Detailed information for compound 952335

Basic information

Technical information
  • TDR Targets ID: 952335
  • Name: 3-hydroxy-1,5-di(phenyl)pentan-1-one
  • MW: 254.324 | Formula: C17H18O2
  • H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(CC(=O)c1ccccc1)CCc1ccccc1
  • InChi: 1S/C17H18O2/c18-16(12-11-14-7-3-1-4-8-14)13-17(19)15-9-5-2-6-10-15/h1-10,16,18H,11-13H2
  • InChiKey: QJUWGGININGVSC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) Smad1 0.0185 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0426 0.152 0.152
Toxoplasma gondii isocitrate dehydrogenase 0.0098 0.0302 0.3059
Echinococcus multilocularis mothers against decapentaplegic 2 0.0083 0.0247 0.0858
Schistosoma mansoni tar DNA-binding protein 0.0793 0.2878 0.8582
Echinococcus multilocularis Aminotransferase class III 0.0067 0.0187 0.0651
Echinococcus granulosus nibrin 0.0039 0.0084 0.0291
Brugia malayi RNA binding protein 0.0793 0.2878 0.2874
Echinococcus granulosus segment polarity protein dishevelled 0.0026 0.0038 0.0133
Loa Loa (eye worm) RasGEF domain-containing protein 0.0019 0.001 0.001
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0067 0.0187 1
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0019 0.001 0.0035
Echinococcus multilocularis regulator of G protein signaling 7 0.0026 0.0038 0.0133
Brugia malayi N-terminal motif family protein 0.0535 0.1921 0.1916
Schistosoma mansoni regulator of G protein signaling 0.0026 0.0038 0.0097
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0793 0.2878 0.2878
Echinococcus granulosus regulator of G protein signaling 7 0.0026 0.0038 0.0133
Brugia malayi Smad1 0.0185 0.0626 0.0621
Mycobacterium ulcerans L-lysine aminotransferase 0.0067 0.0187 0.0652
Schistosoma mansoni topbp1 0.0039 0.0084 0.0233
Trichomonas vaginalis replication factor C large subunit, putative 0.0039 0.0084 0.0499
Schistosoma mansoni Smad4 0.0185 0.0626 0.1854
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0426 0.152 0.5281
Loa Loa (eye worm) transcription factor SMAD2 0.2716 1 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0026 0.0038 0.0133
Trypanosoma cruzi PAB1-binding protein , putative 0.0279 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.032 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0084 0.0499
Loa Loa (eye worm) hypothetical protein 0.0039 0.0084 0.0084
Plasmodium vivax ataxin-2 like protein, putative 0.0279 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0279 0.0975 0.0975
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0006
Brugia malayi MH1 domain containing protein 0.0185 0.0626 0.0621
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0216 0.063
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0019 0.001 0.0035
Schistosoma mansoni Smad4 0.0083 0.0247 0.0721
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0106 0.0334 0.2466
Echinococcus multilocularis Protein son of sevenless 0.0019 0.001 0.0035
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0098 0.0302 0.105
Echinococcus multilocularis segment polarity protein dishevelled 0.0026 0.0038 0.0133
Loa Loa (eye worm) hypothetical protein 0.0083 0.0247 0.0247
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0098 0.0302 0.3099
Brugia malayi hypothetical protein 0.0026 0.0038 0.0032
Echinococcus granulosus Aminotransferase class III 0.0067 0.0187 0.0651
Schistosoma mansoni topbp1 0.0039 0.0084 0.0233
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0084 0.0858
Loa Loa (eye worm) RasGEF domain-containing protein 0.0019 0.001 0.001
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0067 0.0187 0.0652
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0067 0.0187 0.0652
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0067 0.0187 0.0652
Loa Loa (eye worm) hypothetical protein 0.0921 0.3352 0.3352
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0098 0.0302 0.0886
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0039 0.0084 0.0499
Brugia malayi N-terminal motif family protein 0.0019 0.001 0.0004
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0019 0.001 0.0035
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0426 0.152 0.5281
Schistosoma mansoni tar DNA-binding protein 0.0793 0.2878 0.8582
Schistosoma mansoni dishevelled 0.0026 0.0038 0.0097
Echinococcus granulosus GPCR family 2 0.0426 0.152 0.5281
Loa Loa (eye worm) MH1 domain-containing protein 0.0185 0.0626 0.0626
Brugia malayi MH1 domain containing protein 0.0185 0.0626 0.0621
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0098 0.0302 0.3099
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0038
Toxoplasma gondii proteasome regulatory subunit 0.0021 0.0019 0.0134
Trypanosoma cruzi PAB1-binding protein , putative 0.0279 0.0975 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0098 0.0302 0.3099
Schistosoma mansoni smad1 5 8 and 0.0185 0.0626 0.1854
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0021 0.0019 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0106 0.0299
Brugia malayi Latrophilin receptor protein 2 0.0426 0.152 0.1515
Trichomonas vaginalis ras GTP exchange factor, putative 0.0019 0.001 0.0061
Echinococcus multilocularis nibrin 0.0039 0.0084 0.0291
Echinococcus multilocularis tar DNA binding protein 0.0793 0.2878 1
Echinococcus multilocularis son of sevenless 1 0.0019 0.001 0.0035
Plasmodium falciparum ataxin-2 like protein, putative 0.0279 0.0975 1
Echinococcus multilocularis ras GTP exchange factor 0.0019 0.001 0.0035
Echinococcus multilocularis ornithine aminotransferase 0.0067 0.0187 0.0651
Entamoeba histolytica hypothetical protein 0.0074 0.0216 0.1572
Giardia lamblia Replication factor C, subunit 1 0.0039 0.0084 0.0633
Onchocerca volvulus 0.0039 0.0084 0.0407
Schistosoma mansoni tar DNA-binding protein 0.0793 0.2878 0.8582
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0106 0.0367
Schistosoma mansoni hypothetical protein 0.0426 0.152 0.4524
Brugia malayi TAR-binding protein 0.0793 0.2878 0.2874
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1347 0.4931 0.4928
Echinococcus multilocularis segment polarity protein dishevelled 0.0026 0.0038 0.0133
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0039 0.0084 0.0561
Schistosoma mansoni chromosome transmission fidelity factor 0.0039 0.0084 0.0233
Brugia malayi hypothetical protein 0.0443 0.1583 0.1578
Brugia malayi RasGEF domain containing protein 0.0019 0.001 0.0004
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0019 0.001 0.0013
Echinococcus granulosus Protein son of sevenless 0.0019 0.001 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0084 0.0499
Plasmodium falciparum ornithine aminotransferase 0.0067 0.0187 0.1875
Trypanosoma brucei PAB1-binding protein , putative 0.0279 0.0975 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0026 0.0038 0.0133
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0019 0.001 0.0104
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0125 0.0405 0.1406
Loa Loa (eye worm) hypothetical protein 0.0535 0.1921 0.1921
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0039 0.0084 0.0858
Toxoplasma gondii hypothetical protein 0.0026 0.0038 0.0335
Echinococcus multilocularis isocitrate dehydrogenase 0.0098 0.0302 0.105
Brugia malayi MH2 domain containing protein 0.0083 0.0247 0.0241
Loa Loa (eye worm) latrophilin receptor protein 2 0.0426 0.152 0.152
Schistosoma mansoni z-protein (S1r protein) 0.0026 0.0038 0.0097
Echinococcus granulosus mothers against decapentaplegic 6 0.0083 0.0247 0.0858
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0038
Echinococcus multilocularis GPCR, family 2 0.0426 0.152 0.5281
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0098 0.0302 0.105
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0019 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0084 0.0084
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0426 0.152 0.1515
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0106 0.0299
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0026 0.0038 0.0097
Entamoeba histolytica hypothetical protein 0.0074 0.0216 0.1572
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0021 0.0019 0.0013
Echinococcus granulosus ornithine aminotransferase 0.0067 0.0187 0.0651
Echinococcus granulosus smad 0.0185 0.0626 0.2176
Schistosoma mansoni DNA ligase IV 0.0039 0.0084 0.0233
Schistosoma mansoni dep domain containing protein 0.0026 0.0038 0.0097
Plasmodium vivax ornithine aminotransferase, putative 0.0067 0.0187 0.1875
Loa Loa (eye worm) MH1 domain-containing protein 0.0083 0.0247 0.0247
Trypanosoma cruzi FHA domain containing protein, putative 0.0039 0.0084 0.0858
Entamoeba histolytica hypothetical protein 0.0106 0.0334 0.2466
Schistosoma mansoni smad 0.0185 0.0626 0.1854
Leishmania major hypothetical protein, conserved 0.0018 0.0006 0.0058
Echinococcus granulosus segment polarity protein dishevelled 0.0026 0.0038 0.0133
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0098 0.0302 0.105
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0026 0.0038 0.017
Brugia malayi hypothetical protein 0.0279 0.0975 0.097
Brugia malayi latrophilin 2 splice variant baaae 0.0921 0.3352 0.3348
Echinococcus multilocularis smad 0.0185 0.0626 0.2176
Loa Loa (eye worm) hypothetical protein 0.0039 0.0084 0.0084
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0021 0.0019 0.0134
Brugia malayi hypothetical protein 0.018 0.0608 0.0603
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0067 0.0187 0.0652
Brugia malayi regulator of G-protein signaling egl-10 0.0026 0.0038 0.0032
Leishmania major hypothetical protein, conserved 0.0279 0.0975 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0039 0.0084 0.0499
Schistosoma mansoni smad 0.0083 0.0247 0.0721
Schistosoma mansoni hypothetical protein 0.0426 0.152 0.4524
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0084 0.0084
Mycobacterium tuberculosis Probable aminotransferase 0.0469 0.1677 1
Brugia malayi RasGEF domain containing protein 0.0019 0.001 0.0004
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0039 0.0084 0.0499
Onchocerca volvulus 0.0026 0.0038 0.017
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0019 0.001 0.0061
Brugia malayi MH1 domain containing protein 0.0102 0.032 0.0314
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0021 0.0019 0.0065
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0067 0.0187 1
Mycobacterium ulcerans acetylornithine aminotransferase 0.0067 0.0187 0.0652
Loa Loa (eye worm) hypothetical protein 0.0039 0.0084 0.0084
Brugia malayi RNA recognition motif domain containing protein 0.0793 0.2878 0.2874
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0098 0.0302 0.105
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0039 0.0084 0.0858
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0018 0.0007 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0106 0.0367
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0067 0.0187 0.1875
Giardia lamblia DNA repair protein RAD52 0.0373 0.1322 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0279 0.0975 1
Trichomonas vaginalis ras GTP exchange factor, putative 0.0019 0.001 0.0061
Schistosoma mansoni hypothetical protein 0.0921 0.3352 1
Schistosoma mansoni tar DNA-binding protein 0.0793 0.2878 0.8582
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0098 0.0302 0.3099
Schistosoma mansoni hypothetical protein 0.0125 0.0405 0.1192
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0067 0.0187 0.0182
Onchocerca volvulus 0.0019 0.001 0.0023
Plasmodium falciparum replication factor C subunit 1, putative 0.0039 0.0084 0.0805
Echinococcus multilocularis ornithine aminotransferase 0.0067 0.0187 0.0651
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0426 0.152 0.5281
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0021 0.0019 0.0134
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0026 0.0038 0.0032
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0426 0.152 0.5281
Brugia malayi Isocitrate dehydrogenase 0.0098 0.0302 0.0297
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0106 0.0106
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0019 0.001 0.0061
Brugia malayi topoisomerase 0.0039 0.0084 0.0078
Echinococcus granulosus Smad4 0.0185 0.0626 0.2176
Toxoplasma gondii ATPase, AAA family protein 0.0039 0.0084 0.0805
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0185 0.0626 0.2176
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0067 0.0187 0.0652
Trypanosoma cruzi hypothetical protein 0.0019 0.001 0.0104
Mycobacterium ulcerans hypothetical protein 0.0469 0.1677 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0083 0.0247 0.0241
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0373 0.1322 1
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0006 0.002
Loa Loa (eye worm) nuclear factor I 0.0102 0.032 0.032
Echinococcus granulosus regulator of G protein signaling 7 0.0026 0.0038 0.0133
Brugia malayi Calcitonin receptor-like protein seb-1 0.1347 0.4931 0.4928
Brugia malayi hypothetical protein 0.0026 0.0038 0.0032
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0125 0.0405 0.1406
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0019 0.001 0.0035
Schistosoma mansoni smad1 5 8 and 0.0185 0.0626 0.1854
Schistosoma mansoni hypothetical protein 0.0426 0.152 0.4524
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0019 0.001 0.0023
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0098 0.0302 0.3059
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0098 0.0302 0.3099
Brugia malayi Pax transcription activation domain interacting protein 0.0039 0.0084 0.0078
Entamoeba histolytica hypothetical protein 0.0074 0.0216 0.1572
Loa Loa (eye worm) hypothetical protein 0.1347 0.4931 0.4931
Echinococcus multilocularis replication factor c subunit 1 0.0039 0.0084 0.0291
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0185 0.0626 0.1854
Loa Loa (eye worm) hypothetical protein 0.0039 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0084 0.0499
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0039 0.0084 0.0805
Brugia malayi hypothetical protein 0.0039 0.0084 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0106 0.0367
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0006 0.0006
Echinococcus multilocularis Smad4 0.0185 0.0626 0.2176
Echinococcus multilocularis mothers against decapentaplegic 5 0.0185 0.0626 0.2176
Schistosoma mansoni smad1 5 8 and 0.0185 0.0626 0.1854
Brugia malayi RasGEF domain containing protein 0.0019 0.001 0.0004
Echinococcus granulosus ras GTP exchange factor 0.0019 0.001 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0216 0.0752
Echinococcus multilocularis mothers against decapentaplegic 6 0.0083 0.0247 0.0858
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0216 0.0752
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0469 0.1677 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.0026 0.0038 0.0133
Brugia malayi DIX domain containing protein 0.0026 0.0038 0.0032
Brugia malayi isocitrate dehydrogenase 0.0098 0.0302 0.0297
Loa Loa (eye worm) hypothetical protein 0.0443 0.1583 0.1583
Schistosoma mansoni Smad4 0.0083 0.0247 0.0721
Schistosoma mansoni hypothetical protein 0.0426 0.152 0.4524
Schistosoma mansoni ras GTP exchange factor 0.0019 0.001 0.0013
Brugia malayi MH2 domain containing protein 0.0185 0.0626 0.0621
Echinococcus granulosus son of sevenless 1 0.0019 0.001 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0106 0.0299
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0067 0.0187 0.0543
Brugia malayi MH1 domain containing protein 0.0102 0.032 0.0314
Toxoplasma gondii isocitrate dehydrogenase 0.0098 0.0302 0.3059
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0098 0.0302 0.0771
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0006 0.0058
Entamoeba histolytica hypothetical protein 0.0039 0.0084 0.0561
Schistosoma mansoni tar DNA-binding protein 0.0793 0.2878 0.8582
Brugia malayi hypothetical protein 0.0039 0.0084 0.0078
Toxoplasma gondii LsmAD domain-containing protein 0.0279 0.0975 1
Treponema pallidum DNA ligase (lig) 0.0039 0.0084 0.5
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0067 0.0187 0.0652
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1347 0.4931 0.4931
Loa Loa (eye worm) MH2 domain-containing protein 0.0185 0.0626 0.0626
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0026 0.0038 0.0038
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0106 0.01
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0535 0.1921 1
Loa Loa (eye worm) TAR-binding protein 0.0793 0.2878 0.2878
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0469 0.1677 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0084 0.0858
Brugia malayi MH2 domain containing protein 0.0185 0.0626 0.0621
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0106 0.0367
Loa Loa (eye worm) MH2 domain-containing protein 0.2716 1 1
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0019 0.001 0.0013
Loa Loa (eye worm) MH2 domain-containing protein 0.0083 0.0247 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0084 0.0499
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0021 0.0019 0.0013
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0021 0.0019 0.0065
Loa Loa (eye worm) RNA binding protein 0.0793 0.2878 0.2878
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0006 0.002
Brugia malayi hypothetical protein 0.0074 0.0216 0.0211
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0039 0.0084 0.0499
Loa Loa (eye worm) isocitrate dehydrogenase 0.0098 0.0302 0.0302
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0021 0.0019 0.0019
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0067 0.0187 0.0652
Loa Loa (eye worm) DIX domain-containing protein 0.0026 0.0038 0.0038
Schistosoma mansoni dishevelled 0.0026 0.0038 0.0097
Brugia malayi N-terminal motif family protein 0.0019 0.001 0.0004
Entamoeba histolytica hypothetical protein 0.0074 0.0216 0.1572
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0469 0.1677 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0098 0.0302 0.105
Echinococcus granulosus mothers against decapentaplegic 2 0.0083 0.0247 0.0858
Echinococcus granulosus tar DNA binding protein 0.0793 0.2878 1
Echinococcus granulosus replication factor c subunit 1 0.0039 0.0084 0.0291
Schistosoma mansoni hypothetical protein 0.0074 0.0216 0.063
Echinococcus granulosus mothers against decapentaplegic 5 0.0185 0.0626 0.2176
Echinococcus granulosus TGF beta signal transducer SmadC 0.0185 0.0626 0.2176
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0019 0.001 0.0013
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0098 0.0302 0.3059
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0084 0.0499
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0083 0.0247 0.126
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0039 0.0084 0.0078
Onchocerca volvulus 0.0443 0.1583 0.8235
Loa Loa (eye worm) RasGEF domain-containing protein 0.0019 0.001 0.001
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0026 0.0038 0.0032
Brugia malayi DKFZp564C0469 protein 0.0039 0.0084 0.0078
Trypanosoma cruzi hypothetical protein 0.0019 0.001 0.0104
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0469 0.1677 1
Plasmodium vivax replication factor C subunit 1, putative 0.0039 0.0084 0.0805

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 13 % Activation of human estrogen receptor alpha expressed in HEK293 cells at 10 uM by beta-galactosidase reporter gene assay relative to 3,17 beta-estradiol ChEMBL. 18517258
Activity (binding) = 15.4 % Activation of human estrogen receptor beta expressed in HEK293 cells at 10 uM beta-galactosidase reporter gene assay relative to 3,17-beta-estradiol ChEMBL. 18517258

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.