Detailed information for compound 955384

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 629.704 | Formula: C36H33F2N9
  • H donors: 1 H acceptors: 6 LogP: 5.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: FC1(F)CCN(C1)c1ncc2c(n1)nc(c(c2)c1ccccc1)c1ccc(cc1)CN1CCC(CC1)c1nnc([nH]1)c1ccccn1
  • InChi: 1S/C36H33F2N9/c37-36(38)15-19-47(23-36)35-40-21-28-20-29(25-6-2-1-3-7-25)31(41-32(28)43-35)26-11-9-24(10-12-26)22-46-17-13-27(14-18-46)33-42-34(45-44-33)30-8-4-5-16-39-30/h1-12,16,20-21,27H,13-15,17-19,22-23H2,(H,42,44,45)
  • InChiKey: PXLDHSKDCUXBTE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-akt murine thymoma viral oncogene homolog 2 Starlite/ChEMBL References
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0287
Entamoeba histolytica protein kinase, putative 0.003 0.0287 0.2524
Echinococcus granulosus tar DNA binding protein 0.0317 0.433 1
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0287 0.0422
Giardia lamblia Kinase, AGC PKA 0.0058 0.0686 0.2101
Trichomonas vaginalis AGC family protein kinase 0.009 0.1137 0.7719
Echinococcus multilocularis serine:threonine protein kinase 38 0.003 0.0287 0.0663
Schistosoma mansoni tar DNA-binding protein 0.0317 0.433 0.6375
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0997 0.2303
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0058 0.0686 0.1584
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0118 0.0273
Loa Loa (eye worm) latrophilin receptor protein 2 0.0227 0.307 0.307
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0322 0.2186
Loa Loa (eye worm) hypothetical protein 0.0044 0.0477 0.0477
Echinococcus granulosus protein kinase c iota type 0.003 0.0287 0.0663
Schistosoma mansoni smad1 5 8 and 0.0041 0.0435 0.0641
Echinococcus multilocularis serine threonine protein kinase 0.003 0.0287 0.0663
Schistosoma mansoni Smad4 0.0018 0.0118 0.0174
Trichomonas vaginalis AGC family protein kinase 0.009 0.1137 0.7719
Brugia malayi MH2 domain containing protein 0.0018 0.0118 0.0118
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0061 0.0721 0.0444
Loa Loa (eye worm) nuclear factor I 0.0022 0.0179 0.0179
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0029 0.0278 0.1886
Trypanosoma brucei rac serine-threonine kinase, putative 0.009 0.1137 0.2933
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0114 0.1473 0.1473
Trichomonas vaginalis AGC family protein kinase 0.009 0.1137 0.7719
Echinococcus granulosus serine:threonine protein kinase N2 0.003 0.0287 0.0663
Loa Loa (eye worm) AGC/NDR protein kinase 0.003 0.0287 0.0287
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.008 0.0997 0.1468
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0058 0.0686 0.2101
Brugia malayi protein kinase C II. 0.003 0.0287 0.0287
Leishmania major leucyl-tRNA synthetase, putative 0.0044 0.0477 0.3238
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0118 0.0118
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0114 0.1473 1
Brugia malayi Smad1 0.0041 0.0435 0.0435
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0435 0.1005
Schistosoma mansoni Smad4 0.0018 0.0118 0.0174
Loa Loa (eye worm) transcription factor SMAD2 0.0596 0.8275 0.8275
Entamoeba histolytica protein kinase, putative 0.009 0.1137 1
Schistosoma mansoni hypothetical protein 0.0227 0.307 0.452
Brugia malayi p70 ribosomal S6 kinase beta 0.0088 0.1102 0.1102
Echinococcus granulosus GPCR family 2 0.0227 0.307 0.7089
Trichomonas vaginalis AGC family protein kinase 0.003 0.0287 0.1948
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.2328 1
Brugia malayi MH2 domain containing protein 0.0596 0.8275 0.8275
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0114 0.1473 1
Schistosoma mansoni tar DNA-binding protein 0.0317 0.433 0.6375
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0114 0.1473 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0058 0.0677 0.1563
Echinococcus granulosus Protein kinase C brain isozyme 0.003 0.0287 0.0663
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.003 0.0287 0.0663
Echinococcus granulosus methionine tRNA synthetase 0.0114 0.1473 0.34
Treponema pallidum methionyl-tRNA synthetase 0.0044 0.0477 0.5
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0287 0.0422
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0435 0.1005
Trichomonas vaginalis AGC family protein kinase 0.009 0.1137 0.7719
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.008 0.0997 0.2303
Echinococcus multilocularis Protein kinase C, brain isozyme 0.003 0.0287 0.0663
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.003 0.0287 0.0663
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0044 0.0477 0.1101
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0435 0.1005
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0118 0.0273
Brugia malayi Calcitonin receptor-like protein seb-1 0.0719 1 1
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0287 0.0422
Plasmodium falciparum methionine--tRNA ligase 0.0114 0.1473 1
Schistosoma mansoni serine/threonine-protein kinase 0.0061 0.0721 0.1062
Loa Loa (eye worm) MH2 domain-containing protein 0.0596 0.8275 0.8275
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.003 0.0287 0.0663
Loa Loa (eye worm) hypothetical protein 0.0175 0.2328 0.2328
Brugia malayi MH2 domain containing protein 0.0041 0.0435 0.0435
Echinococcus multilocularis tar DNA binding protein 0.0317 0.433 1
Schistosoma mansoni smad1 5 8 and 0.0041 0.0435 0.0641
Echinococcus multilocularis rac serine:threonine kinase 0.0061 0.0721 0.1665
Trichomonas vaginalis AGC family protein kinase 0.009 0.1137 0.7719
Giardia lamblia Methionyl-tRNA synthetase 0.0114 0.1473 1
Schistosoma mansoni hypothetical protein 0.0227 0.307 0.452
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.003 0.0287 0.0663
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0118 0.0273
Loa Loa (eye worm) AGC/PKN protein kinase 0.003 0.0287 0.0287
Loa Loa (eye worm) RNA binding protein 0.0317 0.433 0.433
Trichomonas vaginalis AGC family protein kinase 0.003 0.0287 0.1948
Echinococcus granulosus Glutaredoxin protein 5 0.0058 0.0677 0.1563
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0287 0.0422
Plasmodium vivax methionine--tRNA ligase, putative 0.0114 0.1473 1
Brugia malayi RNA recognition motif domain containing protein 0.0317 0.433 0.433
Echinococcus multilocularis methionine tRNA synthetase 0.0114 0.1473 0.34
Leishmania major methionyl-tRNA synthetase, putative 0.0114 0.1473 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.008 0.0997 0.2303
Echinococcus granulosus serine/threonine protein kinase 0.0061 0.0721 0.1665
Brugia malayi methionyl-tRNA synthetase 0.0044 0.0477 0.0477
Echinococcus multilocularis protein kinase c epsilon type 0.003 0.0287 0.0663
Echinococcus multilocularis leucyl tRNA synthetase 0.0044 0.0477 0.1101
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0227 0.307 0.307
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0287 0.0422
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0719 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0227 0.307 0.7089
Brugia malayi Protein kinase domain containing protein 0.003 0.0287 0.0287
Loa Loa (eye worm) TAR-binding protein 0.0317 0.433 0.433
Brugia malayi RNA binding protein 0.0317 0.433 0.433
Chlamydia trachomatis leucine--tRNA ligase 0.0044 0.0477 0.5
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0114 0.1473 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0477 0.0477
Trichomonas vaginalis AGC family protein kinase 0.009 0.1137 0.7719
Brugia malayi protein ZK524.3 0.0044 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0491 0.6792 0.6792
Schistosoma mansoni Smad4 0.0041 0.0435 0.0641
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0088 0.1102 0.1102
Brugia malayi Protein kinase domain containing protein 0.009 0.1137 0.1137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0118 0.0118
Echinococcus multilocularis serine:threonine protein kinase N2 0.003 0.0287 0.0663
Schistosoma mansoni tar DNA-binding protein 0.0317 0.433 0.6375
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.003 0.0287 0.0663
Brugia malayi MH1 domain containing protein 0.0022 0.0179 0.0179
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0227 0.307 0.7089
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0435 0.0435
Schistosoma mansoni serine/threonine-protein kinase 0.0061 0.0721 0.1062
Schistosoma mansoni smad 0.0041 0.0435 0.0641
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0317 0.433 0.433
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0997 0.3957
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0287 0.0422
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.008 0.0997 0.5227
Echinococcus multilocularis nervana 2 0.0058 0.0677 0.1563
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.008 0.0997 0.3957
Brugia malayi isocitrate dehydrogenase 0.008 0.0997 0.0997
Loa Loa (eye worm) Smad1 0.0041 0.0435 0.0435
Echinococcus multilocularis isocitrate dehydrogenase 0.008 0.0997 0.2303
Schistosoma mansoni hypothetical protein 0.0227 0.307 0.452
Echinococcus multilocularis Smad4 0.0041 0.0435 0.1005
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0044 0.0477 0.3238
Schistosoma mansoni atypical protein kinase C 0.003 0.0287 0.0422
Echinococcus granulosus protein kinase c epsilon type 0.003 0.0287 0.0663
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0287 0.0422
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.003 0.0287 0.0663
Echinococcus granulosus smad 0.0041 0.0435 0.1005
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0118 0.0273
Echinococcus granulosus protein kinase C gamma type 0.003 0.0287 0.0663
Brugia malayi Isocitrate dehydrogenase 0.008 0.0997 0.0997
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.003 0.0287 0.0287
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0227 0.307 0.7089
Brugia malayi latrophilin 2 splice variant baaae 0.0491 0.6792 0.6792
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0071 0.0858 0.0858
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0997 0.6773
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0058 0.0677 0.1563
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0721 0.6343
Chlamydia trachomatis methionine--tRNA ligase 0.0044 0.0477 0.5
Loa Loa (eye worm) isocitrate dehydrogenase 0.008 0.0997 0.0997
Echinococcus granulosus nervana 2 0.0058 0.0677 0.1563
Echinococcus multilocularis smad 0.0041 0.0435 0.1005
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0435 0.0435
Echinococcus multilocularis GPCR, family 2 0.0227 0.307 0.7089
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0997 0.2303
Loa Loa (eye worm) hypothetical protein 0.0227 0.307 0.307
Loa Loa (eye worm) hypothetical protein 0.0719 1 1
Brugia malayi TAR-binding protein 0.0317 0.433 0.433
Brugia malayi N-terminal motif family protein 0.0175 0.2328 0.2328
Brugia malayi Protein kinase domain containing protein 0.003 0.0287 0.0287
Echinococcus multilocularis protein kinase c iota type 0.003 0.0287 0.0663
Echinococcus multilocularis nervana 2 0.0058 0.0677 0.1563
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0058 0.0686 0.2101
Treponema pallidum leucyl-tRNA synthetase 0.0044 0.0477 0.5
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0114 0.1473 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.003 0.0287 0.0287
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0997 0.2303
Trichomonas vaginalis AGC family protein kinase 0.003 0.0287 0.1948
Loa Loa (eye worm) hypothetical protein 0.0022 0.0179 0.0179
Entamoeba histolytica protein kinase, putative 0.0088 0.1102 0.9692
Schistosoma mansoni tar DNA-binding protein 0.0317 0.433 0.6375
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.008 0.0997 0.6773
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0114 0.1473 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0058 0.0686 0.1584
Echinococcus granulosus serine threonine protein kinase nrc 0.0058 0.0686 0.1584
Schistosoma mansoni methionine-tRNA synthetase 0.0044 0.0477 0.0702
Schistosoma mansoni leucyl-tRNA synthetase 0.0044 0.0477 0.0702
Entamoeba histolytica protein kinase, putative 0.009 0.1137 1
Toxoplasma gondii methionyl-tRNA synthetase 0.0114 0.1473 1
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0997 0.5227
Trypanosoma cruzi Protein kinase B 0.0061 0.0721 0.0444
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.008 0.0997 0.5227
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0435 0.1005
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0044 0.0477 0.1101
Schistosoma mansoni serine/threonine kinase 0.003 0.0287 0.0422
Echinococcus granulosus nervana 2 0.0058 0.0677 0.1563
Brugia malayi Latrophilin receptor protein 2 0.0227 0.307 0.307
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0227 0.307 0.7089
Echinococcus multilocularis serine:threonine protein kinase N2 0.003 0.0287 0.0663
Toxoplasma gondii AGC kinase 0.0088 0.1102 0.6276
Brugia malayi Hr1 repeat family protein 0.003 0.0287 0.0287
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0118 0.0118
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0114 0.1473 1
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0044 0.0477 0.4195
Echinococcus granulosus Smad4 0.0041 0.0435 0.1005
Schistosoma mansoni hypothetical protein 0.0491 0.6792 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0435 0.0641
Schistosoma mansoni methionine-tRNA synthetase 0.0114 0.1473 0.2168
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0997 0.5227
Echinococcus granulosus NDR protein kinase 0.003 0.0287 0.0663
Brugia malayi MH1 domain containing protein 0.0041 0.0435 0.0435
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.003 0.0287 0.0287
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0044 0.0477 0.3238
Brugia malayi methionyl-tRNA synthetase 0.0114 0.1473 0.1473
Onchocerca volvulus 0.0071 0.0858 0.3347
Schistosoma mansoni smad 0.0018 0.0118 0.0174
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0721 0.6343
Loa Loa (eye worm) hypothetical protein 0.0044 0.0477 0.0477
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0118 0.0118
Loa Loa (eye worm) AGC/AKT protein kinase 0.009 0.1137 0.1137
Brugia malayi MH2 domain containing protein 0.0041 0.0435 0.0435
Trichomonas vaginalis AGC family protein kinase 0.009 0.1137 0.7719
Brugia malayi MH1 domain containing protein 0.0022 0.0179 0.0179
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.003 0.0287 0.0287
Entamoeba histolytica protein kinase 2, putative 0.0058 0.0686 0.6036
Schistosoma mansoni smad1 5 8 and 0.0041 0.0435 0.0641
Schistosoma mansoni tar DNA-binding protein 0.0317 0.433 0.6375
Echinococcus multilocularis Glutaredoxin protein 5 0.0058 0.0677 0.1563
Schistosoma mansoni hypothetical protein 0.0227 0.307 0.452
Brugia malayi MH1 domain containing protein 0.0041 0.0435 0.0435

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 20 nM Inhibition of Akt1 phosphorylation by HTRF assay ChEMBL. 18539456
IC50 (binding) = 75 nM Inhibition of Akt1 phosphorylation in human by C33a cells by IPKA assay ChEMBL. 18539456
IC50 (binding) = 252 nM Inhibition of Akt2 phosphorylation by HTRF assay ChEMBL. 18539456
IC50 (binding) = 462 nM Inhibition of Akt2 phosphorylation in human by C33a cells by IPKA assay ChEMBL. 18539456

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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