Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0492 | 0.5576 | 0.5576 |
Echinococcus granulosus | acetylcholinesterase | 0.0492 | 0.5576 | 0.5576 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0535 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0492 | 0.5576 | 0.5576 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0492 | 0.5576 | 0.5576 |
Loa Loa (eye worm) | carboxylesterase | 0.0492 | 0.5576 | 0.5576 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0535 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0438 | 0 | 0.5 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0438 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0535 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0492 | 0.5576 | 0.5576 |
Echinococcus granulosus | acetylcholinesterase | 0.0492 | 0.5576 | 0.5576 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0492 | 0.5576 | 0.5576 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0438 | 0 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0438 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0492 | 0.5576 | 0.5576 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0535 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0492 | 0.5576 | 0.5576 |
Echinococcus multilocularis | acetylcholinesterase | 0.0492 | 0.5576 | 0.5576 |
Echinococcus multilocularis | acetylcholinesterase | 0.0492 | 0.5576 | 0.5576 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.