Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0418 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0217 | 0.286 | 0.286 |
Loa Loa (eye worm) | fibroinase | 0.0418 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0418 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0418 | 1 | 1 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Loa Loa (eye worm) | ctsf protein | 0.0418 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0418 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.021 | 0.2616 | 0.2616 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0418 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0217 | 0.286 | 0.286 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.021 | 0.2616 | 0.2616 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0418 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0418 | 1 | 1 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0418 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0418 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0217 | 0.286 | 0.286 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0418 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0418 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0418 | 1 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0418 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0418 | 1 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0418 | 1 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0418 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0418 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0418 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0418 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.5132 | 0.5132 |
Plasmodium vivax | unspecified product | 0.0217 | 0.286 | 0.286 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.2616 | 0.2616 |
Echinococcus granulosus | cysteine protease | 0.0217 | 0.286 | 0.0331 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0418 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0418 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0418 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0281 | 0.5132 | 0.5132 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0418 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0418 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0418 | 1 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0418 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0418 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0217 | 0.286 | 0.286 |
Trypanosoma cruzi | cysteine protease, putative | 0.0217 | 0.286 | 0.286 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0217 | 0.286 | 0.0331 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0418 | 1 | 1 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0418 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0418 | 1 | 1 |
Plasmodium vivax | vivapain-3 | 0.0217 | 0.286 | 0.286 |
Brugia malayi | Cathepsin L-like precursor | 0.0418 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0418 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0217 | 0.286 | 0.286 |
Brugia malayi | Cathepsin L-like precursor | 0.0281 | 0.5132 | 0.5132 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0418 | 1 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0281 | 0.5132 | 0.5132 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.021 | 0.2616 | 0.2616 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0418 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0281 | 0.5132 | 0.3407 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.5132 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0418 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 1 | 1 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0281 | 0.5132 | 0.5132 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0217 | 0.286 | 0.286 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0418 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0217 | 0.286 | 0.286 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0418 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0418 | 1 | 0.5 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0418 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0418 | 1 | 1 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.021 | 0.2616 | 0.2616 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0418 | 1 | 1 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.021 | 0.2616 | 0.2616 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Plasmodium vivax | vivapain-1 | 0.0217 | 0.286 | 0.286 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0418 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.0217 | 0.286 | 0.0331 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0418 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0217 | 0.286 | 0.286 |
Toxoplasma gondii | cathepsin CPL | 0.0418 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.5132 | 0.5132 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0418 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0418 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0418 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0418 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0418 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.021 | 0.2616 | 0.2616 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0418 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0418 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0418 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0418 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0281 | 0.5132 | 0.5132 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0281 | 0.5132 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.5132 | 0.3182 |
Echinococcus multilocularis | cathepsin L | 0.0217 | 0.286 | 0.0331 |
Brugia malayi | Cathepsin L-like precursor | 0.0281 | 0.5132 | 0.5132 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.5132 | 0.5132 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0217 | 0.286 | 0.286 |
Plasmodium vivax | vivapain-2 | 0.0418 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Cytotoxicity against human Raji cells after 3 days | ChEMBL. | 10843573 |
IC50 (functional) | > 100 uM | Cytotoxicity against human Calu1 cells after 3 days | ChEMBL. | 10843573 |
IC50 (functional) | > 100 uM | Cytotoxicity against human K562 cells after 3 days | ChEMBL. | 10843573 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human Wish cells after 3 days | ChEMBL. | 10843573 |
IC50 (functional) | > 100 uM | Cytotoxicity against human HeLa cells after 3 days | ChEMBL. | 10843573 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.