Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0276 | 0.0276 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0654 | 0.0654 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0046 | 0.0276 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome c, putative | 0.01 | 0.2631 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0251 | 0.9166 | 1 |
Onchocerca volvulus | 0.0046 | 0.0276 | 0.0488 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0046 | 0.0276 | 1 |
Trypanosoma brucei | cytochrome c | 0.01 | 0.2631 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0276 | 0.0276 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0052 | 0.0052 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0271 | 1 | 1 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0071 | 0.1351 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0654 | 0.0654 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0046 | 0.0276 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0052 | 0.5 |
Toxoplasma gondii | cytochrome c, putative | 0.01 | 0.2631 | 1 |
Brugia malayi | Fli-1 protein | 0.0248 | 0.9011 | 0.9011 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0046 | 0.0276 | 0.0301 |
Brugia malayi | Ets-domain containing protein | 0.0082 | 0.1827 | 0.1827 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0046 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0276 | 0.0276 |
Echinococcus granulosus | cytochrome c | 0.01 | 0.2631 | 0.2631 |
Echinococcus granulosus | neuroligin | 0.0046 | 0.0276 | 0.0276 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0046 | 0.0276 | 0.0276 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c2 | 0.01 | 0.2631 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0046 | 0.0276 | 0.0276 |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0276 | 0.0276 |
Brugia malayi | Ets-domain containing protein | 0.0082 | 0.1827 | 0.1827 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0276 | 0.0276 |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0276 | 0.0276 |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0276 | 0.0276 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0046 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5661 | 0.5661 |
Echinococcus multilocularis | acetylcholinesterase | 0.0271 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0654 | 0.0654 |
Brugia malayi | hypothetical protein | 0.017 | 0.5661 | 0.5661 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0046 | 0.0276 | 0.0276 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0046 | 0.0276 | 0.0276 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0046 | 0.0276 | 0.0301 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0271 | 1 | 1 |
Onchocerca volvulus | 0.0046 | 0.0276 | 0.0488 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0276 | 0.0276 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0046 | 0.0276 | 0.0276 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0654 | 0.0654 |
Schistosoma mansoni | gabp alpha | 0.0082 | 0.1827 | 0.1827 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0052 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0046 | 0.0276 | 0.0276 |
Echinococcus granulosus | acetylcholinesterase | 0.0271 | 1 | 1 |
Brugia malayi | Cytochrome c type-1 | 0.01 | 0.2631 | 0.2631 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0082 | 0.1827 | 0.1827 |
Schistosoma mansoni | cytochrome c | 0.01 | 0.2631 | 0.2631 |
Plasmodium falciparum | cytochrome c, putative | 0.01 | 0.2631 | 0.5 |
Schistosoma mansoni | ets-related | 0.0248 | 0.9011 | 0.9011 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1351 | 0.1351 |
Loa Loa (eye worm) | carboxylesterase | 0.0271 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0276 | 0.0276 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0046 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | carboxylesterase | 0.0046 | 0.0276 | 0.0276 |
Onchocerca volvulus | 0.017 | 0.5661 | 1 | |
Onchocerca volvulus | 0.0046 | 0.0276 | 0.0488 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0276 | 0.0276 |
Echinococcus multilocularis | cytochrome c | 0.01 | 0.2631 | 0.2631 |
Leishmania major | cytochrome c, putative | 0.01 | 0.2631 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0046 | 0.0276 | 0.0301 |
Leishmania major | cytochrome c, putative | 0.01 | 0.2631 | 1 |
Onchocerca volvulus | 0.0046 | 0.0276 | 0.0488 | |
Onchocerca volvulus | 0.0071 | 0.1351 | 0.2387 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0052 | 0.0052 |
Echinococcus granulosus | acetylcholinesterase | 0.0271 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0046 | 0.0276 | 0.0276 |
Echinococcus multilocularis | neuroligin | 0.0046 | 0.0276 | 0.0276 |
Echinococcus multilocularis | acetylcholinesterase | 0.0271 | 1 | 1 |
Loa Loa (eye worm) | cytochrome c type-1 | 0.01 | 0.2631 | 0.2631 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0052 | 0.0052 |
Plasmodium vivax | cytochrome c, putative | 0.01 | 0.2631 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0271 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0046 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | carboxylesterase | 0.0046 | 0.0276 | 0.0276 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0052 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0271 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0052 | 0.0052 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0052 | 0.5 |
Trypanosoma cruzi | cytochrome c, putative | 0.01 | 0.2631 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0082 | 0.1827 | 0.1827 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1316 | 0.1316 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0046 | 0.0276 | 0.0276 |
Onchocerca volvulus | 0.0046 | 0.0276 | 0.0488 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0046 | 0.0276 | 0.0276 |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0276 | 0.0276 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0082 | 0.1827 | 0.1827 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0071 | 0.1351 | 0.1351 |
Loa Loa (eye worm) | fli-1 protein | 0.0248 | 0.9011 | 0.9011 |
Echinococcus granulosus | carboxylesterase 5A | 0.0271 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0052 | 0.0052 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 79.4 uM | Antiproliferative activity against human HT1080 cells by MTT assay | ChEMBL. | 11325233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.