Detailed information for compound 955989

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 358.817 | Formula: C16H23ClN2O5
  • H donors: 2 H acceptors: 3 LogP: 1.73 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)[C@H](Cc1ccc(c(c1)OC(=O)C)OC(=O)C)N)C.Cl
  • InChi: 1S/C16H22N2O5.ClH/c1-9(2)18-16(21)13(17)7-12-5-6-14(22-10(3)19)15(8-12)23-11(4)20;/h5-6,8-9,13H,7,17H2,1-4H3,(H,18,21);1H/t13-;/m0./s1
  • InChiKey: ZDLCTTOYYFDLPC-ZOWNYOTGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0051 0.0143
Onchocerca volvulus 0.0017 0.0051 0.0599
Brugia malayi hypothetical protein 0.0063 0.0281 0.0281
Trypanosoma brucei PAB1-binding protein , putative 0.0179 0.0875 1
Trichomonas vaginalis ran, putative 0.0024 0.0086 0.029
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0007 0.0021
Schistosoma mansoni smad 0.006 0.0269 0.075
Plasmodium vivax ataxin-2 like protein, putative 0.0179 0.0875 0.577
Plasmodium falciparum sentrin-specific protease 1 0.0046 0.0196 0.1291
Plasmodium falciparum importin beta, putative 0.0033 0.0129 0.0853
Brugia malayi hypothetical protein 0.0153 0.0743 0.0743
Schistosoma mansoni hypothetical protein 0.0288 0.1428 0.3982
Schistosoma mansoni hypothetical protein 0.0355 0.177 0.4934
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0072 0.02
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0038 0.0385
Trypanosoma cruzi cysteine protease, putative 0.0009 0.0009 0.01
Echinococcus multilocularis sentrin specific protease 1 0.0046 0.0196 0.0433
Brugia malayi Cathepsin L-like precursor 0.0017 0.0051 0.0051
Leishmania major cytochrome p450-like protein 0.0024 0.0084 0.0957
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0072 0.0243
Toxoplasma gondii hypothetical protein 0.0009 0.0007 0.0049
Plasmodium vivax vivapain-3 0.0009 0.0009 0.0058
Schistosoma mansoni smad 0.0135 0.0647 0.1805
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0051 0.0523
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.1005
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0125 0.1432
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0306 0.1517 0.4229
Onchocerca volvulus 0.0024 0.0088 0.1025
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0038 0.0385
Echinococcus granulosus sentrin specific protease 7 0.0013 0.0028 0.0078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0056 0.0056
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0288 0.1428 0.1428
Loa Loa (eye worm) hypothetical protein 0.0074 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0179 0.0875 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0281 0.0955
Plasmodium vivax unspecified product 0.0009 0.0009 0.0058
Brugia malayi CXXC zinc finger family protein 0.0029 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0176 0.0858 0.0858
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0038 0.0385
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0281 0.3215
Onchocerca volvulus 0.0017 0.0051 0.0599
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0038 0.0385
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0282 0.0958
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.008 0.0372 0.1038
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0306 0.1517 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0125 0.1277
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0298 0.341
Schistosoma mansoni importin beta-1 0.0033 0.0129 0.0361
Schistosoma mansoni dishevelled 0.0009 0.0007 0.0021
Schistosoma mansoni dishevelled 0.0009 0.0007 0.0021
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0897 0.4519 1
Leishmania major cathepsin L-like protease 0.0017 0.0051 0.0587
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0282 0.0958
Brugia malayi Cathepsin L-like precursor 0.0017 0.0051 0.0051
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0125 0.0277
Onchocerca volvulus 0.0017 0.0051 0.0599
Plasmodium falciparum ataxin-2 like protein, putative 0.0179 0.0875 0.577
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0038 0.0128
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0072 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0051 0.0174
Entamoeba histolytica hypothetical protein 0.015 0.0724 1
Echinococcus multilocularis tar DNA binding protein 0.0593 0.2975 0.6582
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0454 0.1004
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0009 0.0024
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0022 0.0062
Echinococcus granulosus replication factor c subunit 1 0.0063 0.0281 0.0785
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0348 0.1734 0.1734
Brugia malayi MH2 domain containing protein 0.0135 0.0647 0.0647
Loa Loa (eye worm) hypothetical protein 0.0033 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0063 0.0281 0.1451
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0088 0.058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0593 0.2975 0.2975
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0051 0.0523
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0282 0.0958
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0281 0.3215
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0028 0.0028
Echinococcus multilocularis GPCR, family 2 0.0288 0.1428 0.316
Plasmodium falciparum ataxin-2 like protein, putative 0.0179 0.0875 0.577
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0007 0.0021
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0084 0.0284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0298 0.341
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0028 0.0384
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Brugia malayi MH2 domain containing protein 0.0135 0.0647 0.0647
Loa Loa (eye worm) Ulp1 protease 0.0013 0.0028 0.0028
Chlamydia trachomatis DNA ligase 0.0063 0.0281 0.1703
Schistosoma mansoni hypothetical protein 0.0015 0.0038 0.0105
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.2331 0.5157
Brugia malayi Importin beta-1 subunit 0.0033 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0063 0.0281 0.0281
Plasmodium vivax replication factor C subunit 1, putative 0.0063 0.0281 0.1855
Mycobacterium ulcerans glutaminase 0.0587 0.2945 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.0196 0.0546
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0051 0.0114
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0038 0.0128
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0038 0.0128
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0105 0.0499 0.3287
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0072 0.0819
Schistosoma mansoni hypothetical protein 0.0288 0.1428 0.3982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Echinococcus granulosus TGF beta signal transducer SmadC 0.0135 0.0647 0.1805
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0009 0.0009
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0051 0.0051
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0007 0.0007
Echinococcus multilocularis mothers against decapentaplegic 6 0.006 0.0269 0.0595
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0088 0.058
Echinococcus granulosus Smad4 0.0135 0.0647 0.1805
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0009 0.0024
Echinococcus granulosus smad 0.0135 0.0647 0.1805
Brugia malayi Cathepsin L-like precursor 0.0017 0.0051 0.0051
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0038 0.0128
Trichomonas vaginalis glutaminase, putative 0.0587 0.2945 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.011 0.011
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0009 0.0121
Loa Loa (eye worm) transcription factor SMAD2 0.1975 1 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0135 0.0647 0.1805
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0281 0.0955
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0086 0.0189
Onchocerca volvulus Mothers against decapentaplegic homolog 0.006 0.0269 0.3136
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0028 0.0094
Loa Loa (eye worm) fibroinase 0.0017 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0022 0.0076
Schistosoma mansoni Smad4 0.006 0.0269 0.075
Leishmania major GTP-binding protein, putative 0.0024 0.0086 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0281 0.0955
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0084 0.0084
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0125 0.0826
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0454 0.1004
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0238 0.0238
Schistosoma mansoni cpg binding protein 0.003 0.0118 0.0329
Loa Loa (eye worm) TAR-binding protein 0.0593 0.2975 0.2975
Trypanosoma cruzi FHA domain containing protein, putative 0.0063 0.0281 0.3215
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0063 0.0281 0.0955
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0911 0.4593 0.4593
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0288 0.1428 0.3982
Schistosoma mansoni peptidase Clp (S14 family) 0.0306 0.1517 0.4229
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0038 0.0128
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0298 0.341
Brugia malayi TAR-binding protein 0.0593 0.2975 0.2975
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0038 0.0128
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0288 0.1428 0.3982
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0298 0.341
Loa Loa (eye worm) hypothetical protein 0.0623 0.3128 0.3128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0051 0.0174
Leishmania major cathepsin L-like protease 0.0066 0.0298 0.341
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Onchocerca volvulus 0.0153 0.0743 0.8653
Echinococcus multilocularis cathepsin L 0.0009 0.0009 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0135 0.0647 0.1805
Echinococcus multilocularis peptidase Clp (S14 family) 0.02 0.0982 0.2172
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0125 0.1432
Brugia malayi Probable ClpP-like protease 0.0306 0.1517 0.1517
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.02 0.0982 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0028 0.0094
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0051 0.0599
Echinococcus granulosus nibrin 0.0063 0.0281 0.0784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0009 0.003
Onchocerca volvulus 0.0017 0.0051 0.0599
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0007 0.0021
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.0858 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0298 0.341
Schistosoma mansoni cytochrome P450 0.0015 0.0038 0.0105
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0038 0.0128
Loa Loa (eye worm) hypothetical protein 0.0063 0.0281 0.0281
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0911 0.4593 0.4593
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0086 0.0238
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0038 0.0128
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0028 0.0028
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0063 0.0281 0.3885
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0125 0.0349
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0051 0.0174
Onchocerca volvulus 0.0017 0.0051 0.0599
Echinococcus granulosus sentrin specific protease 8 0.0013 0.0028 0.0078
Echinococcus granulosus microtubule associated protein 2 0.0713 0.3587 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0028 0.0078
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0072 0.0243
Echinococcus granulosus GPCR family 2 0.0288 0.1428 0.3982
Loa Loa (eye worm) hypothetical protein 0.0018 0.0056 0.0056
Brugia malayi Cathepsin L-like precursor 0.0017 0.0051 0.0051
Echinococcus multilocularis cpg binding protein 0.003 0.0118 0.0261
Plasmodium falciparum replication factor C subunit 1, putative 0.0063 0.0281 0.1855
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0125 0.0349
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0063 0.0281 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0051 0.0174
Echinococcus multilocularis smad 0.0135 0.0647 0.1432
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0051 0.0709
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0125 0.0277
Trypanosoma cruzi PAB1-binding protein , putative 0.0179 0.0875 1
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0007 0.0021
Schistosoma mansoni Smad4 0.0135 0.0647 0.1805
Echinococcus granulosus cathepsin l1 0.0012 0.0022 0.0062
Entamoeba histolytica hypothetical protein 0.015 0.0724 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0281 0.0281
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Entamoeba histolytica hypothetical protein 0.0063 0.0281 0.3885
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0306 0.1517 0.515
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Onchocerca volvulus 0.0063 0.0281 0.3279
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0038 0.0385
Echinococcus multilocularis mothers against decapentaplegic 5 0.0135 0.0647 0.1432
Brugia malayi Cathepsin L-like precursor 0.0017 0.0051 0.0051
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0125 0.1432
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.02 0.0982 0.6472
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0038 0.0385
Loa Loa (eye worm) MH2 domain-containing protein 0.1975 1 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0038 0.0128
Brugia malayi hypothetical protein 0.0179 0.0875 0.0875
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0282 0.2876
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0013 0.0028 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0072 0.0159
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0028 0.0183
Loa Loa (eye worm) ctsf protein 0.0017 0.0051 0.0051
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Toxoplasma gondii cathepsin CPL 0.0017 0.0051 0.0339
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0051 0.0709
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0072 0.0243
Schistosoma mansoni tar DNA-binding protein 0.0593 0.2975 0.8294
Echinococcus granulosus peptidase Clp S14 family 0.02 0.0982 0.2737
Brugia malayi DIX domain containing protein 0.0009 0.0007 0.0007
Schistosoma mansoni ran 0.0024 0.0086 0.0238
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0072 0.0472
Loa Loa (eye worm) latrophilin receptor protein 2 0.0288 0.1428 0.1428
Schistosoma mansoni hypothetical protein 0.0348 0.1734 0.4835
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0007 0.0017
Brugia malayi cathepsin L-like precursor 0.0012 0.0022 0.0022
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0282 0.1861
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0051 0.0523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Echinococcus multilocularis sentrin specific protease 8 0.0013 0.0028 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0009 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.1005
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0028 0.0384
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0086 0.0086
Brugia malayi Cytochrome P450 family protein 0.0015 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0028 0.0384
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0288 0.1428 0.316
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0051 0.0599
Schistosoma mansoni cpg binding protein 0.0029 0.011 0.0306
Schistosoma mansoni smad1 5 8 and 0.0135 0.0647 0.1805
Schistosoma mansoni tar DNA-binding protein 0.0593 0.2975 0.8294
Leishmania major cytochrome p450-like protein 0.0015 0.0038 0.0432
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0282 0.0787
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0098 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0088
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0088 0.0299
Toxoplasma gondii LsmAD domain-containing protein 0.0179 0.0875 0.577
Schistosoma mansoni hypothetical protein 0.0288 0.1428 0.3982
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0038 0.0385
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0038 0.0385
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0056 0.0372
Loa Loa (eye worm) MH2 domain-containing protein 0.006 0.0269 0.0269
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0051 0.0339
Loa Loa (eye worm) hypothetical protein 0.0063 0.0281 0.0281
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0022 0.0022
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0028 0.0094
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0306 0.1517 0.3356
Loa Loa (eye worm) cytochrome P450 0.0015 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0281 0.0955
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.008 0.0372 0.0824
Loa Loa (eye worm) MH1 domain-containing protein 0.0135 0.0647 0.0647
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0086 0.0977
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0038 0.0432
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0007
Mycobacterium leprae putative cytochrome p450 0.0015 0.0038 0.0249
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0007 0.0087
Brugia malayi Pax transcription activation domain interacting protein 0.0063 0.0281 0.0281
Echinococcus granulosus dnaJ subfamily B 0.041 0.2047 0.5706
Loa Loa (eye worm) hypothetical protein 0.0063 0.0281 0.0281
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0084 0.0957
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0038 0.0385
Schistosoma mansoni ap endonuclease 0.0021 0.0072 0.02
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0084 0.0957
Schistosoma mansoni hypothetical protein 0.041 0.2047 0.5706
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Brugia malayi MH1 domain containing protein 0.0135 0.0647 0.0647
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0018 0.0056 0.0056
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0086 0.0086
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0084 0.0084
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0007 0.0007
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0051 0.0114
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0009 0.0121
Trypanosoma cruzi PAB1-binding protein , putative 0.0179 0.0875 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.0196 0.0546
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.1005
Loa Loa (eye worm) MH1 domain-containing protein 0.006 0.0269 0.0269
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0088
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0028 0.0078
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0038 0.0432
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0046 0.0196 0.0665
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0028 0.0384
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0129 0.1478
Brugia malayi Cathepsin L-like precursor 0.0017 0.0051 0.0051
Brugia malayi RNA, U transporter 1 0.0093 0.0435 0.0435
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Brugia malayi latrophilin 2 splice variant baaae 0.0623 0.3128 0.3128
Schistosoma mansoni tar DNA-binding protein 0.0593 0.2975 0.8294
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0028 0.0384
Brugia malayi DKFZp564C0469 protein 0.0063 0.0281 0.0281
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0084 0.0957
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0051 0.0143
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0038 0.0385
Leishmania major cathepsin L-like protease 0.0017 0.0051 0.0587
Entamoeba histolytica cysteine proteinase 1, putative 0.0009 0.0009 0.0121
Entamoeba histolytica hypothetical protein 0.015 0.0724 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0269 0.0269
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0009 0.0009
Leishmania major cathepsin L-like protease 0.0066 0.0298 0.341
Brugia malayi Latrophilin receptor protein 2 0.0288 0.1428 0.1428
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0022
Onchocerca volvulus 0.0017 0.0051 0.0599
Schistosoma mansoni hypothetical protein 0.0355 0.177 0.4934
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0298 0.341
Echinococcus granulosus tar DNA binding protein 0.0593 0.2975 0.8294
Echinococcus granulosus cathepsin L 0.0009 0.0009 0.0024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0911 0.4593 0.4593
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0056 0.0193
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0028 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0038 0.0385
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0007 0.0021
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0038 0.0432
Loa Loa (eye worm) glutaminase 0.0587 0.2945 0.2945
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0051
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0125 0.0826
Loa Loa (eye worm) hypothetical protein 0.0306 0.1517 0.1517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0051 0.0174
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0038 0.0128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0056 0.0056
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0298 0.341
Plasmodium vivax sentrin-specific protease 1, putative 0.0046 0.0196 0.1291
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0281 0.0955
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0051 0.0339
Echinococcus multilocularis 0.0015 0.0038 0.0084
Schistosoma mansoni DNA ligase IV 0.0063 0.0281 0.0784
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0454 0.0454
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0038 0.0385
Brugia malayi hypothetical protein 0.0009 0.0007 0.0007
Loa Loa (eye worm) cysteine protease 0.0017 0.0051 0.0051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.0724 0.1603
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0038 0.0385
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0084 0.0084
Echinococcus granulosus sentrin specific protease 1 0.0046 0.0196 0.0546
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0051 0.0143
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0038 0.0128
Echinococcus granulosus geminin 0.0355 0.177 0.4934
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0454 0.1266
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0227 0.259
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0072 0.0819
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.2331 0.5157
Brugia malayi Cytochrome P450 family protein 0.0024 0.0084 0.0084
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0038 0.0128
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0038 0.0385
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0028 0.0094
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0306 0.1517 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0038 0.0249
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0038 0.0128
Brugia malayi RNA recognition motif domain containing protein 0.0593 0.2975 0.2975
Echinococcus multilocularis cysteine protease 0.0017 0.0051 0.0114
Plasmodium vivax sentrin-specific protease 2, putative 0.0013 0.0028 0.0183
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0298 0.341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Leishmania major cytochrome p450-like protein 0.0015 0.0038 0.0432
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0028 0.0183
Schistosoma mansoni hypothetical protein 0.008 0.0372 0.1038
Brugia malayi mothers against decapentaplegic homolog 3 0.006 0.0269 0.0269
Schistosoma mansoni ap endonuclease 0.0021 0.0072 0.02
Giardia lamblia Replication factor C, subunit 1 0.0063 0.0281 1
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0009 0.0121
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0007 0.0021
Entamoeba histolytica cysteine proteinase 2 0.0009 0.0009 0.0121
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0306 0.1517 1
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0009 0.0121
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0072 0.0819
Brugia malayi Cytochrome P450 family protein 0.0024 0.0084 0.0084
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0009 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0298 0.341
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0038 0.0432
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0038 0.0432
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0088 0.0299
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0125 0.1432
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0306 0.1517 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0051 0.0051
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.3587 0.7936
Brugia malayi Cytochrome P450 family protein 0.0054 0.0238 0.0238
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0051 0.0599
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0038 0.0128
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0038 0.0385
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0086 0.0977
Plasmodium vivax vivapain-2 0.0017 0.0051 0.0339
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0282 0.3225
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0013 0.0028 0.0318
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0038 0.0385
Schistosoma mansoni hypothetical protein 0.0288 0.1428 0.3982
Schistosoma mansoni cpg binding protein 0.003 0.0118 0.0329
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0046 0.0196 0.2704
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0051 0.0587
Echinococcus granulosus cathepsin l1 0.0017 0.0051 0.0143
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0098 0.0333
Brugia malayi cytochrome P450 0.0015 0.0038 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0298 0.341
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0063 0.0281 0.0281
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0125 0.1432
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0038 0.0128
Loa Loa (eye worm) Ulp1 protease 0.0013 0.0028 0.0028
Toxoplasma gondii hypothetical protein 0.0105 0.0499 0.3287
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0028 0.0094
Onchocerca volvulus 0.0017 0.0051 0.0599
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0038 0.0105
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0051 0.0339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0009 0.01
Echinococcus multilocularis cysteine protease 0.0017 0.0051 0.0114
Brugia malayi RNA binding protein 0.0593 0.2975 0.2975
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0063 0.0281 0.0955
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0009 0.0024
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0028 0.0094
Loa Loa (eye worm) hypothetical protein 0.0046 0.0196 0.0196
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0072 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0593 0.2975 0.8294
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0007 0.0021
Schistosoma mansoni hypothetical protein 0.015 0.0724 0.2019
Plasmodium vivax vivapain-2 0.0017 0.0051 0.0339
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0105 0.0499 0.3287
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0038 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0088 0.0896
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0007 0.0017
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0088 0.1214
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0051 0.0114
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0454 0.1266
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0063 0.0281 0.3215
Schistosoma mansoni topbp1 0.0063 0.0281 0.0784
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0051 0.0587
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0063 0.0281 0.3215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0051 0.0174
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0063 0.0281 0.0955
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0009 0.01
Schistosoma mansoni glutaminase 0.0587 0.2945 0.8211
Echinococcus granulosus importin subunit beta 1 0.0033 0.0129 0.0361
Loa Loa (eye worm) nuclear factor I 0.0074 0.0342 0.0342
Leishmania major hypothetical protein, conserved 0.0179 0.0875 1
Brugia malayi Smad1 0.0135 0.0647 0.0647
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0088 0.1214
Echinococcus granulosus cysteine protease 0.0009 0.0009 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0125 0.0826
Leishmania major cathepsin L-like protease 0.0017 0.0051 0.0587
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0125 0.0277
Loa Loa (eye worm) glutaminase 2 0.0587 0.2945 0.2945
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0098 0.1119
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0086 0.0564
Onchocerca volvulus 0.0012 0.0022 0.026
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0135 0.0647 0.1432
Loa Loa (eye worm) Smad1 0.0135 0.0647 0.0647
Schistosoma mansoni smad1 5 8 and 0.0135 0.0647 0.1805
Echinococcus granulosus neuropeptide s receptor 0.0466 0.2331 0.6498
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.2331 0.6498
Echinococcus granulosus mothers against decapentaplegic 6 0.006 0.0269 0.075
Echinococcus multilocularis Smad4 0.0135 0.0647 0.1432
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 0.0299
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.02 0.0982 1
Schistosoma mansoni ran 0.0024 0.0086 0.0238
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0125 0.0277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0051 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0072 0.0819
Trichomonas vaginalis replication factor C large subunit, putative 0.0063 0.0281 0.0955
Loa Loa (eye worm) hypothetical protein 0.0288 0.1428 0.1428
Brugia malayi hypothetical protein 0.0116 0.0552 0.0552
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0282 0.0787
Leishmania major cathepsin L-like protease 0.0066 0.0298 0.341
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0063 0.0281 0.1855
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0129 0.0853
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0125 0.0277
Echinococcus multilocularis snurportin 1 0.0348 0.1734 0.3837
Brugia malayi hypothetical protein 0.0009 0.0007 0.0007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0288 0.1428 0.316
Loa Loa (eye worm) hypothetical protein 0.0153 0.0743 0.0743
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0072 0.1729
Echinococcus granulosus snurportin 1 0.0348 0.1734 0.4835
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0282 0.0625
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0241 0.1586
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0063 0.0281 0.1855
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0051 0.0174
Schistosoma mansoni topbp1 0.0063 0.0281 0.0784
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0086 0.0977
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0454 0.1266
Trypanosoma brucei SUMO1/Ulp2, putative 0.0013 0.0028 0.0318
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0088
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.3587 1
Brugia malayi N-terminal motif family protein 0.0176 0.0858 0.0858
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0008 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 0.0299
Brugia malayi MH1 domain containing protein 0.0074 0.0342 0.0342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0298 0.341
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0038 0.0385
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0038 0.0128
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0086 0.0564
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0051 0.0143
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0046 0.0196 0.1291
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0072 0.0072
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0009 0.0009
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0056 0.0575
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0022 0.0308
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0454 0.1266
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0009 0.0024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.0724 0.2019
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0086 0.2277
Echinococcus multilocularis sentrin specific protease 7 0.0013 0.0028 0.0062
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0038 0.0385
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0038 0.0128
Leishmania major cathepsin L-like protease 0.0017 0.0051 0.0587
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0306 0.1517 1
Leishmania major cathepsin L-like protease 0.0017 0.0051 0.0587
Toxoplasma gondii ATPase, AAA family protein 0.0063 0.0281 0.1855
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0306 0.1517 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0051 0.0174
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0072 0.0472
Brugia malayi MH2 domain containing protein 0.006 0.0269 0.0269
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0098 0.0333
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0051 0.0523
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0454 0.0454
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0038 0.0249
Schistosoma mansoni chromosome transmission fidelity factor 0.0063 0.0281 0.0785
Treponema pallidum DNA ligase (lig) 0.0063 0.0281 0.1451
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0028 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0088
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0125 0.0125
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0046 0.0196 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0298 0.341
Echinococcus multilocularis nibrin 0.0063 0.0281 0.0623
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0056 0.0192
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0088 0.0299
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0269 0.3077
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0038 0.0385
Loa Loa (eye worm) RNA binding protein 0.0593 0.2975 0.2975
Echinococcus multilocularis dnaJ subfamily B 0.041 0.2047 0.4528
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0051 0.0174
Entamoeba histolytica Ran family GTPase 0.0024 0.0086 0.1181
Entamoeba histolytica hypothetical protein 0.0026 0.0098 0.1352
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0009 0.01
Brugia malayi Cathepsin L-like precursor 0.0012 0.0022 0.0022
Echinococcus granulosus cpg binding protein 0.003 0.0118 0.0329
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0051 0.0174
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0038 0.0128
Schistosoma mansoni transcription factor LCR-F1 0.015 0.0724 0.2019
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0105 0.0499 0.3287
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0051 0.0114
Schistosoma mansoni hypothetical protein 0.0623 0.3128 0.8722
Mycobacterium ulcerans hypothetical protein 0.0024 0.0088 0.0299
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0088
Echinococcus multilocularis mothers against decapentaplegic 2 0.006 0.0269 0.0595
Brugia malayi hypothetical protein 0.015 0.0724 0.0724
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0125 0.0826
Entamoeba histolytica cysteine protease, putative 0.0017 0.0051 0.0709
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0105 0.0499 0.2955
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0454 0.1266
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0007 0.0021
Plasmodium falciparum cysteine proteinase falcipain 1 0.0009 0.0009 0.0058
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0088 0.0896
Loa Loa (eye worm) hypothetical protein 0.0018 0.0056 0.0056
Schistosoma mansoni Smad4 0.006 0.0269 0.075
Toxoplasma gondii exonuclease III APE 0.0021 0.0072 0.0472
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0129 0.1478
Onchocerca volvulus 0.0013 0.0028 0.0324
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0088 0.1214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0298 0.341
Onchocerca volvulus 0.0009 0.0007 0.0087
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0009 0.0009 0.01
Trypanosoma cruzi cysteine peptidase, putative 0.0009 0.0009 0.01
Schistosoma mansoni smad1 5 8 and 0.0135 0.0647 0.1805
Echinococcus granulosus mothers against decapentaplegic 2 0.006 0.0269 0.075
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0274 0.0763
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0306 0.1517 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0024
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0051 0.0051
Brugia malayi MH1 domain containing protein 0.0135 0.0647 0.0647
Brugia malayi MH1 domain containing protein 0.0074 0.0342 0.0342
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0007 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0088 0.0299
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0306 0.1517 1
Brugia malayi hypothetical protein 0.0063 0.0281 0.0281
Trypanosoma cruzi hypothetical protein 0.0013 0.0028 0.0318
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0028 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0063 0.0281 0.0955
Schistosoma mansoni tar DNA-binding protein 0.0593 0.2975 0.8294
Entamoeba histolytica hypothetical protein 0.015 0.0724 1
Trichomonas vaginalis Sentrin-specific protease, putative 0.0013 0.0028 0.0094
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0086 0.0564
Schistosoma mansoni dep domain containing protein 0.0009 0.0007 0.0021
Echinococcus multilocularis replication factor c subunit 1 0.0063 0.0281 0.0623
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0063 0.0281 0.0955
Entamoeba histolytica cysteine protease, putative 0.0009 0.0009 0.0121
Brugia malayi glutaminase DH11.1 0.0587 0.2945 0.2945
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 0.0299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0298 0.341
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0129 0.0286
Plasmodium vivax importin-beta 2, putative 0.0033 0.0129 0.0853
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0306 0.1517 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0007 0.0017
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0038 0.0128
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.0647 0.0647
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0282 0.0787
Plasmodium vivax vivapain-1 0.0009 0.0009 0.0058
Echinococcus multilocularis geminin 0.0355 0.177 0.3915
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0298 0.341
Loa Loa (eye worm) hypothetical protein 0.0911 0.4593 0.4593
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0038 0.0385
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0028 0.0094
Leishmania major importin beta-1 subunit, putative 0.0026 0.0098 0.1119
Brugia malayi topoisomerase 0.0063 0.0281 0.0281
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0056 0.0372
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0072 0.073
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0306 0.1517 0.515
Onchocerca volvulus 0.0029 0.011 0.1279
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0022 0.0076
Brugia malayi isocitrate dehydrogenase 0.0032 0.0125 0.0125
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0013 0.0028 0.0318
Brugia malayi Cathepsin L-like precursor 0.0012 0.0022 0.0022
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0125 0.0125
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0007 0.0017
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0013 0.0028 0.0094

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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