Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0472 | 0.8163 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0571 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0167 | 0.2487 | 0.3016 |
Onchocerca volvulus | 0.0036 | 0.0035 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0214 | 0.022 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0035 | 0.0043 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0214 | 0.022 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0214 | 0.022 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.1522 | 0.1864 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.029 | 0.0355 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0035 | 0.0104 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0214 | 0.0262 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2487 | 0.3046 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.3599 | 0.7868 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0279 | 0.4565 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0035 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0035 | 0.0043 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.1522 | 0.4456 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0279 | 0.4565 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0035 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0035 | 0.0043 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2487 | 0.3046 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0035 | 0.0043 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0035 | 0.0043 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.029 | 0.0848 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.029 | 0.0848 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0472 | 0.8163 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.2487 | 0.3016 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0214 | 0.0262 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0571 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0571 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0571 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0214 | 0.022 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0571 | 1 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0035 | 0.0104 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0571 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0571 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0035 | 0.0104 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0035 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0035 | 0.0043 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0571 | 1 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0035 | 0.5 |
Brugia malayi | hypothetical protein | 0.0217 | 0.3415 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0214 | 0.0262 |
Onchocerca volvulus | 0.0036 | 0.0035 | 0.5 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0571 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.029 | 0.0355 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0571 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0035 | 0.0043 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0571 | 1 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0035 | 0.0043 |
Onchocerca volvulus | 0.0036 | 0.0035 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0035 | 0.0043 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0035 | 0.0104 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0214 | 0.0262 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0214 | 0.0627 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0279 | 0.4565 | 1 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0472 | 0.8163 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0472 | 0.8163 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.1522 | 0.1864 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 98 % | Antiproliferative activity against PHA-stimulated human PBMC at 20 ug/mL after 72 hrs by MTT assay relative to control | ChEMBL. | 18222568 |
IC50 (functional) | = 12.6 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake | ChEMBL. | 18222568 |
IC50 (ADMET) | = 35.2 uM | Antiproliferative activity against PHA-stimulated human PBMC after 72 hrs by MTT assay | ChEMBL. | 18222568 |
Inhibition (functional) | = 100 % | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 in human erythrocytes at 20 ug/mL by [3H]hypoxanthine uptake | ChEMBL. | 18222568 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18222568 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.