Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.0924 | 0.0924 |
Onchocerca volvulus | 0.0292 | 0.0924 | 0.5 | |
Plasmodium falciparum | thioredoxin reductase | 0.0903 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0903 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0313 | 0.1234 | 0.5 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0313 | 0.1234 | 0.0342 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0903 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0313 | 0.1234 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0903 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0313 | 0.1234 | 0.5 |
Leishmania major | trypanothione reductase | 0.0903 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0313 | 0.1234 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0903 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0313 | 0.1234 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0313 | 0.1234 | 0.1234 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0313 | 0.1234 | 0.0342 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0903 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0313 | 0.1234 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0313 | 0.1234 | 0.5 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0313 | 0.1234 | 0.0342 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0313 | 0.1234 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0313 | 0.1234 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0903 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0313 | 0.1234 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0313 | 0.1234 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0903 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0903 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0903 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0903 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0903 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0903 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 111 nM | Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK cells | ChEMBL. | 19201198 |
IC50 (binding) | = 3392 nM | Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK cells | ChEMBL. | 19201198 |
IC50 (binding) | = 18680 nM | Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK cells | ChEMBL. | 19201198 |
Ki (binding) | = 151 nM | Displacement of [125I]RTI55 from human SERT expressed in HEK cells | ChEMBL. | 19201198 |
Ki (binding) | = 9085 nM | Displacement of [125I]RTI55 from human NET expressed in HEK cells | ChEMBL. | 19201198 |
Ki (binding) | = 97180 nM | Displacement of [125I]RTI55 from human DAT expressed in HEK cells | ChEMBL. | 19201198 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.