Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.0688 | 0.119 |
Brugia malayi | EGF-like domain containing protein | 0.003 | 0.0282 | 0.0457 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0408 | 0.0304 |
Echinococcus multilocularis | neural cadherin | 0.003 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | phosphofructokinase | 0.0119 | 0.1921 | 0.3449 |
Brugia malayi | Animal haem peroxidase family protein | 0.0183 | 0.3103 | 0.5549 |
Plasmodium falciparum | pyruvate kinase | 0.0036 | 0.0408 | 0.5493 |
Onchocerca volvulus | 0.0183 | 0.3103 | 0.67 | |
Onchocerca volvulus | 0.0033 | 0.0338 | 0.0137 | |
Onchocerca volvulus | 0.003 | 0.0282 | 0.0005 | |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.1921 | 0.3368 |
Giardia lamblia | High cysteine protein | 0.003 | 0.0282 | 0.6297 |
Onchocerca volvulus | 0.0183 | 0.3103 | 0.67 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0258 | 0.4494 | 0.8045 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.003 | 0.0282 | 0.0457 |
Schistosoma mansoni | slit | 0.003 | 0.0282 | 0.0216 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0307 | 0.5381 | 0.9662 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0032 | 0.0328 | 0.4201 |
Toxoplasma gondii | EGF family domain-containing protein | 0.003 | 0.0282 | 0.0404 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0036 | 0.0408 | 0.0641 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.028 | 0.0503 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0114 | 0.1837 | 0.333 |
Brugia malayi | EGF-like domain containing protein | 0.003 | 0.0282 | 0.0457 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.1921 | 0.3368 |
Brugia malayi | 6-phosphofructokinase | 0.0119 | 0.1921 | 0.3415 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0119 | 0.1921 | 0.8706 |
Brugia malayi | EGF-like domain containing protein | 0.003 | 0.0282 | 0.0457 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.003 | 0.0282 | 0.0282 |
Echinococcus multilocularis | fibropellin Ia | 0.003 | 0.0282 | 0.0282 |
Brugia malayi | Cadherin domain containing protein | 0.003 | 0.0282 | 0.0457 |
Brugia malayi | glutaminase DH11.1 | 0.0317 | 0.557 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0317 | 0.557 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0036 | 0.0408 | 0.0619 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0032 | 0.0328 | 0.049 |
Onchocerca volvulus | 0.0258 | 0.4494 | 1 | |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.0688 | 0.1167 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0119 | 0.1921 | 0.3368 |
Schistosoma mansoni | notch | 0.003 | 0.0282 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Giardia lamblia | Pyruvate kinase | 0.0019 | 0.0082 | 0.0434 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.028 | 0.0214 |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.0082 | 0.0082 |
Brugia malayi | GCC2 and GCC3 family protein | 0.003 | 0.0282 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Echinococcus multilocularis | slit 2 protein | 0.003 | 0.0282 | 0.0282 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0307 | 0.5381 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0119 | 0.1921 | 0.1921 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0338 | 0.4358 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0338 | 0.0338 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0282 | 0.0216 |
Onchocerca volvulus | Peroxidasin homolog | 0.0183 | 0.3103 | 0.67 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.027 | 0.0485 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0131 | 0.2146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0025 | 0.0206 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0282 | 0.0216 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0119 | 0.1921 | 0.3487 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0119 | 0.1921 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0183 | 0.3103 | 0.5549 |
Loa Loa (eye worm) | glutathione reductase | 0.0052 | 0.0688 | 0.1235 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0119 | 0.1921 | 0.3487 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0282 | 0.0216 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0307 | 0.5381 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0558 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0183 | 0.3103 | 0.5549 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0119 | 0.1921 | 0.3449 |
Leishmania major | 0.0307 | 0.5381 | 1 | |
Brugia malayi | intermediate filament protein | 0.0029 | 0.028 | 0.0454 |
Loa Loa (eye worm) | Notch2 | 0.003 | 0.0282 | 0.0507 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0307 | 0.5381 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0131 | 0.2146 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0657 | 0.0593 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0307 | 0.5381 | 1 |
Schistosoma mansoni | septate junction protein | 0.003 | 0.0282 | 0.0216 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0657 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Schistosoma mansoni | glutaminase | 0.0317 | 0.557 | 0.554 |
Echinococcus multilocularis | pyruvate kinase | 0.0029 | 0.0267 | 0.0267 |
Echinococcus granulosus | delta-like protein 1 | 0.003 | 0.0282 | 0.0282 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.0688 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.1921 | 0.3368 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0118 | 0.1904 | 0.8837 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0114 | 0.1837 | 0.333 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.028 | 0.0454 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0114 | 0.1837 | 0.333 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.0408 | 0.0641 |
Echinococcus granulosus | fibropellin Ia | 0.003 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0119 | 0.1921 | 0.3449 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0338 | 0.0338 |
Echinococcus granulosus | neural cadherin | 0.003 | 0.0282 | 0.0282 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0307 | 0.5381 | 0.535 |
Brugia malayi | EGF-like domain containing protein | 0.003 | 0.0282 | 0.0457 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0307 | 0.5381 | 0.5381 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Echinococcus multilocularis | peroxidasin | 0.0183 | 0.3103 | 0.3103 |
Echinococcus granulosus | notch | 0.003 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Brugia malayi | EGF-like domain containing protein | 0.003 | 0.0282 | 0.0457 |
Plasmodium vivax | pyruvate kinase, putative | 0.0036 | 0.0408 | 0.5493 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0119 | 0.1921 | 0.8918 |
Brugia malayi | EGF-like domain containing protein | 0.003 | 0.0282 | 0.0457 |
Echinococcus granulosus | neurogenic locus notch protein | 0.003 | 0.0282 | 0.0282 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.0408 | 0.0408 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0328 | 0.0474 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.0688 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0036 | 0.0408 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0338 | 0.0338 |
Echinococcus granulosus | neurogenic locus protein delta | 0.003 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0408 | 0.0733 |
Trichomonas vaginalis | glutaminase, putative | 0.0317 | 0.557 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0183 | 0.3103 | 0.5572 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0036 | 0.0408 | 0.0685 |
Schistosoma mansoni | pyruvate kinase | 0.0019 | 0.0082 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.028 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0338 | 0.0558 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0657 | 0.1134 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0036 | 0.0408 | 0.164 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0068 | 0.5 |
Onchocerca volvulus | 0.0183 | 0.3103 | 0.67 | |
Onchocerca volvulus | Slit protein homolog | 0.003 | 0.0282 | 0.0005 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.0082 | 0.0082 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.0082 | 0.0082 |
Schistosoma mansoni | lamin | 0.0029 | 0.028 | 0.0214 |
Schistosoma mansoni | pyruvate kinase | 0.0036 | 0.0408 | 0.0343 |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.0082 | 0.0082 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0036 | 0.0408 | 0.0641 |
Brugia malayi | EGF-like domain containing protein | 0.003 | 0.0282 | 0.0457 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0657 | 0.0657 |
Onchocerca volvulus | Peroxidase homolog | 0.0183 | 0.3103 | 0.67 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0114 | 0.1837 | 0.333 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0206 | 0.0369 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0119 | 0.1921 | 0.1866 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.0019 | 0.0082 | 0.0238 |
Brugia malayi | phosphofructokinase | 0.0119 | 0.1921 | 0.3415 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0328 | 0.0474 |
Schistosoma mansoni | hypothetical protein | 0.0558 | 1 | 1 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0032 | 0.0328 | 0.7648 |
Onchocerca volvulus | Peroxidase homolog | 0.0183 | 0.3103 | 0.67 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.003 | 0.0282 | 0.0282 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0657 | 0.0657 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0328 | 0.0474 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0029 | 0.0052 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0032 | 0.0328 | 0.049 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.0688 | 1 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0119 | 0.1921 | 0.3487 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0131 | 0.2146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0032 | 0.0328 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Schistosoma mansoni | lamin | 0.0029 | 0.028 | 0.0214 |
Onchocerca volvulus | 0.003 | 0.0282 | 0.0005 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0338 | 0.0272 |
Onchocerca volvulus | Putative cubilin | 0.003 | 0.0282 | 0.0005 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0657 | 0.0593 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0657 | 0.0657 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0282 | 0.0216 |
Loa Loa (eye worm) | notch protein | 0.003 | 0.0282 | 0.0507 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.003 | 0.0282 | 0.0457 |
Echinococcus granulosus | neurogenic locus notch protein | 0.003 | 0.0282 | 0.0282 |
Schistosoma mansoni | pyruvate kinase | 0.0036 | 0.0408 | 0.0343 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0408 | 0.0304 |
Schistosoma mansoni | peroxidasin | 0.0183 | 0.3103 | 0.3056 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.0688 | 0.1167 |
Brugia malayi | Pre-SET motif family protein | 0.0227 | 0.3917 | 0.7017 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Brugia malayi | notch-like transmembrane receptor | 0.003 | 0.0282 | 0.0457 |
Echinococcus multilocularis | protein jagged 1 | 0.003 | 0.0282 | 0.0282 |
Brugia malayi | Animal haem peroxidase family protein | 0.0183 | 0.3103 | 0.5549 |
Plasmodium falciparum | pyruvate kinase 2 | 0.0019 | 0.0082 | 0.0238 |
Echinococcus granulosus | protein jagged 2 | 0.003 | 0.0282 | 0.0282 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.028 | 0.028 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0282 | 0.0216 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0119 | 0.1921 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0338 | 0.0607 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0328 | 0.0474 |
Schistosoma mansoni | notch | 0.003 | 0.0282 | 0.0216 |
Loa Loa (eye worm) | glutaminase 2 | 0.0317 | 0.557 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0317 | 0.557 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0657 | 0.0657 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.0688 | 0.1167 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0118 | 0.1904 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0338 | 0.0272 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.003 | 0.0282 | 0.0282 |
Brugia malayi | Blistered cuticle protein 3 | 0.0183 | 0.3103 | 0.5549 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.003 | 0.0282 | 0.0457 |
Schistosoma mansoni | notch | 0.003 | 0.0282 | 0.0216 |
Echinococcus granulosus | pyruvate kinase | 0.0036 | 0.0408 | 0.0408 |
Schistosoma mansoni | notch | 0.003 | 0.0282 | 0.0216 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0036 | 0.0408 | 0.0641 |
Leishmania major | pyruvate kinase | 0.0036 | 0.0408 | 0.0641 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0118 | 0.1904 | 0.8837 |
Echinococcus granulosus | peroxidasin | 0.0183 | 0.3103 | 0.3103 |
Schistosoma mansoni | laminin gamma-3 chain | 0.003 | 0.0282 | 0.0216 |
Echinococcus granulosus | pyruvate kinase | 0.0036 | 0.0408 | 0.0408 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0032 | 0.0328 | 0.4201 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0119 | 0.1921 | 0.1866 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0032 | 0.0328 | 0.1406 |
Brugia malayi | 6-phosphofructokinase | 0.0119 | 0.1921 | 0.3415 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0307 | 0.5381 | 0.5381 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0328 | 0.0474 |
Onchocerca volvulus | Peroxidasin homolog | 0.0183 | 0.3103 | 0.67 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0183 | 0.3103 | 0.5572 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0408 | 0.0733 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0657 | 0.0593 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.0688 | 0.0688 |
Brugia malayi | Muscle positioning protein 4 | 0.003 | 0.0282 | 0.0457 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.0408 | 0.0641 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0282 | 0.0216 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.0068 | 0.0068 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0338 | 0.0509 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0183 | 0.3103 | 0.5572 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.003 | 0.0282 | 0.0282 |
Echinococcus granulosus | protein jagged 1 | 0.003 | 0.0282 | 0.0282 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.003 | 0.0282 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Brugia malayi | glutathione reductase | 0.0052 | 0.0688 | 0.119 |
Schistosoma mansoni | notch | 0.003 | 0.0282 | 0.0216 |
Mycobacterium tuberculosis | Probable reductase | 0.0118 | 0.1904 | 0.8837 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.003 | 0.0282 | 0.0282 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0032 | 0.0328 | 0.4201 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0052 | 0.0688 | 0.2985 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0036 | 0.0408 | 0.0685 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.003 | 0.0282 | 0.0282 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.0408 | 0.0619 |
Echinococcus granulosus | slit 2 protein | 0.003 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0183 | 0.3103 | 0.5572 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0183 | 0.3103 | 0.67 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0408 | 0.0733 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0119 | 0.1921 | 0.1921 |
Chlamydia trachomatis | pyruvate kinase | 0.0036 | 0.0408 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0316 | 0.0316 |
Echinococcus multilocularis | geminin | 0.0558 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0119 | 0.1921 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0032 | 0.0328 | 0.7648 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0131 | 0.2146 | 1 |
Echinococcus multilocularis | lamin | 0.0029 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Brugia malayi | Delta serrate ligand family protein | 0.003 | 0.0282 | 0.0457 |
Echinococcus multilocularis | protein jagged 1 | 0.003 | 0.0282 | 0.0282 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0118 | 0.1904 | 0.8837 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0019 | 0.0082 | 0.0028 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0068 | 0.007 |
Echinococcus granulosus | lamin | 0.0029 | 0.028 | 0.028 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.003 | 0.0282 | 0.0282 |
Echinococcus multilocularis | musashi | 0.0029 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0119 | 0.1921 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0052 | 0.0688 | 0.1235 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.003 | 0.0282 | 0.0005 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.0688 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0338 | 0.0272 |
Onchocerca volvulus | 0.003 | 0.0282 | 0.0005 | |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0328 | 0.0474 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0032 | 0.0328 | 0.049 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.028 | 0.0503 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0032 | 0.0328 | 0.4201 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.0408 | 0.0408 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.028 | 0.028 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0227 | 0.3917 | 0.7032 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.003 | 0.0282 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Leishmania major | pyruvate kinase | 0.0036 | 0.0408 | 0.0641 |
Schistosoma mansoni | notch | 0.003 | 0.0282 | 0.0216 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0338 | 0.0272 |
Brugia malayi | Cadherin domain containing protein | 0.003 | 0.0282 | 0.0457 |
Brugia malayi | Animal haem peroxidase family protein | 0.0183 | 0.3103 | 0.5549 |
Leishmania major | trypanothione reductase | 0.0052 | 0.0688 | 0.1167 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0408 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.1921 | 0.3368 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.0408 | 0.0619 |
Brugia malayi | hypothetical protein | 0.0183 | 0.3103 | 0.5549 |
Echinococcus multilocularis | protein jagged 2 | 0.003 | 0.0282 | 0.0282 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0307 | 0.5381 | 0.966 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.003 | 0.0282 | 0.0216 |
Echinococcus granulosus | protein jagged 2 | 0.003 | 0.0282 | 0.0282 |
Schistosoma mansoni | cell polarity protein | 0.003 | 0.0282 | 0.0216 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0118 | 0.1904 | 0.8837 |
Echinococcus multilocularis | notch | 0.003 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0183 | 0.3103 | 0.5572 |
Schistosoma mansoni | peroxidasin | 0.0183 | 0.3103 | 0.3056 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.028 | 0.028 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0114 | 0.1837 | 0.333 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3103 | 0.5572 |
Echinococcus granulosus | protein jagged 1 | 0.003 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Onchocerca volvulus | Dual oxidase homolog | 0.0183 | 0.3103 | 0.67 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0408 | 0.0733 |
Onchocerca volvulus | 0.003 | 0.0282 | 0.0005 | |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0118 | 0.1904 | 0.8609 |
Brugia malayi | Animal haem peroxidase family protein | 0.0183 | 0.3103 | 0.5549 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.0688 | 0.0688 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0032 | 0.0328 | 0.7648 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0282 | 0.0216 |
Onchocerca volvulus | 0.003 | 0.0282 | 0.0005 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0282 | 0.0507 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0068 | 0.5 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0032 | 0.0328 | 0.0714 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 70 % | Antitumor activity against mouse P388 cells xenografted in mouse assessed as increase in life span at 12.5 mg/kg/day, ip after 9 days | ChEMBL. | 541685 |
ID50 (functional) | = 0.15 mg/ml | Cytotoxicity against mouse L1210 cells | ChEMBL. | 541685 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.