Detailed information for compound 956143

Basic information

Technical information
  • TDR Targets ID: 956143
  • Name: 17-hydroxyoctadeca-9,11,13,15-tetraynoic acid
  • MW: 284.35 | Formula: C18H20O3
  • H donors: 2 H acceptors: 3 LogP: 3.67 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCCCCCCC#CC#CC#CC#CC(O)C
  • InChi: 1S/C18H20O3/c1-17(19)15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-18(20)21/h17,19H,4,6,8,10,12,14,16H2,1H3,(H,20,21)
  • InChiKey: MTWGWIOCIREVRF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Minquartynoic acid
  • NSC692984

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone deacetylase SIR2-like 0.0066 0.0045 0.072
Plasmodium vivax LCCL domain-containing protein 0.0042 0.0016 0.0251
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0173 0.0175 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0042 0.0016 0.0019
Plasmodium falciparum plasmepsin IV 0.0035 0.0007 0.0099
Toxoplasma gondii aspartyl protease 0.0035 0.0007 0.0099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0081 0.0062 0.1383
Onchocerca volvulus 0.0146 0.0141 0.2262
Giardia lamblia Tenascin-37 0.0173 0.0175 0.0442
Brugia malayi ADAMTS-like protease 0.0137 0.0131 0.0131
Echinococcus multilocularis chromatin regulatory protein sir2 0.0448 0.0507 0.0641
Loa Loa (eye worm) hypothetical protein 0.3174 0.3809 0.3809
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Echinococcus granulosus discoidin domain receptor 0.0042 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0069 0.0048 0.0048
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0308 0.0337 0.0341
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.006 0.0037 0.0037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Brugia malayi Protein kinase domain containing protein 0.0042 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0547 0.0627 0.0627
Brugia malayi angiogenesis inhibito 0.0137 0.0131 0.0131
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0066 0.0045 0.095
Entamoeba histolytica hypothetical protein, conserved 0.0066 0.0045 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0235 0.0249 0.0252
Echinococcus multilocularis glutamate receptor 2 0.0052 0.0027 0.0034
Toxoplasma gondii subtilisin SUB12 0.0373 0.0417 0.6796
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0448 0.0507 1
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0007 0.0007
Schistosoma mansoni furin-1 (S08 family) 0.3548 0.4262 0.4311
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0042 0.0016 0.0025
Schistosoma mansoni septate junction protein 0.0046 0.0021 0.0021
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0045 0.0073
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0066 0.0045 0.0056
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0045 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Brugia malayi hypothetical protein 0.0308 0.0337 0.0337
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0081 0.0062 0.0882
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0045 0.0073
Onchocerca volvulus 0.0173 0.0175 0.2804
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.0007 0.0006
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1635 0.1945 0.322
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0373 0.0417 0.0417
Giardia lamblia High cysteine protein 0.0173 0.0175 0.0442
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0006 0.0006
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0045 0.0045
Echinococcus granulosus glutamate NMDA receptor subunit 0.0288 0.0313 0.0317
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0373 0.0417 0.0689
Loa Loa (eye worm) hypothetical protein 0.0144 0.0139 0.0139
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Schistosoma mansoni discoidin domain receptor 0.0042 0.0016 0.0016
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0122 0.0113 0.26
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0235 0.0249 0.0252
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0448 0.0507 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Mycobacterium leprae Polyketide synthase Pks13 0.0122 0.0113 0.241
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0263 0.0283 0.0283
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0086 0.0069 0.1318
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0398 0.0447 0.8771
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0102 0.0088 0.1427
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Echinococcus granulosus protein will die slowly 0.007 0.005 0.005
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0042 0.0016 0.0016
Echinococcus multilocularis membrane bound transcription factor site 1 0.0373 0.0417 0.0527
Brugia malayi Disintegrin family protein 0.0097 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Trichomonas vaginalis hypothetical protein 0.1635 0.1945 0.322
Onchocerca volvulus 0.0078 0.0059 0.0951
Brugia malayi Pepsin A precursor 0.0035 0.0007 0.0007
Echinococcus granulosus adam 0.0481 0.0547 0.0553
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0052 0.0028 0.0305
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0102 0.0088 0.1539
Toxoplasma gondii histone deacetylase SIR2 0.0066 0.0045 0.072
Schistosoma mansoni chromatin regulatory protein sir2 0.0448 0.0507 0.0512
Mycobacterium ulcerans thioesterase TesA 0.007 0.0049 0.0537
Giardia lamblia Neurogenic locus Notch protein precursor 0.0173 0.0175 0.0442
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0086 0.0069 0.1318
Echinococcus multilocularis discoidin domain containing receptor 2 0.0042 0.0016 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0006
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0042 0.0016 0.0016
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.0007 0.0007
Giardia lamblia Hypothetical protein 0.0448 0.0507 0.1367
Toxoplasma gondii type I fatty acid synthase, putative 0.006 0.0037 0.0591
Plasmodium falciparum plasmepsin VI 0.0035 0.0007 0.0099
Echinococcus multilocularis integrin alpha 3 0.0836 0.0977 0.1236
Brugia malayi hypothetical protein 0.0102 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.1635 0.1945 0.1967
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.819 0.9884 1
Loa Loa (eye worm) reprolysin 0.0235 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0173 0.0175 0.0175
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0088 0.0071 0.5
Mycobacterium ulcerans monoamine oxidase 0.0102 0.0088 0.1539
Giardia lamblia Furin precursor putative serine protease 0.1635 0.1945 0.5371
Trichomonas vaginalis conserved hypothetical protein 0.1635 0.1945 0.322
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0102 0.0088 0.1427
Brugia malayi neuroendocrine convertase 1 precursor 0.5183 0.6242 0.6242
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0064 0.0043 0.0373
Mycobacterium ulcerans polyketide synthase 0.0081 0.0062 0.0882
Echinococcus multilocularis integrin alpha ps 0.0667 0.0773 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0373 0.0417 1
Toxoplasma gondii PA14 domain-containing protein 0.0042 0.0016 0.0251
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0042 0.0016 0.0019
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0081 0.0063 0.1391
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0018
Echinococcus multilocularis discoidin domain containing receptor 2 0.0042 0.0016 0.0019
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0045 0.0073
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0235 0.0249 0.0315
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0448 0.0507 1
Onchocerca volvulus 0.0042 0.0016 0.0256
Trypanosoma brucei SIR2-like protein 4, putative 0.0066 0.0045 0.0492
Loa Loa (eye worm) hypothetical protein 0.0235 0.0249 0.0249
Echinococcus multilocularis integrin alpha ps 0.029 0.0315 0.0398
Loa Loa (eye worm) hypothetical protein 0.0544 0.0623 0.0623
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0088 0.1427
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0016
Toxoplasma gondii subtilisin SUB6 0.0373 0.0417 0.6796
Schistosoma mansoni amine oxidase 0.0102 0.0088 0.0088
Plasmodium falciparum plasmepsin I 0.0035 0.0007 0.0099
Brugia malayi hypothetical protein 0.0035 0.0007 0.0007
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0007 0.0006
Brugia malayi EGF-like domain containing protein 0.0173 0.0175 0.0175
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0448 0.0507 0.0839
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0066 0.0045 0.008
Brugia malayi celfurPC protein 0.6555 0.7904 0.7904
Mycobacterium ulcerans thioesterase 0.007 0.0049 0.0537
Plasmodium falciparum plasmepsin IX 0.0035 0.0007 0.0099
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0081 0.0062 0.1383
Brugia malayi transcriptional regulator, Sir2 family protein 0.0448 0.0507 0.0507
Schistosoma mansoni dock 0.0042 0.0016 0.0016
Toxoplasma gondii type I fatty acid synthase, putative 0.0086 0.0069 0.1113
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0373 0.0417 0.0527
Leishmania major sir2-family protein-like protein 0.0066 0.0045 0.0871
Echinococcus granulosus integrin alpha ps 0.029 0.0315 0.0319
Brugia malayi hypothetical protein 0.1274 0.1507 0.1507
Schistosoma mansoni integrin alpha 0.1151 0.1358 0.1374
Echinococcus granulosus membrane bound transcription factor site 1 0.0373 0.0417 0.0421
Loa Loa (eye worm) glutamate receptor 1 0.0034 0.0006 0.0006
Brugia malayi SWIRM domain containing protein 0.0042 0.0016 0.0016
Loa Loa (eye worm) subtilase 0.0373 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0779 0.0908 0.0908
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.006 0.0037 0.0046
Plasmodium vivax plasmepsin IV, putative 0.0035 0.0007 0.0099
Plasmodium vivax subtilisin-like serine protease, putative 0.0373 0.0417 0.6796
Schistosoma mansoni protein kinase 0.0129 0.0121 0.0122
Toxoplasma gondii F5/8 type C domain-containing protein 0.0042 0.0016 0.0251
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Plasmodium vivax subtilisin-like protease 1 0.0536 0.0613 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0052 0.0027 0.0034
Echinococcus granulosus integrin alpha ps 0.0667 0.0773 0.0782
Toxoplasma gondii subtilisin SUB2 0.0373 0.0417 0.6796
Schistosoma mansoni glutamate receptor NMDA 0.0052 0.0027 0.0027
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0137 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0102 0.0088 0.0088
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2008 0.2397 0.3968
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0046 0.0021 0.0097
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0045 0.072
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1635 0.1945 0.322
Loa Loa (eye worm) hypothetical protein 0.0046 0.0021 0.0021
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0086 0.0068 0.0068
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0373 0.0417 1
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.0007 0.0099
Mycobacterium ulcerans dehydrogenase 0.0102 0.0088 0.1539
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Loa Loa (eye worm) hypothetical protein 0.1274 0.1507 0.1507
Mycobacterium leprae Possible secreted protease 0.0373 0.0417 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0052 0.0027 0.0034
Giardia lamblia Tenascin-like 0.0173 0.0175 0.0442
Brugia malayi Protein kinase domain containing protein 0.0069 0.0048 0.0048
Schistosoma mansoni integrin alpha-ps 0.0604 0.0696 0.0704
Loa Loa (eye worm) hypothetical protein 0.0102 0.0088 0.0088
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0113 0.0101 0.0101
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0034 0.0006 0.0006
Echinococcus granulosus fibrillin 2 0.0173 0.0175 0.0176
Echinococcus granulosus disintegrin and metalloproteinase 0.0097 0.0083 0.0083
Loa Loa (eye worm) WD40 repeat protein 0.007 0.005 0.005
Brugia malayi transcriptional regulator, Sir2 family protein 0.0066 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.006 0.0037 0.0773
Brugia malayi hypothetical protein 0.0035 0.0007 0.0007
Mycobacterium ulcerans NAD-dependent deacetylase 0.0066 0.0045 0.0424
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0054 0.003 0.0486
Echinococcus granulosus integrin beta 2 0.6113 0.7368 0.7455
Brugia malayi AMP-binding enzyme family protein 0.0078 0.0059 0.0059
Echinococcus granulosus serine:threonine protein kinase N2 0.007 0.0049 0.0049
Plasmodium vivax subtilisin-like protease 2, putative 0.0373 0.0417 0.6796
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0052 0.0027 0.0027
Trypanosoma cruzi UDP-galactopyranose mutase 0.0102 0.0088 0.1383
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0373 0.0417 0.8147
Schistosoma mansoni ATP-binding cassette transporter 0.0035 0.0008 0.0007
Plasmodium vivax aspartyl protease, putative 0.0035 0.0007 0.0099
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0034 0.0006 0.0006
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0398 0.0447 0.8771
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0234 0.0248 0.025
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0042 0.0016 0.002
Echinococcus granulosus neuropeptides capa receptor 0.0214 0.0224 0.0226
Trypanosoma cruzi subtilisin peptidase 0.0373 0.0417 0.8147
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0129 0.0121 0.0152
Schistosoma mansoni integrin beta subunit 0.4839 0.5826 0.5894
Trichomonas vaginalis conserved hypothetical protein 0.1635 0.1945 0.322
Schistosoma mansoni hypothetical protein 0.007 0.005 0.005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0006
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0086 0.0069 0.1535
Leishmania major subtilisin-like serine peptidase 0.0373 0.0417 0.8221
Toxoplasma gondii subtilisin SUB11 0.0373 0.0417 0.6796
Mycobacterium ulcerans polyketide synthase Pks13 0.0122 0.0113 0.2171
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.007 0.0049 0.0826
Loa Loa (eye worm) hypothetical protein 0.0066 0.0045 0.0045
Mycobacterium leprae Probable polyketide synthase Pks1 0.0086 0.0069 0.1318
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0288 0.0313 0.0396
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0078 0.0059 0.0059
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0006 0.0006
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0006 0.0006
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0102 0.0088 0.1539
Plasmodium vivax NAD-dependent deacetylase, putative 0.0066 0.0045 0.072
Trichomonas vaginalis conserved hypothetical protein 0.0373 0.0417 0.0689
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0007 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0078 0.0059 0.1305
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2008 0.2397 0.3968
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0064 0.0043 0.0373
Echinococcus granulosus discoidin domain containing receptor 2 0.0042 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0373 0.0417 0.0689
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0373 0.0417 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0034 0.0006 0.0007
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0088 0.0071 0.1582
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.0062 0.0882
Loa Loa (eye worm) angiogenesis inhibito 0.0065 0.0043 0.0043
Echinococcus multilocularis neuropeptides capa receptor 0.0214 0.0224 0.0282
Brugia malayi Reprolysin 0.0138 0.0131 0.0131
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0064 0.0043 0.0667
Schistosoma mansoni chromatin regulatory protein sir2 0.0448 0.0507 0.0512
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0066 0.0044 0.0934
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0066 0.0045 0.0045
Brugia malayi protein kinase C II. 0.0086 0.0068 0.0068
Loa Loa (eye worm) transcriptional regulator 0.0066 0.0045 0.0045
Brugia malayi hypothetical protein 0.0069 0.0048 0.0048
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0052 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0373 0.0417 0.0417
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0102 0.0088 0.1427
Toxoplasma gondii subtilisin SUB8 0.0373 0.0417 0.6796
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2008 0.2397 0.3968
Loa Loa (eye worm) transcriptional regulator 0.0448 0.0507 0.0507
Schistosoma mansoni serine/threonine protein kinase 0.0263 0.0283 0.0286
Schistosoma mansoni site-1 peptidase (S08 family) 0.0373 0.0417 0.0421
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0045 0.0045
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.0062 0.0882
Loa Loa (eye worm) hypothetical protein 0.0063 0.0041 0.0041
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0373 0.0417 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.1635 0.1945 0.322
Loa Loa (eye worm) glutamate receptor 2 0.0034 0.0006 0.0006
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0448 0.0507 0.0839
Brugia malayi EGF-like domain containing protein 0.0173 0.0175 0.0175
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Echinococcus granulosus epidermal growth factor receptor 0.0537 0.0615 0.0622
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0016 0.0251
Leishmania major UDP-galactopyranose mutase 0.0102 0.0088 0.1727
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1285 0.1521 0.1538
Trichomonas vaginalis conserved hypothetical protein 0.1635 0.1945 0.322
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0066 0.0045 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Onchocerca volvulus 0.0137 0.013 0.2094
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0006
Echinococcus multilocularis discoidin domain receptor 0.0042 0.0016 0.0019
Loa Loa (eye worm) fatty acid synthase 0.0082 0.0065 0.0065
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1299 0.1538 0.1538
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0066 0.0045 0.0492
Mycobacterium ulcerans Sir2-like regulatory protein 0.0066 0.0045 0.0424
Loa Loa (eye worm) hypothetical protein 0.0501 0.0572 0.0572
Echinococcus granulosus adam 17 protease 0.0097 0.0083 0.0083
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0016 0.025
Schistosoma mansoni dihydroceramide desaturase 0.0097 0.0083 0.0083
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0102 0.0088 0.1427
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0156 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0067 0.0046 0.0046
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0034 0.0006 0.0007
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0097 0.0083 0.0104
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0016
Echinococcus granulosus c-Jun N-terminal kinases 0.0263 0.0283 0.0286
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0081 0.0062 0.0062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.006 0.0037 0.0037
Brugia malayi ADAM-TS Spacer 1 family protein 0.0137 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.029 0.0315 0.0319
Onchocerca volvulus 0.0042 0.0016 0.0256
Brugia malayi Will die slowly protein 0.007 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0137 0.0131 0.0131
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0052 0.0027 0.0027
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.006 0.0037 0.0037
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0033 0.0005 0.0005
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0045 0.0073
Echinococcus granulosus discoidin domain containing receptor 2 0.0042 0.0016 0.0016
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0113 0.0101 0.0101
Brugia malayi metalloprotease 0.0065 0.0043 0.0043
Toxoplasma gondii subtilisin SUB7 0.0373 0.0417 0.6796
Toxoplasma gondii aspartyl protease ASP1 0.0035 0.0007 0.0099
Onchocerca volvulus 0.0373 0.0417 0.6692
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Loa Loa (eye worm) hypothetical protein 0.0138 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0069 0.0048 0.0048
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0042 0.0016 0.0251
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0086 0.0069 0.1535
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0747 0.0869 0.0879
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0129 0.0121 0.0122
Giardia lamblia hypothetical protein 0.0173 0.0175 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.1635 0.1945 0.322
Brugia malayi SWIRM domain containing protein 0.0544 0.0623 0.0623
Plasmodium falciparum subtilisin-like protease 1 0.0536 0.0613 1
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0006 0.0006
Toxoplasma gondii subtilisin SUB5 0.0373 0.0417 0.6796
Brugia malayi hypothetical protein 0.0046 0.0021 0.0021
Echinococcus granulosus chromatin regulatory protein sir2 0.0448 0.0507 0.0512
Echinococcus multilocularis integrin beta 2 0.6113 0.7368 0.9322
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5016 0.6039 1
Echinococcus multilocularis adam 0.0481 0.0547 0.0692
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0398 0.0447 0.8771
Trichomonas vaginalis conserved hypothetical protein 0.1635 0.1945 0.322
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0373 0.0417 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0066 0.0045 0.0045
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0081 0.0062 0.1161
Schistosoma mansoni site-1 peptidase (S08 family) 0.0373 0.0417 0.0421
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0006
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0102 0.0088 0.1539
Onchocerca volvulus Fatty acid synthase homolog 0.0151 0.0147 0.2363
Trichomonas vaginalis conserved hypothetical protein 0.1635 0.1945 0.322
Echinococcus multilocularis protein jagged 2 0.0173 0.0175 0.022
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0102 0.0088 0.0088
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0373 0.0417 1
Toxoplasma gondii F5/8 type C domain-containing protein 0.0042 0.0016 0.0251
Loa Loa (eye worm) TK/ALK protein kinase 0.0069 0.0048 0.0048
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1635 0.1945 0.322
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0006
Giardia lamblia Sirtuin type 2 0.0066 0.0045 0.008
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0006
Loa Loa (eye worm) integrin beta-2 0.8286 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Loa Loa (eye worm) TK/EGFR protein kinase 0.0537 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0353 0.0392 0.0392
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0045 0.0073
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0066 0.0045 0.0584
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0373 0.0417 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0066 0.0045 0.0584
Trichomonas vaginalis hypothetical protein 0.0173 0.0175 0.0288
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0086 0.0069 0.1044
Schistosoma mansoni integrin alpha-ps 0.0378 0.0422 0.0427
Trypanosoma cruzi UDP-galactopyranose mutase 0.0102 0.0088 0.1383
Schistosoma mansoni protein kinase 0.0129 0.0121 0.0122
Brugia malayi Glutamate receptor 2 precursor 0.0034 0.0006 0.0006
Schistosoma mansoni discoidin domain receptor 0.0042 0.0016 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2008 0.2397 0.3968
Echinococcus granulosus lysine specific histone demethylase 1A 0.0102 0.0088 0.0088
Brugia malayi amine oxidase, flavin-containing family protein 0.0144 0.0139 0.0139
Toxoplasma gondii F5/8 type C domain-containing protein 0.0042 0.0016 0.0251
Schistosoma mansoni glutamate receptor NMDA 0.0288 0.0313 0.0317
Entamoeba histolytica hypothetical protein 0.0046 0.0021 0.0097
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0373 0.0417 0.0421
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0173 0.0175 0.0175
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2008 0.2397 0.3968
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0086 0.0069 0.1535
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Echinococcus multilocularis 0.6555 0.7904 1
Giardia lamblia High cysteine protein 0.0173 0.0175 0.0442
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0088 0.1427
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0007 0.0099
Plasmodium falciparum plasmepsin VII 0.0035 0.0007 0.0099
Plasmodium falciparum plasmepsin II 0.0035 0.0007 0.0099
Brugia malayi EGF-like domain containing protein 0.0173 0.0175 0.0175
Plasmodium falciparum protoporphyrinogen oxidase 0.0102 0.0088 0.1427
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0235 0.0249 0.0252
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0006 0.0006
Onchocerca volvulus 0.0035 0.0007 0.0106
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0007 0.0006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0035 0.0007 0.001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0088 0.2003
Mycobacterium tuberculosis Possible oxidoreductase 0.0102 0.0088 0.2003
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0066 0.0045 0.0492
Onchocerca volvulus 0.007 0.005 0.0797
Echinococcus multilocularis serine:threonine protein kinase N2 0.0078 0.006 0.0075
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0034 0.0006 0.0007
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0066 0.0045 0.0492
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0066 0.0045 0.072
Echinococcus multilocularis Furin 1 0.2008 0.2397 0.3032
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0065 0.0043 0.0043
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0081 0.0063 0.1391
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.1635 0.1945 0.322
Giardia lamblia Neurogenic locus notch-like protein 0.0173 0.0175 0.0442
Schistosoma mansoni hypothetical protein 0.0042 0.0016 0.0016
Schistosoma mansoni SWI/SNF complex-related 0.0042 0.0016 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0448 0.0507 0.0512
Loa Loa (eye worm) hypothetical protein 0.0378 0.0422 0.0422
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0448 0.0507 0.0641
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0747 0.0869 0.1099
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0045 0.0045
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0035 0.0007 0.0099
Brugia malayi NAD-dependent deacetylase SIRT1 0.0066 0.0045 0.0045
Loa Loa (eye worm) sirtuin 4 0.0066 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0069 0.0048 0.0048
Loa Loa (eye worm) integrin alpha pat-2 0.1577 0.1874 0.1874
Loa Loa (eye worm) hypothetical protein 0.819 0.9884 0.9884
Schistosoma mansoni tyrosine kinase 0.0537 0.0615 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Loa Loa (eye worm) metalloprotease 0.0065 0.0043 0.0043
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0102 0.0088 0.1797
Echinococcus granulosus nmda type glutamate receptor 0.0122 0.0112 0.0113
Mycobacterium tuberculosis Probable thioesterase TesA 0.007 0.0049 0.1056
Giardia lamblia Tenascin-X 0.0173 0.0175 0.0442
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Echinococcus multilocularis neuroendocrine convertase 2 0.5183 0.6242 0.7897
Echinococcus multilocularis fibrillin 2 0.0173 0.0175 0.022
Loa Loa (eye worm) hypothetical protein 0.0065 0.0043 0.0043
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0007 0.0099
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0097 0.0083 0.0083
Giardia lamblia Transcriptional regulator, Sir2 family 0.0066 0.0045 0.008
Trichomonas vaginalis conserved hypothetical protein 0.1635 0.1945 0.322
Echinococcus multilocularis nmda type glutamate receptor 0.0122 0.0112 0.0141
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0048 0.0022 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5016 0.6039 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0102 0.0088 1
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0042 0.0016 0.0025
Plasmodium falciparum plasmepsin V 0.0389 0.0436 0.7113
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5016 0.6039 0.7641
Loa Loa (eye worm) hypothetical protein 0.0072 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0069 0.0048 0.0048
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0081 0.0062 0.1383
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0102 0.0088 0.1427
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0007 0.0007
Leishmania major silent information regulator 2, putative 0.0448 0.0507 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0016 0.0251
Trichomonas vaginalis hypothetical protein 0.0042 0.0016 0.0025
Echinococcus granulosus fibrillin 1 0.0176 0.0177 0.0179
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0007 0.0099
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5016 0.6039 0.611
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0373 0.0417 1
Plasmodium vivax aspartyl protease, putative 0.0035 0.0007 0.0099
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0045 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Onchocerca volvulus 0.0544 0.0623 1
Loa Loa (eye worm) proprotein convertase 2 0.2008 0.2397 0.2397
Echinococcus multilocularis protoporphyrinogen oxidase 0.0102 0.0088 0.0111
Toxoplasma gondii histone lysine-specific demethylase 0.0102 0.0088 0.1427
Echinococcus granulosus discoidin domain containing receptor 2 0.0042 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.006 0.0037 0.0037
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0122 0.0112 0.0141
Echinococcus granulosus Furin 1 0.2008 0.2397 0.2425
Echinococcus multilocularis NMDA receptor 0.0034 0.0006 0.0007
Brugia malayi Kelch motif family protein 0.1299 0.1538 0.1538
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0066 0.0045 0.072
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0045 0.0045
Echinococcus multilocularis discoidin domain containing receptor 2 0.0042 0.0016 0.0019
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0448 0.0507 1
Echinococcus multilocularis fibrillin 1 0.0176 0.0177 0.0224
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0066 0.0045 0.0045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Toxoplasma gondii SWIRM domain-containing protein 0.0042 0.0016 0.0252
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0263 0.0283 0.0358
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0081 0.0062 0.1161
Brugia malayi EGF-like domain containing protein 0.0173 0.0175 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0373 0.0417 0.0689
Echinococcus granulosus glutamate receptor subunit protein glur 0.0034 0.0006 0.0006
Brugia malayi endoprotease bli-4 precursor 0.819 0.9884 0.9884
Loa Loa (eye worm) endoprotease bli-4 0.819 0.9884 0.9884
Loa Loa (eye worm) hypothetical protein 0.0173 0.0175 0.0175
Echinococcus granulosus glutamate receptor 2 0.0052 0.0027 0.0027
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0042 0.0016 0.0025
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0373 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0861 0.1008 0.1008
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0373 0.0417 0.0421
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.0062 0.0882
Onchocerca volvulus 0.0069 0.0048 0.077
Loa Loa (eye worm) hypothetical protein 0.006 0.0037 0.0037
Loa Loa (eye worm) apoptosis regulator protein 0.006 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.1635 0.1945 0.322
Schistosoma mansoni btb and poz domain-containing protein 0.0042 0.0016 0.0016
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0066 0.0045 0.0056
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0052 0.0027 0.0027
Echinococcus multilocularis integrin alpha ps 0.0604 0.0696 0.088
Schistosoma mansoni amine oxidase 0.0102 0.0088 0.0088
Plasmodium vivax plasmepsin V, putative 0.0389 0.0436 0.7113
Giardia lamblia High cysteine membrane protein Group 2 0.3007 0.3607 1
Echinococcus multilocularis glutamate receptor 2 0.0034 0.0006 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2008 0.2397 0.3968
Brugia malayi transcriptional regulator, Sir2 family protein 0.0066 0.0045 0.0045
Echinococcus multilocularis MAM 0.0069 0.0048 0.006
Echinococcus granulosus integrin alpha 3 0.0836 0.0977 0.0988
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0026
Schistosoma mansoni chromatin regulatory protein sir2 0.0448 0.0507 0.0512
Echinococcus multilocularis disintegrin and metalloproteinase 0.0097 0.0083 0.0104
Plasmodium vivax aspartyl protease, putative 0.0035 0.0007 0.0099
Schistosoma mansoni hypothetical protein 0.006 0.0037 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0068 0.0069
Schistosoma mansoni hypothetical protein 0.0034 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0069 0.0048 0.0048
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0049 0.0681
Plasmodium vivax LCCL domain-containing protein 0.0042 0.0016 0.0251
Loa Loa (eye worm) acyl carrier protein 0.0038 0.0011 0.0011
Schistosoma mansoni apoptosis regulator bax 0.006 0.0037 0.0037
Toxoplasma gondii subtilisin SUB1 0.0536 0.0613 1
Echinococcus granulosus furin 0.819 0.9884 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0122 0.0113 0.26
Loa Loa (eye worm) transcriptional regulator 0.0066 0.0045 0.0045
Brugia malayi Glutamate receptor 1 precursor 0.0034 0.0006 0.0006
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0052 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.0173 0.0175 0.0175
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0045 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0373 0.0417 0.0689
Echinococcus granulosus neuroendocrine convertase 2 0.5183 0.6242 0.6315
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Onchocerca volvulus 0.0035 0.0007 0.0106
Plasmodium falciparum plasmepsin X 0.0035 0.0007 0.0099
Brugia malayi Integrin alpha pat-2 precursor 0.1151 0.1358 0.1358
Brugia malayi Subtilase family protein 0.0373 0.0417 0.0417
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0779 0.0908 0.0908
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0052 0.0027 0.0034
Plasmodium falciparum plasmepsin III 0.0035 0.0007 0.0099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0007
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0007 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0066 0.0045 0.0871
Plasmodium falciparum subtilisin-like protease 2 0.0373 0.0417 0.6796
Onchocerca volvulus 0.0069 0.0048 0.077
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0045 0.0073
Mycobacterium ulcerans polyketide synthase 0.0086 0.0069 0.1044
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0025
Trypanosoma brucei subtilisin peptidase 0.0373 0.0417 0.8147
Loa Loa (eye worm) hypothetical protein 0.0501 0.0572 0.0572
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2008 0.2397 0.2425
Brugia malayi Furin-like cysteine rich region family protein 0.0537 0.0615 0.0615
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0088 0.0071 0.1093
Trichomonas vaginalis WD repeat domain, putative 0.007 0.005 0.0081
Echinococcus multilocularis epidermal growth factor receptor 0.0537 0.0615 0.0777
Brugia malayi proprotein convertase 2 0.5183 0.6242 0.6242
Echinococcus multilocularis protein will die slowly 0.007 0.005 0.0062
Mycobacterium ulcerans oxidoreductase 0.0102 0.0088 0.1539
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0373 0.0417 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0501 0.0572 0.0723
Schistosoma mansoni hypothetical protein 0.006 0.0037 0.0037
Toxoplasma gondii subtilisin SUB10 0.0373 0.0417 0.6796
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Schistosoma mansoni protein kinase 0.0129 0.0121 0.0122
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0088 0.0071 0.5
Toxoplasma gondii subtilisin SUB4 0.0373 0.0417 0.6796
Brugia malayi Stress-activated protein kinase jnk-1 0.0263 0.0283 0.0283
Echinococcus granulosus MAM 0.0069 0.0048 0.0048
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0086 0.0069 0.1044
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0501 0.0572 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.1635 0.1945 0.322
Giardia lamblia Tenascin precursor 0.0173 0.0175 0.0442
Toxoplasma gondii hypothetical protein 0.0173 0.0175 0.2843
Toxoplasma gondii aspartyl protease ASP5 0.0355 0.0394 0.6428
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0006
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0373 0.0417 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0083 0.0083
Plasmodium falciparum subtilisin-like protease 3 0.0373 0.0417 0.6796
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0034 0.0006 0.0006
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0448 0.0507 1
Echinococcus multilocularis 0.0102 0.0088 0.0111
Toxoplasma gondii subtilisin SUB9 0.0373 0.0417 0.6796
Echinococcus granulosus lysine specific histone demethylase 1A 0.0501 0.0572 0.0578
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Echinococcus multilocularis protein kinase c epsilon type 0.0086 0.0068 0.0086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0373 0.0417 0.0689
Echinococcus granulosus protein kinase c epsilon type 0.0086 0.0068 0.0069
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0007 0.0007

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.53 ug ml-1 Cytotoxicity against mouse P388 cells ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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