Detailed information for compound 954411

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 449.883 | Formula: C20H17ClFN3O4S
  • H donors: 1 H acceptors: 5 LogP: 2.79 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(Cc2c1c(O)c1c(c2N(S(=O)(=O)C)C)cccn1)Cc1cccc(c1F)Cl
  • InChi: 1S/C20H17ClFN3O4S/c1-24(30(2,28)29)18-12-6-4-8-23-17(12)19(26)15-13(18)10-25(20(15)27)9-11-5-3-7-14(21)16(11)22/h3-8,26H,9-10H2,1-2H3
  • InChiKey: ICURCJQMZRIVGC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.0004
Brugia malayi Cathepsin L-like precursor 0.0023 0.005 0.0449
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0111 0.035 0.0347
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0208 0.0683 0.068
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0011 0.0008
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.046 0.1549 0.1549
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0004 0.000000093294
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0189 0.0185
Onchocerca volvulus 0.0015 0.0024 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0004
Leishmania major cathepsin L-like protease 0.0088 0.0272 0.0233
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0012 0.0011 0.0011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0013 0.001
Leishmania major DNA polymerase eta, putative 0.0118 0.0373 0.0335
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Brugia malayi Bromodomain containing protein 0.0106 0.0334 0.322
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.2926 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.0004
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.004 0.004
Echinococcus multilocularis zinc finger protein 0.003 0.0072 0.0069
Leishmania major hypothetical protein, conserved 0.0021 0.0043 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0048 0.0135 0.0132
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0027 0.0064 0.7841
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0189 0.0185
Echinococcus multilocularis dna polymerase eta 0.0118 0.0373 0.037
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0132 0.1253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.005 0.0046
Mycobacterium ulcerans hypothetical protein 0.002 0.004 0.11
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0071 0.0656
Schistosoma mansoni transcription factor LCR-F1 0.0048 0.0135 0.0135
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0004 0.000000093294
Loa Loa (eye worm) hypothetical protein 0.0037 0.0098 0.0951
Echinococcus multilocularis muscleblind protein 1 0.01 0.0313 0.0309
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0155 0.0152
Plasmodium vivax SET domain protein, putative 0.0021 0.0042 0.5026
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0041 0.011 0.0106
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0028 0.0068 0.0068
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0065 0.0194 0.0191
Onchocerca volvulus 0.0047 0.0132 0.1253
Schistosoma mansoni hypothetical protein 0.0111 0.035 0.035
Schistosoma mansoni DNA ligase IV 0.001 0.0004 0.0004
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0155 0.0152
Toxoplasma gondii ThiF family protein 0.0021 0.0043 0.1377
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.2691 0.2688
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0155 0.0152
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0155 0.0152
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.005 0.1403
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0021 0.0043 0.0382
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0375
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0111 0.035 0.0347
Loa Loa (eye worm) hypothetical protein 0.031 0.1031 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0112 0.1088
Loa Loa (eye worm) hypothetical protein 0.0231 0.0764 0.7405
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0028 0.0068 0.0064
Schistosoma mansoni cpg binding protein 0.0053 0.0151 0.0151
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.005 0.0046
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0485
Giardia lamblia Rrm3p helicase 0.2926 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.029
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0155 0.0152
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0012 0.0011 0.0008
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0301 0.0297
Echinococcus multilocularis lamin dm0 0.0037 0.0098 0.0095
Brugia malayi ThiF family protein 0.0021 0.0043 0.0386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.0272 0.0269
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0021 0.0043 0.0043
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.003 0.0105
Brugia malayi ThiF family protein 0.0032 0.0081 0.0753
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0301 0.2892
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0388
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0013 0.0013
Plasmodium vivax unspecified product 0.0012 0.0011 0.1003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0028 0.0068 0.0064
Loa Loa (eye worm) ctsf protein 0.0023 0.005 0.0482
Brugia malayi Cathepsin L-like precursor 0.0023 0.005 0.0449
Echinococcus granulosus bloom syndrome protein 0.0029 0.0071 0.0067
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0039 0.0341
Leishmania major cathepsin L-like protease 0.0023 0.005 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0021 0.0043 0.0039
Trypanosoma cruzi ISWI complex protein 0.0021 0.0043 0.0039
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0021 0.0043 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0683 0.068
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0068 0.066
Schistosoma mansoni DNA helicase recq5 0.002 0.0039 0.0039
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0036 0.0036
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0194 0.0191
Brugia malayi AMP-binding enzyme family protein 0.0023 0.005 0.0452
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0683 0.068
Schistosoma mansoni hypothetical protein 0.0021 0.0043 0.0043
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.2926 1 1
Echinococcus granulosus lamin dm0 0.0037 0.0098 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0004
Brugia malayi Cathepsin L-like precursor 0.0015 0.0024 0.0194
Brugia malayi hypothetical protein 0.031 0.1031 1
Trypanosoma cruzi cysteine protease, putative 0.0012 0.0011 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.2926 1 1
Brugia malayi Muscleblind-like protein 0.01 0.0313 0.3009
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0011 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.004 0.0036
Loa Loa (eye worm) apoptosis regulator protein 0.0111 0.035 0.3393
Plasmodium vivax vivapain-3 0.0012 0.0011 0.1003
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0023 0.005 0.0482
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.005 0.0046
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0023 0.005 0.5962
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.0004
Trichomonas vaginalis DNA polymerase eta, putative 0.0065 0.0194 0.0191
Loa Loa (eye worm) intermediate filament protein 0.0037 0.0098 0.0951
Brugia malayi Cathepsin L-like cysteine proteinase 0.0015 0.0024 0.0194
Echinococcus granulosus cysteine protease 0.0012 0.0011 0.0008
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0032 0.0081 0.0081
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0039 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0194 0.0191
Trypanosoma cruzi cysteine peptidase, putative 0.0088 0.0272 0.0269
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Plasmodium falciparum cysteine proteinase falcipain 3 0.0023 0.005 0.5962
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.1582
Echinococcus granulosus microtubule associated protein 2 0.1384 0.4714 0.4713
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0072 0.0219 0.748
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0021 0.0042 0.0042
Echinococcus granulosus zinc finger protein 0.003 0.0072 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.005 0.1403
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0065 0.0194 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.005 0.0046
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.003 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0018 0.0032 0.0029
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.005 0.1403
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0123 0.0123
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.2926 1 1
Trypanosoma cruzi ISWI complex protein 0.0021 0.0043 0.0039
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0065 0.0194 0.1885
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0155 0.0115
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0155 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.0272 0.0269
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.029
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0155 0.0152
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0155 0.0152
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.011 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.005 0.001
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Entamoeba histolytica DNA repair and recombination protein, putative 0.2926 1 1
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0004 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0013 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0125 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.005 0.0046
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.002 0.0039 0.0377
Echinococcus multilocularis muscleblind protein 0.01 0.0313 0.0309
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.005 0.0046
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.0764 0.0761
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0202 0.0663 0.0659
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.005 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.004 0.0036
Schistosoma mansoni hypothetical protein 0.0021 0.0043 0.0043
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0004 0.000000093294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.005 0.0046
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0004 0.000000093294
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0443 0.0439
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.004 0.0036
Trypanosoma brucei DNA polymerase eta, putative 0.0118 0.0373 0.037
Echinococcus granulosus methyl CpG binding domain protein 2 0.0024 0.0051 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.011 0.3201
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0039 0.0035
Echinococcus multilocularis dnaJ subfamily B 0.0273 0.0908 0.0905
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0101 0.0317 0.0317
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0194 0.5759
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.0036
Plasmodium falciparum cysteine proteinase falcipain 1 0.0012 0.0011 0.1003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0021 0.0042 0.1352
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.2926 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0189 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.0272 0.0269
Brugia malayi Pre-SET motif family protein 0.0021 0.0042 0.0379
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Echinococcus multilocularis geminin 0.046 0.1549 0.1546
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.005 0.005
Mycobacterium ulcerans hypothetical protein 0.0106 0.0335 1
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0011 0.0076
Trypanosoma cruzi polo-like protein kinase, putative 0.0064 0.0189 0.0185
Brugia malayi CXXC zinc finger family protein 0.0047 0.0133 0.1256
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.001 0.0005 0.0001
Trypanosoma brucei polo-like protein kinase 0.0064 0.0189 0.0185
Onchocerca volvulus Cathepsin L homolog 0.0023 0.005 0.0449
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0194 0.5759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.005 0.0046
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0071 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0189 0.0185
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.004 0.0036
Trichomonas vaginalis helicase, putative 0.0011 0.0007 0.0004
Echinococcus granulosus cpg binding protein 0.0053 0.0151 0.0147
Trypanosoma cruzi polo-like protein kinase, putative 0.0064 0.0189 0.0185
Trypanosoma cruzi cysteine proteinase, putative 0.0012 0.0011 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0065 0.0194 0.0194
Onchocerca volvulus Cathepsin F homolog 0.0023 0.005 0.0449
Trypanosoma brucei unspecified product 0.0045 0.0125 0.0121
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.001 0.0005 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Brugia malayi Cathepsin L-like precursor 0.0023 0.005 0.0449
Schistosoma mansoni DNA polymerase eta 0.0118 0.0373 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.0272 0.0269
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0085 0.0262 0.0259
Trypanosoma cruzi major cysteine proteinase, putative 0.0069 0.0208 0.0204
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.005 0.0046
Entamoeba histolytica cysteine proteinase 1, putative 0.0012 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0485
Echinococcus granulosus dnaJ subfamily B 0.0273 0.0908 0.0905
Echinococcus granulosus cathepsin L cysteine protease 0.0012 0.0011 0.0008
Brugia malayi intermediate filament protein 0.0037 0.0098 0.092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0039 0.4532
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.005 0.0046
Onchocerca volvulus Serine\/threonine kinase homolog 0.0064 0.0189 0.1801
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.0219 0.0215
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0032 0.0081 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0024 0.002
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0155 0.0152
Onchocerca volvulus 0.0023 0.005 0.0449
Onchocerca volvulus 0.0159 0.0517 0.4994
Brugia malayi ImpB/MucB/SamB family protein 0.0118 0.0373 0.3597
Loa Loa (eye worm) hypothetical protein 0.0034 0.0088 0.0856
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.005 0.001
Trypanosoma brucei hypothetical protein, conserved 0.002 0.004 0.0036
Toxoplasma gondii aldehyde dehydrogenase 0.0041 0.011 0.3686
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0039 0.1219
Brugia malayi Calcitonin receptor-like protein seb-1 0.0067 0.0199 0.1901
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0071 0.0067
Trypanosoma brucei unspecified product 0.0045 0.0125 0.0121
Treponema pallidum fructose-bisphosphate aldolase 0.0208 0.0683 1
Echinococcus multilocularis microtubule associated protein 2 0.1384 0.4714 0.4713
Toxoplasma gondii hypothetical protein 0.0032 0.0081 0.269
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0102 0.0319 0.9505
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0683 0.068
Echinococcus multilocularis protein dispatched 1 0.0047 0.0132 0.0129
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0034
Loa Loa (eye worm) DEAH box polypeptide 35 0.0034 0.0088 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.005 0.0047
Loa Loa (eye worm) RecQ helicase 0.0029 0.0071 0.0688
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0004 0.000000093294
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0065 0.0194 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.005 0.1403
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0125 0.0121
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.005 0.0449
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0023 0.002
Brugia malayi Pre-SET motif family protein 0.014 0.0451 0.4353
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0228
Schistosoma mansoni bromodomain containing protein 0.009 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0062 0.0181 0.1759
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0155 0.0152
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0045 0.0042
Echinococcus granulosus dna polymerase eta 0.0118 0.0373 0.037
Onchocerca volvulus 0.0047 0.0133 0.1256
Loa Loa (eye worm) hypothetical protein 0.01 0.0313 0.3033
Mycobacterium tuberculosis Conserved hypothetical protein 0.0065 0.0194 0.5441
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.004 0.0036
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0208 0.0683 0.068
Plasmodium vivax vivapain-2 0.0023 0.005 0.5962
Giardia lamblia Fructose-bisphosphate aldolase 0.0208 0.0683 0.068
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.004 0.1267
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.004 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0228
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0415
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0928
Brugia malayi Cathepsin L-like precursor 0.0023 0.005 0.0449
Loa Loa (eye worm) ThiF family protein 0.0021 0.0043 0.0419
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0045 0.0042
Brugia malayi Bromodomain containing protein 0.0053 0.0152 0.1441
Entamoeba histolytica serine/threonine protein kinase, putative 0.0064 0.0189 0.0185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0683 0.068
Echinococcus multilocularis cysteine protease 0.0023 0.005 0.0046
Brugia malayi serine/threonine-protein kinase plk-2 0.0064 0.0189 0.1801
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.005 0.014 0.0137
Trypanosoma cruzi cysteine peptidase, putative 0.0088 0.0272 0.0269
Trypanosoma cruzi ubiquitin-activating enzyme-like protein 0.001 0.0005 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0189 0.0185
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0034
Giardia lamblia DNA damage repair protein 0.002 0.004 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0155 0.0155
Echinococcus granulosus fetal alzheimer antigen falz 0.0034 0.0086 0.0083
Echinococcus granulosus dna polymerase kappa 0.0065 0.0194 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0012 0.0011 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.0004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.005 0.1403
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0024 0.0024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0021 0.0043 0.0039
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0111 0.035 0.0347
Loa Loa (eye worm) hypothetical protein 0.0018 0.0032 0.0311
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0004
Loa Loa (eye worm) cysteine protease 0.0023 0.005 0.0482
Echinococcus multilocularis protein patched 0.0041 0.0112 0.0109
Trypanosoma brucei ISWI complex protein 0.0021 0.0043 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Leishmania major cathepsin L-like protease 0.0023 0.005 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0189 0.0185
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0021 0.0043 0.004
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.2926 1 1
Plasmodium vivax vivapain-1 0.0012 0.0011 0.1003
Schistosoma mansoni zinc finger protein 0.0021 0.0043 0.0043
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.005 0.0047
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0041 0.011 0.007
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0028 0.0068 0.0064
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0065 0.0194 0.5441
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0046 0.0127 0.1228
Brugia malayi cathepsin L-like precursor 0.0015 0.0024 0.0194
Echinococcus multilocularis cpg binding protein 0.0053 0.0151 0.0147
Trichomonas vaginalis set domain proteins, putative 0.0159 0.0517 0.0513
Onchocerca volvulus Cathepsin L homolog 0.0023 0.005 0.0449
Brugia malayi Intermediate filament tail domain containing protein 0.0037 0.0098 0.092
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0021 0.0043 0.5121
Toxoplasma gondii cathepsin CPL 0.0023 0.005 0.1604
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.029
Brugia malayi Cathepsin L-like precursor 0.0015 0.0024 0.0194
Brugia malayi CHE-14 protein 0.0041 0.0112 0.1058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0012 0.0011 0.0008
Leishmania major cathepsin L-like protease 0.0088 0.0272 0.0233
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0107
Loa Loa (eye worm) histone methyltransferase 0.0015 0.0023 0.0225
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0067 0.0199 0.1901
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0032 0.0081 1
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0021 0.0043 0.5121
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0039 0.1219
Loa Loa (eye worm) hypothetical protein 0.0045 0.0123 0.1194
Schistosoma mansoni lamin 0.0037 0.0098 0.0098
Brugia malayi Cytochrome P450 family protein 0.0052 0.0148 0.1409
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0004
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0011 0.0076
Onchocerca volvulus 0.0023 0.005 0.0449
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.008 0.0246 0.0243
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0482
Loa Loa (eye worm) transcription factor SMAD2 0.0085 0.0262 0.2536
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0039 0.0375
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0039 0.0341
Schistosoma mansoni microtubule-associated protein tau 0.1384 0.4714 0.4714
Onchocerca volvulus 0.0037 0.0098 0.092
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.005 0.0482
Loa Loa (eye worm) hypothetical protein 0.0053 0.0152 0.1474
Schistosoma mansoni hypothetical protein 0.2926 1 1
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Schistosoma mansoni survival motor neuron protein 0.0047 0.0132 0.0132
Echinococcus granulosus lamin 0.0037 0.0098 0.0095
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0306 0.0306
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0034
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.029
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0194 0.0191
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0064 0.0189 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Brugia malayi hypothetical protein 0.0048 0.0135 0.1283
Schistosoma mansoni apoptosis regulator bax 0.0111 0.035 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Entamoeba histolytica hypothetical protein 0.0048 0.0135 0.0132
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0011 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0683 0.068
Brugia malayi MAP kinase sur-1 0.0054 0.0155 0.1474
Trypanosoma cruzi cysteine proteinase, putative 0.0012 0.0011 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Onchocerca volvulus 0.0023 0.005 0.0449
Entamoeba histolytica hypothetical protein 0.0048 0.0135 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.005 0.0046
Onchocerca volvulus 0.031 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0288
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0485
Echinococcus granulosus mixed lineage leukemia protein mll 0.0012 0.0013 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Plasmodium vivax ubiquitin activating enzyme, putative 0.0032 0.0081 1
Schistosoma mansoni hypothetical protein 0.046 0.1549 0.1549
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0155 0.0152
Schistosoma mansoni topbp1 0.001 0.0004 0.0004
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0031 0.3527
Entamoeba histolytica cysteine protease, putative 0.0023 0.005 0.0046
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.005 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0024 0.0051 0.0048
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0005 0.0059
Brugia malayi AMP-binding enzyme family protein 0.0023 0.005 0.0452
Brugia malayi Probable ATP-dependent helicase DHX35 0.0034 0.0088 0.0824
Leishmania major cathepsin L-like protease 0.0088 0.0272 0.0233
Onchocerca volvulus 0.0023 0.005 0.0449
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0096 0.0298 0.0259
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0023 0.005 0.5962
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0034 0.0086 0.0083
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0064 0.0189 0.0185
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0064 0.0189 0.1829
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.005 0.0757
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.0272 0.0269
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.004 0.4711
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.0272 0.0269
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0021 0.0043 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.0272 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Onchocerca volvulus 0.0023 0.005 0.0452
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.0272 0.0269
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0011 0.0008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.005 0.014 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0189 0.0185
Echinococcus granulosus intermediate filament protein 0.0037 0.0098 0.0095
Echinococcus granulosus cathepsin l cysteine peptidase 0.0023 0.005 0.0046
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0155 0.0115
Schistosoma mansoni hypothetical protein 0.0046 0.0127 0.0127
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0021 0.0042 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.005 0.0046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.005 0.1476
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0018 0.0033 0.003
Schistosoma mansoni kinase 0.0033 0.0082 0.0082
Leishmania major cathepsin L-like protease 0.0023 0.005 0.001
Brugia malayi PHD-finger family protein 0.0037 0.0098 0.0915
Schistosoma mansoni methyl-cpg binding protein mbd 0.0024 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0011 0.0008
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0004 0.0000032394
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0155 0.0152
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.003 0.0903
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Schistosoma mansoni cpg binding protein 0.0053 0.0151 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0125 0.0121
Leishmania major ubiquitin-activating enzyme-like protein 0.0021 0.0043 0.0003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0047 0.0133 0.1286
Schistosoma mansoni zinc finger protein 0.003 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0118 0.0373 0.3619
Brugia malayi hypothetical protein 0.0231 0.0764 0.7396
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0102 0.0319 0.9468
Schistosoma mansoni terminal deoxycytidyl transferase 0.0065 0.0194 0.0194
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.005 0.0046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0301 0.2916
Loa Loa (eye worm) hypothetical protein 0.0098 0.0305 0.2957
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.2926 1 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.005 0.1403
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0065 0.0194 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.0272 0.0269
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0112 0.0109
Brugia malayi Cathepsin L-like precursor 0.0023 0.005 0.0449
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0045 0.0123 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0024 0.002
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0029 0.0071 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.0272 0.0269
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0301 0.0297
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.029
Leishmania major cathepsin L-like protease 0.0023 0.005 0.001
Schistosoma mansoni hypothetical protein 0.0111 0.035 0.035
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0202 0.0663 0.0659
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0054 0.0524
Schistosoma mansoni hypothetical protein 0.0111 0.035 0.035
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0111 0.035 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.014 0.0451 0.4372
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0039 0.0035
Entamoeba histolytica hypothetical protein 0.0048 0.0135 0.0132
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0051
Schistosoma mansoni hypothetical protein 0.0021 0.0043 0.0043
Echinococcus multilocularis musashi 0.0037 0.0098 0.0095
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.004 0.0036
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0155 0.5262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.0272 0.0269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0021 0.0043 0.0415
Loa Loa (eye worm) fibroinase 0.0023 0.005 0.0482
Schistosoma mansoni hypothetical protein 0.0273 0.0908 0.0908
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0045 0.0005
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0041 0.011 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0112 0.0109
Schistosoma mansoni methyl-cpg binding protein mbd 0.0024 0.0051 0.0051
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.005 0.0046
Schistosoma mansoni DNA helicase recq1 0.002 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0228
Entamoeba histolytica cysteine proteinase 2 0.0012 0.0011 0.0008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0094 0.0291 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.003 0.0796
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0005 0.0002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0037 0.0098 0.0951
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0189 0.0185
Entamoeba histolytica hypothetical protein 0.0048 0.0135 0.0132
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.0764 0.0761
Echinococcus granulosus GPCR family 2 0.0021 0.0043 0.0039
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0079 0.0076
Schistosoma mansoni hypothetical protein 0.0047 0.0132 0.0132
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0045 0.0042
Trypanosoma brucei protein kinase, putative 0.0054 0.0155 0.0152
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0045 0.0042
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.011 0.011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0683 0.068
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0107
Onchocerca volvulus 0.0021 0.0042 0.0379
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.003 0.3409
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Loa Loa (eye worm) hypothetical protein 0.0067 0.0199 0.1929
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0005 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0034
Loa Loa (eye worm) hypothetical protein 0.0041 0.0112 0.1088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.011 0.3201
Trypanosoma cruzi cysteine peptidase, putative 0.0088 0.0272 0.0269
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0021 0.0043 0.004
Trypanosoma cruzi DNA polymerase eta, putative 0.0118 0.0373 0.037
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0148 0.1438
Onchocerca volvulus 0.0023 0.005 0.0449
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0005 0.0002
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0039 0.0035
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0111 0.035 0.0347
Echinococcus granulosus geminin 0.046 0.1549 0.1546
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.005 0.1403
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0155 0.1503
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0067 0.0199 0.1929
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0024 0.002
Schistosoma mansoni lamin 0.0037 0.0098 0.0098
Echinococcus multilocularis cysteine protease 0.0023 0.005 0.0046
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0202 0.0663 0.0659
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0039 0.0035
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0018 0.0032 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0012 0.0011 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0011 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.002 0.004 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.005 0.0046
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0071 0.0067
Echinococcus granulosus cathepsin L 0.0012 0.0011 0.0008
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.004 0.4711
Brugia malayi Latrophilin receptor protein 2 0.0021 0.0043 0.0382
Onchocerca volvulus 0.0037 0.0098 0.092
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0112 0.0109
Brugia malayi Cathepsin L-like precursor 0.0023 0.005 0.0449
Loa Loa (eye worm) hypothetical protein 0.0051 0.0144 0.1397
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0032 0.0273
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0155 0.0152
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0064 0.0189 0.0185
Echinococcus granulosus muscleblind protein 0.01 0.0313 0.0309
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0012 0.0013 0.001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0096 0.0298 0.0295
Leishmania major DNA polymerase eta, putative 0.0072 0.0219 0.018
Echinococcus granulosus cathepsin l1 0.0023 0.005 0.0046
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0096 0.0298 0.0295
Echinococcus granulosus expressed conserved protein 0.0091 0.0281 0.0277
Leishmania major cathepsin L-like protease 0.0023 0.005 0.001
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0021 0.0043 0.004
Entamoeba histolytica deoxycytidyl transferase, putative 0.0065 0.0194 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Echinococcus granulosus cathepsin L cysteine proteinase 0.0023 0.005 0.0046
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0004 0.0048
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0301 0.0297
Brugia malayi latrophilin 2 splice variant baaae 0.0046 0.0127 0.1198
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0034 0.0086 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.011 0.3201
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0035 0.0089 0.0086
Entamoeba histolytica recQ family DNA helicase 0.001 0.0005 0.0002
Brugia malayi polk-prov protein 0.002 0.004 0.0355
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.005 0.1476
Brugia malayi MH2 domain containing protein 0.0085 0.0262 0.2511
Echinococcus multilocularis dna polymerase kappa 0.0065 0.0194 0.0191
Schistosoma mansoni intermediate filament proteins 0.0037 0.0098 0.0098
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0012 0.0011 0.0011
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0028 0.0068 0.0064
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0023 0.002
Leishmania major cysteine peptidase A (CPA) 0.0023 0.005 0.001
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0194 0.1857
Brugia malayi cytoplasmic intermediate filament protein 0.002 0.0039 0.0343
Schistosoma mansoni patched 1 0.0041 0.0112 0.0112
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0021 0.0043 0.004
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0112 0.0109
Trypanosoma cruzi cruzipain precursor, putative 0.0088 0.0272 0.0269
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0041 0.011 0.269
Leishmania major mitochondrial DNA polymerase beta 0.0202 0.0663 0.0625
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Giardia lamblia DINP protein human, muc B family 0.0065 0.0194 0.0191
Loa Loa (eye worm) hypothetical protein 0.0032 0.0081 0.0785
Echinococcus multilocularis cathepsin L 0.0012 0.0011 0.0008
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0155 0.0152
Giardia lamblia Ubiquitin-activating enzyme E1 1 0.001 0.0005 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0683 0.068
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.004 0.1267
Echinococcus granulosus replication factor c subunit 1 0.001 0.0004 0.000000093294
Entamoeba histolytica cysteine protease, putative 0.0012 0.0011 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0111 0.035 0.3393
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.005 0.0757
Echinococcus granulosus cathepsin l1 0.0015 0.0024 0.002
Plasmodium vivax vivapain-2 0.0023 0.005 0.5962
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0012 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.005 0.0046
Onchocerca volvulus 0.0023 0.005 0.0449
Trypanosoma brucei unspecified product 0.0065 0.0194 0.0191
Schistosoma mansoni hypothetical protein 0.0048 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0021 0.0043 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Loa Loa (eye worm) hypothetical protein 0.0088 0.0271 0.2623
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0048 0.0135 0.0132
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0443 0.0439
Leishmania major DNA polymerase kappa, putative 0.0065 0.0194 0.0155
Entamoeba histolytica hypothetical protein, conserved 0.2926 1 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.2926 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.005 0.0046
Schistosoma mansoni hypothetical protein 0.0021 0.0043 0.0043
Echinococcus multilocularis lamin 0.0037 0.0098 0.0095
Schistosoma mansoni topbp1 0.001 0.0004 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0683 0.068
Echinococcus granulosus histone lysine methyltransferase setb 0.0045 0.0123 0.012
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0111 0.035 0.3371
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0032 0.0081 0.0077
Loa Loa (eye worm) hypothetical protein 0.01 0.0313 0.3033
Echinococcus multilocularis expressed conserved protein 0.0091 0.0281 0.0277
Onchocerca volvulus 0.0023 0.005 0.0449
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0102 0.0319 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.005 0.001
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.003 0.3409
Brugia malayi AMP-binding enzyme family protein 0.0023 0.005 0.0452
Toxoplasma gondii hypothetical protein 0.0033 0.0082 0.273
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0288
Echinococcus multilocularis GPCR, family 2 0.0021 0.0043 0.0039
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0107
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.2926 1 1
Giardia lamblia Kinase, PLK 0.0064 0.0189 0.0185
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0019 0.0036 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.0085 0.0262 0.2536
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0085 0.0262 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.0191
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.005 0.0047
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.005 0.1403
Schistosoma mansoni cpg binding protein 0.0047 0.0133 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0079 0.0076

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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