Detailed information for compound 957670

Basic information

Technical information
  • TDR Targets ID: 957670
  • Name: (Z)-N-[(E)-2-(3,5-dibromo-4-hydroxyphenyl)eth enyl]-3-(4-hydroxyphenyl)-2-methoxyprop-2-ena mide
  • MW: 469.124 | Formula: C18H15Br2NO4
  • H donors: 3 H acceptors: 3 LogP: 4.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO/C(=C\c1ccc(cc1)O)/C(=O)N/C=C/c1cc(Br)c(c(c1)Br)O
  • InChi: 1S/C18H15Br2NO4/c1-25-16(10-11-2-4-13(22)5-3-11)18(24)21-7-6-12-8-14(19)17(23)15(20)9-12/h2-10,22-23H,1H3,(H,21,24)/b7-6+,16-10-
  • InChiKey: DIAAHMADUFVQJZ-OCSBKKPVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)vinyl]-3-(4-hydroxyphenyl)-2-methoxy-prop-2-enamide
  • (Z)-N-[(E)-2-(3,5-dibromo-4-hydroxyphenyl)vinyl]-3-(4-hydroxyphenyl)-2-methoxyprop-2-enamide
  • (Z)-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)vinyl]-3-(4-hydroxyphenyl)-2-methoxy-acrylamide
  • (Z)-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)ethenyl]-3-(4-hydroxyphenyl)-2-methoxy-prop-2-enamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Cryptosporidium parvum ABC transporter, AAA domain Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ATP-binding cassette sub-family G member 1, putative Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative Get druggable targets OG5_126574 All targets in OG5_126574
Giardia lamblia ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium vivax ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Neospora caninum hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ko:K05681 ATP-binding cassette, subfamily G (WHITE), member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium berghei ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania infantum ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium knowlesi ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Cryptosporidium hominis ABC transporter protein Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium falciparum ABC transporter G family member 2 Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Brugia malayi ABC transporter family protein Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania donovani ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei ABC transporter, putative ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 611 aa 557 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0115 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0059 0.4687 0.4687
Onchocerca volvulus Cathepsin F homolog 0.0115 1 1
Leishmania major cathepsin L-like protease 0.0115 1 1
Plasmodium falciparum serine repeat antigen 8 0.0021 0.1064 0.0908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0077 0.6377 0.6377
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0021 0.1064 0.1064
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0021 0.1064 0.1064
Echinococcus granulosus cathepsin l1 0.0077 0.6377 0.6314
Brugia malayi Cathepsin L-like precursor 0.0077 0.6377 0.6377
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.4687 0.4687
Brugia malayi cathepsin B-like cysteine proteinase 0.0021 0.1064 0.1064
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.4687 0.4687
Echinococcus multilocularis cathepsin L 0.0021 0.1064 0.0908
Giardia lamblia Cathepsin L precursor 0.0021 0.1064 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0021 0.1064 0.1064
Plasmodium vivax vivapain-2 0.0115 1 1
Giardia lamblia Cathepsin B precursor 0.0021 0.1064 1
Brugia malayi cathepsin L-like precursor 0.0077 0.6377 0.6377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0115 1 1
Plasmodium falciparum serine repeat antigen 9 0.0021 0.1064 0.0908
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0115 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.1064 0.1064
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0021 0.1064 0.0908
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0021 0.1064 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.2664 0.2664
Entamoeba histolytica cysteine protease, putative 0.0115 1 1
Leishmania major cysteine peptidase A (CPA) 0.0115 1 1
Toxoplasma gondii cathepsin CPC1 0.0021 0.1064 0.0908
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.1064 0.1064
Giardia lamblia Cathepsin B precursor 0.0021 0.1064 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.1064 0.1064
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.1064 0.1064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.1064 0.1064
Plasmodium falciparum serine repeat antigen 2 0.0021 0.1064 0.0908
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Entamoeba histolytica cysteine proteinase 1, putative 0.0059 0.4687 0.4594
Echinococcus granulosus cathepsin L cysteine protease 0.0059 0.4687 0.4594
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.4687 0.4594
Entamoeba histolytica cysteine protease, putative 0.0021 0.1064 0.0908
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.2664 0.2664
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0021 0.1064 0.0908
Loa Loa (eye worm) cysteine protease 0.0115 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0021 0.1064 0.0908
Brugia malayi cathepsin L-like cysteine proteinase 0.0021 0.1064 0.1064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.2664 0.2536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.6377 0.5946
Echinococcus granulosus cathepsin b 0.0021 0.1064 0.0908
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0021 0.1064 0.0908
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0021 0.1064 1
Plasmodium vivax unspecified product 0.0038 0.2664 0.2536
Giardia lamblia Cathepsin L-like protease 0.0021 0.1064 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0115 1 1
Entamoeba histolytica hypothetical protein 0.0021 0.1064 0.0908
Trypanosoma cruzi cruzipain precursor, putative 0.0115 1 1
Entamoeba histolytica cysteine protease, putative 0.0021 0.1064 0.0908
Loa Loa (eye worm) hypothetical protein 0.0021 0.1064 0.1064
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.1064 0.1064
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.1064 0.1064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 1 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0021 0.1064 0.0908
Giardia lamblia Hypothetical protein 0.0021 0.1064 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.6377 0.5946
Onchocerca volvulus Cathepsin L homolog 0.0115 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.1064 0.1064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.1064 0.1064
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0021 0.1064 0.0908
Echinococcus granulosus cathepsin L 0.0059 0.4687 0.4594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.4687 0.4054
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Brugia malayi Cathepsin L-like precursor 0.0115 1 1
Giardia lamblia Hypothetical protein 0.0021 0.1064 1
Giardia lamblia Cysteine protease 0.0021 0.1064 1
Echinococcus granulosus cathepsin l1 0.0115 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.1064 0.1064
Trypanosoma cruzi major cysteine proteinase, putative 0.0021 0.1064 0.0908
Plasmodium vivax vivapain-1 0.0059 0.4687 0.4594
Onchocerca volvulus 0.0115 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0115 1 1
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.1064 0.1064
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0059 0.4687 0.4687
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0021 0.1064 0.0908
Loa Loa (eye worm) hypothetical protein 0.0021 0.1064 0.1064
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Echinococcus multilocularis cathepsin b 0.0021 0.1064 0.0908
Trypanosoma cruzi cysteine peptidase, putative 0.0115 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0059 0.4687 0.4594
Loa Loa (eye worm) hypothetical protein 0.0077 0.6377 0.6377
Brugia malayi Papain family cysteine protease containing protein 0.0115 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0172 0.5
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0021 0.1064 0.0908
Leishmania major cathepsin L-like protease 0.0115 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0021 0.1064 0.1064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0059 0.4687 0.4594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.2664 0.2664
Plasmodium falciparum serine repeat antigen 5 0.0021 0.1064 0.0908
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0115 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.4687 0.4054
Plasmodium vivax unspecified product 0.0059 0.4687 0.4594
Echinococcus multilocularis cathepsin L cysteine protease 0.0115 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0038 0.2664 0.2664
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0021 0.1064 0.1064
Plasmodium falciparum serine repeat antigen 3 0.0021 0.1064 0.0908
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0021 0.1064 0.0908
Brugia malayi Cathepsin L-like precursor 0.0038 0.2664 0.2664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 1 1
Giardia lamblia Cysteine protease 0.0021 0.1064 1
Giardia lamblia Cathepsin B precursor 0.0021 0.1064 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.1064 0.1064
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0021 0.1064 0.0908
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.4687 0.4594
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0172 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0115 1 1
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Loa Loa (eye worm) hypothetical protein 0.0077 0.6377 0.6377
Onchocerca volvulus 0.0115 1 1
Loa Loa (eye worm) fibroinase 0.0115 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0115 1 1
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Brugia malayi Cathepsin L-like precursor 0.0115 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.1064 0.1064
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0021 0.1064 0.1064
Plasmodium vivax vivapain-3 0.0059 0.4687 0.4594
Plasmodium vivax unspecified product 0.0021 0.1064 0.0908
Trypanosoma cruzi cysteine protease, putative 0.0059 0.4687 0.4594
Giardia lamblia Cathepsin B precursor 0.0021 0.1064 1
Plasmodium falciparum serine repeat antigen 4 0.0021 0.1064 0.0908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0021 0.1064 0.1064
Onchocerca volvulus 0.0115 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Giardia lamblia Cathepsin B precursor 0.0021 0.1064 1
Trypanosoma cruzi cysteine proteinase, putative 0.0059 0.4687 0.4594
Brugia malayi Cathepsin L-like precursor 0.0115 1 1
Giardia lamblia Cysteine protease 0.0021 0.1064 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.1064 0.1064
Echinococcus granulosus cathepsin L 0.0021 0.1064 0.0908
Entamoeba histolytica cysteine proteinase 2 0.0059 0.4687 0.4594
Plasmodium vivax serine-repeat antigen (SERA) 0.0021 0.1064 0.0908
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0021 0.1064 0.1064
Entamoeba histolytica cysteine protease, putative 0.0021 0.1064 0.0908
Toxoplasma gondii cathepsin CPL 0.0115 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0077 0.6377 0.6314
Giardia lamblia Cathepsin L-like protease 0.0021 0.1064 1
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.4687 0.4594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 1 1
Plasmodium falciparum serine repeat antigen 6 0.0021 0.1064 0.0908
Loa Loa (eye worm) hypothetical protein 0.0115 1 1
Giardia lamblia Cathepsin L precursor 0.0021 0.1064 1
Onchocerca volvulus 0.0115 1 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0021 0.1064 0.0908
Loa Loa (eye worm) hypothetical protein 0.0038 0.2664 0.2664
Onchocerca volvulus Cathepsin L homolog 0.0115 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.4687 0.4594
Brugia malayi cathepsin L precursor 0.0021 0.1064 0.1064
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0021 0.1064 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.1064 0.1064
Toxoplasma gondii cathepsin CPC2 0.0021 0.1064 0.0908
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0021 0.1064 0.1064
Giardia lamblia Encystation-specific protease 0.0021 0.1064 1
Loa Loa (eye worm) ctsf protein 0.0115 1 1
Leishmania major cathepsin L-like protease 0.0115 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0115 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0077 0.6377 0.6314
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0115 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0021 0.1064 1
Leishmania major cathepsin L-like protease 0.0115 1 1
Plasmodium falciparum serine repeat antigen 7 0.0021 0.1064 0.0908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.4687 0.4594
Brugia malayi Cathepsin L-like precursor 0.0115 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0021 0.1064 0.0908
Brugia malayi Cathepsin L-like precursor 0.0115 1 1
Entamoeba histolytica cysteine protease, putative 0.0021 0.1064 0.0908
Trypanosoma brucei cysteine peptidase C (CPC) 0.0021 0.1064 0.0908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 1 1
Brugia malayi fibroinase precursor 0.0021 0.1064 0.1064
Echinococcus multilocularis cathepsin L 0.0059 0.4687 0.4594
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0115 1 1
Echinococcus multilocularis cysteine protease 0.0115 1 1
Echinococcus granulosus cysteine protease 0.0059 0.4687 0.4594
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.4687 0.4594
Giardia lamblia Cathepsin B precursor 0.0021 0.1064 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0021 0.1064 0.0908
Entamoeba histolytica cysteine protease, putative 0.0021 0.1064 0.0908
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0021 0.1064 0.0908
Brugia malayi cathepsin Z-like cysteine proteinase 0.0021 0.1064 0.1064
Onchocerca volvulus 0.0115 1 1
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Onchocerca volvulus 0.0115 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 1 1
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Schistosoma mansoni cathepsin s 0.0038 0.2664 0.2664
Giardia lamblia Cathepsin L precursor 0.0021 0.1064 1
Giardia lamblia Cathepsin B precursor 0.0021 0.1064 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.1064 0.1064
Schistosoma mansoni cathepsin C 0.0021 0.1064 0.1064
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0059 0.4687 0.4687
Echinococcus multilocularis cathepsin b 0.0021 0.1064 0.0908
Trypanosoma cruzi major cysteine proteinase, putative 0.0021 0.1064 0.0908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Onchocerca volvulus 0.0077 0.6377 0.5946
Leishmania major cathepsin L-like protease 0.0115 1 1
Echinococcus granulosus cathepsin b 0.0021 0.1064 0.0908
Leishmania major cathepsin L-like protease 0.0115 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0021 0.1064 0.1064
Entamoeba histolytica cysteine proteinase, putative 0.0115 1 1
Echinococcus multilocularis cysteine protease 0.0115 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0115 1 1
Schistosoma mansoni cathepsin S (C01 family) 0.0021 0.1064 0.1064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.1064 0.1064
Giardia lamblia Cathepsin L precursor 0.0021 0.1064 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0021 0.1064 0.0908
Trypanosoma cruzi cysteine peptidase, putative 0.0115 1 1
Entamoeba histolytica cysteine protease, putative 0.0021 0.1064 0.0908
Toxoplasma gondii preprocathepsin c precursor, putative 0.0021 0.1064 0.0908
Onchocerca volvulus 0.0115 1 1
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0012 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Giardia lamblia Cathepsin B precursor 0.0021 0.1064 1
Loa Loa (eye worm) cathepsin B 0.0021 0.1064 0.1064
Loa Loa (eye worm) hypothetical protein 0.0077 0.6377 0.6377
Plasmodium vivax vivapain-2 0.0115 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0021 0.1064 0.0908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 1 1
Toxoplasma gondii cathepsin B 0.0021 0.1064 0.0908
Leishmania major cathepsin L-like protease 0.0115 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0038 0.2664 0.2536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Plasmodium falciparum serine repeat antigen 1 0.0021 0.1064 0.0908
Leishmania major cathepsin L-like protease 0.0115 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 1 1
Giardia lamblia Cysteine protease 0.0021 0.1064 1
Giardia lamblia Cathepsin L precursor 0.0021 0.1064 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0059 0.4687 0.4594
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0115 1 1
Entamoeba histolytica cysteine protease, putative 0.0059 0.4687 0.4594
Schistosoma mansoni cathepsin B (C01 family) 0.0021 0.1064 0.1064
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0115 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0077 0.6377 0.6377
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0021 0.1064 0.0908
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0172 0.5
Plasmodium vivax serine-repeat antigen (SERA) 0.0021 0.1064 0.0908
Brugia malayi Cathepsin L-like precursor 0.0077 0.6377 0.6377
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0021 0.1064 0.1064
Plasmodium falciparum cysteine proteinase falcipain 3 0.0115 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0021 0.1064 0.0908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0038 0.2664 0.2664
Echinococcus granulosus cathepsin L cysteine proteinase 0.0115 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0115 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.4687 0.4594
Giardia lamblia Cathepsin L precursor 0.0021 0.1064 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6900 nM BindingDB_Patents: Inhibition Assay. Inhibition assay using ABCG2 or BCRP1. ChEMBL. No reference
IC50 (binding) = 6900 nM BindingDB_Patents: Inhibition Assay. Inhibition assay using ABCG2 or BCRP1. ChEMBL. No reference
IC50 (functional) = 110 uM Cytotoxicity against human HCT116 cells after 72 hrs by MTS/PMS assay ChEMBL. 15217298

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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