Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0038 | 0.0066 | 0.0074 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0038 | 0.0066 | 0.0066 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0038 | 0.0066 | 0.0074 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0194 | 0.8979 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0038 | 0.0066 | 0.0074 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0038 | 0.0066 | 0.0074 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0194 | 0.8979 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0083 | 0.2639 | 0.2939 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0038 | 0.0066 | 0.0074 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0194 | 0.8979 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0056 | 0.1087 | 0.1211 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0037 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0038 | 0.0066 | 0.0074 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0083 | 0.2639 | 0.2939 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0038 | 0.0066 | 0.0066 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0038 | 0.0066 | 0.0074 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0037 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0083 | 0.2639 | 0.2939 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0083 | 0.2639 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0038 | 0.0066 | 0.0074 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0037 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0507 | 0.0565 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0181 | 0.8248 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0038 | 0.0066 | 0.0066 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0038 | 0.0066 | 0.0066 |
Trypanosoma brucei | cytochrome P450, putative | 0.0083 | 0.2639 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0038 | 0.0066 | 0.0074 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0038 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0083 | 0.2639 | 0.2939 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0037 | 0 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0037 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1087 | 0.1211 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0194 | 0.8979 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0056 | 0.1087 | 0.1211 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0056 | 0.1087 | 0.1211 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0083 | 0.2639 | 0.2939 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0037 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0083 | 0.2639 | 1 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0038 | 0.0066 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.7512 | 0.8366 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0056 | 0.1087 | 0.1211 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0038 | 0.0066 | 0.0074 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0056 | 0.1087 | 0.1087 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0056 | 0.1087 | 0.1087 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0037 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0037 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0083 | 0.2639 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0038 | 0.0066 | 0.0074 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0056 | 0.1087 | 0.1211 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0212 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0181 | 0.8248 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0037 | 0 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0038 | 0.0066 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0066 | 0.0074 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0037 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0037 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0038 | 0.0066 | 0.0066 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0083 | 0.2639 | 1 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0038 | 0.0066 | 0.0074 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 87 % | Inhibition of human GDT-fused recombinant PI3K-C2beta assessed as residual activity at 10 uM by nonradiometric ADP-Glo assay | ChEMBL. | 24983663 |
Activity (binding) | = 94 % | Inhibition of human GDT-fused recombinant PI3K-C2gamma assessed as residual activity at 10 uM by nonradiometric ADP-Glo assay | ChEMBL. | 24983663 |
Activity (binding) | = 100 % | Inhibition of human GDT-fused recombinant Vps34 assessed as residual activity at 10 uM by nonradiometric ADP-Glo assay | ChEMBL. | 24983663 |
Activity (binding) | = 104 % | Inhibition of human GDT-fused recombinant PI3K-C2alpha assessed as residual activity at 10 uM by nonradiometric ADP-Glo assay | ChEMBL. | 24983663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.