Detailed information for compound 955983

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.393 | Formula: C18H12N6S
  • H donors: 1 H acceptors: 4 LogP: 3.74 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cnn(c1N)c1ncnc2c1c1c(s2)CCc2c1cccc2
  • InChi: 1S/C18H12N6S/c19-7-11-8-23-24(16(11)20)17-15-14-12-4-2-1-3-10(12)5-6-13(14)25-18(15)22-9-21-17/h1-4,8-9H,5-6,20H2
  • InChiKey: RASHGUWASGANHW-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus AMP dependent ligase 0.007 0.046 0.0478
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0392 0.2946 0.3699
Brugia malayi hypothetical protein 0.0014 0.0034 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0044 0.0259 0.0007
Echinococcus granulosus microtubule associated protein 2 0.1258 0.9623 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0159
Toxoplasma gondii acyl transferase domain-containing protein 0.0044 0.0259 0.0428
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0012 0.0015 0.0026
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0102 0.0713 0.5512
Trypanosoma cruzi cruzipain precursor, putative 0.006 0.0386 0.3008
Loa Loa (eye worm) hypothetical protein 0.0386 0.2902 0.3274
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.007 0.046 0.0271
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0045 0.0046
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.046 0.0518
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.007 0.046 0.0518
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0689 0.524 0.6635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Brugia malayi hypothetical protein 0.0115 0.0812 0.0808
Onchocerca volvulus 0.0016 0.0045 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Onchocerca volvulus 0.0049 0.0302 0.0313
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0689 0.524 0.6635
Mycobacterium ulcerans polyketide synthase MbtD 0.0212 0.1558 0.1713
Echinococcus multilocularis lysosomal alpha glucosidase 0.0144 0.1031 0.1071
Leishmania major cathepsin L-like protease 0.0016 0.0045 0.0199
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0054 0.034 0.0364
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0057
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.0145 0.0151
Echinococcus multilocularis survival motor neuron protein 1 0.0223 0.164 0.1704
Mycobacterium ulcerans acyl carrier protein 0.007 0.046 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0048 0.0293 0.0489
Echinococcus multilocularis cysteine protease 0.0016 0.0045 0.0046
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0169 0.1081
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0099 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0173 0.1258 0.8231
Brugia malayi AMP-binding enzyme family protein 0.0644 0.489 0.4888
Schistosoma mansoni hypothetical protein 0.0029 0.0145 0.0151
Loa Loa (eye worm) hypothetical protein 0.0091 0.0624 0.07
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0011 0.0007
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0259 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0293 0.0305
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.007 0.046 0.2059
Loa Loa (eye worm) hypothetical protein 0.0048 0.0295 0.0329
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.008 0.0523
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.007 0.046 0.0518
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0386 0.3008
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.008 0.0432
Loa Loa (eye worm) hypothetical protein 0.0024 0.0108 0.0117
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0281
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0013 0.0022 0.0055
Loa Loa (eye worm) acetyltransferase 0.0157 0.1135 0.1277
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0043 0.0253 0.0418
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.0145 0.0151
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0253 0.0249
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0045 0.004
Entamoeba histolytica cysteine protease, putative 0.0016 0.0045 0.0882
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0012 0.0015 0.0223
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.046 0.0271
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0644 0.489 0.5521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0281
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0106 0.0739 0.0875
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0048 0.0293 0.224
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0035 0.0192 0.0199
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0055 0.0057
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0253 0.1942
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0732 0.557 0.7058
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.008 0.043
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0055 0.0057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0234 0.0243
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0055 0.0326
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0044 0.0259 0.0269
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0456 0.3439 0.4183
Leishmania major nuclear receptor binding factor-like protein 0.0043 0.0253 0.1581
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.007 0.046 0.0271
Echinococcus granulosus NADH dehydrogenase 0.007 0.046 0.0478
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0732 0.557 0.6981
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0555 0.4201 0.5183
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0169 0.1081
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0055 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0011
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0279 0.0465
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0763 0.581 0.6037
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0253 0.1942
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.002 0.008 0.165
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0169 0.1081
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0138 0.1017
Echinococcus granulosus neutral alpha glucosidase AB 0.0032 0.0169 0.0176
Echinococcus multilocularis AMP dependent ligase 0.007 0.046 0.0478
Onchocerca volvulus 0.0045 0.0273 0.0283
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0015 0.0067
Plasmodium falciparum acyl carrier protein 0.007 0.046 0.3425
Mycobacterium ulcerans Type I modular polyketide synthase 0.0689 0.524 0.6547
Echinococcus granulosus mitogen activated protein kinase 0.0048 0.0293 0.0305
Mycobacterium ulcerans polyketide synthase Pks13 0.103 0.7869 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.1135 0.1179
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0555 0.4201 0.5183
Loa Loa (eye worm) hypothetical protein 0.0115 0.0812 0.0913
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.007 0.046 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Schistosoma mansoni hypothetical protein 0.0385 0.2892 0.3006
Toxoplasma gondii type I fatty acid synthase, putative 0.0491 0.3708 0.6644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0106 0.0739 0.0875
Echinococcus granulosus survival motor neuron protein 1 0.0223 0.164 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Giardia lamblia Methyltransferase like 2 0.0208 0.1525 1
Mycobacterium ulcerans polyketide synthase 0.0689 0.524 0.6547
Mycobacterium tuberculosis Probable oxidoreductase 0.0043 0.0253 0.0254
Mycobacterium ulcerans thioesterase 0.0574 0.4353 0.5384
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.008 0.0548
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0253 0.1942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0043 0.0253 0.1942
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.008 0.0105
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0169 0.1081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.008 0.0523
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0094 0.041
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0386 0.3008
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0921 0.1036
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0192 0.0199
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0144 0.1031 0.1159
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0048 0.0293 0.1843
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0348 0.261 0.4665
Mycobacterium tuberculosis Hypothetical protein 0.0208 0.1525 0.1881
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0106 0.0739 0.0637
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0138 0.0134
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.1135 0.1179
Schistosoma mansoni cpg binding protein 0.0027 0.0132 0.0137
Loa Loa (eye worm) hypothetical protein 0.0223 0.164 0.1848
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0173 0.1258 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0094 0.041
Mycobacterium tuberculosis Possible dehydrogenase 0.0043 0.0253 0.0254
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0173 0.1258 0.1307
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0055 0.0326
Leishmania major acyl carrier protein, putative 0.007 0.046 0.295
Giardia lamblia Kinase, CMGC MAPK 0.0048 0.0293 0.1477
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0055 0.0057
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0043 0.0253 0.0254
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0273 0.0269
Trichomonas vaginalis sucrase-isomaltase, putative 0.0032 0.0169 0.1081
Mycobacterium ulcerans acyl carrier protein 0.007 0.046 0.0271
Toxoplasma gondii type I fatty acid synthase, putative 0.0732 0.557 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Echinococcus granulosus cpg binding protein 0.0029 0.0144 0.0149
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0044 0.0259 0.0269
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0293 0.1898
Brugia malayi hypothetical protein 0.0223 0.164 0.1636
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0169 0.1081
Brugia malayi Methyltransferase-like protein 4 0.0208 0.1525 0.1521
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0043 0.0253 0.0263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Echinococcus multilocularis geminin 0.0676 0.5138 0.5339
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0192 0.1446
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0043 0.0253 0.0281
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0043 0.0253 0.0254
Schistosoma mansoni lamin 0.0049 0.0302 0.0314
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.008 0.0083
Trypanosoma brucei glucosidase, putative 0.0032 0.0169 0.1241
Loa Loa (eye worm) hypothetical protein 0.0062 0.0402 0.0449
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0169 0.1264
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0689 0.524 0.5237
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0192 0.1231
Echinococcus granulosus ubiquitin specific protease 41 0.0035 0.0192 0.0199
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0168 0.1222 0.1493
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0044 0.0259 0.0053
Schistosoma mansoni hypothetical protein 0.0045 0.0273 0.0284
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0055 0.0061
Brugia malayi Glycosyl hydrolases family 31 protein 0.0032 0.0169 0.0164
Loa Loa (eye worm) acyl carrier protein 0.0317 0.2368 0.267
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0054 0.034 0.0353
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0192 0.1231
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.008 0.0523
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.007 0.046 0.0271
Mycobacterium leprae Probable polyketide synthase Pks1 0.0732 0.557 0.6981
Leishmania major cathepsin L-like protease 0.0016 0.0045 0.0199
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0281
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0055 0.0051
Echinococcus granulosus lamin dm0 0.0049 0.0302 0.0314
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0011 0.0152
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0689 0.524 0.6635
Echinococcus multilocularis cpg binding protein 0.0029 0.0144 0.0149
Onchocerca volvulus 0.0016 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0302 0.0336
Mycobacterium tuberculosis Conserved protein 0.0208 0.1525 0.1881
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.008 0.0083
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0555 0.4201 0.5183
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0668 0.5077 0.6426
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0447 0.3372 0.6039
Leishmania major zinc-binding dehydrogenase-like protein 0.0043 0.0253 0.1581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0173 0.1258 1
Schistosoma mansoni zinc binding dehydrogenase 0.0043 0.0253 0.0263
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0169 0.3608
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.103 0.7869 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.008 0.0083
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0045 0.0046
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0043 0.0253 0.5462
Schistosoma mansoni hypothetical protein 0.0029 0.0145 0.0151
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0057
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0138 0.0144
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0253 0.1581
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0259 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Leishmania major cathepsin L-like protease 0.0016 0.0045 0.0199
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0279 0.1935
Mycobacterium ulcerans Type I modular polyketide synthase 0.0689 0.524 0.6547
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.007 0.046 0.3601
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.008 0.043
Echinococcus multilocularis microtubule associated protein 2 0.1258 0.9623 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0012 0.0015 0.0067
Mycobacterium leprae Polyketide synthase Pks13 0.103 0.7869 1
Echinococcus granulosus cathepsin l1 0.0011 0.0005 0.0005
Schistosoma mansoni cpg binding protein 0.0029 0.0144 0.0149
Trichomonas vaginalis maltase-glucoamylase, putative 0.0032 0.0169 0.1081
Mycobacterium ulcerans polyketide synthase MbtC 0.0173 0.1258 0.1319
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0689 0.524 0.6547
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0253 0.1637
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.007 0.046 0.0518
Schistosoma mansoni alcohol dehydrogenase 0.0043 0.0253 0.0263
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0012 0.0015 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Schistosoma mansoni hypothetical protein 0.007 0.046 0.0478
Onchocerca volvulus 0.0016 0.0045 0.0042
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0035 0.0192 0.0187
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0094 0.0642
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0108 0.0775
Echinococcus granulosus intermediate filament protein 0.0049 0.0302 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0348 0.0588
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0045 0.0045
Trypanosoma brucei acyl transferase-like protein 0.0044 0.0259 0.1964
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0169 0.1264
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0668 0.5077 0.6426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0011 0.0152
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.007 0.046 0.0271
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0044 0.0259 0.1765
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0045 0.0042
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0048 0.0293 0.0326
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0132 0.0144
Brugia malayi Intermediate filament tail domain containing protein 0.0049 0.0302 0.0298
Schistosoma mansoni methyltransferase-related 0.0208 0.1525 0.1584
Echinococcus multilocularis neutral alpha glucosidase AB 0.0032 0.0169 0.0176
Onchocerca volvulus 0.0016 0.0045 0.0042
Leishmania major quinone oxidoreductase, putative 0.0043 0.0253 0.1581
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0234 0.0243
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0192 0.0199
Mycobacterium tuberculosis Possible dehydrogenase 0.0043 0.0253 0.0254
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0138 0.0993
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0173 0.1258 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0049 0.0302 0.0336
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0732 0.557 0.7058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Onchocerca volvulus Huntingtin homolog 0.0115 0.0812 0.085
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0044 0.0259 0.0254
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0138 0.0144
Toxoplasma gondii cathepsin CPL 0.0016 0.0045 0.0042
Mycobacterium tuberculosis Probable thioesterase TesA 0.0574 0.4353 0.5501
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.025 0.1177
Echinococcus multilocularis cysteine protease 0.0016 0.0045 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0234 0.0243
Leishmania major hypothetical protein, conserved 0.0044 0.0259 0.1616
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.0365 0.038
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0173 0.1258 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0456 0.3439 0.4183
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.008 0.055
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.002 0.008 0.165
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0043 0.0253 0.0254
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Onchocerca volvulus Putative alcohol dehydrogenase 0.0043 0.0253 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Toxoplasma gondii type I fatty acid synthase 0.0106 0.0739 0.1292
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0138 0.0144
Brugia malayi Alcohol dehydrogenase class III 0.0043 0.0253 0.0249
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0138 0.021
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0253 0.0249
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Brugia malayi hypothetical protein 0.0022 0.0094 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.008 0.0548
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0012 0.0015 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0106 0.0739 0.0875
Leishmania major cathepsin L-like protease 0.006 0.0386 0.2461
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.034 0.0335
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0048 0.0293 0.226
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0293 0.1898
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Brugia malayi MH2 domain containing protein 0.0129 0.0921 0.0917
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0024 0.0106 0.011
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.005 0.0312 0.0347
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0035 0.0192 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.007 0.046 0.3584
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.007 0.046 0.0478
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0045 0.0264
Loa Loa (eye worm) fibroinase 0.0016 0.0045 0.0045
Onchocerca volvulus Fatty acid synthase homolog 0.1242 0.9507 1
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0043 0.0253 0.1942
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0173 0.1258 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0253 0.1637
Loa Loa (eye worm) hypothetical protein 0.0115 0.0812 0.0913
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0043 0.0253 0.0254
Schistosoma mansoni hypothetical protein 0.0062 0.0402 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Onchocerca volvulus Huntingtin homolog 0.0115 0.0812 0.085
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0011 0.0012
Schistosoma mansoni hypothetical protein 0.0029 0.0145 0.0151
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0043 0.0253 0.0254
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0115
Brugia malayi isocitrate dehydrogenase 0.0017 0.0055 0.0051
Loa Loa (eye worm) intermediate filament protein 0.0049 0.0302 0.0336
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.008 0.043
Onchocerca volvulus 0.0016 0.0045 0.0042
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Leishmania major cathepsin L-like protease 0.0016 0.0045 0.0199
Echinococcus granulosus lamin 0.0049 0.0302 0.0314
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0055 0.0061
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.007 0.046 0.0515
Echinococcus multilocularis GPCR, family 2 0.0029 0.0145 0.0151
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.007 0.046 0.0479
Mycobacterium ulcerans Type I modular polyketide synthase 0.0689 0.524 0.6547
Mycobacterium ulcerans short-chain dehydrogenase 0.0046 0.0281 0.0037
Schistosoma mansoni alpha glucosidase 0.0032 0.0169 0.0176
Leishmania major zinc binding dehydrogenase-like protein 0.0043 0.0253 0.1581
Onchocerca volvulus 0.0049 0.0302 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0253 0.1942
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0173 0.1258 0.1319
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.034 0.0113
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0045 0.0045
Schistosoma mansoni acyl carrier protein 0.007 0.046 0.0478
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0043 0.0253 0.0254
Schistosoma mansoni hypothetical protein 0.0029 0.0145 0.0151
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0091 0.0624 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0138 0.0879
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0011 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0212 0.1558 0.1554
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.1432 0.1502
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0015 0.0067
Schistosoma mansoni microtubule-associated protein tau 0.1258 0.9623 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.008 0.0083
Leishmania major cathepsin L-like protease 0.006 0.0386 0.2461
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.007 0.046 0.0271
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0713 0.5512
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0043 0.0253 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Brugia malayi Phosphopantetheine attachment site family protein 0.007 0.046 0.0456
Leishmania major cathepsin L-like protease 0.0016 0.0045 0.0199
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0279 0.0465
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0015 0.0067
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0192 0.1446
Brugia malayi cytoplasmic intermediate filament protein 0.0026 0.0126 0.0122
Schistosoma mansoni alpha-glucosidase 0.0124 0.0876 0.0911
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0386 0.3008
Schistosoma mansoni intermediate filament proteins 0.0049 0.0302 0.0314
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0106 0.0739 0.0875
Echinococcus multilocularis ubiquitin specific protease 41 0.0035 0.0192 0.0199
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0145 0.014
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0057
Entamoeba histolytica hypothetical protein 0.0028 0.0138 0.2933
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0216 0.1593 0.1759
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0644 0.489 0.6188
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0259 0.0269
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0173 0.1258 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0048 0.0293 0.226
Leishmania major hypothetical protein, conserved 0.0022 0.0094 0.0529
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0921 0.1036
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0045 0.0046
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0689 0.524 0.6547
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.0234 0.0259
Brugia malayi Calcitonin receptor-like protein seb-1 0.0091 0.0624 0.062
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0048 0.0293 0.1843
Loa Loa (eye worm) hypothetical protein 0.0022 0.0094 0.0102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0234 0.0243
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.008 0.0548
Loa Loa (eye worm) hypothetical protein 0.0196 0.1432 0.1613
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.1101 0.1144
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0035 0.0192 0.1172
Brugia malayi MAP kinase sur-1 0.0048 0.0293 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0045 0.0264
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.007 0.046 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Schistosoma mansoni survival motor neuron protein 0.0045 0.0273 0.0284
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0237 0.1751 0.217
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.007 0.046 0.0271
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0012 0.0015 0.0011
Onchocerca volvulus 0.0016 0.0045 0.0042
Mycobacterium ulcerans fatty acid synthase Fas 0.0216 0.1593 0.1759
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.008 0.0523
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0094 0.0667
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.025 0.1691
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0173 0.1258 0.1254
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.025 0.5382
Toxoplasma gondii quinone oxidoreductase, putative 0.0043 0.0253 0.0418
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0192 0.1423
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.0112
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0293 0.1898
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.008 0.0075
Leishmania major oxidoreductase-like protein 0.0043 0.0253 0.1581
Mycobacterium ulcerans hypothetical protein 0.007 0.046 0.0271
Echinococcus granulosus cathepsin l1 0.0016 0.0045 0.0046
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0212 0.1558 0.1923
Echinococcus multilocularis mitogen activated protein kinase 0.0048 0.0293 0.0305
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.046 0.0271
Trypanosoma brucei protein kinase, putative 0.0048 0.0293 0.224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0495 0.3742 0.4719
Loa Loa (eye worm) hypothetical protein 0.0035 0.0192 0.0211
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0054 0.034 0.0353
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0253 0.1942
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0234 0.0243
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0094 0.0667
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.046 0.0518
Echinococcus granulosus acyl carrier protein mitochondrial 0.007 0.046 0.0478
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0055 0.0351
Mycobacterium leprae conserved hypothetical protein 0.007 0.046 0.0271
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0192 0.0199
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.007 0.046 0.0518
Onchocerca volvulus 0.12 0.9177 0.9652
Mycobacterium ulcerans polyketide synthase 0.0732 0.557 0.6981
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.007 0.046 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0011 0.0012
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0048 0.0293 0.226
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.034 0.0113
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.046 1
Echinococcus multilocularis NADH dehydrogenase 0.007 0.046 0.0478
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0564 0.4271 0.5395
Echinococcus granulosus mitogen activated protein kinase 3 0.0048 0.0293 0.0305
Trypanosoma cruzi acyl transferase-like protein 0.0044 0.0259 0.1985
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0045 0.0042
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0279 0.029
Treponema pallidum acyl carrier protein 0.007 0.046 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0279 0.2073 0.2582
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0055 0.0087
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0045 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0169 0.1081
Loa Loa (eye worm) hypothetical protein 0.1158 0.8854 1
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0216 0.1593 0.1968
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.008 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0022 0.0112
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0035 0.0192 0.0774
Trypanosoma brucei oxidoreductase, putative 0.0043 0.0253 0.1921
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.008 0.0083
Echinococcus multilocularis lamin 0.0049 0.0302 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.1525 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0192 0.1231
Schistosoma mansoni hypothetical protein 0.0676 0.5138 0.5339
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0055 0.0346 0.2685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Onchocerca volvulus 0.0027 0.0132 0.0134
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0055 0.0351
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0173 0.1258 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0054 0.034 0.0353
Onchocerca volvulus 0.0644 0.489 0.5142
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0045 0.0882
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0287
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.1135 0.1131
Onchocerca volvulus 0.0016 0.0045 0.0042
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0045 0.0046
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.007 0.046 0.0271
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.007 0.046 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Onchocerca volvulus 0.0073 0.0488 0.0509
Echinococcus granulosus dnaJ subfamily B 0.0385 0.2892 0.3006
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0145 0.014
Brugia malayi intermediate filament protein 0.0049 0.0302 0.0298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Schistosoma mansoni hypothetical protein 0.0676 0.5138 0.5339
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0043 0.0253 0.0263
Leishmania major oxidoreductase, putative 0.0043 0.0253 0.1581
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.008 0.0083
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0689 0.524 0.6547
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0253 0.1637
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0045 0.0046
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.008 0.043
Leishmania major d-xylulose reductase, putative 0.0043 0.0253 0.1581
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0574 0.4353 0.5384
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.008 0.0075
Schistosoma mansoni cpg binding protein 0.0029 0.0144 0.0149
Loa Loa (eye worm) hypothetical protein 0.0023 0.0099 0.0107
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.0234 0.023
Brugia malayi Glycosyl hydrolases family 31 protein 0.0012 0.0015 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0145 0.0151
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0045 0.0267
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0732 0.557 0.6981
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0015 0.0067
Mycobacterium ulcerans thioesterase TesA 0.0574 0.4353 0.5384
Trypanosoma cruzi acyl transferase-like protein, putative 0.0044 0.0259 0.1985
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0173 0.1258 0.1319
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0005 0.0005
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.046 1
Echinococcus multilocularis musashi 0.0049 0.0302 0.0314
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0732 0.557 0.6981
Brugia malayi latrophilin 2 splice variant baaae 0.0062 0.0402 0.0398
Trypanosoma cruzi major cysteine proteinase, putative 0.0047 0.0287 0.2212
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0173 0.1258 0.1416
Onchocerca volvulus 0.0043 0.0253 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0169 0.1081
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0026 0.0126 0.0138
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.008 0.0085
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0043 0.0253 0.0254
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0145 0.0159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0234 0.0243
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.008 0.0548
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0279 0.1808
Loa Loa (eye worm) hypothetical protein 0.0106 0.0739 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0045 0.0046
Echinococcus granulosus lysosomal alpha glucosidase 0.0144 0.1031 0.1071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0234 0.0243
Echinococcus multilocularis lysosomal alpha glucosidase 0.0144 0.1031 0.1071
Mycobacterium tuberculosis Polyketide synthase Pks13 0.103 0.7869 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0253 0.5462
Echinococcus multilocularis dnaJ subfamily B 0.0385 0.2892 0.3006
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0192 0.0199
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0048 0.0293 0.226
Loa Loa (eye worm) acyl carrier protein 0.007 0.046 0.0515
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0169 0.3608
Onchocerca volvulus 0.0083 0.0564 0.0588
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0173 0.1258 0.1307
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0094 0.041
Chlamydia trachomatis acyl carrier protein 0.007 0.046 0.2016
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0032 0.0169 0.0266
Plasmodium vivax acyl carrier protein, putative 0.007 0.046 0.3425
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0015 0.0067
Loa Loa (eye worm) ctsf protein 0.0016 0.0045 0.0045
Brugia malayi N-terminal motif family protein 0.0196 0.1432 0.1428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0043 0.0253 0.1921
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0055 0.0087
Brugia malayi Glycosyl hydrolases family 31 protein 0.0144 0.1031 0.1027
Trypanosoma brucei oxidoreductase, putative 0.0043 0.0253 0.1921
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0173 0.1258 0.2228
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0054 0.034 0.2152
Brugia malayi CXXC zinc finger family protein 0.0027 0.0132 0.0127
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.008 0.043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Echinococcus granulosus GPCR family 2 0.0029 0.0145 0.0151
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0253 0.0249
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0253 0.1942
Loa Loa (eye worm) hypothetical protein 0.0106 0.0739 0.083
Loa Loa (eye worm) fatty acid synthase 0.068 0.5169 0.5835
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0045 0.0046
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0032 0.0169 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.046 0.0456
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0732 0.557 0.6981
Schistosoma mansoni alpha-glucosidase 0.0124 0.0876 0.0911
Onchocerca volvulus 0.0043 0.0253 0.0262
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0044 0.0259 0.1765
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.008 0.0548
Leishmania major hypothetical protein, conserved 0.0208 0.1525 1
Leishmania major cathepsin L-like protease 0.006 0.0386 0.2461
Toxoplasma gondii acyl carrier protein ACP 0.007 0.046 0.0791
Echinococcus multilocularis mitogen activated protein kinase 3 0.0048 0.0293 0.0305
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0732 0.557 0.7058
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0024 0.0106 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0045 0.0042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0145 0.0151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0253 0.5462
Echinococcus granulosus geminin 0.0676 0.5138 0.5339
Loa Loa (eye worm) cysteine protease 0.0016 0.0045 0.0045
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0279 0.1808
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.008 0.0085
Schistosoma mansoni lamin 0.0049 0.0302 0.0314
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0293 0.1898
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0045 0.0882
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0173 0.1258 0.1307
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0045 0.0199
Mycobacterium ulcerans polyketide synthase Pks9 0.0456 0.3439 0.4183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0091 0.0624 0.062
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0035 0.0192 0.4106
Trichomonas vaginalis maltase-glucoamylase, putative 0.0012 0.0015 0.0067
Leishmania major alpha glucosidase II subunit, putative 0.0032 0.0169 0.1021
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0094 0.0132
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0253 0.1942
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0043 0.0253 0.0254
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0055 0.0268
Echinococcus multilocularis lamin dm0 0.0049 0.0302 0.0314

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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