Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | two component sensory transduction histidine kinase MtrB | 0.0104 | 0.0053 | 0.0046 |
Toxoplasma gondii | heat shock protein 90, putative | 0.013 | 0.0071 | 0.0717 |
Trypanosoma brucei | oligopeptidase b | 0.0043 | 0.001 | 0.002 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0158 | 0.009 | 0.0918 |
Mycobacterium tuberculosis | Two component sensor kinase MprB | 0.0104 | 0.0053 | 0.0046 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.013 | 0.0071 | 0.0469 |
Plasmodium vivax | endoplasmin, putative | 0.013 | 0.0071 | 0.0495 |
Plasmodium falciparum | DNA gyrase subunit B | 0.2006 | 0.1388 | 1 |
Toxoplasma gondii | DNA topoisomerase family protein | 0.0158 | 0.009 | 0.0918 |
Trichomonas vaginalis | sensory transduction histidine kinase bacterial, putative | 0.0104 | 0.0053 | 0.0481 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0002 | 0.0024 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0043 | 0.001 | 0.0101 |
Trypanosoma brucei | heat shock protein, putative | 0.013 | 0.0071 | 0.0469 |
Trypanosoma brucei | heat shock protein, putative | 0.013 | 0.0071 | 0.0469 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0628 | 0.042 | 0.4367 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0628 | 0.042 | 0.2979 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.001 | 0.002 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbA | 1.4273 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.1396 | 0.0959 | 1 |
Mycobacterium ulcerans | two component sensor kinase MprB | 0.0104 | 0.0053 | 0.0046 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0304 | 0.0193 | 0.2008 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.2006 | 0.1388 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0298 | 0.0188 | 0.1965 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0028 | 0.0156 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0002 | 0.0024 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0228 | 0.0139 | 0.1452 |
Echinococcus granulosus | heat shock protein 90 | 0.013 | 0.0071 | 0.074 |
Trichomonas vaginalis | receptor histidine kinase, putative | 0.0104 | 0.0053 | 0.0481 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0628 | 0.042 | 0.3017 |
Trichomonas vaginalis | mismatch repair protein Mlh1C (mutL homolog) | 0.0104 | 0.0053 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0725 | 0.0488 | 0.5092 |
Leishmania major | DNA topoisomerase 1A | 0.0158 | 0.009 | 0.061 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0028 | 0.0156 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.013 | 0.0071 | 0.0469 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.1395 | 0.0959 | 0.9993 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0043 | 0.001 | 0.0101 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0028 | 0.0156 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.1395 | 0.0959 | 0.6887 |
Mycobacterium ulcerans | DNA topoisomerase I | 0.0158 | 0.009 | 0.0083 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0007 | 0.0072 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0628 | 0.042 | 0.2753 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0007 | 0.0072 |
Echinococcus granulosus | prolyl endopeptidase | 0.0043 | 0.001 | 0.0101 |
Onchocerca volvulus | 0.0039 | 0.0007 | 0.0095 | |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0183 | 0.0108 | 0.1104 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0104 | 0.0053 | 0.055 |
Mycobacterium leprae | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) | 1.4273 | 1 | 1 |
Trichomonas vaginalis | sensory transduction histidine kinase bacterial, putative | 0.0104 | 0.0053 | 0.0481 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0196 | 0.0117 | 0.011 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0028 | 0.0156 |
Brugia malayi | prolyl oligopeptidase family protein | 0.03 | 0.019 | 0.198 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0883 | 0.0599 | 0.6251 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0028 | 0.0156 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0158 | 0.009 | 0.094 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.0109 | 0.1136 |
Plasmodium vivax | DNA topoisomerase 3, putative | 0.0158 | 0.009 | 0.0634 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0002 | 0.0024 |
Echinococcus granulosus | heat shock protein | 0.013 | 0.0071 | 0.074 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0028 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0053 | 0.055 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0028 | 0.0156 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.1068 | 0.0729 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0104 | 0.0053 | 0.0527 |
Leishmania major | DNA topoisomerase ii | 0.1237 | 0.0848 | 0.6166 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0158 | 0.009 | 0.0848 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0043 | 0.001 | 0.0077 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0028 | 0.0156 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0043 | 0.001 | 0.002 |
Trypanosoma brucei | heat shock protein 90, putative | 0.013 | 0.0071 | 0.0469 |
Toxoplasma gondii | heat shock protein HSP90 | 0.013 | 0.0071 | 0.0717 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.03 | 0.019 | 0.1341 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0007 | 0.0072 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.013 | 0.0071 | 0.0469 |
Mycobacterium ulcerans | glutaminase | 0.0298 | 0.0188 | 0.0182 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0028 | 0.0156 |
Trypanosoma brucei | heat shock protein, putative | 0.013 | 0.0071 | 0.0469 |
Entamoeba histolytica | heat shock protein 90, putative | 0.013 | 0.0071 | 0.0645 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0007 | 0.0072 |
Mycobacterium leprae | Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( | 0.0158 | 0.009 | 0.0083 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0158 | 0.009 | 0.028 |
Treponema pallidum | DNA topoisomerase I (topA) | 0.0158 | 0.009 | 0.028 |
Trypanosoma cruzi | oligopeptidase b | 0.0043 | 0.001 | 0.002 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0007 | 0.0072 |
Trichomonas vaginalis | heat shock protein, putative | 0.0118 | 0.0062 | 0.058 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.2006 | 0.1388 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0007 | 0.0072 |
Mycobacterium ulcerans | two component sensor histidine kinase PrrB | 0.0104 | 0.0053 | 0.0046 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0628 | 0.042 | 0.2753 |
Giardia lamblia | Pms1-like protein | 0.0104 | 0.0053 | 0.0492 |
Schistosoma mansoni | endoplasmin | 0.013 | 0.0071 | 0.074 |
Plasmodium falciparum | DNA topoisomerase VI, b subunit, putative | 0.0104 | 0.0053 | 0.0312 |
Schistosoma mansoni | glutaminase | 0.0298 | 0.0188 | 0.1965 |
Mycobacterium leprae | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) | 1.4273 | 1 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.1395 | 0.0959 | 0.6904 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0104 | 0.0053 | 0.0336 |
Trypanosoma brucei | heat shock protein, putative | 0.013 | 0.0071 | 0.0469 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.2006 | 0.1388 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.1395 | 0.0959 | 1 |
Mycobacterium tuberculosis | Probable sensor protein KdpD | 0.0104 | 0.0053 | 0.0046 |
Loa Loa (eye worm) | glutaminase 2 | 0.0298 | 0.0188 | 0.1965 |
Trypanosoma brucei | heat shock protein, putative | 0.013 | 0.0071 | 0.0469 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0158 | 0.009 | 0.0848 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) | 1.4273 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0078 | 0.081 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0007 | 0.0072 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.03 | 0.019 | 0.198 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.013 | 0.0071 | 0.0469 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.013 | 0.0071 | 0.0469 |
Loa Loa (eye worm) | heat shock protein 90 | 0.013 | 0.0071 | 0.074 |
Loa Loa (eye worm) | endoplasmin | 0.013 | 0.0071 | 0.074 |
Plasmodium falciparum | heat shock protein 90 | 0.013 | 0.0071 | 0.0444 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0043 | 0.001 | 0.0101 |
Brugia malayi | Pre-SET motif family protein | 0.0228 | 0.0139 | 0.1452 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.025 | 0.0155 | 0.0148 |
Trypanosoma cruzi | oligopeptidase b | 0.0043 | 0.001 | 0.002 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0304 | 0.0193 | 0.2008 |
Plasmodium falciparum | DNA topoisomerase 3, putative | 0.0158 | 0.009 | 0.0584 |
Trypanosoma brucei | prolyl endopeptidase | 0.0043 | 0.001 | 0.002 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0158 | 0.009 | 0.061 |
Brugia malayi | hypothetical protein | 0.014 | 0.0078 | 0.081 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.1395 | 0.0959 | 1 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0043 | 0.001 | 0.002 |
Mycobacterium tuberculosis | Possible two component system response sensor kinase membrane associated PhoR | 0.0104 | 0.0053 | 0.0046 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0104 | 0.0053 | 0.055 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0158 | 0.009 | 0.094 |
Leishmania major | DNA topoisomerase III, putative | 0.0158 | 0.009 | 0.061 |
Brugia malayi | Probable DNA topoisomerase II | 0.1395 | 0.0959 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.1237 | 0.0848 | 0.6166 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0043 | 0.001 | 0.002 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0002 | 0.0024 |
Onchocerca volvulus | 0.0259 | 0.0161 | 0.2211 | |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Loa Loa (eye worm) | glutaminase | 0.0298 | 0.0188 | 0.1965 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.03 | 0.019 | 0.1341 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0043 | 0.001 | 0.0003 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0028 | 0.0156 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0158 | 0.009 | 0.094 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0043 | 0.001 | 0.0029 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0158 | 0.009 | 0.061 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.013 | 0.0071 | 0.0469 |
Giardia lamblia | DNA topoisomerase II | 0.129 | 0.0885 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0055 | 0.0018 | 0.0079 |
Mycobacterium leprae | Probable two component sensor kinase MprB | 0.0104 | 0.0053 | 0.0046 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.0007 | 0.0033 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0028 | 0.0156 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.1395 | 0.0959 | 1 |
Brugia malayi | heat shock protein 90 | 0.013 | 0.0071 | 0.074 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbB | 1.4273 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0028 | 0.0156 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0158 | 0.009 | 0.061 |
Mycobacterium ulcerans | two component system membrane associated sensor kinase | 0.0104 | 0.0053 | 0.0046 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.0007 | 0.0048 |
Mycobacterium tuberculosis | Probable two component sensor kinase | 0.0104 | 0.0053 | 0.0046 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0007 | 0.0072 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0104 | 0.0053 | 0.0336 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1982 | 0.1371 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0077 | 0.0799 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0043 | 0.001 | 0.0029 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Brugia malayi | DNA topoisomerase III | 0.0158 | 0.009 | 0.094 |
Onchocerca volvulus | 0.0039 | 0.0007 | 0.0095 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0028 | 0.0156 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0043 | 0.001 | 0.0101 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Trichomonas vaginalis | sensor histidine kinase, putative | 0.0104 | 0.0053 | 0.0481 |
Mycobacterium tuberculosis | Two component sensory transduction histidine kinase MtrB | 0.0104 | 0.0053 | 0.0046 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0001 | 0.0015 |
Leishmania major | oligopeptidase b | 0.0043 | 0.001 | 0.002 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.1395 | 0.0959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0077 | 0.0799 |
Giardia lamblia | DNA topoisomerase III | 0.0158 | 0.009 | 0.0919 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0158 | 0.009 | 0.061 |
Mycobacterium tuberculosis | Possible two component sensor kinase | 0.0104 | 0.0053 | 0.0046 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1419 | 0.0976 | 0.6913 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.001 | 0.0101 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1982 | 0.1371 | 1 |
Mycobacterium tuberculosis | Two component sensor histidine kinase PrrB | 0.0104 | 0.0053 | 0.0046 |
Trichomonas vaginalis | set domain proteins, putative | 0.0259 | 0.0161 | 0.1622 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0043 | 0.001 | 0.0101 |
Schistosoma mansoni | heat shock protein | 0.013 | 0.0071 | 0.074 |
Mycobacterium tuberculosis | Two component sensor kinase [second part] | 0.0104 | 0.0053 | 0.0046 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.03 | 0.019 | 0.1341 |
Loa Loa (eye worm) | hypothetical protein | 0.0651 | 0.0436 | 0.4552 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0304 | 0.0193 | 0.2008 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0104 | 0.0053 | 0.0046 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) | 1.4273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0092 | 0.0955 |
Trichomonas vaginalis | two component sensor and regulator histidine kinase bacteria, putative | 0.0104 | 0.0053 | 0.0481 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0007 | 0.0072 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.03 | 0.019 | 0.198 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.1237 | 0.0848 | 0.6166 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0043 | 0.001 | 0.0003 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0043 | 0.001 | 0.0101 |
Brugia malayi | GRF zinc finger family protein | 0.0158 | 0.009 | 0.094 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0158 | 0.009 | 0.094 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0043 | 0.001 | 0.0101 |
Schistosoma mansoni | DNA topoisomerase II | 0.1395 | 0.0959 | 1 |
Schistosoma mansoni | endoplasmin | 0.013 | 0.0071 | 0.074 |
Mycobacterium ulcerans | two component sensor histidine kinase SenX3 | 0.0104 | 0.0053 | 0.0046 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.2006 | 0.1388 | 0.1382 |
Brugia malayi | kinase, mitochondrial precursor | 0.0104 | 0.0053 | 0.055 |
Onchocerca volvulus | 0.0033 | 0.0002 | 0.0032 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0028 | 0.0156 |
Trypanosoma brucei | heat shock protein 90, putative | 0.013 | 0.0071 | 0.0469 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0043 | 0.001 | 0.0003 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0043 | 0.001 | 0.0101 |
Trichomonas vaginalis | receptor histidine kinase, putative | 0.0104 | 0.0053 | 0.0481 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0002 | 0.0024 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.1395 | 0.0959 | 1 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0104 | 0.0053 | 0.0336 |
Toxoplasma gondii | prolyl endopeptidase | 0.0043 | 0.001 | 0.0077 |
Onchocerca volvulus | 0.0039 | 0.0007 | 0.0095 | |
Plasmodium vivax | heat shock protein 86, putative | 0.013 | 0.0071 | 0.0495 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0043 | 0.001 | 0.0101 |
Trichomonas vaginalis | endoplasmin, putative | 0.0118 | 0.0062 | 0.058 |
Trichomonas vaginalis | heat shock protein, putative | 0.013 | 0.0071 | 0.0672 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0002 | 0.0024 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.013 | 0.0071 | 0.0699 |
Trypanosoma brucei | heat shock protein, putative | 0.013 | 0.0071 | 0.0469 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) | 1.4273 | 1 | 1 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0158 | 0.009 | 0.0874 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0007 | 0.0072 |
Mycobacterium tuberculosis | Possible two component sensor kinase TcrY | 0.0104 | 0.0053 | 0.0046 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0043 | 0.001 | 0.002 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0043 | 0.001 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0725 | 0.0488 | 0.5092 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.2006 | 0.1388 | 0.1382 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.03 | 0.019 | 0.1341 |
Leishmania major | hypothetical protein, conserved | 0.0104 | 0.0053 | 0.0336 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0726 | 0.0489 | 0.0482 |
Trichomonas vaginalis | glutaminase, putative | 0.0298 | 0.0188 | 0.1906 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0158 | 0.009 | 0.094 |
Mycobacterium leprae | PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 | 0.0104 | 0.0053 | 0.0046 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0104 | 0.0053 | 0.055 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0304 | 0.0193 | 0.2008 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0628 | 0.042 | 0.0414 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0259 | 0.0162 | 0.0815 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0043 | 0.001 | 0.0101 |
Trypanosoma brucei | DNA topoisomerase IA, putative | 0.0158 | 0.009 | 0.061 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0069 | 0.0028 | 0.0156 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0158 | 0.009 | 0.061 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.0109 | 0.1136 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0043 | 0.001 | 0.002 |
Giardia lamblia | DNA topoisomerase III | 0.0158 | 0.009 | 0.0919 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0104 | 0.0053 | 0.055 |
Onchocerca volvulus | 0.0158 | 0.009 | 0.1236 | |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0158 | 0.009 | 0.094 |
Mycobacterium ulcerans | two component regulator - sensor kinase | 0.0104 | 0.0053 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0007 | 0.0072 |
Echinococcus multilocularis | heat shock protein 90 | 0.013 | 0.0071 | 0.074 |
Plasmodium falciparum | endoplasmin, putative | 0.0118 | 0.0062 | 0.038 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0117 | 0.0062 | 0.0401 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.1395 | 0.0959 | 1 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0028 | 0.0156 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0028 | 0.0156 |
Mycobacterium tuberculosis | Probable peptidase | 0.0043 | 0.001 | 0.0003 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0043 | 0.001 | 0.0101 |
Entamoeba histolytica | heat shock protein 90, putative | 0.013 | 0.0071 | 0.0645 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0628 | 0.042 | 0.0414 |
Mycobacterium ulcerans | two component sensor histidine kinase TrcS | 0.0104 | 0.0053 | 0.0046 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0028 | 0.0156 |
Echinococcus multilocularis | geminin | 0.0185 | 0.0109 | 0.1136 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DosT | 0.0104 | 0.0053 | 0.0046 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.1395 | 0.0959 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0007 | 0.0072 |
Trypanosoma cruzi | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative | 0.0104 | 0.0053 | 0.0336 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0158 | 0.009 | 0.094 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0628 | 0.042 | 0.2753 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0158 | 0.009 | 0.094 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.03 | 0.019 | 0.198 |
Trypanosoma brucei | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative | 0.0104 | 0.0053 | 0.0336 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.001 | 0.0053 |
Trypanosoma brucei | heat shock protein, putative | 0.013 | 0.0071 | 0.0469 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.1068 | 0.0729 | 1 |
Brugia malayi | Endoplasmin precursor | 0.013 | 0.0071 | 0.074 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0043 | 0.001 | 0.002 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1982 | 0.1371 | 1 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0043 | 0.001 | 0.002 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0304 | 0.0193 | 0.2008 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0063 | 0.0024 | 0.0125 |
Wolbachia endosymbiont of Brugia malayi | topoisomerase IA, TopA | 0.0158 | 0.009 | 0.028 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Mycobacterium tuberculosis | Conserved protein | 0.0104 | 0.0053 | 0.0046 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.1068 | 0.0729 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.2006 | 0.1388 | 1 |
Mycobacterium ulcerans | two component system response phosphate sensor kinase, PhoR | 0.0104 | 0.0053 | 0.0046 |
Echinococcus multilocularis | heat shock protein | 0.013 | 0.0071 | 0.074 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1982 | 0.1371 | 1 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbC | 1.4273 | 1 | 1 |
Mycobacterium ulcerans | sensor kinase from two component regulatory system | 0.0104 | 0.0053 | 0.0046 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.001 | 0.002 |
Mycobacterium tuberculosis | Two component sensor histidine kinase TrcS | 0.0104 | 0.0053 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0077 | 0.0799 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0304 | 0.0193 | 0.264 |
Trichomonas vaginalis | sensory transduction histidine kinase, putative | 0.0104 | 0.0053 | 0.0481 |
Mycobacterium leprae | TWO COMPONENT SENSOR HISTIDINE KINASE PRRB | 0.0104 | 0.0053 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0007 | 0.0072 |
Schistosoma mansoni | heat shock protein | 0.013 | 0.0071 | 0.074 |
Leishmania major | DNA topoisomerase III, putative | 0.0158 | 0.009 | 0.061 |
Mycobacterium ulcerans | putative regultory protein | 0.0104 | 0.0053 | 0.0046 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0002 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.001 | 0.0101 |
Echinococcus granulosus | geminin | 0.0185 | 0.0109 | 0.1136 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0007 | 0.0072 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.03 | 0.019 | 0.1341 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0002 | 0.0024 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.001 | 0.0029 |
Mycobacterium leprae | Probable two-component sensor kinase | 0.0104 | 0.0053 | 0.0046 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0158 | 0.009 | 0.0874 |
Toxoplasma gondii | hypothetical protein | 0.0043 | 0.001 | 0.0077 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0158 | 0.009 | 0.061 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.1237 | 0.0848 | 0.6166 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0104 | 0.0053 | 0.0046 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0158 | 0.009 | 0.094 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0104 | 0.0053 | 0.0527 |
Loa Loa (eye worm) | hypothetical protein | 0.0651 | 0.0436 | 0.4552 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0158 | 0.009 | 0.061 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0002 | 0.0024 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0043 | 0.001 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0007 | 0.0072 |
Leishmania major | heat shock protein 83-1 | 0.013 | 0.0071 | 0.0469 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.1237 | 0.0848 | 0.6166 |
Trypanosoma brucei | heat shock protein, putative | 0.013 | 0.0071 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0007 | 0.0072 |
Plasmodium vivax | hypothetical protein, conserved | 0.0104 | 0.0053 | 0.0364 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 40000 nM | OSM: Inhibition of Plasmodium falciparum 3D7 growth. IC50 values determined from 21 point dose response curves. Avery Group Griffith. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.