Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.0885 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2519 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2519 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2519 | 1 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.0885 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.0885 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2519 | 1 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0271 | 0.0885 | 0.0885 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0963 | 0.3693 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0963 | 0.3693 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0963 | 0.3693 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.2519 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0963 | 0.3693 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2519 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.2519 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.0547 | 0.1027 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2519 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.0885 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0271 | 0.0885 | 0.0885 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0963 | 0.3693 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.0547 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.0885 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0963 | 0.3693 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.0885 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0178 | 0.0508 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2519 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.