Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ctsf protein | 0.0019 | 0.1472 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.1472 | 0.2968 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.1472 | 0.2968 |
Onchocerca volvulus | 0.0019 | 0.1472 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0019 | 0.1472 | 0.1472 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0019 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0019 | 0.1472 | 0.2968 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0013 | 0.0468 | 0.0944 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.4958 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0019 | 0.1472 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0013 | 0.0468 | 0.0944 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.1472 | 0.2968 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1472 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0056 | 0.7525 | 0.7525 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0019 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1472 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0013 | 0.0468 | 0.3182 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0019 | 0.1472 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.1472 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Onchocerca volvulus | 0.0019 | 0.1472 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.4958 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0013 | 0.0468 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0013 | 0.0468 | 0.0944 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1472 | 0.2968 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0013 | 0.0468 | 0.0944 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0019 | 0.1472 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.1472 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Leishmania major | cathepsin L-like protease | 0.0072 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.1472 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.1472 | 1 |
Onchocerca volvulus | 0.0019 | 0.1472 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.1472 | 0.2968 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0072 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.4958 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0013 | 0.0468 | 0.0944 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0019 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.4958 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.4958 | 1 |
Onchocerca volvulus | 0.0019 | 0.1472 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.4958 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0019 | 0.1472 | 0.2968 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1472 | 0.2968 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.1472 | 0.2968 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.1472 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0013 | 0.0468 | 0.0944 |
Onchocerca volvulus | 0.0019 | 0.1472 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.4958 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0019 | 0.1472 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0013 | 0.0468 | 0.0944 |
Onchocerca volvulus | 0.0019 | 0.1472 | 1 | |
Loa Loa (eye worm) | cysteine protease | 0.0019 | 0.1472 | 1 |
Onchocerca volvulus | 0.0019 | 0.1472 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.1472 | 0.2968 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.1472 | 0.2968 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1472 | 0.2968 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1472 | 0.2968 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.4958 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0019 | 0.1472 | 0.2968 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.4958 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0065 | 0.8997 | 0.8997 |
Leishmania major | cathepsin L-like protease | 0.0072 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1472 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of FtsZ-mediated cell division in Bacillus subtilis 168 assessed as effect on cell morphology | ChEMBL. | 19064318 | |
CC50 (ADMET) | = 570 uM | Cytotoxicity against human HuH7 cells expressing luc/neo after 72 hrs by MTT assay | ChEMBL. | 24035094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.