Detailed information for compound 955983

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.393 | Formula: C18H12N6S
  • H donors: 1 H acceptors: 4 LogP: 3.74 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cnn(c1N)c1ncnc2c1c1c(s2)CCc2c1cccc2
  • InChi: 1S/C18H12N6S/c19-7-11-8-23-24(16(11)20)17-15-14-12-4-2-1-3-10(12)5-6-13(14)25-18(15)22-9-21-17/h1-4,8-9H,5-6,20H2
  • InChiKey: RASHGUWASGANHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0281
Schistosoma mansoni lamin 0.0049 0.0302 0.0314
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0173 0.1258 1
Leishmania major zinc binding dehydrogenase-like protein 0.0043 0.0253 0.1581
Mycobacterium tuberculosis Probable oxidoreductase 0.0043 0.0253 0.0254
Loa Loa (eye worm) hypothetical protein 0.0049 0.0302 0.0336
Trichomonas vaginalis maltase-glucoamylase, putative 0.0032 0.0169 0.1081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0234 0.0243
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0253 0.1637
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0045 0.0264
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0012 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0115
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0713 0.5512
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0091 0.0624 0.062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Loa Loa (eye worm) fibroinase 0.0016 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.007 0.046 0.0478
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0043 0.0253 0.1942
Echinococcus multilocularis cysteine protease 0.0016 0.0045 0.0046
Schistosoma mansoni survival motor neuron protein 0.0045 0.0273 0.0284
Brugia malayi Glycosyl hydrolases family 31 protein 0.0144 0.1031 0.1027
Schistosoma mansoni hypothetical protein 0.0029 0.0145 0.0151
Loa Loa (eye worm) cysteine protease 0.0016 0.0045 0.0045
Loa Loa (eye worm) intermediate filament protein 0.0049 0.0302 0.0336
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0564 0.4271 0.5395
Schistosoma mansoni intermediate filament proteins 0.0049 0.0302 0.0314
Loa Loa (eye worm) hypothetical protein 0.0115 0.0812 0.0913
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0045 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0234 0.0243
Loa Loa (eye worm) acetyltransferase 0.0157 0.1135 0.1277
Brugia malayi cytoplasmic intermediate filament protein 0.0026 0.0126 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Mycobacterium ulcerans Type I modular polyketide synthase 0.0689 0.524 0.6547
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0456 0.3439 0.4183
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0054 0.034 0.2152
Onchocerca volvulus 0.0016 0.0045 0.0042
Onchocerca volvulus 0.0016 0.0045 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0234 0.0243
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.007 0.046 0.0518
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0279 0.029
Mycobacterium ulcerans acyl carrier protein 0.007 0.046 0.0271
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.008 0.0523
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0043 0.0253 0.0418
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0689 0.524 0.5237
Brugia malayi hypothetical protein 0.0014 0.0034 0.0029
Schistosoma mansoni hypothetical protein 0.0062 0.0402 0.0418
Leishmania major cathepsin L-like protease 0.006 0.0386 0.2461
Echinococcus granulosus cathepsin l1 0.0011 0.0005 0.0005
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0054 0.034 0.0353
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0169 0.1081
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0644 0.489 0.6188
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.046 0.0271
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0012 0.0015 0.0067
Onchocerca volvulus 0.12 0.9177 0.9652
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0106 0.0739 0.0875
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Loa Loa (eye worm) hypothetical protein 0.0386 0.2902 0.3274
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0279 0.1808
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0013 0.0022 0.0055
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0044 0.0259 0.0269
Leishmania major cathepsin L-like protease 0.0016 0.0045 0.0199
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0044 0.0259 0.0254
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0045 0.0882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0043 0.0253 0.5462
Echinococcus granulosus ubiquitin specific protease 41 0.0035 0.0192 0.0199
Mycobacterium ulcerans polyketide synthase Pks9 0.0456 0.3439 0.4183
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0049 0.0302 0.0336
Echinococcus multilocularis mitogen activated protein kinase 3 0.0048 0.0293 0.0305
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0035 0.0192 0.0187
Mycobacterium tuberculosis Probable thioesterase TesA 0.0574 0.4353 0.5501
Echinococcus granulosus lamin 0.0049 0.0302 0.0314
Mycobacterium ulcerans polyketide synthase MbtD 0.0212 0.1558 0.1713
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0173 0.1258 0.8231
Mycobacterium ulcerans thioesterase TesA 0.0574 0.4353 0.5384
Leishmania major hypothetical protein, conserved 0.0044 0.0259 0.1616
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0279 0.0465
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.008 0.0548
Trypanosoma brucei oxidoreductase, putative 0.0043 0.0253 0.1921
Brugia malayi isocitrate dehydrogenase 0.0017 0.0055 0.0051
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0043 0.0253 0.0254
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.007 0.046 0.0518
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.007 0.046 0.0518
Mycobacterium ulcerans polyketide synthase Pks13 0.103 0.7869 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Onchocerca volvulus Putative alcohol dehydrogenase 0.0043 0.0253 0.0262
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0173 0.1258 1
Treponema pallidum acyl carrier protein 0.007 0.046 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0138 0.0134
Loa Loa (eye worm) acyl carrier protein 0.007 0.046 0.0515
Schistosoma mansoni alcohol dehydrogenase 0.0043 0.0253 0.0263
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0173 0.1258 1
Leishmania major nuclear receptor binding factor-like protein 0.0043 0.0253 0.1581
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0011 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0091 0.0624 0.07
Brugia malayi Glycosyl hydrolases family 31 protein 0.0032 0.0169 0.0164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0192 0.0199
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0045 0.0045
Schistosoma mansoni cpg binding protein 0.0027 0.0132 0.0137
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0048 0.0293 0.226
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0138 0.0993
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0138 0.1017
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0447 0.3372 0.6039
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.008 0.0083
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0057
Leishmania major cathepsin L-like protease 0.0016 0.0045 0.0199
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0035 0.0192 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.005 0.0312 0.0347
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0392 0.2946 0.3699
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0386 0.3008
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.007 0.046 0.0518
Leishmania major acyl carrier protein, putative 0.007 0.046 0.295
Onchocerca volvulus 0.0016 0.0045 0.0042
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0145 0.014
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0253 0.0249
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0293 0.1898
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0689 0.524 0.6547
Schistosoma mansoni lamin 0.0049 0.0302 0.0314
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0169 0.1264
Trypanosoma brucei oxidoreductase, putative 0.0043 0.0253 0.1921
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0055 0.0346 0.2685
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0043 0.0253 0.0263
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0048 0.0293 0.224
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.007 0.046 0.0518
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0273 0.0269
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0138 0.021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0091 0.0624 0.062
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0732 0.557 0.7058
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.1135 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.0112
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0253 0.1942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.008 0.0523
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.008 0.043
Leishmania major quinone oxidoreductase, putative 0.0043 0.0253 0.1581
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0043 0.0253 0.0254
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0668 0.5077 0.6426
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.008 0.0075
Echinococcus multilocularis NADH dehydrogenase 0.007 0.046 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Onchocerca volvulus 0.0043 0.0253 0.0262
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.008 0.0083
Brugia malayi Alcohol dehydrogenase class III 0.0043 0.0253 0.0249
Mycobacterium leprae conserved hypothetical protein 0.007 0.046 0.0271
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0055 0.0057
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0094 0.0667
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0094 0.0642
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0048 0.0293 0.0489
Loa Loa (eye worm) acyl carrier protein 0.0317 0.2368 0.267
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0253 0.0249
Entamoeba histolytica cysteine protease, putative 0.0016 0.0045 0.0882
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0732 0.557 0.6981
Leishmania major cathepsin L-like protease 0.006 0.0386 0.2461
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0159
Echinococcus multilocularis neutral alpha glucosidase AB 0.0032 0.0169 0.0176
Leishmania major cathepsin L-like protease 0.0016 0.0045 0.0199
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0094 0.041
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0106 0.0739 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0045 0.0046
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0044 0.0259 0.0053
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0054 0.034 0.0353
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Loa Loa (eye worm) hypothetical protein 0.0106 0.0739 0.083
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.002 0.008 0.165
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.1135 0.1179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Toxoplasma gondii type I fatty acid synthase, putative 0.0732 0.557 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0035 0.0192 0.0199
Echinococcus granulosus mitogen activated protein kinase 0.0048 0.0293 0.0305
Onchocerca volvulus 0.0016 0.0045 0.0042
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0045 0.0267
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0012 0.0015 0.0026
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0689 0.524 0.6547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Trichomonas vaginalis sucrase-isomaltase, putative 0.0032 0.0169 0.1081
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0138 0.0144
Echinococcus granulosus lamin dm0 0.0049 0.0302 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Onchocerca volvulus 0.0073 0.0488 0.0509
Onchocerca volvulus 0.0049 0.0302 0.0313
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0253 0.1581
Schistosoma mansoni alpha glucosidase 0.0032 0.0169 0.0176
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0253 0.1637
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0044 0.0259 0.1765
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0024 0.0106 0.011
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.008 0.0085
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0012 0.0015 0.0011
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0253 0.1942
Mycobacterium ulcerans polyketide synthase MbtC 0.0173 0.1258 0.1319
Echinococcus multilocularis lysosomal alpha glucosidase 0.0144 0.1031 0.1071
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0279 0.0465
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.046 0.0518
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.025 0.1691
Trypanosoma cruzi acyl transferase-like protein 0.0044 0.0259 0.1985
Mycobacterium tuberculosis Possible dehydrogenase 0.0043 0.0253 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.1525 1
Brugia malayi Intermediate filament tail domain containing protein 0.0049 0.0302 0.0298
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.1101 0.1144
Toxoplasma gondii type I fatty acid synthase 0.0106 0.0739 0.1292
Loa Loa (eye worm) fatty acid synthase 0.068 0.5169 0.5835
Schistosoma mansoni hypothetical protein 0.0676 0.5138 0.5339
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Brugia malayi hypothetical protein 0.0115 0.0812 0.0808
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0106 0.0739 0.0875
Mycobacterium ulcerans Type I modular polyketide synthase 0.0689 0.524 0.6547
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0281
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0043 0.0253 0.0254
Trypanosoma brucei acyl transferase-like protein 0.0044 0.0259 0.1964
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.007 0.046 0.0478
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.046 0.0518
Toxoplasma gondii acyl carrier protein ACP 0.007 0.046 0.0791
Loa Loa (eye worm) hypothetical protein 0.0106 0.0739 0.083
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0192 0.1423
Echinococcus granulosus survival motor neuron protein 1 0.0223 0.164 0.1704
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.007 0.046 0.3584
Leishmania major hypothetical protein, conserved 0.0022 0.0094 0.0529
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.008 0.055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0192 0.0199
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0055 0.0351
Onchocerca volvulus Fatty acid synthase homolog 0.1242 0.9507 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0015 0.0067
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0555 0.4201 0.5183
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.008 0.0523
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0259 0.0269
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0689 0.524 0.6635
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0169 0.3608
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0055 0.0057
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0011 0.0152
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.008 0.0105
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.046 0.0456
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.007 0.046 0.0515
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.007 0.046 0.0271
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.008 0.0548
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Loa Loa (eye worm) hypothetical protein 0.0048 0.0295 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.046 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0169 0.1081
Schistosoma mansoni hypothetical protein 0.0676 0.5138 0.5339
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0192 0.0199
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0293 0.0305
Onchocerca volvulus 0.0644 0.489 0.5142
Plasmodium falciparum acyl carrier protein 0.007 0.046 0.3425
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Brugia malayi MAP kinase sur-1 0.0048 0.0293 0.0289
Onchocerca volvulus 0.0027 0.0132 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0173 0.1258 0.2228
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0043 0.0253 0.0281
Schistosoma mansoni hypothetical protein 0.0029 0.0145 0.0151
Leishmania major cathepsin L-like protease 0.0016 0.0045 0.0199
Trypanosoma brucei glucosidase, putative 0.0032 0.0169 0.1241
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.008 0.043
Mycobacterium leprae Probable polyketide synthase Pks1 0.0732 0.557 0.6981
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.002 0.008 0.165
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0456 0.3439 0.4183
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.008 0.0432
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0045 0.0042
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0043 0.0253 0.0254
Trichomonas vaginalis maltase-glucoamylase, putative 0.0012 0.0015 0.0067
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.007 0.046 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0022 0.0112
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0293 0.1898
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0192 0.0199
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.007 0.046 0.0518
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0057
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0045 0.0199
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.007 0.046 0.3601
Leishmania major alpha glucosidase II subunit, putative 0.0032 0.0169 0.1021
Loa Loa (eye worm) ctsf protein 0.0016 0.0045 0.0045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.0234 0.023
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0044 0.0259 0.0007
Mycobacterium ulcerans hypothetical protein 0.007 0.046 0.0271
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0055 0.0057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0055 0.0087
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0043 0.0253 0.1921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0192 0.1231
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0045 0.0046
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0495 0.3742 0.4719
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Echinococcus multilocularis cpg binding protein 0.0029 0.0144 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0293 0.1898
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.103 0.7869 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0138 0.0144
Echinococcus granulosus dnaJ subfamily B 0.0385 0.2892 0.3006
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.008 0.0085
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0173 0.1258 0.1307
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0216 0.1593 0.1968
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0055 0.0057
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0253 0.1942
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0234 0.0243
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.008 0.0523
Leishmania major zinc-binding dehydrogenase-like protein 0.0043 0.0253 0.1581
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.046 1
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0921 0.1036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0055 0.0326
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0045 0.0046
Schistosoma mansoni hypothetical protein 0.0385 0.2892 0.3006
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0386 0.3008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0048 0.0293 0.226
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0169 0.1081
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0668 0.5077 0.6426
Chlamydia trachomatis acyl carrier protein 0.007 0.046 0.2016
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Echinococcus multilocularis lamin 0.0049 0.0302 0.0314
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0012 0.0015 0.0223
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.008 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Leishmania major oxidoreductase-like protein 0.0043 0.0253 0.1581
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0169 0.1081
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0043 0.0253 0.0254
Schistosoma mansoni alpha-glucosidase 0.0124 0.0876 0.0911
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0045 0.0042
Echinococcus multilocularis geminin 0.0676 0.5138 0.5339
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0192 0.1231
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.025 0.1177
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Leishmania major d-xylulose reductase, putative 0.0043 0.0253 0.1581
Mycobacterium tuberculosis Possible dehydrogenase 0.0043 0.0253 0.0254
Brugia malayi intermediate filament protein 0.0049 0.0302 0.0298
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0145 0.014
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0048 0.0293 0.226
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.1432 0.1502
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0253 0.1942
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0234 0.0243
Toxoplasma gondii cathepsin CPL 0.0016 0.0045 0.0042
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0279 0.1808
Echinococcus granulosus mitogen activated protein kinase 3 0.0048 0.0293 0.0305
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0234 0.0243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Loa Loa (eye worm) hypothetical protein 0.0024 0.0108 0.0117
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.025 0.5382
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0386 0.3008
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0732 0.557 0.6981
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0045 0.0046
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0732 0.557 0.6981
Schistosoma mansoni acyl carrier protein 0.007 0.046 0.0478
Brugia malayi hypothetical protein 0.0022 0.0094 0.009
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.007 0.046 0.0271
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0732 0.557 0.7058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0644 0.489 0.5521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Schistosoma mansoni cpg binding protein 0.0029 0.0144 0.0149
Echinococcus multilocularis survival motor neuron protein 1 0.0223 0.164 0.1704
Brugia malayi Glycosyl hydrolases family 31 protein 0.0012 0.0015 0.001
Echinococcus multilocularis mitogen activated protein kinase 0.0048 0.0293 0.0305
Echinococcus granulosus NADH dehydrogenase 0.007 0.046 0.0478
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Entamoeba histolytica hypothetical protein 0.0028 0.0138 0.2933
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0168 0.1222 0.1493
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0169 0.1264
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0192 0.1446
Brugia malayi hypothetical protein 0.0223 0.164 0.1636
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Mycobacterium leprae Polyketide synthase Pks13 0.103 0.7869 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0145 0.0159
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.008 0.0548
Trypanosoma cruzi cruzipain precursor, putative 0.006 0.0386 0.3008
Loa Loa (eye worm) hypothetical protein 0.0062 0.0402 0.0449
Trypanosoma cruzi acyl transferase-like protein, putative 0.0044 0.0259 0.1985
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0253 0.1942
Loa Loa (eye worm) hypothetical protein 0.0023 0.0099 0.0107
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.034 0.0113
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0173 0.1258 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.034 0.0113
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0011
Onchocerca volvulus Huntingtin homolog 0.0115 0.0812 0.085
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0173 0.1258 0.1307
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0287
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0132 0.0144
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0144 0.1031 0.1159
Loa Loa (eye worm) hypothetical protein 0.0022 0.0094 0.0102
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0057
Brugia malayi Methyltransferase-like protein 4 0.0208 0.1525 0.1521
Toxoplasma gondii acyl transferase domain-containing protein 0.0044 0.0259 0.0428
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0106 0.0739 0.0875
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0055 0.0268
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.007 0.046 0.0271
Toxoplasma gondii type I fatty acid synthase, putative 0.0491 0.3708 0.6644
Brugia malayi CXXC zinc finger family protein 0.0027 0.0132 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0138 0.0879
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0045 0.0882
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0169 0.1081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0055 0.0326
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0035 0.0192 0.0199
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.008 0.0548
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0173 0.1258 0.1416
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Schistosoma mansoni microtubule-associated protein tau 0.1258 0.9623 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0045 0.0264
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0192 0.1446
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0237 0.1751 0.217
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0574 0.4353 0.5384
Giardia lamblia Methyltransferase like 2 0.0208 0.1525 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.0234 0.0259
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0732 0.557 0.6981
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0035 0.0192 0.4106
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0055 0.0051
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0045 0.0046
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0169 0.1081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0234 0.0243
Echinococcus granulosus cathepsin l1 0.0016 0.0045 0.0046
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0043 0.0253 0.1942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0145 0.0151
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0055 0.0351
Echinococcus multilocularis musashi 0.0049 0.0302 0.0314
Echinococcus granulosus cpg binding protein 0.0029 0.0144 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0055 0.0087
Onchocerca volvulus Huntingtin homolog 0.0115 0.0812 0.085
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0689 0.524 0.6635
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0253 0.5462
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0145 0.0151
Loa Loa (eye worm) hypothetical protein 0.0223 0.164 0.1848
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0048 0.0293 0.1843
Echinococcus granulosus neutral alpha glucosidase AB 0.0032 0.0169 0.0176
Mycobacterium ulcerans polyketide synthase 0.0689 0.524 0.6547
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.008 0.043
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.008 0.0548
Mycobacterium ulcerans acyl carrier protein 0.007 0.046 0.0271
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0279 0.1935
Echinococcus multilocularis lamin dm0 0.0049 0.0302 0.0314
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.046 0.0271
Echinococcus granulosus geminin 0.0676 0.5138 0.5339
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Echinococcus granulosus lysosomal alpha glucosidase 0.0144 0.1031 0.1071
Onchocerca volvulus 0.0016 0.0045 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0094 0.041
Echinococcus multilocularis cysteine protease 0.0016 0.0045 0.0046
Echinococcus multilocularis lysosomal alpha glucosidase 0.0144 0.1031 0.1071
Mycobacterium ulcerans fatty acid synthase Fas 0.0216 0.1593 0.1759
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0169 0.3608
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0035 0.0192 0.0774
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0102 0.0713 0.5512
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0011 0.0012
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0043 0.0253 0.0254
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0108 0.0775
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Mycobacterium ulcerans Type I modular polyketide synthase 0.0689 0.524 0.6547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.1135 0.1179
Schistosoma mansoni alpha-glucosidase 0.0124 0.0876 0.0911
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0253 0.1942
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0293 0.1898
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0011 0.0012
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0048 0.0293 0.226
Onchocerca volvulus 0.0043 0.0253 0.0262
Onchocerca volvulus 0.0083 0.0564 0.0588
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0043 0.0253 0.0254
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.007 0.046 0.2059
Toxoplasma gondii quinone oxidoreductase, putative 0.0043 0.0253 0.0418
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0048 0.0293 0.1843
Leishmania major oxidoreductase, putative 0.0043 0.0253 0.1581
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.0145 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Brugia malayi MH2 domain containing protein 0.0129 0.0921 0.0917
Echinococcus granulosus microtubule associated protein 2 0.1258 0.9623 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0045 0.0046
Schistosoma mansoni zinc binding dehydrogenase 0.0043 0.0253 0.0263
Giardia lamblia Kinase, CMGC MAPK 0.0048 0.0293 0.1477
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0094 0.041
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0763 0.581 0.6037
Brugia malayi AMP-binding enzyme family protein 0.0212 0.1558 0.1554
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.007 0.046 0.0518
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.008 0.043
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0689 0.524 0.6635
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.008 0.0083
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.007 0.046 0.0271
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0555 0.4201 0.5183
Leishmania major cathepsin L-like protease 0.006 0.0386 0.2461
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0216 0.1593 0.1759
Loa Loa (eye worm) hypothetical protein 0.1158 0.8854 1
Brugia malayi latrophilin 2 splice variant baaae 0.0062 0.0402 0.0398
Mycobacterium ulcerans polyketide synthase 0.0732 0.557 0.6981
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0026 0.0126 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0173 0.1258 0.1254
Brugia malayi Phosphopantetheine attachment site family protein 0.007 0.046 0.0456
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0094 0.0132
Leishmania major cathepsin L-like protease 0.0016 0.0045 0.0199
Echinococcus multilocularis GPCR, family 2 0.0029 0.0145 0.0151
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0054 0.034 0.0353
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0045 0.0046
Leishmania major hypothetical protein, conserved 0.0208 0.1525 1
Onchocerca volvulus 0.0045 0.0273 0.0283
Echinococcus multilocularis dnaJ subfamily B 0.0385 0.2892 0.3006
Mycobacterium tuberculosis Hypothetical protein 0.0208 0.1525 0.1881
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0106 0.0739 0.0875
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0169 0.1081
Brugia malayi Cathepsin L-like precursor 0.0016 0.0045 0.004
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.007 0.046 0.0271
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0259 0.0269
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.007 0.046 0.0271
Echinococcus multilocularis microtubule associated protein 2 0.1258 0.9623 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0281
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.008 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.007 0.046 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0173 0.1258 0.1319
Echinococcus granulosus GPCR family 2 0.0029 0.0145 0.0151
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0012 0.0015 0.0026
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0279 0.2073 0.2582
Brugia malayi AMP-binding enzyme family protein 0.0644 0.489 0.4888
Loa Loa (eye worm) hypothetical protein 0.0035 0.0192 0.0211
Mycobacterium ulcerans short-chain dehydrogenase 0.0046 0.0281 0.0037
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0173 0.1258 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.1432 0.1613
Trypanosoma brucei protein kinase, putative 0.0048 0.0293 0.224
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0173 0.1258 0.1319
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0253 0.1637
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0015 0.0067
Echinococcus granulosus intermediate filament protein 0.0049 0.0302 0.0314
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.034 0.0335
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.0145 0.0151
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0138 0.0144
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0043 0.0253 0.0263
Schistosoma mansoni hypothetical protein 0.0029 0.0145 0.0151
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.0115 0.0812 0.0913
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0192 0.1231
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0043 0.0253 0.0254
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0048 0.0293 0.0326
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0099 0.0107
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0055 0.0061
Schistosoma mansoni methyltransferase-related 0.0208 0.1525 0.1584
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0032 0.0169 0.0186
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0045 0.0046
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.008 0.0075
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0348 0.261 0.4665
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0253 0.0249
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0044 0.0259 0.0269
Onchocerca volvulus 0.0049 0.0302 0.0313
Schistosoma mansoni hypothetical protein 0.0029 0.0145 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0253 0.5462
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0173 0.1258 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.008 0.0494
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0015 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Brugia malayi N-terminal motif family protein 0.0196 0.1432 0.1428
Echinococcus granulosus AMP dependent ligase 0.007 0.046 0.0478
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0024 0.0106 0.011
Mycobacterium tuberculosis Polyketide synthase Pks13 0.103 0.7869 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0011 0.0012
Schistosoma mansoni hypothetical protein 0.0045 0.0273 0.0284
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0259 0.0269
Echinococcus granulosus acyl carrier protein mitochondrial 0.007 0.046 0.0478
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.007 0.046 0.0479
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0555 0.4201 0.5183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Loa Loa (eye worm) hypothetical protein 0.0091 0.0624 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0011 0.0045
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.008 0.0083
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0173 0.1258 0.1307
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0732 0.557 0.7058
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0035 0.0192 0.0199
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.008 0.043
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0094 0.0667
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0044 0.0259 0.1765
Schistosoma mansoni cpg binding protein 0.0029 0.0144 0.0149
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0173 0.1258 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.0365 0.038
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0689 0.524 0.6547
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0253 0.1942
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.008 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0386 0.299
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0921 0.1036
Mycobacterium ulcerans thioesterase 0.0574 0.4353 0.5384
Trypanosoma cruzi major cysteine proteinase, putative 0.0047 0.0287 0.2212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0045 0.0264
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0054 0.034 0.0364
Plasmodium vivax acyl carrier protein, putative 0.007 0.046 0.3425
Onchocerca volvulus 0.0016 0.0045 0.0042
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0043 0.0253 0.0254
Mycobacterium tuberculosis Conserved protein 0.0208 0.1525 0.1881
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0011 0.0152
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0055 0.0061
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0212 0.1558 0.1923
Onchocerca volvulus 0.0016 0.0045 0.0042
Echinococcus multilocularis AMP dependent ligase 0.007 0.046 0.0478
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0348 0.0588
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0032 0.0169 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0045 0.0264

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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