Detailed information for compound 954832

Basic information

Technical information
  • TDR Targets ID: 954832
  • Name: 2-nitro-6-[[4-(trifluoromethoxy)phenyl]methox y]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
  • MW: 359.257 | Formula: C14H12F3N3O5
  • H donors: 0 H acceptors: 3 LogP: 2.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cn2c(n1)OCC(C2)OCc1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2
  • InChiKey: ZLHZLMOSPGACSZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-nitro-6-[4-(trifluoromethoxy)benzyl]oxy-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0116 0.0473
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0116 0.0473
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0006 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0296 0.1209
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.008 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0185 0.0173
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0473
Echinococcus multilocularis cysteine protease 0.0019 0.0006 0.0006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0053 0.0116 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0034 0.0028
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0042 0.0079 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0185 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0185 0.0173
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0236
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0042 0.0079 0.0074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0053 0.0116 0.0116
Schistosoma mansoni lamin 0.0057 0.0129 0.0129
Brugia malayi intermediate filament protein 0.0057 0.0129 0.0525
Trichomonas vaginalis esterase, putative 0.0119 0.0334 0.0328
Loa Loa (eye worm) hypothetical protein 0.0119 0.0334 0.1362
Loa Loa (eye worm) hypothetical protein 0.0119 0.0334 0.1362
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Brugia malayi beta-lactamase family protein 0.0119 0.0334 0.1362
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.0262 0.0762
Loa Loa (eye worm) prolyl oligopeptidase 0.0069 0.0171 0.0697
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0069 0.0171 0.0165
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Mycobacterium tuberculosis Probable lipase LipE 0.0119 0.0334 0.1064
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0125 0.012
Brugia malayi Heterochromatin protein 1 0.0063 0.0149 0.0607
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0138
Loa Loa (eye worm) hypothetical protein 0.0042 0.0079 0.0323
Echinococcus granulosus FTZ F1 alpha 0.0053 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Loa Loa (eye worm) steroid hormone receptor 0.0053 0.0116 0.0473
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.004 0.038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0052 0.0047
Brugia malayi tailless protein 0.0025 0.0024 0.0098
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Loa Loa (eye worm) hypothetical protein 0.0027 0.0032 0.013
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0034 0.0138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0095 0.0095
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0138
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.0116 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0079 0.0203 0.0203
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0024 0.0075
Brugia malayi MH2 domain containing protein 0.026 0.0798 0.3253
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.008 0.008
Brugia malayi prolyl oligopeptidase family protein 0.0069 0.0171 0.0697
Brugia malayi hypothetical protein 0.0042 0.008 0.0325
Echinococcus multilocularis microtubule associated protein 2 0.1589 0.5182 0.5182
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.041 0.041
Brugia malayi Serine carboxypeptidase S28 family protein 0.0042 0.0079 0.0323
Loa Loa (eye worm) acetyltransferase 0.0146 0.0423 0.1726
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0066 0.0161 0.0161
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0034 0.0034
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0119 0.0334 0.1362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0116 0.0116
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0125 0.0511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0185 0.0173
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0054 0.0054
Echinococcus granulosus ecdysone induced protein 78C 0.0053 0.0116 0.0116
Brugia malayi Ets-domain containing protein 0.0071 0.0176 0.0717
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0077 0.0072
Brugia malayi prolyl oligopeptidase family protein 0.0351 0.1099 0.4481
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0125 0.0125
Entamoeba histolytica hypothetical protein 0.0042 0.008 0.0074
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0042 0.0079 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0053 0.0116 0.0473
Schistosoma mansoni intermediate filament proteins 0.0057 0.0129 0.0129
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.0169 0.0169
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.0262 0.0762
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0184 0.0751
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0176 0.0176
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.0298 0.0913
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.305 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0053 0.0116 0.0473
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0034 0.0034
Giardia lamblia Alanyl dipeptidyl peptidase 0.0069 0.0171 0.01
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0083 0.0854
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0071 0.3982
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0053 0.0116 0.0116
Schistosoma mansoni zinc finger protein 0.0025 0.0024 0.0024
Toxoplasma gondii thioredoxin reductase 0.0043 0.0082 0.0844
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0077 0.0065
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0024 0.0024
Echinococcus multilocularis beta LACTamase domain containing family member 0.0119 0.0334 0.0334
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.0334 0.0328
Loa Loa (eye worm) hypothetical protein 0.0056 0.0125 0.0511
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0351 0.1099 0.1093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0116 0.0116
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0067 0.0249
Onchocerca volvulus 0.0119 0.0334 0.1342
Echinococcus multilocularis ecdysone induced protein 78C 0.0053 0.0116 0.0116
Trypanosoma brucei hypothetical protein, conserved 0.0119 0.0334 0.0322
Schistosoma mansoni hypothetical protein 0.305 1 1
Toxoplasma gondii hypothetical protein 0.0069 0.0171 0.1819
Trichomonas vaginalis chromobox protein, putative 0.0063 0.0149 0.0143
Brugia malayi hypothetical protein 0.0225 0.0685 0.2793
Trichomonas vaginalis penicillin-binding protein, putative 0.0119 0.0334 0.0328
Leishmania major trypanothione reductase 0.0043 0.0082 0.0077
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.305 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0063
Echinococcus multilocularis chromobox protein 1 0.0063 0.0149 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0185 0.0173
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.0112 0.01
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0082 0.0082
Brugia malayi hypothetical protein 0.0025 0.0024 0.0098
Schistosoma mansoni hypothetical protein 0.0073 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0042 0.0079 0.0323
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.004 0.1052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0185 0.0173
Loa Loa (eye worm) hypothetical protein 0.0286 0.0885 0.3611
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0024 0.0098
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0083 0.0854
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Echinococcus granulosus beta LACTamase domain containing family member 0.0119 0.0334 0.0334
Loa Loa (eye worm) fibroinase 0.0019 0.0006 0.0023
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0006 0.0006
Trypanosoma cruzi oligopeptidase b 0.0069 0.0171 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0185 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0169 0.0169
Onchocerca volvulus 0.0025 0.0024 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0053 0.0116 0.0473
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0125 0.012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0054 0.0054
Trypanosoma brucei protein kinase, putative 0.0056 0.0125 0.0113
Loa Loa (eye worm) transcription factor SMAD2 0.026 0.0798 0.3253
Brugia malayi MAP kinase sur-1 0.0056 0.0125 0.0511
Leishmania major hypothetical protein, conserved 0.0119 0.0334 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0077 0.0072
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0044 0.0038
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0069 0.0171 0.1819
Brugia malayi prolyl oligopeptidase family protein 0.0069 0.0171 0.0697
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0082 0.0336
Plasmodium vivax SET domain protein, putative 0.0069 0.0169 0.4977
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0053 0.0116 0.0116
Echinococcus multilocularis chromobox protein 1 0.0063 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.0298 0.0913
Brugia malayi beta-lactamase family protein 0.0119 0.0334 0.1362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0185 0.0173
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0042 0.0079 0.0079
Onchocerca volvulus 0.0119 0.0334 0.1342
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0071 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0171 0.5034
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0006 0.0023
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0069 0.0171 0.0165
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0034 0.0138
Brugia malayi hypothetical protein 0.011 0.0304 0.1239
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0079 0.0074
Loa Loa (eye worm) beta-lactamase 0.0119 0.0334 0.1362
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0042 0.0079 0.0074
Loa Loa (eye worm) hypothetical protein 0.0042 0.0079 0.0323
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0116 0.0116
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0053 0.0116 0.0116
Mycobacterium ulcerans beta-lactamase 0.0119 0.0334 1
Schistosoma mansoni hypothetical protein 0.0047 0.0095 0.0095
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Plasmodium falciparum glutathione reductase 0.0043 0.0082 0.4639
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0053 0.0116 0.0116
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0776 0.25 0.25
Brugia malayi steroid hormone receptor 0.0053 0.0116 0.0473
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0185 0.0173
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0024 0.0098
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0032 0.0032
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0069 0.0171 0.0159
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0761 0.2451 0.2451
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.0112 0.0107
Brugia malayi conserved hypotetical protein 0.0025 0.0024 0.0098
Loa Loa (eye worm) hypothetical protein 0.0042 0.0079 0.0323
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.0112 0.0107
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0133 0.0128
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0351 0.1099 0.1087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0023
Echinococcus granulosus acylamino acid releasing enzyme 0.0069 0.0171 0.0171
Brugia malayi Cytochrome P450 family protein 0.002 0.0009 0.0037
Trypanosoma cruzi oligopeptidase b 0.0069 0.0171 0.0165
Toxoplasma gondii prolyl endopeptidase 0.0069 0.0171 0.1819
Mycobacterium tuberculosis Conserved protein 0.0119 0.0334 0.1064
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.0112 0.0112
Echinococcus granulosus chromobox protein 1 0.0063 0.0149 0.0149
Loa Loa (eye worm) heterochromatin protein 1 0.0063 0.0149 0.0607
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0171 0.0165
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0112 0.0458
Echinococcus multilocularis musashi 0.0057 0.0129 0.0129
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0024 0.0024
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0024 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0185 0.018
Onchocerca volvulus Protein ultraspiracle homolog 0.0053 0.0116 0.0451
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0119 0.0334 0.0334
Echinococcus multilocularis tumor protein p63 0.1773 0.5788 0.5788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0043 0.0037
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.004 0.0035
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0164 0.0159
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.305 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0473
Brugia malayi glutathione reductase 0.0043 0.0082 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0053 0.0116 0.0473
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.0262 0.0762
Onchocerca volvulus 0.0042 0.0079 0.03
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.0262 0.0762
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0069 0.0171 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0077 0.0072
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0129 0.0525
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0473
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0067 0.0061
Mycobacterium tuberculosis Possible penicillin-binding protein 0.076 0.2447 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0119 0.0334 0.0328
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0069 0.0171 0.0165
Schistosoma mansoni chromobox protein 0.0063 0.0149 0.0149
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0053 0.0116 0.0451
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0042 0.0079 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0024 0.0018
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0138
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0058 0.0052
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.0298 0.0913
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0053 0.0116 0.0473
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0125 0.012
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0125 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0077 0.0072
Loa Loa (eye worm) prolyl oligopeptidase 0.0761 0.2451 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0054 0.0054
Trypanosoma cruzi prolyl endopeptidase 0.0069 0.0171 0.0165
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0034 0.0034
Brugia malayi Steroid receptor seven-up type 2 0.0053 0.0116 0.0473
Echinococcus granulosus lamin 0.0057 0.0129 0.0129
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0042 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0185 0.0173
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0423 0.1726
Brugia malayi nuclear hormone receptor 0.0053 0.0116 0.0473
Schistosoma mansoni cellular tumor antigen P53 0.0259 0.0797 0.0797
Brugia malayi follicle stimulating hormone receptor 0.0242 0.074 0.3017
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.0334 0.0328
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0095 0.0389
Brugia malayi ecdysone receptor 0.0025 0.0024 0.0098
Loa Loa (eye worm) hypothetical protein 0.0126 0.0356 0.1451
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Brugia malayi nuclear receptor NHR-88 0.0025 0.0024 0.0098
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0125 0.012
Mycobacterium leprae Probable lipase LipE 0.0119 0.0334 1
Plasmodium vivax hypothetical protein, conserved 0.0119 0.0334 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0053 0.0116 0.0473
Mycobacterium tuberculosis Probable esterase LipL 0.0119 0.0334 0.1064
Leishmania major cathepsin L-like protease 0.0074 0.0185 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0087 0.0082
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0125 0.012
Mycobacterium tuberculosis Conserved protein 0.0119 0.0334 0.1064
Giardia lamblia Rrm3p helicase 0.305 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0079 0.0074
Onchocerca volvulus 0.0025 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.0119 0.0334 0.1362
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0119 0.0334 0.1064
Echinococcus multilocularis FTZ F1 alpha 0.0053 0.0116 0.0116
Loa Loa (eye worm) fli-1 protein 0.0215 0.0652 0.2661
Brugia malayi Pre-SET motif family protein 0.0481 0.1527 0.6227
Brugia malayi beta-lactamase 0.0119 0.0334 0.1362
Echinococcus granulosus lamin dm0 0.0057 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0069 0.0169 0.1799
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0042 0.0079 0.0074
Brugia malayi nuclear receptor RXR 0.0025 0.0024 0.0098
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0069 0.0171 0.0374
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0069 0.0171 0.0165
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0125 0.0113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Brugia malayi photoreceptor-specific nuclear receptor 0.0053 0.0116 0.0473
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Schistosoma mansoni RAR-like nuclear receptor 0.0053 0.0116 0.0116
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.0112 0.0112
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0042 0.0079 0.0079
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0032 0.0032
Echinococcus granulosus GPCR family 2 0.0034 0.0054 0.0054
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0129 0.0525
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0473
Onchocerca volvulus 0.0057 0.0129 0.0503
Loa Loa (eye worm) hypothetical protein 0.0179 0.0532 0.2171
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0351 0.1099 0.1099
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0034 0.0138
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0176 0.0176
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0119 0.0334 0.1064
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0069 0.0171 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0077 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0119 0.0334 0.0334
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0069 0.0171 0.0171
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0024 0.0024
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.074 0.3017
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0125 0.0125
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0042 0.0079 0.0074
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Entamoeba histolytica hypothetical protein 0.0042 0.008 0.0074
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0053 0.0116 0.0473
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0185 0.0173
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0006 0.0006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0053 0.0116 0.0116
Schistosoma mansoni microtubule-associated protein tau 0.1589 0.5182 0.5182
Schistosoma mansoni steroid hormone receptor ad4bp 0.0053 0.0116 0.0116
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0125 0.012
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0351 0.1099 0.1099
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0053 0.0116 0.0116
Echinococcus granulosus intermediate filament protein 0.0057 0.0129 0.0129
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0119 0.0334 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0295 0.0914 1
Giardia lamblia GTOR 0.0052 0.0112 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0053 0.0116 0.0473
Schistosoma mansoni ets-related 0.0215 0.0652 0.0652
Entamoeba histolytica hypothetical protein 0.0042 0.008 0.0074
Loa Loa (eye worm) hypothetical protein 0.0259 0.0797 0.3253
Onchocerca volvulus 0.0079 0.0203 0.0806
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0138
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0125 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0034 0.0028
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0024 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0095 0.0095
Mycobacterium tuberculosis Probable peptidase 0.0069 0.0171 0.0374
Brugia malayi nuclear receptor RXR 0.0028 0.0034 0.0138
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0082 0.2335
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0112 0.0458
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.0262 0.0762
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0116 0.0116
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0069 0.0171 0.0697
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0169 0.0169
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.0112 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0024 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0095 0.0095
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0296 0.1209
Mycobacterium tuberculosis Probable reductase 0.0097 0.0262 0.0762
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0053 0.0116 0.0116
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0761 0.2451 0.2451
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0024 0.0024
Trypanosoma brucei trypanothione reductase 0.0043 0.0082 0.007
Loa Loa (eye worm) hypothetical protein 0.0073 0.0184 0.0751
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0125 0.0054
Entamoeba histolytica hypothetical protein 0.0042 0.008 0.0074
Loa Loa (eye worm) hypothetical protein 0.0108 0.0296 0.1209
Onchocerca volvulus 0.0179 0.0532 0.2153
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0083 0.0083
Loa Loa (eye worm) ctsf protein 0.0019 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0171 0.0165
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0082 0.0077
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0069 0.0171 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0169 0.0169
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0006 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0185 0.0173
Loa Loa (eye worm) glutathione reductase 0.0043 0.0082 0.0336
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0053 0.0116 0.0116
Brugia malayi Serine protease Z688.6 precursor 0.0042 0.0079 0.0323
Entamoeba histolytica prolyl oligopeptidase family protein 0.0069 0.0171 0.0165
Mycobacterium leprae conserved hypothetical protein 0.0119 0.0334 1
Schistosoma mansoni lamin 0.0057 0.0129 0.0129
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0069 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0116 0.0116
Echinococcus multilocularis lamin 0.0057 0.0129 0.0129
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0054 0.022
Onchocerca volvulus 0.0028 0.0033 0.0111
Schistosoma mansoni chromobox protein 0.0063 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0134
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0185 0.018
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.0116 0.0473
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.0112 0.0107
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0053 0.0116 0.0116
Mycobacterium ulcerans esterase/lipase LipP 0.0119 0.0334 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0024 0.0024
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0024 0.0098
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0024 0.0098
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0125 0.0125
Brugia malayi Serine protease Z688.6 precursor 0.0042 0.0079 0.0323
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0068 0.0692
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0116
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0024 0.0024
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0006 0.0006
Echinococcus multilocularis lamin dm0 0.0057 0.0129 0.0129
Brugia malayi Ets-domain containing protein 0.0071 0.0176 0.0717
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0473
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0042 0.0079 0.0809
Onchocerca volvulus 0.0053 0.0116 0.0451
Onchocerca volvulus 0.0259 0.0797 0.3237
Echinococcus multilocularis acylamino acid releasing enzyme 0.0069 0.0171 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0077 0.0072
Entamoeba histolytica prolyl oligopeptidase family protein 0.0069 0.0171 0.0165
Giardia lamblia Thymus-specific serine protease precursor 0.0042 0.0079 0.0008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0242
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.008 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0053 0.0116 0.0473
Entamoeba histolytica hypothetical protein, conserved 0.305 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0024 0.0098
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0006 0.0006
Brugia malayi Thioredoxin reductase 0.0043 0.0082 0.0336
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0112 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0063
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0125 0.012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0095 0.0095
Brugia malayi hypothetical protein 0.0019 0.0005 0.0022
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0024 0.0024
Mycobacterium tuberculosis Probable lipase LipD 0.0119 0.0334 0.1064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0063
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0043 0.0037
Loa Loa (eye worm) hypothetical protein 0.0069 0.0169 0.0689
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0119 0.0334 0.1362
Giardia lamblia Alanyl dipeptidyl peptidase 0.0069 0.0171 0.01
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0053 0.0116 0.0473
Trypanosoma brucei oligopeptidase b 0.0069 0.0171 0.0159
Entamoeba histolytica prolyl oligopeptidase family protein 0.0069 0.0171 0.0165
Echinococcus granulosus Dipeptidyl peptidase 9 0.0351 0.1099 0.1099
Giardia lamblia Serine peptidase, putative 0.0042 0.0079 0.0008
Echinococcus granulosus chromobox protein 1 0.0063 0.0149 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0112 0.0107
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0077 0.0072
Plasmodium falciparum peptidase, putative 0.0069 0.0171 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0069 0.0171 0.0165
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0024 0.0098
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0053 0.0116 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0063
Leishmania major hypothetical protein, conserved 0.003 0.004 0.0035
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0351 0.1099 0.1087
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0164
Schistosoma mansoni retinoic acid receptor RXR 0.0053 0.0116 0.0116
Schistosoma mansoni nuclear receptor 0.0025 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0119 0.0334 0.1362
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0042 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0116 0.0473
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.0112 0.0107
Schistosoma mansoni coup transcription factor 0.0053 0.0116 0.0116
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0056 0.005
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0024 0.0075
Toxoplasma gondii ABC1 family protein 0.0119 0.0334 0.3613
Mycobacterium ulcerans lipase LipD 0.0119 0.0334 1
Echinococcus multilocularis cysteine protease 0.0019 0.0006 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0067 0.0061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0473
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0083 0.2364
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0095 0.0389
Brugia malayi prolyl oligopeptidase family protein 0.0069 0.0171 0.0697
Echinococcus multilocularis prolyl endopeptidase 0.0069 0.0171 0.0171
Brugia malayi nuclear hormone receptor 0.0025 0.0024 0.0098
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.305 1 1
Brugia malayi prolyl oligopeptidase family protein 0.0761 0.2451 1
Mycobacterium tuberculosis Probable hydrolase 0.0119 0.0334 0.1064
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0053 0.0116 0.0116
Onchocerca volvulus 0.0547 0.1745 0.7114
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0125 0.012
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Trypanosoma brucei prolyl oligopeptidase, putative 0.0069 0.0171 0.0159
Echinococcus granulosus microtubule associated protein 2 0.1589 0.5182 0.5182
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.0169 0.0169
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.004 0.2089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0054 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0063
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0423 0.0423
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0171 0.0165
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0125 0.1317
Leishmania major cathepsin L-like protease 0.0074 0.0185 0.018
Onchocerca volvulus 0.0057 0.0129 0.0503
Brugia malayi ecdysteroid receptor 0.0053 0.0116 0.0473
Loa Loa (eye worm) hypothetical protein 0.0119 0.0334 0.1362
Brugia malayi nuclear receptor NHR-88 0.0053 0.0116 0.0473
Echinococcus multilocularis GPCR, family 2 0.0034 0.0054 0.0054
Leishmania major oligopeptidase b 0.0069 0.0171 0.0165
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.004 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0116 0.0116
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0082 0.0082
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0129 0.0525
Trichomonas vaginalis chromobox protein, putative 0.0063 0.0149 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0053 0.0116 0.0473
Loa Loa (eye worm) hypothetical protein 0.0061 0.0142 0.0578
Brugia malayi chromobox protein homolog 3 0.0035 0.0058 0.0236
Brugia malayi hypothetical protein 0.0179 0.0532 0.2171
Echinococcus granulosus prolyl endopeptidase 0.0069 0.0171 0.0171
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0023
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0053 0.0116 0.0116
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.004 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.305 1 1
Mycobacterium tuberculosis Conserved protein 0.0119 0.0334 0.1064
Brugia malayi Fli-1 protein 0.0215 0.0652 0.2661
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0009 0.0037
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0024 0.0024
Loa Loa (eye worm) DR-78 0.0025 0.0024 0.0098
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0024 0.0024
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.0298 0.7816
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0023
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0351 0.1099 0.1093
Mycobacterium ulcerans hypothetical protein 0.0119 0.0334 1
Plasmodium vivax glutathione reductase, putative 0.0043 0.0082 0.2335
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0023
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0069 0.0171 0.0165
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0473
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0776 0.25 0.25
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0054 0.022
Onchocerca volvulus 0.0119 0.0334 0.1342
Loa Loa (eye worm) hypothetical protein 0.0069 0.0171 0.0697
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0024 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0083 0.0078
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0776 0.25 0.25
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0022 0.001
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0024 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0034 0.0028
Entamoeba histolytica DNA repair and recombination protein, putative 0.305 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0761 0.2451 1
Brugia malayi hypothetical protein 0.003 0.004 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0053 0.0116 0.0473
Schistosoma mansoni gabp alpha 0.0071 0.0176 0.0176
Trichomonas vaginalis penicillin-binding protein, putative 0.0119 0.0334 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0112 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0095 0.0095
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0116 0.0473
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0423 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0044 0.0038
Loa Loa (eye worm) hypothetical protein 0.0225 0.0685 0.2793
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0053 0.0116 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0034 0.0028
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0054 0.0054
Plasmodium falciparum thioredoxin reductase 0.0043 0.0082 0.4639
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.004 0.2089
Loa Loa (eye worm) hypothetical protein 0.0119 0.0334 0.1362
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0083 0.0078
Loa Loa (eye worm) hypothetical protein 0.0057 0.0129 0.0525
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0006 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0547 0.1745 0.1741
Loa Loa (eye worm) MH2 domain-containing protein 0.026 0.0798 0.3253
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0125 0.012
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0069 0.0169 0.0169
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0171 0.0165
Loa Loa (eye worm) cysteine protease 0.0019 0.0006 0.0023
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0024 0.0098
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.305 1 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.0079 0.0074
Trypanosoma brucei prolyl endopeptidase 0.0069 0.0171 0.0159
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0176 0.0717
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0024 0.0098
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0296 0.1209
Brugia malayi Pre-SET motif family protein 0.0069 0.0169 0.0689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0034 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0098
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0042 0.0079 0.0074
Leishmania major cathepsin L-like protease 0.0074 0.0185 0.018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0116 0.0473
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0042 0.0079 0.0074
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.305 1 1
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0125 0.0125
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0035 0.0058 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0119 0.0334 0.0328
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0069 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.022
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.0262 0.562
Brugia malayi hypothetical protein 0.0025 0.0024 0.0098
Echinococcus granulosus tumor protein p63 0.1773 0.5788 0.5788
Onchocerca volvulus Prolyl endopeptidase homolog 0.0069 0.0171 0.0675
Schistosoma mansoni hypothetical protein 0.0042 0.008 0.008
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0024 0.0098
Onchocerca volvulus Bile acid receptor homolog 0.0053 0.0116 0.0451
Brugia malayi nuclear receptor NHR-67 0.0025 0.0024 0.0098
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0069 0.0171 0.0171
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0053 0.0116 0.0473
Brugia malayi hypothetical protein 0.0028 0.0034 0.0138
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0024 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.0334 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0034 0.0028
Schistosoma mansoni nuclear receptor 0.0025 0.0024 0.0024
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.0112 0.0112
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.0112 0.01
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0042 0.0079 0.0074
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.305 1 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0761 0.2451 0.2451
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0024 0.0024
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0119 0.0334 0.1064
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.305 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0058 0.0052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0481 0.1527 0.6227
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0053 0.0116 0.0116
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0185 0.018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0473
Echinococcus granulosus cathepsin l1 0.0019 0.0006 0.0006
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0351 0.1099 0.1093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0063
Brugia malayi Probable ATP-dependent helicase DHX35 0.0036 0.0059 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0034 0.0028
Brugia malayi hypothetical protein 0.0028 0.0034 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0116 0.0473
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.0112 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0044 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0116 0.0116
Loa Loa (eye worm) DEAH box polypeptide 35 0.0036 0.0059 0.0242

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 1.1 uM Antimicrobial activity against Mycobacterium tuberculosis after 8 days in aerobic condition by alamar blue assay ChEMBL. 19099398
MIC (functional) = 4.4 uM Antimicrobial activity against Mycobacterium tuberculosis after 11 days under anaerobic condition by luminescence-based low oxygen recovery assay ChEMBL. 19099398

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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