TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 455.555 | Formula: C26H29N7O
H donors: 4 H acceptors: 4 LogP: 3.97 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)[C@@H]1CC[C@H](CC1)CNc1nc(NCc2ccccc2)cc(n1)c1ccc2c(c1)cn[nH]2
InChi: 1S/C26H29N7O/c27-25(34)19-8-6-18(7-9-19)15-29-26-31-23(20-10-11-22-21(12-20)16-30-33-22)13-24(32-26)28-14-17-4-2-1-3-5-17/h1-5,10-13,16,18-19H,6-9,14-15H2,(H2,27,34)(H,30,33)(H2,28,29,31,32)/t18-,19-
InChiKey: XBDONALUAKOWDJ-WGSAOQKQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	valosin containing protein	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	transitional endoplasmic reticulum atpase	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium yoelii	cell division cycle protein 48 homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania donovani	Valosin-containing protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania major	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma japonicum	ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative	Get druggable targets OG5_126926	All targets in OG5_126926
Neospora caninum	hypothetical protein	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium berghei	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma congolense	Valosin-containing protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Cryptosporidium parvum	CDC48 like AAA ATPase ortholog	Get druggable targets OG5_126926	All targets in OG5_126926
Mycobacterium ulcerans	ATPase	Get druggable targets OG5_126926	All targets in OG5_126926
Entamoeba histolytica	cdc48-like protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium knowlesi	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma brucei gambiense	valosin-containing protein homolog,Transitional endoplasmic reticulum ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium vivax	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Babesia bovis	cell division control protein 48, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania braziliensis	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma cruzi	Valosin-containing protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Candida albicans	microsomal protein of CDC48 family of ATPases	Get druggable targets OG5_126926	All targets in OG5_126926
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	Get druggable targets OG5_126926	All targets in OG5_126926
Cryptosporidium hominis	cell division cycle protein 48	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma mansoni	cell division control protein 48 aaa family protein	Get druggable targets OG5_126926	All targets in OG5_126926
Neospora caninum	hypothetical protein	Get druggable targets OG5_126926	All targets in OG5_126926
Toxoplasma gondii	transitional endoplasmic reticulum ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Trichomonas vaginalis	spermatogenesis associated factor, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Giardia lamblia	AAA family ATPase	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma mansoni	cell division control protein 48 aaa family protein	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania infantum	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Babesia bovis	cell division cycle protein ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Toxoplasma gondii	cell division protein CDC48AP	Get druggable targets OG5_126926	All targets in OG5_126926
Loa Loa (eye worm)	VCP protein	Get druggable targets OG5_126926	All targets in OG5_126926
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	Get druggable targets OG5_126926	All targets in OG5_126926
Brugia malayi	transitional endoplasmic reticulum ATPase TER94, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Theileria parva	cell division cycle protein 48, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Entamoeba histolytica	transitional endoplasmic reticulum ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma brucei	Valosin-containing protein	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma mansoni	cell division control protein 48 aaa family protein	Get druggable targets OG5_126926	All targets in OG5_126926
Candida albicans	microsomal protein of CDC48 family of ATPases	Get druggable targets OG5_126926	All targets in OG5_126926
Theileria parva	cell division cycle protein 48, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania mexicana	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Toxoplasma gondii	cell division protein CDC48CY	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma japonicum	Transitional endoplasmic reticulum ATPase homolog 2, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium falciparum	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Mycobacterium tuberculosis	Putative conserved ATPase	Get druggable targets OG5_126926	All targets in OG5_126926
Onchocerca volvulus	Transitional endoplasmic reticulum ATPase homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium vivax	cell division cycle ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.1592	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0315	0.1916	0.1812
Giardia lamblia	Hypothetical protein	0.0315	0.1916	0.5316
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0833	0.5193	0.5188
Loa Loa (eye worm)	cysteine protease	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1074	0.6723	0.6677
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0574	0.3558	0.3468
Giardia lamblia	Cathepsin B precursor	0.0315	0.1916	0.5316
Brugia malayi	Cathepsin L-like precursor	0.1592	1	1
Giardia lamblia	Cathepsin L precursor	0.0315	0.1916	0.5316
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1592	1	1
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Trypanosoma cruzi	cysteine proteinase, putative	0.0833	0.5193	0.5131
Onchocerca volvulus		0.1592	1	1
Giardia lamblia	Cathepsin B precursor	0.0315	0.1916	0.5316
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0315	0.1916	0.1916
Plasmodium vivax	cell division cycle protein 48 homologue, putative	0.0032	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0315	0.1916	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0315	0.1916	0.1907
Schistosoma mansoni	cathepsin F (C01 family)	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1592	1	1
Toxoplasma gondii	cathepsin B	0.0574	0.3558	0.3525
Loa Loa (eye worm)	hypothetical protein	0.1592	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.1916	0.1803
Trichomonas vaginalis	conserved hypothetical protein	0.0315	0.1916	0.1803
Giardia lamblia	Cathepsin L precursor	0.0315	0.1916	0.5316
Giardia lamblia	Cathepsin L precursor	0.0315	0.1916	0.5316
Giardia lamblia	Cathepsin B precursor	0.0574	0.3558	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0315	0.1916	0.1812
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0315	0.1916	0.1916
Brugia malayi	cathepsin L-like cysteine proteinase	0.0315	0.1916	0.1907
Leishmania major	cysteine peptidase A (CPA)	0.1592	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0037
Echinococcus multilocularis	cathepsin L	0.0833	0.5193	0.5188
Loa Loa (eye worm)	hypothetical protein	0.1074	0.6723	0.6719
Plasmodium falciparum	serine repeat antigen 1	0.0315	0.1916	0.1812
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0315	0.1916	0.1803
Brugia malayi	Papain family cysteine protease containing protein	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1592	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0315	0.1916	0.1907
Brugia malayi	vesicle-fusing ATPase	0.002	0.0048	0.0037
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1074	0.6723	0.668
Echinococcus granulosus	cathepsin L cysteine protease	0.0833	0.5193	0.5126
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0315	0.1916	0.1907
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Plasmodium falciparum	serine repeat antigen 8	0.0315	0.1916	0.1812
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.1916	0.1803
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Plasmodium vivax	unspecified product	0.0833	0.5193	0.5193
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0315	0.1916	0.1907
Onchocerca volvulus		0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.1916	0.1803
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Plasmodium falciparum	serine repeat antigen 7	0.0315	0.1916	0.1812
Entamoeba histolytica	cysteine proteinase, putative	0.0833	0.5193	0.5131
Entamoeba histolytica	cysteine proteinase 1, putative	0.0833	0.5193	0.5131
Brugia malayi	cathepsin L-like precursor	0.1074	0.6723	0.6719
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0315	0.1916	0.1803
Toxoplasma gondii	cathepsin CPC1	0.0315	0.1916	0.1874
Toxoplasma gondii	cell division protein CDC48CY	0.0034	0.0138	0.0087
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0315	0.1916	0.1907
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0315	0.1916	0.1907
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1154	0.7226	0.7223
Onchocerca volvulus		0.1592	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1592	1	1
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	0.0034	0.0138	0.0127
Entamoeba histolytica	cysteine protease, putative	0.0315	0.1916	0.1812
Leishmania major	cathepsin L-like protease	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1592	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0833	0.5193	0.5131
Onchocerca volvulus		0.0315	0.1916	0.1803
Loa Loa (eye worm)	ctsf protein	0.1592	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1074	0.6723	0.668
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0315	0.1916	0.1812
Echinococcus granulosus	cathepsin L	0.0833	0.5193	0.5126
Echinococcus multilocularis	cysteine protease	0.1592	1	1
Loa Loa (eye worm)	vesicle-fusing ATPase	0.002	0.0048	0.0037
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0315	0.1916	0.1907
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0315	0.1916	0.1916
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0833	0.5193	0.5188
Giardia lamblia	Cathepsin L precursor	0.0315	0.1916	0.5316
Giardia lamblia	Cysteine protease	0.0315	0.1916	0.5316
Brugia malayi	Cathepsin L-like precursor	0.1592	1	1
Toxoplasma gondii	cathepsin CPC2	0.0315	0.1916	0.1874
Leishmania major	cathepsin L-like protease	0.1592	1	1
Mycobacterium ulcerans	ATPase	0.002	0.0051	0.5
Onchocerca volvulus		0.1592	1	1
Plasmodium falciparum	serine repeat antigen 3	0.0315	0.1916	0.1812
Plasmodium vivax	vivapain-1	0.0833	0.5193	0.5193
Echinococcus multilocularis	cathepsin L	0.0315	0.1916	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0315	0.1916	0.1907
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Onchocerca volvulus	Cathepsin F homolog	0.1592	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0315	0.1916	0.1907
Loa Loa (eye worm)	fibroinase	0.1592	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0315	0.1916	0.1916
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1592	1	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0518	0.3199	0.3192
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1592	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1592	1	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0315	0.1916	0.1874
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Leishmania major	cathepsin L-like protease	0.1592	1	1
Giardia lamblia	Cysteine protease	0.0315	0.1916	0.5316
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0315	0.1916	0.1907
Loa Loa (eye worm)	hypothetical protein	0.1074	0.6723	0.6719
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1154	0.7226	0.7191
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0315	0.1916	0.1916
Entamoeba histolytica	cysteine proteinase, putative	0.0833	0.5193	0.5131
Echinococcus multilocularis	cathepsin b	0.1154	0.7226	0.7223
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0315	0.1916	0.1916
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0833	0.5193	0.5131
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.1916	0.1803
Schistosoma mansoni	cathepsin S (C01 family)	0.0315	0.1916	0.1907
Brugia malayi	Papain family cysteine protease containing protein	0.0833	0.5193	0.5188
Schistosoma mansoni	cathepsin B (C01 family)	0.0315	0.1916	0.1907
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0315	0.1916	0.1907
Mycobacterium tuberculosis	Putative conserved ATPase	0.002	0.0051	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0315	0.1916	0.1803
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0833	0.5193	0.5131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0833	0.5193	0.5126
Plasmodium vivax	vivapain-2	0.1592	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1154	0.7226	0.7223
Entamoeba histolytica	cysteine proteinase, putative	0.1592	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1592	1	1
Giardia lamblia	Cysteine protease	0.0315	0.1916	0.5316
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0315	0.1916	0.5316
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0315	0.1916	0.1907
Brugia malayi	Papain family cysteine protease containing protein	0.0315	0.1916	0.1907
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0315	0.1916	0.1907
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1592	1	1
Onchocerca volvulus	Cathepsin L homolog	0.1592	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1592	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1154	0.7226	0.7223
Brugia malayi	Cathepsin L-like precursor	0.0518	0.3199	0.3192
Toxoplasma gondii	cathepsin CPL	0.1592	1	1
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0518	0.3199	0.3192
Plasmodium vivax	unspecified product	0.0518	0.3199	0.3199
Leishmania major	cathepsin L-like protease	0.1592	1	1
Echinococcus granulosus	cathepsin b	0.1154	0.7226	0.7187
Loa Loa (eye worm)	hypothetical protein	0.0518	0.3199	0.3192
Schistosoma mansoni	cathepsin s	0.0518	0.3199	0.3192
Plasmodium vivax	unspecified product	0.0315	0.1916	0.1916
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0574	0.3558	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0315	0.1916	0.1907
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0833	0.5193	0.5126
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0034	0.0138	0.0127
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1592	1	1
Giardia lamblia	Cathepsin L-like protease	0.0315	0.1916	0.5316
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1592	1	1
Onchocerca volvulus	Cathepsin L homolog	0.1592	1	1
Giardia lamblia	Cysteine protease	0.0315	0.1916	0.5316
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0315	0.1916	0.5316
Leishmania major	cathepsin L-like protease	0.1592	1	1
Plasmodium falciparum	serine repeat antigen 2	0.0315	0.1916	0.1812
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0315	0.1916	0.1916
Brugia malayi	Cathepsin L-like precursor	0.1074	0.6723	0.6719
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Giardia lamblia	Cathepsin L precursor	0.0315	0.1916	0.5316
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0574	0.3558	0.3475
Trypanosoma cruzi	cysteine protease, putative	0.0833	0.5193	0.5131
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0315	0.1916	0.1812
Trypanosoma cruzi	cysteine peptidase, putative	0.1592	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1074	0.6723	0.6719
Loa Loa (eye worm)	hypothetical protein	0.1154	0.7226	0.7223
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0315	0.1916	0.1803
Entamoeba histolytica	cysteine proteinase, putative	0.1592	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0833	0.5193	0.5131
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0315	0.1916	0.1803
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1592	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1592	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0315	0.1916	0.1907
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.1916	0.1803
Brugia malayi	Cathepsin L-like precursor	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Echinococcus granulosus	cathepsin l1	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0315	0.1916	0.1803
Onchocerca volvulus		0.1592	1	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0574	0.3558	0.3475
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1592	1	1
Schistosoma mansoni	cathepsin C	0.0315	0.1916	0.1907
Trypanosoma cruzi	major cysteine proteinase, putative	0.0315	0.1916	0.1812
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1592	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0315	0.1916	0.1812
Echinococcus granulosus	cathepsin l1	0.1074	0.6723	0.6677
Brugia malayi	Cathepsin L-like precursor	0.1592	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0315	0.1916	0.1907
Plasmodium falciparum	serine repeat antigen 6	0.0315	0.1916	0.1812
Brugia malayi	Papain family cysteine protease containing protein	0.0315	0.1916	0.1907
Entamoeba histolytica	cysteine protease, putative	0.0315	0.1916	0.1812
Brugia malayi	Papain family cysteine protease containing protein	0.0833	0.5193	0.5188
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0315	0.1916	0.1907
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.1916	0.1803
Loa Loa (eye worm)	hypothetical protein	0.1074	0.6723	0.6719
Entamoeba histolytica	cysteine protease, putative	0.0315	0.1916	0.1812
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0315	0.1916	0.1916
Plasmodium falciparum	serine repeat antigen 4	0.0315	0.1916	0.1812
Echinococcus multilocularis	cysteine protease	0.1592	1	1
Loa Loa (eye worm)	hypothetical protein	0.0315	0.1916	0.1907
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0315	0.1916	0.5316
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1592	1	1
Onchocerca volvulus		0.1074	0.6723	0.6677
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1592	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1592	1	1
Entamoeba histolytica	cysteine protease, putative	0.0315	0.1916	0.1812
Entamoeba histolytica	cysteine proteinase, putative	0.0833	0.5193	0.5131
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0032	0.0127	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0518	0.3199	0.3192
Brugia malayi	fibroinase precursor	0.0315	0.1916	0.1907
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1074	0.6723	0.6719
Brugia malayi	cathepsin F-like cysteine proteinase	0.0518	0.3199	0.3192
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Brugia malayi	Cathepsin L-like precursor	0.1074	0.6723	0.6719
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0315	0.1916	0.1907
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Giardia lamblia	Cathepsin L precursor	0.0315	0.1916	0.5316
Loa Loa (eye worm)	hypothetical protein	0.0518	0.3199	0.3192
Giardia lamblia	Cathepsin B precursor	0.0315	0.1916	0.5316
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0315	0.1916	0.1916
Brugia malayi	valosin containing protein	0.002	0.0048	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Leishmania major	cathepsin L-like protease	0.1592	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0315	0.1916	0.1803
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.1916	0.1803
Onchocerca volvulus		0.1592	1	1
Echinococcus granulosus	cysteine protease	0.0833	0.5193	0.5126
Brugia malayi	cathepsin L precursor	0.0315	0.1916	0.1907
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0315	0.1916	0.1803
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1074	0.6723	0.6677
Entamoeba histolytica	cysteine protease, putative	0.1592	1	1
Giardia lamblia	Cathepsin B precursor	0.0315	0.1916	0.5316
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1592	1	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0315	0.1916	0.1916
Giardia lamblia	Cathepsin L-like protease	0.0315	0.1916	0.5316
Echinococcus multilocularis	cathepsin L cysteine protease	0.1592	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0574	0.3558	0.3475
Giardia lamblia	Encystation-specific protease	0.0315	0.1916	0.5316
Onchocerca volvulus		0.1592	1	1
Giardia lamblia	Cathepsin B precursor	0.0574	0.3558	1
Trichomonas vaginalis	conserved hypothetical protein	0.0315	0.1916	0.1803
Entamoeba histolytica	cysteine protease, putative	0.0833	0.5193	0.5131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Echinococcus multilocularis	cathepsin b	0.1154	0.7226	0.7223
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.1916	0.1803
Plasmodium falciparum	serine repeat antigen 5	0.0315	0.1916	0.1812
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0833	0.5193	0.5131
Echinococcus granulosus	cathepsin L	0.0315	0.1916	0.1803
Giardia lamblia	Cathepsin B precursor	0.0574	0.3558	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0833	0.5193	0.5131
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.1916	0.1803
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1592	1	1
Brugia malayi	Cathepsin L-like precursor	0.1592	1	1
Leishmania major	cathepsin L-like protease	0.1592	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0315	0.1916	0.1812
Brugia malayi	cathepsin F-like cysteine proteinase	0.0315	0.1916	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0315	0.1916	0.1907
Trypanosoma cruzi	cysteine peptidase, putative	0.1592	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.1154	0.7226	0.7223
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0833	0.5193	0.5188
Plasmodium vivax	serine-repeat antigen (SERA)	0.0315	0.1916	0.1916
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1592	1	1
Entamoeba histolytica	cysteine protease, putative	0.0315	0.1916	0.1812
Echinococcus granulosus	cathepsin b	0.1154	0.7226	0.7187
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0315	0.1916	0.1907
Plasmodium vivax	vivapain-3	0.0833	0.5193	0.5193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1592	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0518	0.3199	0.3112
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1592	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0315	0.1916	0.1803
Loa Loa (eye worm)	cathepsin B	0.0574	0.3558	0.3551
Entamoeba histolytica	hypothetical protein	0.0315	0.1916	0.1812
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1592	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0833	0.5193	0.5131
Trypanosoma cruzi	cruzipain precursor, putative	0.0518	0.3199	0.3112
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0315	0.1916	0.5316
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1592	1	1
Entamoeba histolytica	cysteine protease, putative	0.0315	0.1916	0.1812
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1592	1	1
Entamoeba histolytica	cysteine proteinase 2	0.0833	0.5193	0.5131
Trypanosoma cruzi	cysteine peptidase, putative	0.1592	1	1
Toxoplasma gondii	cell division protein CDC48AP	0.002	0.0051	0.000000085432
Plasmodium falciparum	serine repeat antigen 9	0.0315	0.1916	0.1812
Plasmodium vivax	vivapain-2	0.1592	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0315	0.1916	0.1916
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1592	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1592	1	1
Giardia lamblia	Hypothetical protein	0.0315	0.1916	0.5316
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1154	0.7226	0.7223
Trypanosoma cruzi	cruzipain precursor, putative	0.1592	1	1
Giardia lamblia	Cathepsin B precursor	0.0315	0.1916	0.5316

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.071 uM	Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP formation by NADH coupled assay	ChEMBL.	25474526

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3361224

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 954687