Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0024 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1849 | 0.1849 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0024 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0861 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0861 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0861 | 0.0861 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.2822 | 0.2822 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1849 | 0.1849 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0861 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.2822 | 0.2822 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1849 | 0.1849 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0712 | 0.0712 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0861 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0861 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.0861 | 0.0861 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0861 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0861 | 1 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0024 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.2822 | 0.2822 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.2822 | 0.2822 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0861 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1849 | 0.1849 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0712 | 0.0712 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.0861 | 1 |
Brugia malayi | RNA binding protein | 0.0061 | 0.2822 | 0.2822 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2822 | 0.3373 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.0861 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0712 | 0.0851 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2822 | 0.3373 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.0861 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0035 | 0.0861 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0035 | 0.0861 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0861 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2822 | 0.3373 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2822 | 0.3373 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.2822 | 0.2822 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.0861 | 1 |
Onchocerca volvulus | 0.0091 | 0.5048 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2822 | 0.3373 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.8364 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0861 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.2822 | 0.2822 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0861 | 0.0861 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.8364 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.2822 | 0.2822 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.0861 | 0.103 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.0861 | 0.0861 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimicrobial activity against Escherichia coli ATCC 10536 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.