Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0134 | 0.1309 | 0.412 | |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1309 | 0.1309 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0134 | 0.1309 | 0.1309 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0307 | 0.0307 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0134 | 0.1309 | 0.1309 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1309 | 0.1309 |
Loa Loa (eye worm) | carboxylesterase | 0.0134 | 0.1309 | 0.1309 |
Onchocerca volvulus | 0.0134 | 0.1309 | 0.412 | |
Loa Loa (eye worm) | carboxylesterase | 0.0134 | 0.1309 | 0.1309 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0134 | 0.1309 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0307 | 0.0307 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1309 | 0.1309 |
Onchocerca volvulus | 0.0134 | 0.1309 | 0.412 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0134 | 0.1309 | 0.1309 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0134 | 0.1309 | 0.1309 |
Schistosoma mansoni | acetylcholinesterase | 0.0134 | 0.1309 | 0.1309 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1309 | 0.1309 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0792 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0242 | 0.2736 | 0.2736 |
Trichomonas vaginalis | set domain proteins, putative | 0.0275 | 0.3177 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1309 | 0.1309 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0134 | 0.1309 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0134 | 0.1309 | 0.1309 |
Echinococcus multilocularis | neuroligin | 0.0134 | 0.1309 | 0.1309 |
Echinococcus granulosus | neuroligin | 0.0134 | 0.1309 | 0.1309 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.1309 | 0.1309 |
Brugia malayi | hypothetical protein | 0.0134 | 0.1309 | 0.1309 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1309 | 0.1309 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.1309 | 0.1309 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1309 | 0.1309 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0134 | 0.1309 | 0.1309 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0134 | 0.1309 | 0.1309 |
Brugia malayi | Carboxylesterase family protein | 0.0792 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0134 | 0.1309 | 0.1309 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0307 | 0.0307 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0065 | 0.0065 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0134 | 0.1309 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0792 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0307 | 0.0307 |
Echinococcus granulosus | acetylcholinesterase | 0.0792 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0792 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0792 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0792 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0792 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0134 | 0.1309 | 0.1309 |
Onchocerca volvulus | 0.0275 | 0.3177 | 1 | |
Onchocerca volvulus | 0.0134 | 0.1309 | 0.412 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0792 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0134 | 0.1309 | 0.1309 |
Brugia malayi | Pre-SET motif family protein | 0.0242 | 0.2736 | 0.2736 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0065 | 0.0065 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.1309 | 0.1309 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0134 | 0.1309 | 0.1309 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0134 | 0.1309 | 0.1309 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0792 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0134 | 0.1309 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.1309 | 0.1309 |
Onchocerca volvulus | 0.0134 | 0.1309 | 0.412 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0792 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0792 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 24 ug ml-1 | Inhibition of FtsZ-mediated cell division in Bacillus subtilis 168 assessed as drug concentration required to produce filamentation | ChEMBL. | 19064318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.