Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.1371 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0176 | 0.0787 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0624 | 0.3621 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0624 | 0.3621 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.1371 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.1371 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0624 | 0.3621 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.1632 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0624 | 0.3621 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1632 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1632 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.1371 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0624 | 0.3621 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.0847 | 0.1027 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0624 | 0.3621 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.0847 | 0.1027 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1632 | 1 | 0.5 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0268 | 0.1371 | 0.1371 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0268 | 0.1371 | 0.1371 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1632 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1632 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1632 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.1371 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.1371 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1632 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1632 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Cytotoxicity against human HCT8 cells by MTT assay | ChEMBL. | 17190442 |
IC50 (functional) | > 10 uM | Cytotoxicity against human Bel-7402 cells by MTT assay | ChEMBL. | 17190442 |
IC50 (functional) | > 10 uM | Cytotoxicity against human BGC-823 cells by MTT assay | ChEMBL. | 17190442 |
IC50 (functional) | > 10 uM | Cytotoxicity against human A549 cells by MTT assay | ChEMBL. | 17190442 |
IC50 (functional) | > 10 uM | Cytotoxicity against human A2780 cells by MTT assay | ChEMBL. | 17190442 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17190442 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.