Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0031 | 0.0341 | 0.018 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0069 | 0.2988 | 0.9552 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0031 | 0.0341 | 0.018 |
Echinococcus granulosus | proteasome prosome macropain | 0.0071 | 0.312 | 0.3005 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0071 | 0.312 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0.0341 | 0.0597 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0337 | 0.0176 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0055 | 0.2017 | 0.3733 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0643 | 0.0486 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.1663 | 0.4765 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0037 | 0.0762 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0272 | 0.0217 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1998 | 0.3696 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0071 | 0.312 | 0.5 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0071 | 0.312 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0337 | 0.0348 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.5127 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.5127 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.5127 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0095 | 0.4815 | 0.4728 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1342 | 0.2374 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0643 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1625 | 0.2943 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0031 | 0.0341 | 0.0597 |
Brugia malayi | Isocitrate dehydrogenase | 0.0031 | 0.0341 | 0.0356 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0643 | 0.0486 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0071 | 0.312 | 0.5957 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1274 | 0.2236 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1663 | 0.302 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0054 | 0.1948 | 0.5789 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0079 | 0.3681 | 0.3576 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1998 | 0.3696 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0337 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1386 | 0.2462 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.005 | 0.165 | 0.4246 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1998 | 0.3696 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0071 | 0.312 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0069 | 0.2988 | 0.2871 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0071 | 0.312 | 0.3005 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0594 | 0.0437 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.1663 | 0.4757 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0055 | 0.2017 | 0.3733 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0071 | 0.312 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0054 | 0.1948 | 0.5789 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.291 | 0.5533 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.005 | 0.165 | 0.4246 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0054 | 0.1948 | 0.5789 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.291 | 0.2791 |
Brugia malayi | hypothetical protein | 0.005 | 0.1663 | 0.302 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0341 | 0.018 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0031 | 0.0341 | 0.0015 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0069 | 0.2988 | 0.9466 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1342 | 0.1198 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0079 | 0.3681 | 0.7087 |
Brugia malayi | Probable DNA topoisomerase II | 0.0069 | 0.2988 | 0.569 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0062 | 0.2498 | 0.7764 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0062 | 0.2498 | 0.7761 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.5127 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0594 | 0.0867 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0062 | 0.2498 | 0.7761 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0069 | 0.2988 | 0.2871 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0095 | 0.4815 | 0.4728 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0031 | 0.0341 | 0.0597 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.1663 | 0.507 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0071 | 0.312 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.1663 | 0.507 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0071 | 0.312 | 1 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0055 | 0.1998 | 0.3696 |
Brugia malayi | hypothetical protein | 0.0055 | 0.1998 | 0.3696 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0341 | 0.018 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0337 | 0.0348 |
Brugia malayi | hypothetical protein | 0.0078 | 0.3663 | 0.705 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0079 | 0.3681 | 0.3576 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.3663 | 0.705 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0337 | 0.0176 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0594 | 0.0437 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.005 | 0.165 | 0.4246 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.1663 | 0.4765 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0337 | 0.0176 |
Echinococcus multilocularis | geminin | 0.0168 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0031 | 0.0341 | 0.0356 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0069 | 0.2988 | 0.569 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0069 | 0.2988 | 0.9552 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.0341 | 0.0015 |
Brugia malayi | hypothetical protein | 0.0055 | 0.2017 | 0.3733 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0071 | 0.312 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0054 | 0.1948 | 0.5782 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.3439 | 0.3329 |
Schistosoma mansoni | DNA polymerase eta | 0.0045 | 0.1274 | 0.1128 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0045 | 0.1274 | 0.2236 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0594 | 0.0867 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1342 | 0.1198 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0643 | 0.0486 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1342 | 0.1198 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1342 | 0.1198 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0272 | 0.0217 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0045 | 0.1274 | 0.3357 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0341 | 0.018 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.0341 | 0.0015 |
Brugia malayi | jmjC domain containing protein | 0.0095 | 0.4815 | 0.9371 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0594 | 0.0437 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.2341 | 0.4386 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0069 | 0.2988 | 0.9552 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.0337 | 0.0583 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1342 | 0.2374 |
Echinococcus multilocularis | dna polymerase eta | 0.0045 | 0.1274 | 0.1128 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.291 | 0.5533 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0062 | 0.2498 | 0.7764 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0337 | 0.0176 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0337 | 0.0176 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0965 | 0.0814 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0071 | 0.312 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0.0341 | 0.0597 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1386 | 0.2462 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0643 | 0.0486 |
Onchocerca volvulus | 0.0078 | 0.3663 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0337 | 0.0176 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0594 | 0.0437 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1342 | 0.1198 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0337 | 0.0348 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0337 | 0.0176 |
Onchocerca volvulus | Protein cycle homolog | 0.0055 | 0.2017 | 0.5295 |
Schistosoma mansoni | aryl hydrocarbon receptor nuclear translocator homolog (darnt) | 0.0055 | 0.2017 | 0.1883 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0071 | 0.312 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0062 | 0.2498 | 0.7764 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1342 | 0.1198 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0071 | 0.312 | 1 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0408 | 0.049 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0337 | 0.0176 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0031 | 0.0341 | 0.0356 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0071 | 0.312 | 0.3005 |
Giardia lamblia | DNA topoisomerase II | 0.0066 | 0.2773 | 0.8825 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0071 | 0.312 | 0.5957 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0337 | 0.0176 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0071 | 0.312 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0337 | 0.0348 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1342 | 0.1198 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0069 | 0.2988 | 0.2871 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1998 | 0.3696 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0341 | 0.018 |
Echinococcus granulosus | dna polymerase eta | 0.0045 | 0.1274 | 0.1128 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.1663 | 0.507 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0055 | 0.2017 | 0.3733 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0965 | 0.0814 |
Leishmania major | DNA polymerase eta, putative | 0.0045 | 0.1274 | 0.3368 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0069 | 0.2988 | 0.569 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0045 | 0.1274 | 0.3368 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0069 | 0.2988 | 0.569 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.1663 | 0.507 |
Mycobacterium ulcerans | proteasome PrcB | 0.0071 | 0.312 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0031 | 0.0341 | 0.018 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.1663 | 0.4765 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Immunostimulation activity in BALB/c mouse assessed as stimulation of peritoneal blood neutrophils measured 1 to 3 days post compound injection | ChEMBL. | 25268857 | |
Activity (functional) | Immunostimulation activity in BALB/c mouse assessed as production of IL-2 in splenocytes measured 1 to 3 days post compound injection | ChEMBL. | 25268857 | |
Activity (functional) | Immunostimulation activity in BALB/c mouse assessed as stimulation of monocytes measured 1 to 3 days post compound injection in presence of polymyxin B | ChEMBL. | 25268857 | |
Activity (functional) | Immunostimulation activity in BALB/c mouse assessed as stimulation of monocytes measured 1 to 3 days post compound injection | ChEMBL. | 25268857 | |
Activity (functional) | Immunostimulation activity in BALB/c mouse assessed as stimulation of peritoneal macrophages measured 1 to 3 days post compound injection | ChEMBL. | 25268857 | |
Activity (functional) | Immunostimulation activity in BALB/c mouse assessed as influx of peritoneal macrophages measured 1 to 3 days post compound injection | ChEMBL. | 25268857 | |
Activity (functional) | Immunostimulation activity in BALB/c mouse assessed as stimulation of peritoneal macrophages measured 1 to 3 days post compound injection in presence of polymyxin B | ChEMBL. | 25268857 | |
Activity (functional) | Immunostimulation activity in BALB/c mouse assessed as production of IL-2 in conA-stimulated splenocytes at 100 ug, ip by EIA | ChEMBL. | 25268857 | |
Activity (functional) | Immunostimulation activity in BALB/c mouse assessed as production of IL-beta in peripheral blood at 100 ug, ip by EIA | ChEMBL. | 25268857 | |
Activity (functional) | Immunostimulation activity in BALB/c mouse assessed as stimulation of peritoneal blood neutrophils measured 1 to 3 days post compound injection in presence of polymyxin B | ChEMBL. | 25268857 | |
Activity (functional) | Immunostimulation activity in BALB/c mouse assessed as production of TNF-alpha in peripheral blood at 100 ug, ip by EIA | ChEMBL. | 25268857 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.