Detailed information for compound 954917

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 351.366 | Formula: C18H20F3N3O
  • H donors: 0 H acceptors: 2 LogP: 3.97 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1cc(OCCCN2CCCC2)nc(n1)c1ccccc1)(F)F
  • InChi: 1S/C18H20F3N3O/c19-18(20,21)15-13-16(25-12-6-11-24-9-4-5-10-24)23-17(22-15)14-7-2-1-3-8-14/h1-3,7-8,13H,4-6,9-12H2
  • InChiKey: HXEMUWDHZSSMEC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Sigma-1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0441 0.1305
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0026 0.0031
Echinococcus multilocularis pyruvate kinase 0.0018 0.0184 0.022
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0104 0.1943 0.3284
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1795 0.3034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5916 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0441 0.0499
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0248 0.028
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0314 0.1775
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0096 0.177 0.212
Onchocerca volvulus 0.0031 0.0462 0.0919
Brugia malayi nuclear receptor RXR 0.0011 0.0049 0.0056
Schistosoma mansoni polycystin 1-related 0.002 0.0238 0.0238
Echinococcus multilocularis pyruvate kinase 0.0027 0.0376 0.045
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.2314 0.2613
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0441 0.0499
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0035 0.0042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0248 0.0248
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0321 0.0362
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0062 0.1096 0.4619
Schistosoma mansoni hypothetical protein 0.0174 0.3357 0.3357
Echinococcus multilocularis cpg binding protein 0.0031 0.0459 0.055
Brugia malayi nuclear hormone receptor 0.0021 0.0248 0.028
Mycobacterium tuberculosis Probable oxidoreductase 0.0221 0.4323 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0321 0.0742
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0238 0.0285
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0176 0.0399
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0462 0.0553
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0441 0.1465
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0096 0.177 0.1998
Schistosoma mansoni nuclear hormone receptor 0.001 0.0026 0.0026
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0278 0.0314
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0026 0.0029
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0321 0.0543
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0196 0.0446
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.0221
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0522 0.0882
Schistosoma mansoni ferritin light chain 0.0009 0.0004 0.0004
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0522 0.0589
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.16 0.1807
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0441 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5916 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0441 0.1465
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0248 0.028
Loa Loa (eye worm) hypothetical protein 0.0031 0.0462 0.0522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0248 0.028
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.2801 0.6477
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0522 0.0589
Schistosoma mansoni microsomal glutathione s-transferase 0.0115 0.2158 0.2158
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0004 0.0013
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0314 0.0742
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.0221
Brugia malayi photoreceptor-specific nuclear receptor 0.0263 0.5166 0.5833
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Echinococcus granulosus dnaJ subfamily B 0.042 0.8348 1
Echinococcus multilocularis ferritin 0.0009 0.0004 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0248 0.0248
Plasmodium falciparum glutathione reductase 0.0087 0.16 0.8053
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0096 0.177 0.1998
Echinococcus granulosus pyruvate kinase 0.0034 0.0522 0.0625
Schistosoma mansoni nuclear receptor 0.001 0.0026 0.0026
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0026 0.0029
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0441 0.0499
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0321 0.1146
Echinococcus multilocularis RUN 0.002 0.0238 0.0285
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0314 0.0355
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0199 0.3872 0.8955
Loa Loa (eye worm) hypothetical protein 0.0034 0.0522 0.0589
Brugia malayi Pre-SET motif family protein 0.0214 0.4176 0.4715
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0337 0.0404
Brugia malayi conserved hypotetical protein 0.001 0.0026 0.0029
Echinococcus multilocularis thioredoxin glutathione reductase 0.0088 0.1611 0.1929
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0248 0.0297
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0314 0.1122
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0248 0.0248
Echinococcus granulosus cpg binding protein 0.0031 0.0459 0.055
Schistosoma mansoni pyruvate kinase 0.0018 0.0184 0.0184
Schistosoma mansoni ferritin 0.0009 0.0004 0.0004
Echinococcus multilocularis expressed protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0026 0.0029
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0031 0.0452 0.0511
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0248 0.0248
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0104 0.1943 0.3284
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0441 0.1576
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.1795 0.2027
Echinococcus multilocularis pyruvate kinase 0.0018 0.0184 0.022
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0522 0.0589
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0321 0.1146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0176 0.0399
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0522 0.0589
Trypanosoma brucei hypothetical protein, conserved 0.0218 0.4259 0.4809
Brugia malayi steroid hormone receptor 0.0021 0.0248 0.028
Loa Loa (eye worm) hypothetical protein 0.002 0.0238 0.0269
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0026 0.0031
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0248 0.0297
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.2314 0.2613
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0049 0.0056
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0248 0.0248
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0026 0.0031
Brugia malayi hypothetical protein 0.001 0.0026 0.0029
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0314 0.0531
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0096 0.177 0.1998
Schistosoma mansoni coup transcription factor 0.0021 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.0221
Schistosoma mansoni cpg binding protein 0.0029 0.0425 0.0425
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.8856 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0312 0.0352
Brugia malayi glucose-6-phosphate dehydrogenase 0.0096 0.177 0.1998
Giardia lamblia Pyruvate kinase 0.0018 0.0184 0.0311
Schistosoma mansoni hypothetical protein 0.0174 0.3357 0.3357
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.1795 0.215
Trypanosoma brucei trypanothione reductase 0.0087 0.16 0.1807
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0314 0.0742
Echinococcus granulosus thioredoxin glutathione reductase 0.0088 0.1611 0.1929
Loa Loa (eye worm) histone methyltransferase 0.001 0.0035 0.004
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0056
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0248 0.0248
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.8856 1
Schistosoma mansoni pyruvate kinase 0.0034 0.0522 0.0522
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0441 1
Schistosoma mansoni ferritin 0.0009 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1795 0.3034
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0441 0.0499
Brugia malayi hypothetical protein 0.002 0.0238 0.0269
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0462 0.1409
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0441 0.0499
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0441 0.0499
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0049 0.0059
Schistosoma mansoni cpg binding protein 0.0031 0.0459 0.0459
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0248 0.028
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0441 0.0529
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.1795 0.3725
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0104 0.1943 0.3284
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0314 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.1795 0.1795
Leishmania major pyruvate kinase 0.0034 0.0522 0.0589
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.028
Schistosoma mansoni pyruvate kinase 0.0034 0.0522 0.0522
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0801 0.1354
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0248 0.0297
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0221 0.4323 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0248 0.0297
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0337 0.0381
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.1559 0.1761
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0026 0.0031
Onchocerca volvulus 0.0024 0.0321 0.0622
Mycobacterium tuberculosis Probable dehydrogenase 0.0199 0.3872 0.8955
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.4259 0.4809
Echinococcus multilocularis pyruvate kinase 0.0034 0.0522 0.0625
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0278 0.0314
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0248 0.0248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0248 0.0297
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.1795 0.2027
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0522 0.1863
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0321 0.0362
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0248 0.0248
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.16 0.3696
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0096 0.177 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.1559 0.1868
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0248 0.028
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0026 0.0031
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0026 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0441 0.0499
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0056
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0248 0.0297
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5916 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0248 0.028
Brugia malayi MH2 domain containing protein 0.0122 0.2314 0.2613
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0441 0.1014
Schistosoma mansoni hypothetical protein 0.042 0.8348 0.8348
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1795 0.3034
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0337 0.0404
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0441 0.1576
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0522 0.0589
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0049 0.0056
Schistosoma mansoni apoferritin-2 0.0009 0.0004 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0462 0.0462
Trichomonas vaginalis set domain proteins, putative 0.0244 0.4775 0.8071
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0337 0.0381
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0035 0.0042
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0221 0.4323 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5916 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0462 0.0553
Plasmodium falciparum thioredoxin reductase 0.003 0.0441 0.1465
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.1795 0.2027
Echinococcus granulosus pyruvate kinase 0.0018 0.0184 0.022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0056
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0248 0.0468
Entamoeba histolytica hypothetical protein 0.0024 0.0314 0.0531
Loa Loa (eye worm) hypothetical protein 0.0445 0.8856 1
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0062 0.1096 0.3912
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0321 0.1146
Plasmodium falciparum glutathione reductase 0.003 0.0441 0.1465
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0248 0.0248
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0321 0.0543
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.5916 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0522 0.1045
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0026 0.0026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0248 0.0297
Leishmania major trypanothione reductase 0.0087 0.16 0.1807
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0248 0.0468
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0441 0.0499
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0248 0.028
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0026 0.0029
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0321 0.0362
Echinococcus multilocularis pyruvate kinase 0.0034 0.0522 0.0625
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0321 0.0543
Brugia malayi CXXC zinc finger family protein 0.0029 0.0425 0.048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.028
Brugia malayi nuclear receptor NHR-88 0.0021 0.0248 0.028
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.4259 0.4809
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0522 0.12
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0004 0.0006
Loa Loa (eye worm) DR-78 0.001 0.0026 0.0029
Schistosoma mansoni kinase 0.0049 0.0827 0.0827
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.16 0.1807
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.5916 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0426 0.051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0176 0.0399
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Brugia malayi ecdysone receptor 0.001 0.0026 0.0029
Schistosoma mansoni ferritin 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.028
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0522 0.1045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0176 0.0399
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.1795 0.3034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.028
Loa Loa (eye worm) doublecortin family protein 0.002 0.0238 0.0269
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1795 0.3034
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0026 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0321 0.0362
Onchocerca volvulus 0.0085 0.1559 0.3229
Brugia malayi Pre-SET motif family protein 0.0031 0.0462 0.0522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0248 0.028
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.1559 0.1559
Echinococcus granulosus ferritin 0.0009 0.0004 0.0004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.4176 0.4715
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0441 0.0499
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0337 0.1204
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0314 0.1122
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0248 0.0297
Schistosoma mansoni ferritin 0.0009 0.0004 0.0004
Schistosoma mansoni ferritin light chain 0.0009 0.0004 0.0004
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0221 0.4323 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0441 0.1576
Loa Loa (eye worm) hypothetical protein 0.0024 0.0321 0.0362
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0196 0.007
Schistosoma mansoni nuclear hormone receptor 0.001 0.0026 0.0026
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0441 0.1465
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.1795 0.2027
Onchocerca volvulus 0.0021 0.0248 0.0468
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0199 0.3872 0.8956
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0248 0.028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.028
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0026 0.0031
Toxoplasma gondii thioredoxin reductase 0.0087 0.16 0.7173
Loa Loa (eye worm) hypothetical protein 0.0263 0.5166 0.5833
Brugia malayi hypothetical protein 0.001 0.0026 0.0029
Echinococcus granulosus expressed protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0248 0.028
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0801 0.1354
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5916 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0441 0.0499
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0026 0.0029
Plasmodium falciparum pyruvate kinase 0.0034 0.0522 0.1923
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0056
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0314 0.0727
Mycobacterium ulcerans hypothetical protein 0.0024 0.0321 0.1146
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0049 0.0056
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0033 0.0501 0.1151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0248 0.028
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0337 0.1204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0248 0.028
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0441 0.2495
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0248 0.028
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0196 0.1108
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0049 0.0049
Onchocerca volvulus 0.0244 0.4775 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0238 0.0307
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0314 0.7093
Brugia malayi hypothetical protein 0.002 0.0238 0.0269
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.5916 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0321 0.0735
Onchocerca volvulus 0.002 0.0238 0.0447
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.1795 0.215
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0248 0.0297
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0441 0.0499
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0522 0.0589
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0441 0.0529
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.2801 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0049 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1795 0.3034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.0221
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0104 0.1943 1
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.8856 1
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0337 0.057
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0096 0.177 0.2991
Treponema pallidum NADH oxidase 0.003 0.0441 0.0746
Schistosoma mansoni apoferritin-2 0.0009 0.0004 0.0004
Brugia malayi hypothetical protein 0.0011 0.0049 0.0056
Brugia malayi Doublecortin family protein 0.002 0.0238 0.0269
Loa Loa (eye worm) hypothetical protein 0.002 0.0238 0.0269
Brugia malayi nuclear receptor NHR-88 0.001 0.0026 0.0029
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0026 0.0026
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0026 0.0031
Brugia malayi nuclear hormone receptor 0.001 0.0026 0.0029
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0004 0.0013
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0104 0.1943 0.3284
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0441 0.1305
Brugia malayi Nuclear hormone receptor E75 0.001 0.0026 0.0029
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0115 0.2158 0.2585
Trypanosoma brucei polo-like protein kinase 0.0097 0.1795 0.2027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0248 0.028
Schistosoma mansoni zinc finger protein 0.001 0.0026 0.0026
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0026 0.0029
Leishmania major pyruvate kinase 0.0034 0.0522 0.0589
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0321 0.1146
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0033 0.0037
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.1559 0.1868
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0096 0.177 0.6317
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0238 0.0285
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0248 0.0248
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0026 0.0031
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0441 0.0746
Loa Loa (eye worm) glutathione reductase 0.0087 0.16 0.1807
Echinococcus multilocularis pyruvate kinase 0.0018 0.0184 0.022
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0522 0.1713
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0248 0.028
Plasmodium falciparum thioredoxin reductase 0.0087 0.16 0.8053
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0337 0.0381
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0522 0.0589
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0248 0.0248
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0248 0.0297
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0441 0.0441
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0026 0.0031
Chlamydia trachomatis pyruvate kinase 0.0034 0.0522 0.295
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0441 0.0499
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.028
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0032 0.0471 0.0532
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0522 0.0589
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0248 0.0297
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0096 0.177 0.212
Echinococcus multilocularis dnaJ subfamily B 0.042 0.8348 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0248 0.0248
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0248 0.0297
Trichomonas vaginalis ferritin, putative 0.0009 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0441 0.0746
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0314 0.0661
Brugia malayi hypothetical protein 0.0011 0.0049 0.0056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0321 0.0742
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5916 1
Echinococcus multilocularis geminin 0.0174 0.3357 0.4021
Giardia lamblia Kinase, PLK 0.0097 0.1795 0.3034
Echinococcus granulosus geminin 0.0174 0.3357 0.4021
Mycobacterium tuberculosis Conserved protein 0.0025 0.0337 0.0773
Echinococcus granulosus RUN 0.002 0.0238 0.0285
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0238 0.0285
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.16 0.8053
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.1795 0.2027
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0337 0.1204
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0196 0.007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0321 0.0735
Plasmodium vivax glutathione reductase, putative 0.0087 0.16 0.8053
Toxoplasma gondii MAPEG family protein 0.0115 0.2158 1
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0026 0.0026
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0238 0.0285
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1795 0.3034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0462 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0248 0.028
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0312 0.0527
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0199 0.3872 0.8955
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0049 0.0049
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.5916 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0248 0.028
Plasmodium vivax SET domain protein, putative 0.0031 0.0462 0.1582
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0248 0.028
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0104 0.1943 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0321 0.1146
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0522 0.1207
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0522 0.0882
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0037 0.0042
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0441 0.1465
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5916 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.8856 1
Mycobacterium tuberculosis Probable reductase 0.0199 0.3872 0.8955
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0441 0.0499
Schistosoma mansoni cpg binding protein 0.0031 0.0459 0.0459
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5916 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0184 0.022
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0029
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0425 0.048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.028
Schistosoma mansoni lipoxygenase 0.002 0.0238 0.0238
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0441 0.0499
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0238 0.0285
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0441 0.0499
Leishmania major hypothetical protein, conserved 0.0218 0.4259 0.4809
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0321 0.1146
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0248 0.0297
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0321 0.0362
Loa Loa (eye worm) hypothetical protein 0.0024 0.0312 0.0352
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0462 0.0462
Brugia malayi nuclear receptor NHR-67 0.001 0.0026 0.0029
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0248 0.0297
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0238 0.0285
Echinococcus granulosus pyruvate kinase 0.0034 0.0522 0.0625
Onchocerca volvulus 0.0029 0.0425 0.0842
Echinococcus granulosus microsomal glutathione S transferase 3 0.0115 0.2158 0.2585
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0096 0.177 0.177
Onchocerca volvulus 0.002 0.0238 0.0447
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0056
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0321 0.1146
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0441 0.0746
Loa Loa (eye worm) hypothetical protein 0.0227 0.4442 0.5016
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0026 0.0031
Schistosoma mansoni rab6-interacting 0.002 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0024 0.0321 0.0362
Brugia malayi Thioredoxin reductase 0.0087 0.16 0.1807
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0248 0.0468
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0248 0.028
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0522 0.0589
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0199 0.3872 0.8955
Mycobacterium ulcerans hypothetical protein 0.0025 0.0337 0.1204
Schistosoma mansoni rab6-interacting 0.002 0.0238 0.0238
Schistosoma mansoni hypothetical protein 0.002 0.0238 0.0238
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0983 0.405
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.2801 0.648
Mycobacterium ulcerans hypothetical protein 0.0025 0.0337 0.1204
Loa Loa (eye worm) hypothetical protein 0.0085 0.1559 0.1761
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.0221
Schistosoma mansoni nuclear receptor 0.001 0.0026 0.0026
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0248 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0248 0.028
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0321 0.0362
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0004 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0462 0.0553
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0441 0.0499
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0199 0.3872 0.8955
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0337 0.0773
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0248 0.028
Brugia malayi nuclear receptor RXR 0.001 0.0026 0.0029
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0522 0.1045
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0522 0.1923
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0314 0.0719
Echinococcus granulosus pyruvate kinase 0.0018 0.0184 0.022
Brugia malayi Nuclear hormone receptor E75 0.001 0.0026 0.0029
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0104 0.1943 0.8908
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0441 0.0499
Schistosoma mansoni loxhd1 0.002 0.0238 0.0238
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0196 0.07
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0321 0.0362
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0248 0.0297
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.1119 0.1119
Giardia lamblia Pyruvate kinase 0.0034 0.0522 0.0882
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0441 0.0499
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0248 0.0297
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0238 0.0307
Brugia malayi tailless protein 0.001 0.0026 0.0029
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0248 0.0297
Brugia malayi ecdysteroid receptor 0.0021 0.0248 0.028
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1795 0.3034
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0096 0.177 0.1998
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0248 0.028
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0248 0.028
Brugia malayi glutathione reductase 0.0087 0.16 0.1807
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0314 0.0355

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 27.6 nM Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in Dunkin Hartley guinea pig brain membranes after 180 mins by liquid scintillation counting analysis ChEMBL. 25420090

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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