Detailed information for compound 957436

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 617.729 | Formula: C36H43NO8
  • H donors: 4 H acceptors: 7 LogP: 3.48 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(O[C@@H]1C[C@@H]2[C@@]3(C)CC[C@@H](CC3=CC[C@]2([C@@]2([C@@]1(C)[C@@](O)(CC2)[C@@H](OC(=O)c1cccnc1)C)O)O)O)/C=C/c1ccccc1
  • InChi: 1S/C36H43NO8/c1-23(44-31(40)25-10-7-19-37-22-25)34(41)17-18-36(43)33(34,3)29(45-30(39)12-11-24-8-5-4-6-9-24)21-28-32(2)15-14-27(38)20-26(32)13-16-35(28,36)42/h4-13,19,22-23,27-29,38,41-43H,14-18,20-21H2,1-3H3/b12-11+/t23-,27-,28+,29+,32-,33+,34+,35-,36+/m0/s1
  • InChiKey: CQLUYSHACKIUHL-LNRKSMJRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cathepsin L cysteine protease 0.0854 0.5138 0.5137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1657 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.1657 1 1
Giardia lamblia Cathepsin B precursor 0.0306 0.1822 0.5
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0306 0.1822 0.1822
Brugia malayi cathepsin F-like cysteine proteinase 0.0306 0.1822 0.1822
Echinococcus multilocularis cathepsin L 0.0854 0.5138 0.5137
Plasmodium falciparum cysteine proteinase falcipain 3 0.1657 1 1
Echinococcus granulosus cathepsin l1 0.1109 0.6685 0.6685
Echinococcus multilocularis cysteine protease 0.1657 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0854 0.5138 0.4054
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0032 0.0032
Brugia malayi Papain family cysteine protease containing protein 0.0854 0.5138 0.5138
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0306 0.1822 0.1822
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.2438 0.2438
Brugia malayi MH2 domain containing protein 0.0009 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1822 0.1813
Brugia malayi Papain family cysteine protease containing protein 0.0854 0.5138 0.5138
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Brugia malayi Cathepsin L-like precursor 0.1109 0.6685 0.6685
Giardia lamblia Cathepsin B precursor 0.0306 0.1822 0.5
Loa Loa (eye worm) hypothetical protein 0.0306 0.1822 0.1822
Loa Loa (eye worm) hypothetical protein 0.0306 0.1822 0.1822
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0004 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1822 0.1822
Giardia lamblia Cysteine protease 0.0306 0.1822 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0306 0.1822 0.1822
Giardia lamblia Cathepsin L-like protease 0.0306 0.1822 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0032 0.0032
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0023 0.0023
Onchocerca volvulus 0.1657 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0588 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 0.5138 0.5132
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0306 0.1822 0.1813
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0023 0.0023
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0032 0.0167 0.0167
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0032 0.0032
Onchocerca volvulus Huntingtin homolog 0.0122 0.071 0.071
Schistosoma mansoni cathepsin S (C01 family) 0.0306 0.1822 0.1822
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0024 0.0024
Brugia malayi cathepsin Z-like cysteine proteinase 0.0306 0.1822 0.1822
Echinococcus multilocularis Smad4 0.0009 0.0023 0.0023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0032 0.0032
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0015 0.0014
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Brugia malayi Cathepsin L-like cysteine proteinase 0.1109 0.6685 0.6685
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0854 0.5138 0.5137
Plasmodium vivax vivapain-2 0.1657 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.1657 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1657 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0032 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.1657 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.1657 1 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0023 0.0023
Plasmodium vivax vivapain-3 0.0854 0.5138 0.4054
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0032 0.0032
Leishmania major cathepsin L-like protease 0.1657 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0032 0.0032
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.4133 0.4132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0306 0.1822 0.1813
Schistosoma mansoni cathepsin F (C01 family) 0.1657 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Leishmania major cathepsin L-like protease 0.1657 1 1
Echinococcus granulosus dnaJ subfamily B 0.0408 0.2438 0.2438
Loa Loa (eye worm) hypothetical protein 0.0122 0.071 0.071
Loa Loa (eye worm) hypothetical protein 0.0306 0.1822 0.1822
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1657 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0306 0.1822 0.1822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.1822 0.1813
Brugia malayi cathepsin F-like cysteine proteinase 0.0548 0.3287 0.3287
Schistosoma mansoni cathepsin B (C01 family) 0.0306 0.1822 0.1822
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0032 0.0032
Echinococcus granulosus cathepsin l1 0.1657 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0548 0.3287 0.3287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1657 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Echinococcus granulosus cathepsin L 0.0854 0.5138 0.5137
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0167 0.0167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1657 1 1
Schistosoma mansoni cpg binding protein 0.003 0.0155 0.0154
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0025 0.0025
Giardia lamblia Cathepsin B precursor 0.0306 0.1822 0.5
Brugia malayi MH2 domain containing protein 0.0125 0.0728 0.0728
Loa Loa (eye worm) ctsf protein 0.1657 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0032 0.0032
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1109 0.6685 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1657 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1657 1 1
Brugia malayi cathepsin L-like precursor 0.1109 0.6685 0.6685
Giardia lamblia Cysteine protease 0.0306 0.1822 0.5
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0854 0.5138 0.4054
Giardia lamblia Cathepsin L precursor 0.0306 0.1822 0.5
Giardia lamblia Encystation-specific protease 0.0306 0.1822 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 0.5138 0.5132
Echinococcus multilocularis cathepsin b 0.0306 0.1822 0.1822
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1822 0.1813
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0306 0.1822 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0032 0.0032
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.4861 0.4861
Brugia malayi Cathepsin L-like precursor 0.1657 1 1
Entamoeba histolytica cysteine protease, putative 0.1657 1 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.1822 0.1813
Brugia malayi hypothetical protein 0.0005 0.0004 0.0004
Leishmania major cysteine peptidase A (CPA) 0.1657 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0032 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0854 0.5138 0.4054
Brugia malayi cathepsin L precursor 0.0306 0.1822 0.1822
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.1657 1 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0023 0.0023
Onchocerca volvulus Cathepsin L homolog 0.1657 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0032 0.0032
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Onchocerca volvulus 0.1657 1 1
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0166
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Giardia lamblia Cathepsin L precursor 0.0306 0.1822 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.1109 0.6685 0.6685
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0306 0.1822 0.1813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1109 0.6685 0.6681
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Loa Loa (eye worm) cysteine protease 0.1657 1 1
Brugia malayi Smad1 0.0009 0.0023 0.0023
Entamoeba histolytica cysteine proteinase, putative 0.0854 0.5138 0.4054
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0306 0.1822 0.1822
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0032 0.0032
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0548 0.3287 0.3287
Brugia malayi nuclear receptor NHR-88 0.001 0.0032 0.0032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0306 0.1822 0.1822
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.1397 0.1397
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0048 0.0262 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.1822 0.1813
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0004 0.0004
Toxoplasma gondii cathepsin B 0.0306 0.1822 0.157
Schistosoma mansoni cathepsin s 0.0548 0.3287 0.3287
Schistosoma mansoni cathepsin F (C01 family) 0.1109 0.6685 0.6685
Echinococcus granulosus smad 0.0009 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Giardia lamblia Cathepsin B precursor 0.0306 0.1822 0.5
Entamoeba histolytica cysteine proteinase 1, putative 0.0854 0.5138 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0306 0.1822 0.1813
Giardia lamblia Cathepsin L precursor 0.0306 0.1822 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1657 1 1
Toxoplasma gondii cathepsin CPL 0.1657 1 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.071 0.071
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1822 0.1822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1657 1 1
Echinococcus granulosus cpg binding protein 0.003 0.0155 0.0154
Echinococcus granulosus cathepsin b 0.0306 0.1822 0.1822
Trypanosoma cruzi cysteine peptidase, putative 0.0548 0.3287 0.1791
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.1822 0.1813
Entamoeba histolytica cysteine proteinase 2 0.0854 0.5138 0.4054
Loa Loa (eye worm) Smad1 0.0009 0.0023 0.0023
Leishmania major cathepsin L-like protease 0.1657 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0306 0.1822 0.1813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.1822 0.1813
Echinococcus multilocularis cysteine protease 0.1657 1 1
Schistosoma mansoni coup transcription factor 0.001 0.0032 0.0032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0032 0.0032
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0306 0.1822 0.1813
Brugia malayi nuclear receptor RXR 0.0005 0.0004 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0004 0.0004
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0306 0.1822 0.1822
Giardia lamblia Cathepsin L precursor 0.0306 0.1822 0.5
Echinococcus multilocularis smad 0.0009 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0032 0.0032
Brugia malayi MH1 domain containing protein 0.0009 0.0023 0.0023
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1822 0.1822
Schistosoma mansoni smad 0.0009 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0548 0.3287 0.3287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1657 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0393 0.0393
Schistosoma mansoni cpg binding protein 0.0029 0.0145 0.0144
Echinococcus granulosus microtubule associated protein 2 0.0688 0.4133 0.4132
Schistosoma mansoni smad1 5 8 and 0.0009 0.0023 0.0023
Schistosoma mansoni thyroid hormone receptor 0.001 0.0032 0.0032
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Brugia malayi Cathepsin L-like precursor 0.1657 1 1
Brugia malayi Cathepsin L-like precursor 0.1657 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1822 0.1822
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0023 0.0023
Giardia lamblia Cathepsin B precursor 0.0306 0.1822 0.5
Brugia malayi Cathepsin L-like precursor 0.1109 0.6685 0.6685
Trypanosoma cruzi cysteine peptidase, putative 0.1657 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0032 0.0032
Giardia lamblia Hypothetical protein 0.0306 0.1822 0.5
Onchocerca volvulus 0.1657 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0032 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0588 0.0588
Toxoplasma gondii cathepsin CPC2 0.0306 0.1822 0.157
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0167 0.0166
Leishmania major cathepsin L-like protease 0.1657 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0032 0.0032
Brugia malayi hypothetical protein 0.0122 0.071 0.071
Onchocerca volvulus 0.0306 0.1822 0.1822
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0306 0.1822 0.1822
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1657 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1657 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1657 1 1
Trypanosoma cruzi cysteine protease, putative 0.0854 0.5138 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1657 1 1
Brugia malayi MH1 domain containing protein 0.0009 0.0023 0.0023
Onchocerca volvulus 0.0048 0.0262 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.1822 0.1813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0145 0.0145
Toxoplasma gondii cathepsin CPC1 0.0306 0.1822 0.157
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0306 0.1822 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0854 0.5138 0.4054
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0032 0.0032
Brugia malayi cathepsin L-like cysteine proteinase 0.0306 0.1822 0.1822
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1657 1 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0032 0.0032
Brugia malayi Cathepsin L-like precursor 0.0548 0.3287 0.3287
Brugia malayi hypothetical protein 0.0236 0.1397 0.1397
Schistosoma mansoni survival motor neuron protein 0.0048 0.0262 0.0262
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0004 0.0003
Brugia malayi fibroinase precursor 0.0306 0.1822 0.1822
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1822 0.1822
Brugia malayi CXXC zinc finger family protein 0.0029 0.0145 0.0145
Giardia lamblia Cysteine protease 0.0306 0.1822 0.5
Loa Loa (eye worm) hypothetical protein 0.0236 0.1397 0.1397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0306 0.1822 0.1822
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0025 0.0025
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Plasmodium falciparum cysteine proteinase falcipain 1 0.0854 0.5138 0.4054
Echinococcus granulosus cathepsin l cysteine peptidase 0.1657 1 1
Brugia malayi ecdysteroid receptor 0.001 0.0032 0.0032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0339 0.0339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1657 1 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0306 0.1822 0.1822
Trypanosoma cruzi cysteine peptidase, putative 0.1657 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0548 0.3287 0.1791
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1657 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Onchocerca volvulus 0.001 0.0032 0.0032
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0306 0.1822 0.1813
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0854 0.5138 0.5137
Entamoeba histolytica cysteine proteinase, putative 0.1109 0.6685 0.5946
Echinococcus multilocularis cathepsin b 0.0306 0.1822 0.1822
Brugia malayi MH2 domain containing protein 0.0009 0.0023 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.1657 1 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.1109 0.6685 0.6685
Echinococcus granulosus cathepsin b 0.0306 0.1822 0.1822
Loa Loa (eye worm) hypothetical protein 0.0102 0.0588 0.0588
Loa Loa (eye worm) hypothetical protein 0.0306 0.1822 0.1822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1657 1 1
Giardia lamblia Cathepsin B precursor 0.0306 0.1822 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0015 0.0014
Schistosoma mansoni hypothetical protein 0.0408 0.2438 0.2438
Schistosoma mansoni smad1 5 8 and 0.0009 0.0023 0.0023
Onchocerca volvulus 0.1109 0.6685 0.6685
Schistosoma mansoni hypothetical protein 0.007 0.0393 0.0393
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0167 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0032 0.0032
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1822 0.1822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0588 0.0588
Schistosoma mansoni Smad4 0.0009 0.0023 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0032 0.0032
Brugia malayi nuclear hormone receptor 0.001 0.0032 0.0032
Brugia malayi Papain family cysteine protease containing protein 0.1657 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0306 0.1822 0.1813
Loa Loa (eye worm) hypothetical protein 0.0548 0.3287 0.3287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1657 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1657 1 1
Giardia lamblia Cathepsin L precursor 0.0306 0.1822 0.5
Brugia malayi Cathepsin L-like precursor 0.1657 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0004 0.0003
Loa Loa (eye worm) fibroinase 0.1657 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0032 0.0032
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0306 0.1822 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.1657 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0122 0.071 0.071
Trypanosoma cruzi cysteine proteinase, putative 0.0854 0.5138 0.4054
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1657 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1822 0.1822
Loa Loa (eye worm) hypothetical protein 0.0306 0.1822 0.1822
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0015 0.0014
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1657 1 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0306 0.1822 0.157
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0548 0.3287 0.3287
Giardia lamblia Hypothetical protein 0.0306 0.1822 0.5
Loa Loa (eye worm) hypothetical protein 0.1109 0.6685 0.6685
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0032 0.0032
Echinococcus multilocularis cathepsin L cysteine protease 0.1657 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Giardia lamblia Cathepsin B precursor 0.0306 0.1822 0.5
Leishmania major cathepsin L-like protease 0.1657 1 1
Giardia lamblia Cysteine protease 0.0306 0.1822 0.5
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0032 0.0032
Giardia lamblia Cathepsin L precursor 0.0306 0.1822 0.5
Echinococcus granulosus GPCR family 2 0.0032 0.0167 0.0166
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1657 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Onchocerca volvulus 0.0029 0.0145 0.0144
Plasmodium vivax unspecified product 0.0854 0.5138 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0306 0.1822 0.1813
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0306 0.1822 0.5
Brugia malayi Cathepsin L-like precursor 0.1657 1 1
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.4133 0.4132
Onchocerca volvulus Cathepsin L homolog 0.1657 1 1
Plasmodium vivax unspecified product 0.0548 0.3287 0.1791
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0306 0.1822 0.1813
Loa Loa (eye worm) hypothetical protein 0.0306 0.1822 0.1822
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0032 0.0032
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0393 0.0393
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0262 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1657 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0032 0.0032
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1657 1 1
Schistosoma mansoni cathepsin C 0.0306 0.1822 0.1822
Trypanosoma cruzi cysteine proteinase, putative 0.0854 0.5138 0.4054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0167 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0306 0.1822 0.1813
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0854 0.5138 0.5137
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0306 0.1822 0.1813
Onchocerca volvulus 0.1657 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0728 0.0728
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1822 0.1822
Entamoeba histolytica cysteine protease, putative 0.0854 0.5138 0.4054
Echinococcus granulosus cathepsin L 0.0306 0.1822 0.1822
Echinococcus multilocularis cpg binding protein 0.003 0.0155 0.0154
Schistosoma mansoni cpg binding protein 0.003 0.0155 0.0154
Brugia malayi steroid hormone receptor 0.001 0.0032 0.0032
Leishmania major cathepsin L-like protease 0.1657 1 1
Brugia malayi hypothetical protein 0.0005 0.0004 0.0004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0167 0.0167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0032 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 0.5138 0.4054
Loa Loa (eye worm) cathepsin B 0.0306 0.1822 0.1822
Onchocerca volvulus Cathepsin F homolog 0.1657 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1657 1 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0167 0.0166
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1657 1 1
Giardia lamblia Cathepsin B precursor 0.0306 0.1822 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0032 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 0.5138 0.4054
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0166
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0032 0.0032
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1822 0.1822
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0023 0.0023
Echinococcus granulosus FTZ F1 alpha 0.001 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0166
Onchocerca volvulus Cathepsin L homolog 0.0306 0.1822 0.1822
Echinococcus granulosus Smad4 0.0009 0.0023 0.0023
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0306 0.1822 0.1822
Brugia malayi cathepsin Z-like cysteine proteinase 0.0306 0.1822 0.1822
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0032 0.0032
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0032 0.0032
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0306 0.1822 0.1822
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0167 0.0166
Entamoeba histolytica cysteine proteinase, putative 0.0854 0.5138 0.4054
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0032 0.0032
Giardia lamblia Cathepsin L-like protease 0.0306 0.1822 0.5
Echinococcus granulosus cysteine protease 0.0854 0.5138 0.5137
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0032 0.0032
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1657 1 1
Loa Loa (eye worm) hypothetical protein 0.1657 1 1
Plasmodium vivax vivapain-2 0.1657 1 1
Leishmania major cathepsin L-like protease 0.1657 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1657 1 1
Leishmania major cathepsin L-like protease 0.1657 1 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1109 0.6685 0.6681
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0166
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0728 0.0728
Brugia malayi Papain family cysteine protease containing protein 0.0306 0.1822 0.1822
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0032 0.0032
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0167 0.0166
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0306 0.1822 0.1822
Entamoeba histolytica cysteine proteinase, putative 0.1657 1 1
Echinococcus multilocularis cathepsin L 0.0306 0.1822 0.1822
Onchocerca volvulus 0.1657 1 1
Plasmodium vivax vivapain-1 0.0854 0.5138 0.4054
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0032 0.0032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0015 0.0014
Onchocerca volvulus 0.1657 1 1
Onchocerca volvulus 0.1657 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.1397 0.1397
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0032 0.0032

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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