Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.2715 | 0.6052 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Schistosoma mansoni | heat shock protein | 0.007 | 0.297 | 0.2788 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Echinococcus multilocularis | heat shock protein | 0.007 | 0.297 | 0.2788 |
Toxoplasma gondii | heat shock protein 90, putative | 0.007 | 0.297 | 1 |
Plasmodium vivax | endoplasmin, putative | 0.007 | 0.297 | 1 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.007 | 0.297 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.007 | 0.297 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0056 | 0.2033 | 0.655 |
Brugia malayi | RNA binding protein | 0.0066 | 0.2715 | 0.6052 |
Echinococcus multilocularis | geminin | 0.0176 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.007 | 0.297 | 1 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.007 | 0.297 | 1 |
Trypanosoma brucei | heat shock protein 84, putative | 0.0029 | 0.0252 | 0.085 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.2715 | 0.2526 |
Plasmodium vivax | heat shock protein 90, putative | 0.0029 | 0.0252 | 0.085 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0056 | 0.2033 | 0.6843 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0056 | 0.2033 | 0.6843 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0029 | 0.0252 | 0.5 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0056 | 0.2033 | 0.5 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0041 | 0.1084 | 0.3648 |
Loa Loa (eye worm) | heat shock protein 75 | 0.0029 | 0.0252 | 0.0563 |
Trichomonas vaginalis | heat shock protein, putative | 0.0056 | 0.2033 | 0.655 |
Trypanosoma brucei | heat shock protein, putative | 0.007 | 0.297 | 1 |
Trypanosoma cruzi | heat shock protein, putative | 0.0029 | 0.0252 | 0.085 |
Plasmodium vivax | heat shock protein 86, putative | 0.007 | 0.297 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0056 | 0.2033 | 0.1826 |
Toxoplasma gondii | heat shock protein 75, putative | 0.0029 | 0.0252 | 0.085 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2715 | 0.2526 |
Trypanosoma brucei | heat shock protein 90, putative | 0.007 | 0.297 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.4486 | 0.4343 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.4486 | 0.4343 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.4486 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.4486 | 0.4343 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.4486 | 0.4343 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0056 | 0.2033 | 0.5 |
Plasmodium vivax | heat shock protein, putative | 0.0029 | 0.0252 | 0.085 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0056 | 0.2033 | 0.1826 |
Trypanosoma brucei | heat shock protein, putative | 0.007 | 0.297 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0056 | 0.2033 | 0.1826 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.4486 | 0.4343 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.007 | 0.297 | 1 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Brugia malayi | Hsp90 protein | 0.0029 | 0.0252 | 0.0563 |
Trichomonas vaginalis | heat shock protein, putative | 0.0056 | 0.2033 | 0.655 |
Trichomonas vaginalis | heat shock protein, putative | 0.0043 | 0.119 | 0.345 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.2715 | 0.2526 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2715 | 0.2526 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.2715 | 0.6052 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.007 | 0.297 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0056 | 0.2033 | 0.5 |
Trichomonas vaginalis | endoplasmin, putative | 0.0043 | 0.119 | 0.345 |
Trypanosoma brucei | heat shock protein, putative | 0.007 | 0.297 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.2715 | 0.6052 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.007 | 0.297 | 0.2788 |
Loa Loa (eye worm) | endoplasmin | 0.007 | 0.297 | 0.6622 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Brugia malayi | heat shock protein 90 | 0.007 | 0.297 | 0.6622 |
Trypanosoma brucei | heat shock protein 90, putative | 0.007 | 0.297 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.2715 | 0.6052 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0056 | 0.2033 | 0.6843 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.007 | 0.297 | 1 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.007 | 0.297 | 1 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Schistosoma mansoni | endoplasmin | 0.007 | 0.297 | 0.2788 |
Loa Loa (eye worm) | heat shock protein 90 | 0.007 | 0.297 | 0.6622 |
Trypanosoma brucei | heat shock protein, putative | 0.007 | 0.297 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.007 | 0.297 | 0.2788 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2715 | 0.2526 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Echinococcus granulosus | endoplasmin | 0.0056 | 0.2033 | 0.1826 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.007 | 0.297 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.007 | 0.297 | 1 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Leishmania major | heat shock protein, putative | 0.0029 | 0.0252 | 0.085 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.007 | 0.297 | 1 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Echinococcus multilocularis | endoplasmin | 0.0056 | 0.2033 | 0.1826 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.4486 | 0.4343 |
Plasmodium falciparum | endoplasmin, putative | 0.0043 | 0.119 | 0.4007 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0029 | 0.0252 | 0.085 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.007 | 0.297 | 1 |
Plasmodium falciparum | heat shock protein 90 | 0.007 | 0.297 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.4486 | 0.4343 |
Entamoeba histolytica | heat shock protein 90, putative | 0.007 | 0.297 | 1 |
Schistosoma mansoni | endoplasmin | 0.007 | 0.297 | 0.2788 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.2715 | 0.6052 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2715 | 0.2526 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2715 | 0.2526 |
Schistosoma mansoni | heat shock protein | 0.007 | 0.297 | 0.2788 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.007 | 0.297 | 1 |
Treponema pallidum | heat shock protein 90 | 0.0056 | 0.2033 | 0.5 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0029 | 0.0252 | 0.085 |
Trypanosoma brucei | heat shock protein, putative | 0.007 | 0.297 | 1 |
Brugia malayi | Endoplasmin precursor | 0.007 | 0.297 | 0.6622 |
Leishmania major | heat shock protein 83-1 | 0.007 | 0.297 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.4486 | 1 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0029 | 0.0252 | 0.085 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Echinococcus granulosus | heat shock protein | 0.007 | 0.297 | 0.2788 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0056 | 0.2033 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 309 uM | Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6 | ChEMBL. | 17582660 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.