Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable dehydrogenase | 0.021 | 0.2214 | 0.2072 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0049 | 0.0369 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.129 | 0.129 |
Brugia malayi | glutathione reductase | 0.0092 | 0.0866 | 0.0866 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.3708 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0227 | 0.6145 |
Plasmodium falciparum | glutathione reductase | 0.0092 | 0.0866 | 0.1948 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0049 | 0.0369 | 0.0369 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0032 | 0.0178 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0113 | 0.3066 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0178 | 0.0481 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.021 | 0.2214 | 0.2072 |
Leishmania major | trypanothione reductase | 0.0092 | 0.0866 | 0.2335 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0049 | 0.0369 | 0.0369 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0042 | 0.0288 | 0.78 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.3708 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0039 | 0.0256 | 0.069 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0049 | 0.0369 | 0.0369 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0178 | 0.0481 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0032 | 0.0178 | 0.0481 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0039 | 0.0256 | 0.069 |
Mycobacterium tuberculosis | Probable reductase | 0.021 | 0.2214 | 0.2072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0114 | 0.3078 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.129 | 0.129 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0049 | 0.0369 | 0.0996 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0049 | 0.0369 | 0.0996 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0234 | 0.2482 | 0.0344 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0049 | 0.0369 | 0.0369 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0227 | 0.6145 |
Toxoplasma gondii | thioredoxin reductase | 0.0092 | 0.0866 | 0.1948 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0113 | 0.3066 |
Trypanosoma brucei | trypanothione reductase | 0.0092 | 0.0866 | 0.2335 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0032 | 0.0178 | 0.0178 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0178 | 0.0481 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0093 | 0.0872 | 0.0872 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0049 | 0.0369 | 0.0996 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0092 | 0.0866 | 0.07 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0178 | 0.0481 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0747 | 0.8344 | 0.8344 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0892 | 1 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.021 | 0.2214 | 0.2072 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0178 | 0.0481 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0747 | 0.8344 | 0.8344 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.021 | 0.2214 | 0.2072 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.3708 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0023 | 0.0082 | 0.0082 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0036 | 0.0227 | 0.0138 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0113 | 0.3066 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0227 | 0.6145 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.002 | 0.0044 | 0.012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0256 | 0.6922 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 0.3708 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0032 | 0.0178 | 0.0178 |
Echinococcus granulosus | dihydrofolate reductase | 0.0892 | 1 | 1 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0049 | 0.0369 | 0.0996 |
Plasmodium falciparum | thioredoxin reductase | 0.0092 | 0.0866 | 0.1948 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0049 | 0.0369 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0178 | 0.0481 |
Loa Loa (eye worm) | glutathione reductase | 0.0092 | 0.0866 | 0.0866 |
Giardia lamblia | GTOR | 0.0049 | 0.0369 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0114 | 0.3078 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0049 | 0.0369 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0092 | 0.0866 | 0.2335 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0032 | 0.0178 | 0.0481 |
Schistosoma mansoni | dihydrofolate reductase | 0.0892 | 1 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0178 | 0.0481 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0256 | 0.6922 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0032 | 0.0178 | 0.4829 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0114 | 0.3078 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0032 | 0.0178 | 0.0481 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0032 | 0.0178 | 0.0481 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0146 | 0.3945 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0032 | 0.0178 | 0.0178 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0032 | 0.0178 | 0.0481 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0032 | 0.0178 | 0.4829 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0186 | 0.5047 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.129 | 0.129 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.021 | 0.2214 | 0.2072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0174 | 0.4722 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0039 | 0.0256 | 0.069 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0023 | 0.0076 | 0.0206 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0092 | 0.0866 | 0.1948 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0234 | 0.2482 | 0.2345 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0023 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0092 | 0.0866 | 0.0866 |
Plasmodium vivax | glutathione reductase, putative | 0.0092 | 0.0866 | 0.1948 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0032 | 0.0178 | 0.0481 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0227 | 0.6145 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0892 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0256 | 0.6922 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0049 | 0.0369 | 0.0996 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.3708 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0142 | 0.3855 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0256 | 0.6922 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.3708 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0234 | 0.2482 | 0.2345 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0049 | 0.0369 | 0.0369 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0747 | 0.8344 | 0.8344 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0049 | 0.0369 | 1 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0049 | 0.0369 | 0.0996 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0032 | 0.0178 | 0.0481 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0178 | 0.0481 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0032 | 0.0178 | 0.0178 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0256 | 0.6922 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0227 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0227 | 0.6145 |
Treponema pallidum | NADH oxidase | 0.0032 | 0.0178 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0093 | 0.0872 | 0.0872 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0032 | 0.0178 | 0.0481 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0032 | 0.0178 | 0.0481 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0146 | 0.3945 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0049 | 0.0369 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0892 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0892 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0892 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0892 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0114 | 0.3078 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0892 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0092 | 0.0866 | 0.0866 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0234 | 0.2482 | 0.2345 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0146 | 0.3945 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0032 | 0.0178 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0142 | 0.3855 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0227 | 0.6145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | < 5 % | Modulation of human adenosine A1 receptor expressed in CHO-K1 cells assessed as stabilization of [125I]ABA-receptor-G protein ternary complex at 50 uM by dissociation kinetic assay | ChEMBL. | 18771255 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.