Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.1139 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.1139 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.1139 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0023 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1139 | 0.1139 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.1139 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1068 | 0.1068 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0023 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1068 | 0.1068 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.1139 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0317 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0245 | 0.759 | 0.759 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0198 | 0.0198 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.1139 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0245 | 0.759 | 0.759 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0551 | 0.0551 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0551 | 0.0551 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.1139 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0051 | 0.1139 | 0.1139 |
Schistosoma mansoni | tar DNA-binding protein | 0.0317 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0317 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0317 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0317 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0317 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0317 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0317 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0245 | 0.759 | 0.759 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1068 | 0.1068 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0317 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.1139 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0551 | 0.0551 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0534 | 0.0534 |
Brugia malayi | TAR-binding protein | 0.0317 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0317 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1068 | 0.1068 |
Loa Loa (eye worm) | RNA binding protein | 0.0317 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20.8 uM | Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay | ChEMBL. | 25453818 |
Inhibition (binding) | = 93 % | Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate at 100 uM after 15 mins by fluorescence assay | ChEMBL. | 25453818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.