania major importin beta-1 subunit, putative 0.0024 0.0136 0.3087
Brugia malayi MBOAT family protein 0.0021 0.0109 0.0142
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0136 0.3087
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0287 0.0448
Echinococcus granulosus metabotropic glutamate receptor 5 0.0061 0.0619 0.1046
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0075 0.0282
Schistosoma mansoni P2X receptor subunit 0.0067 0.0696 0.1083
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0108 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0287 0.0538
Onchocerca volvulus 0.0028 0.0194 0.4741
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0075 0.0011
Schistosoma mansoni zinc finger protein 0.0021 0.0109 0.007
Leishmania major GTP-binding protein, putative 0.0021 0.0108 0.1805
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.2612
Echinococcus granulosus sterol O acyltransferase 1 0.0219 0.266 0.453
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0287 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0498
Onchocerca volvulus 0.0035 0.0287 1
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3092 0.5219
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0109 0.1844
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0075 0.0282
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0011
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0109 0.007
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0468 0.5863 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0287 0.0498
Entamoeba histolytica hypothetical protein 0.0021 0.0109 0.1808
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.0282
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0109 0.0174
Brugia malayi RNA recognition motif domain containing protein 0.0253 0.3092 0.5254
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0287 0.0538
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0075 0.0129
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0287 0.0281
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0075 0.0068
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0136 0.3087
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.2612
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0021 0.0109 0.0174
Mycobacterium leprae Probable lipase LipE 0.0035 0.0287 0.5
Leishmania major hypothetical protein, conserved 0.0021 0.0109 0.1844
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0985 0.1708
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0468 0.5863 1
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0021 0.0109 0.0102
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0045 0.0412 0.0661
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3092 0.5219
Schistosoma mansoni ran 0.0021 0.0108 0.0068
Schistosoma mansoni hypothetical protein 0.0048 0.0449 0.0657
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.0282
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0109 0.1844
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0287 0.0377
Leishmania major glycerol uptake protein, putative 0.0021 0.0109 0.1844
Loa Loa (eye worm) hypothetical protein 0.0103 0.1165 0.2021
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0696 0.1177
Trichomonas vaginalis transmembrane protein nessy, putative 0.0021 0.0109 0.1844
Plasmodium falciparum importin beta, putative 0.0029 0.0207 1
Brugia malayi Hhat protein 0.0021 0.0109 0.0142
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0021 0.0109 0.0174
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.0129
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3092 0.5219
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0109 0.0174
Loa Loa (eye worm) hypothetical protein 0.0061 0.0619 0.1074
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0069 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.021 0.2546 0.254
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0075 0.0116
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0075 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0287 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0253 0.3092 0.5368
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.2612
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0498
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0108 0.377
Echinococcus granulosus snurportin 1 0.031 0.3826 0.6521
Brugia malayi beta-lactamase 0.0035 0.0287 0.0448
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0021 0.0109 0.1808
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0021 0.0109 0.1808
Mycobacterium ulcerans epoxide hydrolase EphA 0.0334 0.4133 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.134 0.2325
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0108 0.1805
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0696 0.1177
Brugia malayi MH2 domain containing protein 0.0117 0.134 0.225
Entamoeba histolytica hypothetical protein 0.0036 0.0292 1
Schistosoma mansoni hypothetical protein 0.0048 0.0449 0.0657
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0021 0.0109 0.1844
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0109 0.007
Trypanosoma brucei unspecified product 0.0019 0.0075 0.2612
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.2612
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0144 0.013
Leishmania major hypothetical protein, conserved 0.0035 0.0287 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0108 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.2612
Schistosoma mansoni importin beta-1 0.0029 0.0207 0.0239
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0207 0.6323
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0042 0.0368 0.0361
Schistosoma mansoni hypothetical protein 0.0343 0.426 0.7233
Leishmania major DNA polymerase eta, putative 0.0019 0.0075 0.0282
Leishmania major glycerol uptake protein, putative 0.0021 0.0109 0.1844
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0109 0.0174
Onchocerca volvulus 0.0035 0.0287 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0449 0.0725
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0075 0.0015
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0108 0.1805
Mycobacterium ulcerans hypothetical protein 0.0035 0.0287 0.0538
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0498
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0069 0.2398
Leishmania major glycerol uptake protein, putative 0.0021 0.0109 0.1844
Entamoeba histolytica hypothetical protein 0.0036 0.0292 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0287 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0985 0.158
Schistosoma mansoni lamin 0.0028 0.0194 0.0215
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0985 0.1642
Schistosoma mansoni hypothetical protein 0.0048 0.0449 0.0657
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0075 0.0011
Onchocerca volvulus 0.0035 0.0287 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0075 0.2612
Mycobacterium tuberculosis Conserved protein 0.0035 0.0287 0.0538
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0109 0.0102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0985 0.1669
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0021 0.0109 0.0174
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0449 0.0443
Echinococcus granulosus tar DNA binding protein 0.0253 0.3092 0.5269
Leishmania major glycerol uptake protein, putative 0.0021 0.0109 0.1844
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0108 0.0173
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0287 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0069 0.0119
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0021 0.0109 0.0102
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0108 0.0141
Loa Loa (eye worm) hypothetical protein 0.0219 0.266 0.4617
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0109 0.1844
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0109 0.0102
Treponema pallidum alginate O-acetylation protein (algI) 0.0021 0.0109 1
Onchocerca volvulus 0.0028 0.0194 0.4741
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0021 0.0109 0.1808
Brugia malayi RNA, U transporter 1 0.0083 0.0897 0.1491
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0287 0.0538
Mycobacterium ulcerans lipase LipD 0.0035 0.0287 0.0538
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0021 0.0109 0.0102
Loa Loa (eye worm) voltage-gated potassium channel 0.046 0.5761 1
Loa Loa (eye worm) RNA binding protein 0.0253 0.3092 0.5368
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.3826 0.664
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.1781 0.3006
Brugia malayi Importin beta-1 subunit 0.0029 0.0207 0.031
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0021 0.0109 0.0189
Trypanosoma cruzi GUP1, putative 0.0021 0.0109 0.1844
Schistosoma mansoni DNA polymerase eta 0.0019 0.0075 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0287 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0985 0.158
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0696 0.0689
Plasmodium vivax importin-beta 2, putative 0.0029 0.0207 0.6323
Giardia lamblia DINP protein human, muc B family 0.0019 0.0075 0.1563
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0021 0.0109 0.007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.1781 0.3091
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3092 0.5219
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.2612
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0194 0.0335
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.2612
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0075 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.2612
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0061 0.0619 0.0613
Loa Loa (eye worm) hypothetical protein 0.0048 0.0449 0.0779
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.0282
Entamoeba histolytica hypothetical protein 0.0036 0.0292 1
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0021 0.0109 0.2916
Toxoplasma gondii ABC1 family protein 0.0035 0.0287 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0287 1
Schistosoma mansoni hypothetical protein 0.0021 0.0109 0.007
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0696 0.0689
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0109 0.0189
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0021 0.0109 0.007
Loa Loa (eye worm) glutamate receptor 0.0019 0.0084 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0287 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0287 0.0538
Loa Loa (eye worm) hhat protein 0.0021 0.0109 0.0189
Entamoeba histolytica Ran family GTPase 0.0021 0.0108 0.1769
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0075 0.0282
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0207 0.7204
Loa Loa (eye worm) hypothetical protein 0.0198 0.2384 0.4137
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0144 0.0202
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0021 0.0109 0.0174
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.0282
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0075 0.0282
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0498
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.021 0.2546 0.4336
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0108 0.1805
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0498
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1165 0.195
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0021 0.0109 0.1844
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0287 0.0538

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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