Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0072 | 1 | 0.5 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0063 | 0.838 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0067 | 0.8997 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0063 | 0.838 | 0.8285 |
Brugia malayi | glutathione reductase | 0.0063 | 0.838 | 0.838 |
Plasmodium vivax | glutathione reductase, putative | 0.0063 | 0.838 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0019 | 0.0551 | 0.0551 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0063 | 0.838 | 1 |
Treponema pallidum | NADH oxidase | 0.0022 | 0.1034 | 0.5 |
Leishmania major | trypanothione reductase | 0.0063 | 0.838 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0067 | 0.8997 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0022 | 0.1034 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0063 | 0.838 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0022 | 0.1034 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0022 | 0.1034 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0022 | 0.1034 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0063 | 0.838 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0063 | 0.838 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0022 | 0.1034 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0063 | 0.838 | 0.9225 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0022 | 0.1034 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0063 | 0.838 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0063 | 0.838 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.8997 | 0.8938 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0063 | 0.838 | 0.9225 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0067 | 0.8997 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0022 | 0.1034 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0022 | 0.1034 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0022 | 0.1034 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0063 | 0.838 | 0.838 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.8997 | 0.8938 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0022 | 0.1034 | 0.1034 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0022 | 0.1034 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0063 | 0.838 | 0.8285 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.69 nM | Cytotoxicity against human MDA-MB-361 cells assessed as cell viability incubated fore 4 days by MTS assay | ChEMBL. | 25431858 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.