Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Serratia marcescens | Chitinase A | Starlite/ChEMBL | References |
Serratia marcescens | Chitinase B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0101 | 0 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0359 | 0.1436 | 0.3344 |
Leishmania major | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0134 | 0.0185 | 0.1288 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0155 | 0.03 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.1901 | 1 | 1 |
Leishmania major | chitinase | 0.0182 | 0.0449 | 0.3129 |
Onchocerca volvulus | Putative endochitinase | 0.0182 | 0.0449 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0369 | 0.0369 |
Loa Loa (eye worm) | chitinase I | 0.0182 | 0.0449 | 0.0449 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0234 | 0.0737 | 0.0737 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.0737 | 0.0737 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.1901 | 1 | 1 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0101 | 0 | 0.5 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0101 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.03 | 0.03 |
Toxoplasma gondii | aminopeptidase N protein | 0.0101 | 0 | 0.5 |
Brugia malayi | Endochitinase | 0.0182 | 0.0449 | 0.1046 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0134 | 0.0185 | 0.1288 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.1436 | 0.1436 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0101 | 0 | 0.5 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0101 | 0 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0182 | 0.0449 | 1 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0155 | 0.03 | 1 |
Brugia malayi | endochitinase | 0.0182 | 0.0449 | 0.1046 |
Onchocerca volvulus | Putative endochitinase | 0.0182 | 0.0449 | 1 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0101 | 0 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0182 | 0.0449 | 1 |
Brugia malayi | hypothetical protein | 0.0874 | 0.4294 | 1 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0134 | 0.0185 | 0.1288 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0182 | 0.0449 | 0.0449 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0359 | 0.1436 | 1 |
Entamoeba histolytica | chitinase, putative | 0.0182 | 0.0449 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0134 | 0.0185 | 0.1288 |
Echinococcus granulosus | geminin | 0.0167 | 0.0369 | 0.0369 |
Trypanosoma brucei | Emopamil binding protein, putative | 0.0134 | 0.0185 | 0.1288 |
Onchocerca volvulus | Putative endochitinase | 0.0182 | 0.0449 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.1901 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0359 | 0.1436 | 1 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0155 | 0.03 | 0.03 |
Brugia malayi | hypothetical protein | 0.0234 | 0.0737 | 0.1717 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0101 | 0 | 0.5 |
Brugia malayi | endochitinase | 0.0182 | 0.0449 | 0.1046 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.046 | 0.046 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0359 | 0.1436 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0369 | 0.0369 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0134 | 0.0185 | 0.1288 |
Echinococcus multilocularis | geminin | 0.0167 | 0.0369 | 0.0369 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0234 | 0.0737 | 0.0737 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0134 | 0.0185 | 0.1288 |
Mycobacterium tuberculosis | Possible chitinase | 0.0155 | 0.03 | 0.5 |
Onchocerca volvulus | 0.0134 | 0.0185 | 0.4116 | |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0101 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.13 uM | Displacement of 4-methylumbelliferydiacetyl-chitobiose from Serratia marcescens ChiB | ChEMBL. | 19297173 |
IC50 (binding) | = 0.14 uM | Displacement of 4-methylumbelliferydiacetyl-chitobiose from Serratia marcescens ChiA | ChEMBL. | 19297173 |
IC50 (binding) | > 30 uM | Displacement of 4-methylumbelliferydiacetyl-chitobiose from Serratia marcescens ChiC | ChEMBL. | 19297173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.