Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | protein kinase C, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0014 | 0.5 |
Toxoplasma gondii | AGC kinase | 0.001 | 0.0014 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2893 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0048 | 0.2422 | 0.2411 |
Echinococcus granulosus | protein kinase C gamma type | 0.0059 | 0.3186 | 0.3176 |
Echinococcus multilocularis | protein kinase c iota type | 0.0018 | 0.0486 | 0.0472 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0014 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0014 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0014 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.001 | 0.0014 | 0.5 |
Brugia malayi | Protein kinase c protein 2 | 0.0057 | 0.3005 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0014 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2223 | 0.2212 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2223 | 0.2212 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.3657 | 0.3648 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2223 | 0.2212 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0067 | 0.3657 | 0.3648 |
Echinococcus multilocularis | geminin | 0.0165 | 1 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0059 | 0.3186 | 0.3176 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0014 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2223 | 0.7386 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0018 | 0.0486 | 0.0472 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0019 | 0.0583 | 0.057 |
Brugia malayi | protein kinase C II. | 0.0019 | 0.0583 | 0.1903 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0014 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0014 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2223 | 0.2212 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.3657 | 0.3648 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0014 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2223 | 0.2212 |
Echinococcus granulosus | protein kinase c iota type | 0.0018 | 0.0486 | 0.0472 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0048 | 0.2422 | 0.2411 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0019 | 0.0583 | 0.1977 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0067 | 0.3657 | 0.3648 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0014 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2223 | 0.7674 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0014 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0019 | 0.0583 | 0.057 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0048 | 0.2422 | 0.2411 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0014 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2223 | 0.2212 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0049 | 0.2534 | 0.8753 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0014 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2223 | 0.2212 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0583 | 0.057 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2422 | 0.8363 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 60.2 nM | Displacement of [3H]PDBu form mouse PKCalpha by scintillation counting | ChEMBL. | 18698758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.