Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.058 | 0.6202 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0811 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.058 | 0.6202 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0811 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0215 | 0.0219 | 0.0219 |
Brugia malayi | Dihydrofolate reductase | 0.0811 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.058 | 0.6202 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0811 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0811 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.058 | 0.6202 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0215 | 0.0219 | 0.0219 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.058 | 0.6202 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.058 | 0.6202 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0811 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0811 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0811 | 1 | 1 |
Onchocerca volvulus | 0.0215 | 0.0219 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.0215 | 0.0219 | 0.0219 |
Schistosoma mansoni | dihydrofolate reductase | 0.0811 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.3 uM | Inhibition of recombinant ChK1 (unknown origin) using AKT substrate by AlphaScreen assay | ChEMBL. | 25453805 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.