Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 0.0468 | 0.0846 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0468 | 0.0468 |
Onchocerca volvulus | 0.0251 | 0.5529 | 1 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0251 | 0.5529 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.022 | 0.4826 | 0.4826 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0441 | 0.1469 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0153 | 0.3264 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0141 | 0.3002 | 0.9197 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0468 | 0.1433 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.0468 | 0.1433 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0468 | 0.1433 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0468 | 0.1433 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.3002 | 0.9197 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.022 | 0.4826 | 0.4826 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0468 | 0.1558 |
Schistosoma mansoni | thyroid hormone receptor | 0.0153 | 0.3264 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.4983 | 0.4983 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0468 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.0468 | 0.1433 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0141 | 0.3002 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0153 | 0.3264 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0468 | 0.0468 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0468 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.0468 | 0.1433 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 36 nM | Displacement of [3H](+)-pentazocine from human sigma 1 receptor in human Jurkat cell membranes incubated for 2 hrs by liquid scintillation counting | ChEMBL. | 25462240 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.