Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | 0.0515 | 0.1175 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.0627 | 0.5178 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0123 | 0.0208 | 0.0208 |
Echinococcus granulosus | geminin | 0.018 | 0.0348 | 0.2965 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0018 | 0.0149 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0275 | 0.0584 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0156 | 0.029 | 0.029 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0238 | 0.0492 | 0.4 |
Brugia malayi | Probable ClpP-like protease | 0.0238 | 0.0492 | 0.4607 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0275 | 0.0584 | 0.0584 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0238 | 0.0492 | 0.7858 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0348 | 0.2965 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0472 | 0.1068 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0066 | 0.0615 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0446 | 0.1006 | 0.8307 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0472 | 0.1068 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.0627 | 0.5178 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0238 | 0.0492 | 0.4607 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0515 | 0.1175 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0066 | 0.0615 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0036 | 0.0338 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0529 | 0.1211 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0472 | 0.1068 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0238 | 0.0492 | 0.4607 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.003 | 0.0244 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0446 | 0.1006 | 0.8307 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0238 | 0.0492 | 0.0492 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0156 | 0.029 | 0.247 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbC | 0.4097 | 1 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0156 | 0.029 | 0.247 |
Giardia lamblia | DNA topoisomerase II | 0.0447 | 0.1008 | 0.5 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0529 | 0.1211 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0293 | 0.0627 | 0.5178 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0036 | 0.0338 |
Echinococcus multilocularis | snurportin 1 | 0.0259 | 0.0543 | 0.4621 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) | 0.4097 | 1 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0259 | 0.0543 | 0.5083 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0244 | 0.0507 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.0693 | 0.6483 |
Schistosoma mansoni | DNA topoisomerase II | 0.0472 | 0.1068 | 0.9092 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.0012 | 0.0102 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0446 | 0.1006 | 0.8307 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0238 | 0.0492 | 0.7858 |
Brugia malayi | MH2 domain containing protein | 0.01 | 0.0153 | 0.1433 |
Onchocerca volvulus | 0.0163 | 0.0309 | 0.4465 | |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.0492 | 0.4607 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0082 | 0.0108 | 0.101 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0007 | 0.0061 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0472 | 0.1068 | 0.9092 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0036 | 0.0338 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0036 | 0.0338 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0472 | 0.1068 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0293 | 0.0627 | 0.5178 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0309 | 0.289 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0138 | 0.0247 | 0.2041 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0238 | 0.0492 | 0.0492 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0529 | 0.1211 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0217 | 0.0441 | 0.6674 |
Echinococcus multilocularis | geminin | 0.018 | 0.0348 | 0.2965 |
Brugia malayi | jmjC domain containing protein | 0.0101 | 0.0155 | 0.1454 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0018 | 0.0149 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0018 | 0.0149 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.01 | 0.0153 | 0.1433 |
Brugia malayi | Probable DNA topoisomerase II | 0.0472 | 0.1068 | 1 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0082 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0379 | 0.3545 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0113 | 0.0185 | 0.1571 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0529 | 0.1211 | 1 |
Mycobacterium leprae | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) | 0.4097 | 1 | 1 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) | 0.4097 | 1 | 1 |
Mycobacterium leprae | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) | 0.4097 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.0693 | 0.6483 |
Leishmania major | DNA topoisomerase ii | 0.0446 | 0.1006 | 0.8307 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0275 | 0.0584 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0472 | 0.1068 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0022 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0036 | 0.0342 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0472 | 0.1068 | 0.9092 |
Brugia malayi | hypothetical protein | 0.0113 | 0.0185 | 0.1728 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0319 | 0.0691 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0259 | 0.0543 | 0.4621 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0238 | 0.0492 | 0.4188 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0238 | 0.0492 | 0.8074 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.0007 | 0.0061 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.0012 | 0.0102 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.0063 | 0.0591 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0018 | 0.0164 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.0247 | 0.2041 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0515 | 0.1175 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0472 | 0.1068 | 1 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0348 | 0.2965 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0018 | 0.0149 |
Brugia malayi | hypothetical protein | 0.0163 | 0.0309 | 0.289 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0101 | 0.0155 | 0.1322 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0275 | 0.0584 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0275 | 0.0584 | 0.5464 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0101 | 0.0156 | 0.101 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0101 | 0.0156 | 0.146 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0156 | 0.029 | 0.029 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0238 | 0.0492 | 0.4607 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0275 | 0.0584 | 0.0584 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0238 | 0.0492 | 0.7858 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0018 | 0.0149 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0101 | 0.0156 | 0.0156 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0113 | 0.0185 | 0.1571 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbB | 0.4097 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0101 | 0.0156 | 0.05 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0113 | 0.0185 | 0.1571 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.0185 | 0.1571 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.0286 | 0.0286 |
Toxoplasma gondii | hypothetical protein | 0.0082 | 0.0108 | 0.101 |
Brugia malayi | RNA, U transporter 1 | 0.0069 | 0.0076 | 0.0708 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0101 | 0.0156 | 0.0156 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0101 | 0.0156 | 0.146 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0472 | 0.1068 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0238 | 0.0492 | 0.0492 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0472 | 0.1068 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0238 | 0.0492 | 0.4188 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0319 | 0.0691 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0018 | 0.0149 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0275 | 0.0584 | 0.5464 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbA | 0.4097 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0156 | 0.029 | 0.029 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0018 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0379 | 0.3545 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0446 | 0.1006 | 0.8307 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.0247 | 0.2041 |
Schistosoma mansoni | jumonji domain containing protein | 0.008 | 0.0104 | 0.0886 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.0007 | 0.0061 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0007 | 0.0061 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.01 | 0.0153 | 0.1433 |
Echinococcus granulosus | snurportin 1 | 0.0259 | 0.0543 | 0.4621 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0275 | 0.0584 | 0.4955 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.0286 | 0.0286 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0101 | 0.0155 | 0.1322 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0319 | 0.0691 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0238 | 0.0492 | 0.4188 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0018 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0066 | 0.0615 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) | 0.4097 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 25 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of growth of epimastigotes at 25 uM after 5 days by MTT assay relative to control | ChEMBL. | 18706821 |
ID50 (functional) | = 28.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Y assessed as parasite viability after 5 days by MTT assay | ChEMBL. | 18706821 |
ID50 (functional) | > 50 uM | Antitrypanosomal activity against Trypanosoma cruzi CL Brener assessed as parasite viability after 5 days by MTT assay | ChEMBL. | 18706821 |
ID50 (functional) | > 50 uM | Antileishmanial activity against Leishmania braziliensis MHOM/BR/00/LTB300 assessed as parasite viability after 5 days by MTT assay | ChEMBL. | 18706821 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.