Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0032 | 0.0032 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0465 | 0.0465 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0042 | 0.0353 | 0.0348 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.0929 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0205 | 0.0068 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0164 | 0.3943 | 0.3943 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0047 | 0.0506 | 0.0374 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0465 | 0.0566 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0353 | 0.0353 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0209 | 0.0394 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0209 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0122 | 0.2708 | 0.2708 |
Schistosoma mansoni | zinc finger protein | 0.004 | 0.0289 | 0.0289 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0293 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0506 | 0.0644 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0042 | 0.0336 | 0.0336 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.532 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0253 | 0.6567 | 0.6567 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0238 | 0.6139 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.6178 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0103 | 0.2137 | 0.4017 |
Onchocerca volvulus | 0.0037 | 0.0209 | 0.0339 | |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.168 | 0.2927 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0047 | 0.0506 | 0.0506 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0209 | 0.0209 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0293 | 0.0293 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0465 | 0.0332 |
Schistosoma mansoni | lipoxygenase | 0.0057 | 0.079 | 0.079 |
Brugia malayi | Latrophilin receptor protein 2 | 0.004 | 0.0293 | 0.0551 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0209 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0209 | 0.0069 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0103 | 0.2137 | 0.2137 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0209 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0103 | 0.2137 | 0.2137 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0072 | 0.1239 | 0.1117 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0209 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0129 | 0.2924 | 0.2924 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0209 | 0.2256 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.004 | 0.0293 | 0.0232 |
Brugia malayi | Bromodomain containing protein | 0.0153 | 0.3631 | 0.6825 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0127 | 0.2852 | 0.5204 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0205 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0209 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0047 | 0.0506 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1422 | 0.2426 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.0929 | 0.1213 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0465 | 0.0465 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0209 | 0.0209 |
Echinococcus multilocularis | geminin | 0.0369 | 1 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0046 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1668 | 0.2902 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0164 | 0.3943 | 0.3859 |
Echinococcus granulosus | 5'partial|3'partial|mitogen activated protein kinase kinase kinase | 0.007 | 0.1189 | 0.1067 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0205 | 0.0205 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0065 | 0.1028 | 0.1028 |
Onchocerca volvulus | 0.0239 | 0.6178 | 1 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0929 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0929 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0072 | 0.1239 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.3373 | 0.6216 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0035 | 0.0137 | 0.0137 |
Schistosoma mansoni | zinc finger protein | 0.0031 | 0.0032 | 0.0032 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0209 | 0.0073 |
Echinococcus multilocularis | kinase protein | 0.007 | 0.1189 | 0.1189 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0042 | 0.0336 | 0.0544 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0465 | 0.0465 |
Onchocerca volvulus | 0.0037 | 0.0209 | 0.0339 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0065 | 0.1028 | 0.1028 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0465 | 0.0332 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0047 | 0.0506 | 0.0506 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0047 | 0.0506 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1028 | 0.1659 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0929 | 0.0929 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.004 | 0.0293 | 0.0158 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0122 | 0.2708 | 0.2607 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0465 | 0.0874 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.1668 | 0.1668 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase 7 | 0.007 | 0.1189 | 0.1189 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0087 | 0.1668 | 0.3135 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0057 | 0.079 | 0.079 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0035 | 0.0137 | 0.0137 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.1418 | 0.2666 |
Echinococcus granulosus | zinc finger protein | 0.004 | 0.0289 | 0.0154 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0205 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0336 | 0.0314 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0205 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.004 | 0.0293 | 0.0293 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0929 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0209 | 0.0069 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.007 | 0.1189 | 0.1189 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0042 | 0.0336 | 0.0336 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0042 | 0.0336 | 0.0201 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0205 | 0.0205 |
Brugia malayi | Protein kinase domain containing protein | 0.0072 | 0.1239 | 0.2329 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.0929 | 0.0802 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0209 | 0.1984 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.532 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.004 | 0.0293 | 0.0158 |
Echinococcus multilocularis | zinc finger protein | 0.004 | 0.0289 | 0.0289 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0205 | 0.0205 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0209 | 0.0069 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0042 | 0.0336 | 0.0336 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0293 | 0.0293 |
Brugia malayi | mbt repeat family protein | 0.0042 | 0.0336 | 0.0632 |
Brugia malayi | mbt repeat family protein | 0.0042 | 0.0336 | 0.0632 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.004 | 0.0293 | 0.0158 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.004 | 0.0293 | 0.0293 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0042 | 0.0336 | 0.0201 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.2852 | 0.5204 |
Loa Loa (eye worm) | MBCTL1 | 0.0047 | 0.0506 | 0.0644 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0127 | 0.2852 | 0.5361 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0057 | 0.079 | 0.0662 |
Loa Loa (eye worm) | TKL/MLK/TAK1 protein kinase | 0.0072 | 0.1239 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0209 | 0.0069 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0209 | 1 |
Echinococcus granulosus | 3'partial|mitogen activated protein kinase kinase kinase | 0.007 | 0.1189 | 0.1067 |
Schistosoma mansoni | hypothetical protein | 0.0369 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0046 | 0.0468 | 0.0468 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0047 | 0.0506 | 0.0506 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0209 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2137 | 0.3814 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0465 | 0.0465 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0205 | 0.0385 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0465 | 0.0465 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.004 | 0.0293 | 0.0293 |
Echinococcus multilocularis | kinase protein | 0.007 | 0.1189 | 0.1189 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.007 | 0.1189 | 0.1189 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0042 | 0.0336 | 0.0314 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0293 | 0.0232 |
Brugia malayi | PHD-finger family protein | 0.0051 | 0.0611 | 0.1149 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0046 | 0.0468 | 0.0336 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0929 | 0.0929 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.007 | 0.1189 | 0.1189 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.004 | 0.0293 | 0.0551 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0209 | 0.0394 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0042 | 0.0336 | 0.0336 |
Schistosoma mansoni | hypothetical protein | 0.0369 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0073 | 0.1275 | 0.1275 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0209 | 0.0069 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0205 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1565 | 0.2703 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0065 | 0.1028 | 0.1028 |
Echinococcus granulosus | muscleblind protein | 0.0103 | 0.2137 | 0.2027 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0209 | 0.0069 |
Onchocerca volvulus | 0.0037 | 0.0209 | 0.0339 | |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0209 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2137 | 0.3814 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0042 | 0.0336 | 0.0336 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0073 | 0.1275 | 0.1154 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0065 | 0.1028 | 0.0903 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.0929 | 0.0929 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0209 | 0.0069 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.0929 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0035 | 0.0137 | 0.0137 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0209 | 0.0209 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0293 | 0.0293 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0209 | 1 |
Onchocerca volvulus | 0.0042 | 0.0336 | 0.0544 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0127 | 0.2852 | 0.5361 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.