Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0217 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0217 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0217 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0217 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0217 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0217 | 0.5 | 0.5 | |
Brugia malayi | nuclear hormone receptor | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0217 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0217 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.42 uM | Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay | ChEMBL. | 17949858 |
IC50 (functional) | = 0.45 uM | Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay | ChEMBL. | 17949858 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17949858 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.