Detailed information for compound 955042

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 613.609 | Formula: C31H35NO12
  • H donors: 5 H acceptors: 8 LogP: 1.26 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCO[C@H]1C[C@](C)(O)[C@@H](c2c1c(O)c1c(c2)C(=O)c2c(C1=O)c(O)cc1c2O[C@@H]2O[C@@]1(C)[C@@H]([C@H]([C@@H]2O)N(C)C)O)C(=O)OC
  • InChi: 1S/C31H35NO12/c1-7-42-15-10-30(2,40)20(28(39)41-6)11-8-12-17(23(35)16(11)15)24(36)18-14(33)9-13-26(19(18)22(12)34)43-29-25(37)21(32(4)5)27(38)31(13,3)44-29/h8-9,15,20-21,25,27,29,33,35,37-38,40H,7,10H2,1-6H3/t15-,20-,21-,25-,27+,29+,30-,31+/m0/s1
  • InChiKey: ZWDYSYAACQRAHJ-OEYOBKQZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0114 0.1837 0.333
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0328 0.7648
Schistosoma mansoni peroxidasin 0.0183 0.3103 0.3056
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.003 0.0282 0.0457
Toxoplasma gondii fructose-bisphospatase I 0.0114 0.1837 0.333
Echinococcus granulosus delta-like protein 1 0.003 0.0282 0.0282
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0328 0.0714
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.1921 1
Loa Loa (eye worm) Notch2 0.003 0.0282 0.0507
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.2146 1
Loa Loa (eye worm) phosphofructokinase 0.0119 0.1921 0.3449
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0408 0.0304
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Brugia malayi Peroxidasin 0.0183 0.3103 0.5549
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0408 0.0619
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0307 0.5381 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0082 0.0082
Echinococcus granulosus protein jagged 2 0.003 0.0282 0.0282
Onchocerca volvulus Neurogenic locus notch homolog 0.003 0.0282 0.0005
Brugia malayi Animal haem peroxidase family protein 0.0183 0.3103 0.5549
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0688 0.1235
Echinococcus granulosus protein jagged 1 0.003 0.0282 0.0282
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0408 0.0733
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0328 0.4201
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.1921 0.3368
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.3917 0.7032
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0082 0.0238
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0328 0.7648
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.1921 1
Trichomonas vaginalis glutaminase, putative 0.0317 0.557 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0328 0.4201
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0408 0.0685
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.1921 0.1921
Echinococcus granulosus lamin dm0 0.0029 0.028 0.028
Echinococcus granulosus slit 2 protein 0.003 0.0282 0.0282
Onchocerca volvulus Peroxidase homolog 0.0183 0.3103 0.67
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Onchocerca volvulus Peroxidasin homolog 0.0183 0.3103 0.67
Brugia malayi Muscle positioning protein 4 0.003 0.0282 0.0457
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0338 0.0272
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0114 0.1837 0.333
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0307 0.5381 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0328 0.0474
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.1921 0.3449
Echinococcus granulosus protein jagged 1 0.003 0.0282 0.0282
Schistosoma mansoni lamin 0.0029 0.028 0.0214
Brugia malayi Calcium binding EGF domain containing protein 0.003 0.0282 0.0457
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0328 0.4201
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Schistosoma mansoni notch 0.003 0.0282 0.0216
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0688 0.0688
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.2146 1
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.1921 0.3368
Brugia malayi glutaminase DH11.1 0.0317 0.557 1
Schistosoma mansoni hypothetical protein 0.003 0.0282 0.0216
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0068 0.5
Brugia malayi Animal haem peroxidase family protein 0.0183 0.3103 0.5549
Echinococcus multilocularis neurogenic locus notch protein 0.003 0.0282 0.0282
Echinococcus granulosus pyruvate kinase 0.0036 0.0408 0.0408
Echinococcus granulosus neural cadherin 0.003 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0485
Brugia malayi notch-like transmembrane receptor 0.003 0.0282 0.0457
Brugia malayi EGF-like domain containing protein 0.003 0.0282 0.0457
Brugia malayi Calcium binding EGF domain containing protein 0.003 0.0282 0.0457
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0408 0.164
Brugia malayi EGF-like domain containing protein 0.003 0.0282 0.0457
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Loa Loa (eye worm) glutaminase 0.0317 0.557 1
Onchocerca volvulus 0.003 0.0282 0.0005
Echinococcus multilocularis pyruvate kinase 0.0019 0.0082 0.0082
Onchocerca volvulus 0.0183 0.3103 0.67
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0657 0.0593
Giardia lamblia Pyruvate kinase 0.0036 0.0408 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.1904 0.8837
Loa Loa (eye worm) hypothetical protein 0.0029 0.028 0.0503
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Plasmodium vivax glutathione reductase, putative 0.0052 0.0688 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0657 0.0657
Onchocerca volvulus 0.003 0.0282 0.0005
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0307 0.5381 1
Schistosoma mansoni notch 0.003 0.0282 0.0216
Brugia malayi Cadherin domain containing protein 0.003 0.0282 0.0457
Schistosoma mansoni hypothetical protein 0.003 0.0282 0.0216
Echinococcus multilocularis musashi 0.0029 0.028 0.028
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0068 0.5
Schistosoma mansoni laminin gamma-3 chain 0.003 0.0282 0.0216
Echinococcus multilocularis pyruvate kinase 0.0029 0.0267 0.0267
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0328 0.0474
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Onchocerca volvulus Peroxidase homolog 0.0183 0.3103 0.67
Echinococcus granulosus intermediate filament protein 0.0029 0.028 0.028
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0338 0.0272
Brugia malayi 6-phosphofructokinase 0.0119 0.1921 0.3415
Plasmodium falciparum pyruvate kinase 0.0036 0.0408 0.5493
Echinococcus multilocularis lamin 0.0029 0.028 0.028
Brugia malayi 6-phosphofructokinase 0.0119 0.1921 0.3415
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.1921 0.3368
Loa Loa (eye worm) intermediate filament protein 0.0029 0.028 0.0503
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0307 0.5381 0.5381
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0328 0.049
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.1921 0.1866
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0408 0.0733
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.028 0.0454
Brugia malayi EGF-like domain containing protein 0.003 0.0282 0.0457
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0029 0.0052
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Echinococcus multilocularis peroxidasin 0.0183 0.3103 0.3103
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.2146 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0183 0.3103 0.5572
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.1921 1
Mycobacterium tuberculosis Probable reductase 0.0118 0.1904 0.8837
Schistosoma mansoni intermediate filament proteins 0.0029 0.028 0.0214
Brugia malayi Animal haem peroxidase family protein 0.0183 0.3103 0.5549
Plasmodium falciparum glutathione reductase 0.0052 0.0688 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0082 0.0082
Onchocerca volvulus Putative cubilin 0.003 0.0282 0.0005
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0328 0.0474
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0408 0.0733
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0338 0.0338
Schistosoma mansoni notch 0.003 0.0282 0.0216
Schistosoma mansoni hypothetical protein 0.003 0.0282 0.0216
Onchocerca volvulus 0.0033 0.0338 0.0137
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0328 0.7648
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0114 0.1837 0.333
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0068 0.0068
Trichomonas vaginalis set domain proteins, putative 0.0258 0.4494 0.8045
Schistosoma mansoni hypothetical protein 0.003 0.0282 0.0216
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.1921 0.3487
Leishmania major pyruvate kinase 0.0036 0.0408 0.0641
Brugia malayi GCC2 and GCC3 family protein 0.003 0.0282 0.0457
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Brugia malayi Animal haem peroxidase family protein 0.0183 0.3103 0.5549
Schistosoma mansoni pyruvate kinase 0.0019 0.0082 0.0015
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Echinococcus granulosus lamin 0.0029 0.028 0.028
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0408 0.0641
Schistosoma mansoni septate junction protein 0.003 0.0282 0.0216
Echinococcus multilocularis geminin 0.0558 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Schistosoma mansoni slit 0.003 0.0282 0.0216
Leishmania major trypanothione reductase 0.0052 0.0688 0.1167
Brugia malayi EGF-like domain containing protein 0.003 0.0282 0.0457
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0206 0.0369
Onchocerca volvulus 0.0258 0.4494 1
Brugia malayi intermediate filament protein 0.0029 0.028 0.0454
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0408 0.0685
Schistosoma mansoni notch 0.003 0.0282 0.0216
Onchocerca volvulus 0.003 0.0282 0.0005
Giardia lamblia Pyruvate kinase 0.0019 0.0082 0.0434
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Loa Loa (eye worm) hypothetical protein 0.0036 0.0408 0.0733
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.1921 0.3449
Brugia malayi Pre-SET motif family protein 0.0033 0.0338 0.0558
Onchocerca volvulus Slit protein homolog 0.003 0.0282 0.0005
Schistosoma mansoni notch 0.003 0.0282 0.0216
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.003 0.0282 0.0216
Echinococcus granulosus neurogenic locus notch protein 0.003 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Loa Loa (eye worm) animal heme peroxidase 0.0183 0.3103 0.5572
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0068 0.007
Onchocerca volvulus 0.0183 0.3103 0.67
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0657 0.0593
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0688 0.2985
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0657 0.0593
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.1921 0.3487
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Brugia malayi EGF-like domain containing protein 0.003 0.0282 0.0457
Toxoplasma gondii EGF family domain-containing protein 0.003 0.0282 0.0404
Echinococcus granulosus neurogenic locus protein delta 0.003 0.0282 0.0282
Schistosoma mansoni pyruvate kinase 0.0036 0.0408 0.0343
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Schistosoma mansoni lamin 0.0029 0.028 0.0214
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0657 0.1134
Echinococcus multilocularis lamin dm0 0.0029 0.028 0.028
Loa Loa (eye worm) animal heme peroxidase 0.0183 0.3103 0.5572
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0082 0.0028
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0328 0.049
Echinococcus multilocularis neurogenic locus protein delta 0.003 0.0282 0.0282
Schistosoma mansoni notch 0.003 0.0282 0.0216
Echinococcus granulosus pyruvate kinase 0.0036 0.0408 0.0408
Loa Loa (eye worm) glutaminase 2 0.0317 0.557 1
Plasmodium vivax SET domain protein, putative 0.0033 0.0338 0.4358
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.1921 0.1921
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0338 0.0338
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.1921 0.3368
Echinococcus granulosus neurogenic locus notch protein 4 0.003 0.0282 0.0282
Echinococcus multilocularis fibropellin Ia 0.003 0.0282 0.0282
Brugia malayi Blistered cuticle protein 3 0.0183 0.3103 0.5549
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0408 0.0641
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.2146 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0082 0.0082
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0408 0.0619
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0307 0.5381 0.9662
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0408 0.0641
Echinococcus multilocularis fat cadherin tumor suppressor 0.003 0.0282 0.0282
Onchocerca volvulus Chorion peroxidase homolog 0.0183 0.3103 0.67
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0688 0.0688
Brugia malayi EGF-like domain containing protein 0.003 0.0282 0.0457
Echinococcus multilocularis pyruvate kinase 0.0036 0.0408 0.0408
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0338 0.0338
Echinococcus multilocularis protein jagged 2 0.003 0.0282 0.0282
Echinococcus multilocularis pyruvate kinase 0.0036 0.0408 0.0408
Brugia malayi phosphofructokinase 0.0119 0.1921 0.3415
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0307 0.5381 0.5381
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0114 0.1837 0.333
Brugia malayi Calcium binding EGF domain containing protein 0.003 0.0282 0.0457
Onchocerca volvulus Dual oxidase homolog 0.0183 0.3103 0.67
Brugia malayi Cadherin domain containing protein 0.003 0.0282 0.0457
Onchocerca volvulus Peroxidasin homolog 0.0183 0.3103 0.67
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0408 0.0641
Schistosoma mansoni peroxidasin 0.0183 0.3103 0.3056
Echinococcus granulosus peroxidasin 0.0183 0.3103 0.3103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0338 0.0272
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0657 0.0657
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.1921 0.1866
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.1921 0.8918
Echinococcus multilocularis neurogenic locus notch protein 0.003 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.1904 0.8837
Echinococcus multilocularis slit 2 protein 0.003 0.0282 0.0282
Echinococcus multilocularis neurogenic locus protein delta 0.003 0.0282 0.0282
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0328 0.4201
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0338 0.0272
Schistosoma mansoni hypothetical protein 0.003 0.0282 0.0216
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0408 0.0619
Trypanosoma brucei trypanothione reductase 0.0052 0.0688 0.1167
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0688 1
Loa Loa (eye worm) animal heme peroxidase 0.0183 0.3103 0.5572
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Schistosoma mansoni hypothetical protein 0.003 0.0282 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0206 0.0369
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.1921 0.3487
Schistosoma mansoni cell polarity protein 0.003 0.0282 0.0216
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0328 0.0474
Brugia malayi glutathione reductase 0.0052 0.0688 0.119
Onchocerca volvulus 0.003 0.0282 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0328 0.0474
Schistosoma mansoni glutaminase 0.0317 0.557 0.554
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Echinococcus multilocularis protein jagged 1 0.003 0.0282 0.0282
Brugia malayi Delta serrate ligand family protein 0.003 0.0282 0.0457
Onchocerca volvulus 0.0183 0.3103 0.67
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.1904 0.8837
Schistosoma mansoni pyruvate kinase 0.0036 0.0408 0.0343
Echinococcus granulosus protein jagged 2 0.003 0.0282 0.0282
Echinococcus multilocularis pyruvate kinase 0.0019 0.0082 0.0082
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0408 0.0641
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0328 0.1406
Echinococcus granulosus fibropellin Ia 0.003 0.0282 0.0282
Loa Loa (eye worm) glutathione reductase 0.0052 0.0688 0.1235
Toxoplasma gondii thioredoxin reductase 0.0052 0.0688 0.1167
Schistosoma mansoni hypothetical protein 0.003 0.0282 0.0216
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0338 0.0509
Brugia malayi hypothetical protein 0.0183 0.3103 0.5549
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0408 0.0304
Echinococcus multilocularis pyruvate kinase 0.0019 0.0082 0.0082
Echinococcus granulosus notch 0.003 0.0282 0.0282
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0328 0.049
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.1921 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0307 0.5381 0.535
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0082 0.0238
Toxoplasma gondii fructose-bisphospatase II 0.0307 0.5381 1
Onchocerca volvulus 0.003 0.0282 0.0005
Echinococcus multilocularis neurogenic locus notch protein 4 0.003 0.0282 0.0282
Brugia malayi EGF-like domain containing protein 0.003 0.0282 0.0457
Loa Loa (eye worm) hypothetical protein 0.0033 0.0338 0.0607
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0316 0.0316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0657 0.0657
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0688 0.1167
Loa Loa (eye worm) hypothetical protein 0.0183 0.3103 0.5572
Loa Loa (eye worm) notch protein 0.003 0.0282 0.0507
Leishmania major 0.0307 0.5381 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Echinococcus multilocularis neural cadherin 0.003 0.0282 0.0282
Echinococcus multilocularis protein jagged 1 0.003 0.0282 0.0282
Leishmania major pyruvate kinase 0.0036 0.0408 0.0641
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.1904 0.8837
Onchocerca volvulus Neurogenic locus notch protein homolog 0.003 0.0282 0.0005
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0408 0.5493
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0408 0.0304
Loa Loa (eye worm) hypothetical protein 0.003 0.0282 0.0507
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0328 0.0474
Giardia lamblia High cysteine protein 0.003 0.0282 0.6297
Brugia malayi Pre-SET motif family protein 0.0227 0.3917 0.7017
Plasmodium falciparum thioredoxin reductase 0.0052 0.0688 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.1921 0.8706
Schistosoma mansoni hypothetical protein 0.0558 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.1904 0.8837
Echinococcus multilocularis notch 0.003 0.0282 0.0282
Schistosoma mansoni hypothetical protein 0.0558 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0657 0.118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0657 0.0657
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0328 0.0474
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.1904 0.8609
Brugia malayi Thioredoxin reductase 0.0052 0.0688 0.119
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.028 0.0503
Loa Loa (eye worm) animal heme peroxidase 0.0183 0.3103 0.5572
Brugia malayi Animal haem peroxidase family protein 0.0183 0.3103 0.5549
Chlamydia trachomatis pyruvate kinase 0.0036 0.0408 1
Echinococcus granulosus neurogenic locus notch protein 0.003 0.0282 0.0282
Mycobacterium ulcerans glutaminase 0.0317 0.557 1
Brugia malayi fructose-1,6-bisphosphatase 0.0307 0.5381 0.966
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.1921 0.3368

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) = 0.16 mg/ml Cytotoxicity against mouse L1210 cells ChEMBL. 541685

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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