Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adenosylhomocysteinase | 0.0113675 | 0.72633 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0113675 | 0.72633 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0113675 | 0.72633 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.00702812 | 0.362512 | 0.499101 |
Schistosoma mansoni | adenosylhomocysteinase | 0.00702812 | 0.362512 | 0.499101 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0113675 | 0.72633 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0113675 | 0.72633 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.00702812 | 0.362512 | 0.499101 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0113675 | 0.72633 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146317 | 1 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0113675 | 0.72633 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0113675 | 0.72633 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.00702812 | 0.362512 | 0.499101 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0113675 | 0.72633 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0113675 | 0.72633 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0113675 | 0.72633 | 0.5 |
Brugia malayi | Adenosylhomocysteinase | 0.0113675 | 0.72633 | 0.72633 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0113675 | 0.72633 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0146317 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0113675 | 0.72633 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0113675 | 0.72633 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0113675 | 0.72633 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0113675 | 0.72633 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0113675 | 0.72633 | 0.72633 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0113675 | 0.72633 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0146317 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 94.6 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as inhibition of parasite growth at 25 uM relative to control | ChEMBL. | 20634064 |
IC50 (functional) | = 2.77 uM | Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake | ChEMBL. | 18215443 |
IC50 (functional) | = 18.9 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes | ChEMBL. | 20634064 |
Inhibition (functional) | = 90 % | Antimicrobial activity against Mycobacterium tuberculosis H37Rv at 6.25 ug/ml by microplate alamar blue assay | ChEMBL. | 19058970 |
MIC (functional) | < 0.2 ug ml-1 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv by microplate alamar blue assay | ChEMBL. | 19058970 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18215443 | |
Trypanosoma cruzi | ChEMBL23 | 20634064 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.