Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0438 | 0.0438 |
Echinococcus multilocularis | lamin | 0.0031 | 0.4263 | 0.4263 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.4263 | 0.4263 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.4263 | 0.4001 |
Onchocerca volvulus | 0.0031 | 0.4263 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0031 | 0.4263 | 0.4263 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.4263 | 0.4263 |
Echinococcus granulosus | lamin | 0.0031 | 0.4263 | 0.4263 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.4263 | 0.4263 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.4263 | 0.4263 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0.4263 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.4263 | 0.4263 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.4113 | 0.4113 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.4263 | 0.4001 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.4263 | 0.4263 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Km (binding) | = 0.19 mM | Activity of rat recombinant peptidylglycine alpha-amidating monooxygenase assessed as stimulation of oxygen consumption | ChEMBL. | 18952446 |
Ratio (binding) | = 2.5 10'4/M/s | Ratio of Vm(app) to Km(app) for rat recombinant peptidylglycine alpha-amidating monooxygenase | ChEMBL. | 18952446 |
Vmax(app) (binding) | = 4.6 /s | Activity of rat recombinant peptidylglycine alpha-amidating monooxygenase assessed as stimulation of oxygen consumption | ChEMBL. | 18952446 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.