TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 222.674 | Formula: C10H11ClN4
H donors: 2 H acceptors: 0 LogP: 1.53 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cl/C(=C\C=N\NC(=N)N)/c1ccccc1
InChi: 1S/C10H11ClN4/c11-9(6-7-14-15-10(12)13)8-4-2-1-3-5-8/h1-7H,(H4,12,13,15)/b9-6-,14-7+
InChiKey: SKTBDZTXCXMFAZ-WLZNRRLWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Avian erythroblastosis virus (strain ES4)	Gag polyprotein	Starlite/ChEMBL	References
Mouse mammary tumor virus (strain GR) (MMTV)	Envelope glycoprotein gp70	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Trypanosoma brucei	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_139608	All targets in OG5_139608
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_156853	All targets in OG5_156853
Trypanosoma congolense	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608
Plasmodium yoelii	integrase-related	Get druggable targets OG5_139608	All targets in OG5_139608
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Loa Loa (eye worm)	nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptide Y receptor	0.0131	0.1161	0.0874
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0083	0.0402	0.0443
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0182	0.1979	0.2179
Schistosoma mansoni	histamine h1 receptor	0.0131	0.1161	0.1161
Echinococcus multilocularis	dro:myosuppressin receptor	0.0131	0.1161	0.0874
Echinococcus multilocularis	fmrfamide receptor	0.0131	0.1161	0.0874
Echinococcus granulosus	7TM GPCR rhodopsin	0.0131	0.1161	0.1278
Brugia malayi	hypothetical protein	0.0131	0.1161	0.1278
Echinococcus granulosus	neuropeptide receptor A26	0.0131	0.1161	0.1278
Brugia malayi	hypothetical protein	0.0131	0.1161	0.1278
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0131	0.1161	0.122
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus multilocularis	neuropeptides capa receptor	0.0131	0.1161	0.0874
Trypanosoma cruzi	cAMP response protein 1, putative	0.0083	0.0402	0.5
Brugia malayi	Dopamine receptor protein 1	0.0131	0.1161	0.1278
Schistosoma mansoni	biogenic amine receptor	0.0131	0.1161	0.1161
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0124	0.106	0.1167
Mycobacterium ulcerans	hypothetical protein	0.0083	0.0402	0.5
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0083	0.0402	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0131	0.1161	0.1161
Echinococcus multilocularis	somatostatin receptor	0.0131	0.1161	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Trypanosoma cruzi	cAMP binding protein, putative	0.0083	0.0402	0.5
Brugia malayi	Serotonin receptor	0.0131	0.1161	0.1278
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0083	0.0402	0.0443
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0131	0.1161	0.122
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0124	0.106	0.106
Brugia malayi	putative neuropeptide receptor	0.0131	0.1161	0.1278
Schistosoma mansoni	amine GPCR	0.0131	0.1161	0.1161
Onchocerca volvulus		0.0131	0.1161	1
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0083	0.0402	0.0402
Brugia malayi	neuropeptide F receptor	0.0131	0.1161	0.1278
Leishmania major	hypothetical protein, conserved	0.0083	0.0402	0.5
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0083	0.0402	0.5
Echinococcus granulosus	voltage gated potassium channel	0.0182	0.1979	0.2179
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0124	0.106	0.0758
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0124	0.106	0.1167
Loa Loa (eye worm)	melatonin receptor type 1A	0.0131	0.1161	0.122
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus multilocularis	neuropeptide Y receptor	0.0131	0.1161	0.0874
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0131	0.1161	0.1161
Brugia malayi	Serotonin receptor	0.0131	0.1161	0.1278
Schistosoma mansoni	serine/threonine protein kinase	0.0083	0.0402	0.0402
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0124	0.106	0.1167
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0083	0.0402	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0131	0.1161	1
Schistosoma mansoni	myosin xvIII	0.0131	0.1161	0.1161
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0083	0.0402	0.5
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Leishmania major	hypothetical protein, conserved	0.0083	0.0402	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0131	0.1161	0.1161
Onchocerca volvulus		0.0131	0.1161	1
Schistosoma mansoni	opsin-like receptor	0.0131	0.1161	0.1161
Schistosoma mansoni	60S ribosomal protein L21	0.0099	0.0658	0.0658
Schistosoma mansoni	voltage-gated potassium channel	0.0686	1	1
Schistosoma mansoni	amine GPCR	0.0131	0.1161	0.1161
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0083	0.0402	0.5
Echinococcus granulosus	hyperpolarization activated cyclic	0.0124	0.106	0.1167
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0131	0.1161	0.0874
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0083	0.0402	0.0402
Brugia malayi	N-terminal motif family protein	0.0083	0.0402	0.0443
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0083	0.0402	0.0443
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0131	0.1161	0.1161
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0124	0.106	0.106
Echinococcus granulosus	serotonin receptor	0.0131	0.1161	0.1278
Echinococcus granulosus	tm gpcr rhodopsin	0.0131	0.1161	0.1278
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0124	0.106	0.106
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0131	0.1161	0.0874
Onchocerca volvulus		0.0131	0.1161	1
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0083	0.0402	0.5
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0083	0.0402	0.5
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Loa Loa (eye worm)	hypothetical protein	0.0299	0.3845	0.4196
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0083	0.0402	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0131	0.1161	0.0874
Schistosoma mansoni	biogenic amine receptor	0.0131	0.1161	0.1161
Onchocerca volvulus		0.0131	0.1161	1
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0083	0.0402	0.0402
Mycobacterium leprae	Conserved hypothetical protein	0.0083	0.0402	1
Brugia malayi	neuropeptide F receptor	0.0131	0.1161	0.1278
Schistosoma mansoni	voltage-gated potassium channel	0.0124	0.106	0.106
Brugia malayi	hypothetical protein	0.0131	0.1161	0.1278
Echinococcus granulosus	g-protein coupled receptor	0.0131	0.1161	0.1278
Mycobacterium ulcerans	transmembrane transport protein	0.0083	0.0402	0.5
Echinococcus granulosus	sex peptide receptor	0.0131	0.1161	0.1278
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0131	0.1161	0.1278
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0083	0.0402	0.5
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0124	0.106	0.106
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0083	0.0402	0.0378
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0131	0.1161	0.1278
Echinococcus granulosus	neuropeptide receptor	0.0131	0.1161	0.1278
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0083	0.0402	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus granulosus	dro:myosuppressin receptor	0.0131	0.1161	0.1278
Brugia malayi	sulfakinin receptor protein	0.0131	0.1161	0.1278
Echinococcus granulosus	neuropeptide Y receptor	0.0131	0.1161	0.1278
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0083	0.0402	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0131	0.1161	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1979	0.2126
Echinococcus multilocularis	g protein coupled receptor	0.0131	0.1161	0.0874
Echinococcus granulosus	biogenic amine 5HT receptor	0.0131	0.1161	0.1278
Onchocerca volvulus		0.0131	0.1161	1
Brugia malayi	Egg laying defective protein 4	0.0083	0.0402	0.0443
Leishmania major	hypothetical protein, unknown function	0.0083	0.0402	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0124	0.106	0.1258
Brugia malayi	larval opioid receptor	0.0131	0.1161	0.1278
Echinococcus multilocularis	g-protein coupled receptor	0.0131	0.1161	0.0874
Echinococcus granulosus	g protein coupled receptor	0.0131	0.1161	0.1278
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0083	0.0402	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Mycobacterium ulcerans	hypothetical protein	0.0083	0.0402	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0131	0.1161	0.1161
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0587	0.8423	1
Echinococcus granulosus	orexin receptor type 2	0.0131	0.1161	0.1278
Brugia malayi	hypothetical protein	0.0131	0.1161	0.1278
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0182	0.1979	0.2179
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0131	0.1161	0.1278
Schistosoma mansoni	hypothetical protein	0.0131	0.1161	0.1161
Mycobacterium ulcerans	hypothetical protein	0.0083	0.0402	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0131	0.1161	0.0874
Trypanosoma brucei	cAMP response protein 1, putative	0.0083	0.0402	0.1313
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0131	0.1161	0.122
Echinococcus granulosus	hyperpolarization activated cyclic	0.0124	0.106	0.1167
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0124	0.106	0.1167
Echinococcus granulosus	neuropeptide s receptor	0.0131	0.1161	0.1278
Echinococcus granulosus	rhodopsin orphan GPCR	0.0131	0.1161	0.1278
Echinococcus multilocularis	serotonin receptor	0.0131	0.1161	0.0874
Schistosoma mansoni	adenoreceptor	0.0131	0.1161	0.1161
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0083	0.0402	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Onchocerca volvulus		0.0131	0.1161	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0083	0.0402	0.0402
Schistosoma mansoni	biogenic amine receptor	0.0131	0.1161	0.1161
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0131	0.1161	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0124	0.106	0.1108
Loa Loa (eye worm)	neuropeptide F receptor	0.0131	0.1161	0.122
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0131	0.1161	0.1278
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0124	0.106	0.1108
Brugia malayi	hypothetical protein	0.0131	0.1161	0.1278
Echinococcus granulosus	neuropeptides capa receptor	0.0131	0.1161	0.1278
Leishmania major	protein kinase, putative	0.0083	0.0402	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0131	0.1161	0.122
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0587	0.8423	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0131	0.1161	0.1278
Schistosoma mansoni	opsin-like receptor	0.0131	0.1161	0.1161
Brugia malayi	ORL1-like opioid receptor	0.0131	0.1161	0.1278
Loa Loa (eye worm)	G-protein coupled receptor	0.0131	0.1161	0.122
Leishmania major	protein kinase, putative	0.0083	0.0402	0.5
Trypanosoma brucei	RNA helicase, putative	0.025	0.3061	1
Mycobacterium ulcerans	hypothetical protein	0.0083	0.0402	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0131	0.1161	0.122
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0131	0.1161	0.0874
Schistosoma mansoni	serine/threonine protein kinase	0.0083	0.0402	0.0402
Schistosoma mansoni	hypothetical protein	0.0131	0.1161	0.1161
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Trypanosoma cruzi	hypothetical protein, conserved	0.0083	0.0402	0.5
Schistosoma mansoni	amine GPCR	0.0131	0.1161	0.1161
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0131	0.1161	0.1161
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0131	0.1161	0.0874
Schistosoma mansoni	opsin-like receptor	0.0131	0.1161	0.1161
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0131	0.1161	0.1161
Brugia malayi	Melatonin receptor type 1A	0.0131	0.1161	0.1278
Echinococcus multilocularis	sex peptide receptor	0.0131	0.1161	0.0874
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0131	0.1161	0.0874
Echinococcus granulosus	rhodopsin orphan GPCR	0.0131	0.1161	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0402	0.0378
Schistosoma mansoni	growth hormone secretagogue receptor	0.0131	0.1161	0.1161
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0083	0.0402	0.5
Onchocerca volvulus		0.0131	0.1161	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0124	0.106	0.0758
Echinococcus granulosus	rhodopsin orphan GPCR	0.0131	0.1161	0.1278
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0131	0.1161	0.1161
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0131	0.1161	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus granulosus	tm gpcr rhodopsin	0.0131	0.1161	0.1278
Echinococcus granulosus	g protein coupled receptor	0.0131	0.1161	0.1278
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0083	0.0402	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0099	0.0658	0.0658
Schistosoma mansoni	amine GPCR	0.0131	0.1161	0.1161
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0124	0.106	0.0758
Echinococcus multilocularis	g protein coupled receptor	0.0131	0.1161	0.0874
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0131	0.1161	0.0874
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0124	0.106	0.0758
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0131	0.1161	0.1161
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0083	0.0402	0.0443
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0131	0.1161	0.1161
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0402	0.0378
Echinococcus granulosus	somatostatin receptor	0.0131	0.1161	0.1278
Echinococcus multilocularis	fmrfamide receptor	0.0131	0.1161	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus granulosus	rhodopsin orphan GPCR	0.0131	0.1161	0.1278
Schistosoma mansoni	voltage-gated potassium channel	0.0182	0.1979	0.1979
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0083	0.0402	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0131	0.1161	0.1278
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0083	0.0402	0.1313
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0083	0.0402	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0545	0.7761	0.8536
Brugia malayi	hypothetical protein	0.0131	0.1161	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0131	0.1161	0.1161
Brugia malayi	putative neuropeptide receptor NPR1	0.0131	0.1161	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0131	0.1161	0.1161
Onchocerca volvulus		0.0131	0.1161	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0131	0.1161	0.0874
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0083	0.0402	0.0402
Echinococcus granulosus	G protein coupled receptor 139	0.0131	0.1161	0.1278
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0131	0.1161	0.0874
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0628	0.9081	1
Echinococcus multilocularis	allatostatin A receptor	0.0131	0.1161	0.0874
Echinococcus multilocularis	voltage gated potassium channel	0.0182	0.1979	0.1816
Brugia malayi	follicle stimulating hormone receptor	0.0131	0.1161	0.1278
Brugia malayi	GnHR receptor homolog	0.0131	0.1161	0.1278
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0083	0.0402	0.0402
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0301	0.3867	0.422
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0083	0.0402	0.5
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Schistosoma mansoni	hypothetical protein	0.0131	0.1161	0.1161
Brugia malayi	G protein-coupled receptor	0.0131	0.1161	0.1278
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0131	0.1161	0.1161
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0124	0.106	0.1258
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0083	0.0402	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0131	0.1161	0.0874
Trypanosoma brucei	Flagellar Member 6	0.0083	0.0402	0.1313
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0131	0.1161	0.1161
Schistosoma mansoni	hypothetical protein	0.025	0.3061	0.3061
Brugia malayi	Cytochrome P450 family protein	0.0062	0.0061	0.0067
Brugia malayi	Nuclear hormone receptor-like 1	0.0312	0.4048	0.4458
Echinococcus granulosus	tm gpcr rhodopsin	0.0131	0.1161	0.1278
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0131	0.1161	0.1278
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0083	0.0402	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0131	0.1161	0.0874
Treponema pallidum	catabolite gene activator (Crp)	0.0083	0.0402	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0131	0.1161	1
Echinococcus granulosus	neuropeptide receptor	0.0131	0.1161	0.1278
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0131	0.1161	0.1278
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0628	0.9081	1
Onchocerca volvulus		0.0131	0.1161	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0131	0.1161	0.0874
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0131	0.1161	0.0874
Treponema pallidum	cyclic nucleotide binding protein	0.0083	0.0402	0.5
Echinococcus granulosus	fmrfamide receptor	0.0131	0.1161	0.1278
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0131	0.1161	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Schistosoma mansoni	serine/threonine protein kinase	0.0083	0.0402	0.0402
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0124	0.106	0.0758
Brugia malayi	Dopamine receptor	0.0131	0.1161	0.1278
Echinococcus granulosus	g protein coupled receptor	0.0131	0.1161	0.1278
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0083	0.0402	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0131	0.1161	0.0874
Brugia malayi	hypothetical protein	0.0131	0.1161	0.1278
Treponema pallidum	cyclic nucleotide binding protein	0.0083	0.0402	0.5
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0083	0.0402	0.0443
Echinococcus granulosus	7tm_1 domain containing protein	0.0131	0.1161	0.1278
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0083	0.0402	0.1313
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0131	0.1161	0.1161
Trypanosoma brucei	protein kinase A regulatory subunit	0.0083	0.0402	0.1313
Trypanosoma cruzi	cAMP response protein 1	0.0083	0.0402	0.5
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Brugia malayi	hypothetical protein	0.0131	0.1161	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0131	0.1161	0.1161
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0131	0.1161	0.0874
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0628	0.9081	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0131	0.1161	0.0874
Echinococcus multilocularis	serotonin receptor	0.0131	0.1161	0.0874
Schistosoma mansoni	hypothetical protein	0.0131	0.1161	0.1161
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0083	0.0402	0.0402
Brugia malayi	Nuclear hormone receptor-like 1	0.0301	0.3867	0.4258
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0083	0.0402	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0131	0.1161	0.1161
Schistosoma mansoni	neuropeptide receptor	0.0131	0.1161	0.1161
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0131	0.1161	0.1278
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0083	0.0402	0.0477
Schistosoma mansoni	neuropeptide receptor	0.0131	0.1161	0.1161
Schistosoma mansoni	amine GPCR	0.0131	0.1161	0.1161
Echinococcus granulosus	neuropeptide Y receptor	0.0131	0.1161	0.1278
Schistosoma mansoni	voltage-gated potassium channel	0.0182	0.1979	0.1979
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0083	0.0402	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0131	0.1161	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Onchocerca volvulus		0.0131	0.1161	1
Schistosoma mansoni	neuropeptide receptor	0.0131	0.1161	0.1161
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0131	0.1161	0.0874
Schistosoma mansoni	hypothetical protein	0.0083	0.0402	0.0402
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0131	0.1161	0.0874
Loa Loa (eye worm)	neuropeptide F receptor	0.0131	0.1161	0.122
Echinococcus granulosus	hypothetical protein	0.0131	0.1161	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0124	0.106	0.1108
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus granulosus	cGMP dependent protein kinase	0.0083	0.0402	0.0443
Mycobacterium ulcerans	transcriptional regulatory protein	0.0083	0.0402	0.5
Mycobacterium tuberculosis	Conserved protein	0.0083	0.0402	0.5
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0083	0.0402	0.0443
Brugia malayi	hypothetical protein	0.0131	0.1161	0.1278
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0402	0.0477
Brugia malayi	G-protein coupled receptor	0.0131	0.1161	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0131	0.1161	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus granulosus	neuropeptide FF receptor 2	0.0131	0.1161	0.1278
Onchocerca volvulus		0.0131	0.1161	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0131	0.1161	0.0874
Onchocerca volvulus		0.0131	0.1161	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0131	0.1161	0.1278
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0083	0.0402	0.0477
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0131	0.1161	0.1161
Echinococcus multilocularis	neuropeptide receptor A26	0.0131	0.1161	0.0874
Plasmodium falciparum	cGMP-dependent protein kinase	0.0083	0.0402	0.5
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0131	0.1161	0.1161
Echinococcus multilocularis	neuropeptides capa receptor	0.0131	0.1161	0.0874
Echinococcus multilocularis	orexin receptor type 2	0.0131	0.1161	0.0874
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0182	0.1979	0.1816
Echinococcus multilocularis	G protein coupled receptor 139	0.0131	0.1161	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0131	0.1161	0.1161
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0131	0.1161	0.1278
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0131	0.1161	0.0874
Echinococcus granulosus	rhodopsin orphan GPCR	0.0131	0.1161	0.1278
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0131	0.1161	0.1161
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0131	0.1161	0.1161
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0131	0.1161	0.0874
Onchocerca volvulus		0.0131	0.1161	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0131	0.1161	0.0874
Treponema pallidum	catabolite gene activator	0.0083	0.0402	0.5
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0083	0.0402	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0131	0.1161	0.1278
Leishmania major	hypothetical protein, conserved	0.0083	0.0402	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0131	0.1161	0.1161
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0083	0.0402	0.0477
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0131	0.1161	0.1161
Schistosoma mansoni	neuropeptide receptor	0.0131	0.1161	0.1161
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0083	0.0402	0.0443
Leishmania major	protein kinase A regulatory subunit, putative	0.0083	0.0402	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0131	0.1161	0.1278
Brugia malayi	G-protein coupled receptor	0.0131	0.1161	0.1278
Mycobacterium ulcerans	regulatory protein	0.0083	0.0402	0.5
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0124	0.106	0.1167
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0131	0.1161	0.1161
Brugia malayi	Dopamine receptor protein 2	0.0131	0.1161	0.1278
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0083	0.0402	0.5
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0083	0.0402	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0131	0.1161	0.1278
Trypanosoma cruzi	Flagellar Member 6	0.0083	0.0402	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0131	0.1161	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Onchocerca volvulus		0.0131	0.1161	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Trypanosoma brucei	cAMP binding protein, putative	0.0083	0.0402	0.1313
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0131	0.1161	0.0874
Onchocerca volvulus		0.0131	0.1161	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0131	0.1161	0.122
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0083	0.0402	0.0402
Brugia malayi	RE15519p	0.0131	0.1161	0.1278
Echinococcus multilocularis	neuropeptide receptor	0.0131	0.1161	0.0874
Echinococcus granulosus	neuropeptides capa receptor	0.0131	0.1161	0.1278
Brugia malayi	hypothetical protein	0.0131	0.1161	0.1278
Onchocerca volvulus		0.0131	0.1161	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0301	0.3867	0.4258
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0131	0.1161	0.1161
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0131	0.1161	0.122
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0083	0.0402	0.5
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0083	0.0402	0.0402
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0131	0.1161	0.1278
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0083	0.0402	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0083	0.0402	0.5
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0083	0.0402	0.0477
Onchocerca volvulus		0.0131	0.1161	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0124	0.106	0.106
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0083	0.0402	0.0443
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0628	0.9081	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Echinococcus granulosus	allatostatin A receptor	0.0131	0.1161	0.1278
Brugia malayi	AKH receptor	0.0131	0.1161	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1161	0.122
Schistosoma mansoni	neuropeptide f receptor 76f	0.0131	0.1161	0.1161
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0131	0.1161	0.1161

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 50 %	Antagonist activity at estrogen receptor alpha expressed in human HEC1 cells assessed as inhibition of estradiol-induced transcriptional activity at 20 uM after 24 hrs by beta-galactosidase reporter gene assay	ChEMBL.	18976929
IC50 (functional)	= 0.9 uM	Antagonist activity at estrogen receptor alpha expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transcriptional activity after 24 hrs by luciferase reporter gene assay	ChEMBL.	18976929
IC50 (binding)	= 4.6 uM	Inhibition of estradiol-induced coactivator peptide SRC1 binding to estrogen receptor alpha expressed in human HEC1 cells after 24 hrs by luciferase based mammalian two-hybrid assay	ChEMBL.	18976929

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL458496

Bibliographic References

No literature references available for this target.

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Detailed information for compound 954778