Detailed information for compound 958193

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 358.436 | Formula: C22H22N4O
  • H donors: 2 H acceptors: 2 LogP: 4.15 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1c1ccccc1)C(C#Cc1c(C)nc(nc1N)N)C
  • InChi: 1S/C22H22N4O/c1-14(9-11-18-15(2)25-22(24)26-21(18)23)17-10-12-19(20(13-17)27-3)16-7-5-4-6-8-16/h4-8,10,12-14H,1-3H3,(H4,23,24,25,26)
  • InChiKey: YYCPXVRHQUEVAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dihydrofolate reductase Starlite/ChEMBL References
Candida albicans dihydrofolate reductase Starlite/ChEMBL References
Bacillus anthracis Dihydrofolate reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania infantum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   162 aa 177 aa 27.7 %
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   162 aa 194 aa 26.3 %
Plasmodium yoelii thymidylate synthase, putative Dihydrofolate reductase   162 aa 147 aa 24.5 %
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   162 aa 167 aa 26.9 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase dihydrofolate reductase 187 aa 202 aa 29.7 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   162 aa 177 aa 27.1 %
Onchocerca volvulus Germline survival defective-1 homolog Dihydrofolate reductase   162 aa 165 aa 33.9 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   162 aa 177 aa 25.4 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   162 aa 153 aa 30.7 %
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Dihydrofolate reductase   162 aa 182 aa 30.2 %
Leishmania donovani dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   162 aa 177 aa 27.7 %
Onchocerca volvulus Putative dihydrofolate reductase Dihydrofolate reductase   162 aa 172 aa 36.6 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   162 aa 134 aa 29.9 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   162 aa 177 aa 29.9 %
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   162 aa 177 aa 29.4 %
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   162 aa 181 aa 27.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0292 0.0802
Loa Loa (eye worm) dihydrofolate reductase 0.0623 0.3641 0.4055
Onchocerca volvulus 0.0028 0.0066 0.0103
Echinococcus granulosus dro:myosuppressin receptor 0.0028 0.0066 0.0074
Echinococcus granulosus snurportin 1 0.0323 0.184 0.206
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0124 0.0139
Schistosoma mansoni ran 0.0022 0.0031 0.0034
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0292 0.0327
Brugia malayi CAAX amino terminal protease family protein 0.019 0.1037 0.116
Brugia malayi Dopamine receptor protein 1 0.0028 0.0066 0.0074
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0055 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0066 0.0074
Brugia malayi Bromodomain containing protein 0.0122 0.0629 0.0705
Echinococcus multilocularis dro:myosuppressin receptor 0.0028 0.0066 0.0066
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0028 0.0066 0.0074
Brugia malayi Dihydrofolate reductase 0.0623 0.3641 0.4075
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus granulosus dihydrofolate reductase 0.0623 0.3641 0.4075
Trypanosoma brucei ISWI complex protein 0.0049 0.0189 0.0212
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0066 0.0074
Brugia malayi RNA, U transporter 1 0.0086 0.0414 0.0464
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0028 0.0066 0.0074
Mycobacterium ulcerans lipase LipD 0.0038 0.0124 0.034
Leishmania major hypothetical protein, conserved 0.0038 0.0124 0.0139
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0066 0.0066
Echinococcus granulosus 7TM GPCR rhodopsin 0.0028 0.0066 0.0074
Echinococcus granulosus neuropeptide FF receptor 2 0.0028 0.0066 0.0074
Onchocerca volvulus Neuropeptide F receptor homolog 0.0028 0.0066 0.0103
Mycobacterium ulcerans beta-lactamase 0.0038 0.0124 0.034
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0028 0.0066 0.0066
Onchocerca volvulus 0.0038 0.0124 0.3425
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.078 0.0874
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0066 0.0066
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0028 0.0066 0.004
Echinococcus granulosus tachykinin peptides receptor 99D 0.0028 0.0066 0.0074
Schistosoma mansoni hypothetical protein 0.0109 0.0553 0.0619
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0028 0.0066 0.0066
Brugia malayi AKH receptor 0.0028 0.0066 0.0074
Echinococcus multilocularis orexin receptor type 2 0.0028 0.0066 0.0066
Brugia malayi MH2 domain containing protein 0.0387 0.2226 0.2492
Plasmodium falciparum importin beta, putative 0.003 0.0079 0.0592
Schistosoma mansoni smad1 5 8 and 0.0026 0.0055 0.0062
Entamoeba histolytica CAAX amino terminal protease family 0.0039 0.0132 0.1007
Echinococcus multilocularis snurportin 1 0.0323 0.184 0.184
Echinococcus granulosus histone lysine methyltransferase setb 0.0055 0.0227 0.0254
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0034
Brugia malayi neuropeptide F receptor 0.0028 0.0066 0.0074
Brugia malayi Melatonin receptor type 1A 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0054
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0195 0.0218
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0073 0.0338 0.0338
Entamoeba histolytica hypothetical protein 0.0109 0.0553 0.5189
Echinococcus granulosus alpha 1A adrenergic receptor 0.0028 0.0066 0.0074
Schistosoma mansoni zinc finger protein 0.0049 0.0189 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0066 0.0074
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0028 0.0066 0.004
Brugia malayi latrophilin 2 splice variant baaae 0.0215 0.1192 0.1334
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0066 0.0066
Loa Loa (eye worm) beta-lactamase 0.0038 0.0124 0.0105
Schistosoma mansoni amine GPCR 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0028 0.0066 0.004
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.078 0.0874
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.019 0.1037 0.116
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0066 0.0074
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0099 0.0272
Echinococcus multilocularis neuropeptide FF receptor 2 0.0028 0.0066 0.0066
Brugia malayi RE15519p 0.0028 0.0066 0.0074
Leishmania major trypanothione reductase 0.005 0.0195 0.0218
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0553 0.0553
Brugia malayi RNA binding protein 0.047 0.272 0.3044
Echinococcus granulosus somatostatin receptor 0.0028 0.0066 0.0074
Onchocerca volvulus 0.0028 0.0066 0.0103
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0099 0.0746
Echinococcus multilocularis CAAX prenyl protease 2 0.019 0.1037 0.1037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0066 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus granulosus neuropeptide s receptor 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Brugia malayi MH2 domain containing protein 0.0026 0.0055 0.0062
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0099 0.0746
Chlamydia trachomatis hypothetical protein 0.0039 0.0132 0.0362
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0066 0.0066
Echinococcus multilocularis serotonin receptor 0.0028 0.0066 0.0066
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0066 0.0074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0066 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0066 0.0066
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0192 0.1049 0.1049
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.1764 0.1975
Loa Loa (eye worm) hypothetical protein 0.019 0.1037 0.113
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0066 0.0066
Echinococcus multilocularis g-protein coupled receptor 0.0028 0.0066 0.0066
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0623 0.3641 1
Schistosoma mansoni cpg binding protein 0.0028 0.0064 0.0072
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0066 0.0074
Echinococcus granulosus neuropeptide receptor 0.0028 0.0066 0.0074
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0028 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Schistosoma mansoni smad1 5 8 and 0.0026 0.0055 0.0062
Loa Loa (eye worm) TYRA-2 protein 0.0028 0.0066 0.004
Brugia malayi G-protein coupled receptor 0.0028 0.0066 0.0074
Leishmania major hypothetical protein, conserved 0.0049 0.0189 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0734 0.0822
Echinococcus granulosus microtubule associated protein 2 0.1503 0.8935 1
Schistosoma mansoni transient receptor potential channel 4 0.0105 0.0529 0.0592
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0028 0.0066 0.0074
Schistosoma mansoni hypothetical protein 0.0028 0.0066 0.0074
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.019 0.1037 0.116
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0028 0.0066 0.0074
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0099 0.0111
Brugia malayi Bromodomain containing protein 0.024 0.1341 0.1501
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0252 0.0282
Brugia malayi Smad1 0.0026 0.0055 0.0062
Brugia malayi Transient-receptor-potential like protein 0.0039 0.0132 0.0147
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.0034
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0553 0.0619
Echinococcus granulosus serotonin receptor 0.0028 0.0066 0.0074
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0654 0.1795
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0159 0.0178
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0028 0.0066 0.0074
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0124 0.1195
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.078 0.0874
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0578 0.1586
Plasmodium falciparum thioredoxin reductase 0.005 0.0195 0.1469
Schistosoma mansoni opsin-like receptor 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.009
Trypanosoma brucei trypanothione reductase 0.005 0.0195 0.0218
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0028 0.0066 0.0074
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0099 0.0111
Onchocerca volvulus 0.0028 0.0066 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0066 0.0074
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0066 0.0066
Echinococcus granulosus CAAX prenyl protease 2 0.019 0.1037 0.116
Brugia malayi dihydrofolate reductase family protein 0.0623 0.3641 0.4075
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0028 0.0066 0.004
Onchocerca volvulus 0.0028 0.0066 0.0103
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0099 0.0746
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0227 0.0254
Onchocerca volvulus 0.0028 0.0066 0.0103
Echinococcus multilocularis zinc finger protein 0.0064 0.0281 0.0281
Brugia malayi Serotonin receptor 0.0028 0.0066 0.0074
Brugia malayi hypothetical protein 0.0028 0.0066 0.0074
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0259 0.1953
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1503 0.8935 1
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0066 0.004
Brugia malayi hypothetical protein 0.0028 0.0066 0.0074
Onchocerca volvulus 0.0028 0.0066 0.0103
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0044 0.0426
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0734 0.0822
Schistosoma mansoni Smad4 0.0026 0.0055 0.0062
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Onchocerca volvulus 0.0028 0.0066 0.0103
Mycobacterium ulcerans hypothetical protein 0.0039 0.0132 0.0362
Schistosoma mansoni transient receptor potential channel 0.0105 0.0529 0.0592
Echinococcus multilocularis geminin 0.0185 0.1008 0.1008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0124 0.034
Loa Loa (eye worm) hypothetical protein 0.0215 0.1192 0.1304
Schistosoma mansoni hypothetical protein 0.0185 0.1008 0.1128
Schistosoma mansoni neuropeptide f receptor 76f 0.0028 0.0066 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0734 0.0822
Loa Loa (eye worm) hypothetical protein 0.0066 0.0294 0.0295
Schistosoma mansoni adenoreceptor 0.0028 0.0066 0.0074
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.019 0.1037 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0292 0.0292
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0623 0.3641 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0066 0.0074
Brugia malayi RNA recognition motif domain containing protein 0.047 0.272 0.3044
Loa Loa (eye worm) PHD-finger family protein 0.0066 0.0291 0.0293
Schistosoma mansoni opsin-like receptor 0.0028 0.0066 0.0074
Brugia malayi CXXC zinc finger family protein 0.0028 0.0064 0.0072
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0195 0.0185
Leishmania major C-8 sterol isomerase-like protein 0.1503 0.8935 1
Entamoeba histolytica CAAX prenyl protease family 0.019 0.1037 1
Mycobacterium tuberculosis Probable oxidoreductase 0.027 0.1523 0.4181
Schistosoma mansoni dihydrofolate reductase 0.0623 0.3641 0.4075
Toxoplasma gondii thioredoxin reductase 0.005 0.0195 0.1469
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.01 0.0496 0.0555
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0124 0.034
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0099 0.0111
Echinococcus granulosus methyl CpG binding domain protein 2 0.0054 0.0223 0.0249
Echinococcus multilocularis importin subunit beta 1 0.003 0.0079 0.0079
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0099 0.0746
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0066 0.0074
Mycobacterium tuberculosis Conserved protein 0.0038 0.0124 0.034
Onchocerca volvulus 0.0028 0.0066 0.0103
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0553 0.0619
Loa Loa (eye worm) hypothetical protein 0.1503 0.8935 1
Brugia malayi glutathione reductase 0.005 0.0195 0.0218
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0124 0.0105
Onchocerca volvulus 0.0028 0.0066 0.0103
Schistosoma mansoni histamine h1 receptor 0.0028 0.0066 0.0074
Echinococcus multilocularis allatostatin A receptor 0.0028 0.0066 0.0066
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0099 0.0111
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0578 0.1586
Entamoeba histolytica hypothetical protein 0.0109 0.0553 0.5189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0066 0.0074
Brugia malayi hypothetical protein 0.0028 0.0066 0.0074
Echinococcus multilocularis tar DNA binding protein 0.047 0.272 0.272
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Brugia malayi beta-lactamase 0.0038 0.0124 0.0139
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0066 0.0074
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0578 0.129
Brugia malayi MH1 domain containing protein 0.0026 0.0055 0.0062
Echinococcus multilocularis G-protein coupled receptor, putative 0.0028 0.0066 0.0066
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.019 0.1037 0.116
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0028 0.0066 0.004
Brugia malayi Latrophilin receptor protein 2 0.01 0.0496 0.0555
Loa Loa (eye worm) hypothetical protein 0.0055 0.0227 0.022
Schistosoma mansoni tar DNA-binding protein 0.047 0.272 0.3044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0105
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0028 0.0066 0.0074
Brugia malayi hypothetical protein 0.0028 0.0066 0.0074
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0124 0.034
Treponema pallidum hypothetical protein 0.0039 0.0132 1
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0238 0.0267
Brugia malayi G protein-coupled receptor F59B2.13 0.0028 0.0066 0.0074
Echinococcus granulosus tumor protein p63 0.0388 0.2233 0.2499
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Mycobacterium tuberculosis Probable reductase 0.0113 0.0578 0.1586
Echinococcus multilocularis short transient receptor potential channel 6 0.007 0.0315 0.0315
Echinococcus granulosus g protein coupled receptor 0.0028 0.0066 0.0074
Echinococcus granulosus geminin 0.0185 0.1008 0.1128
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Schistosoma mansoni methyl-cpg binding protein mbd 0.0054 0.0223 0.0249
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Giardia lamblia Hypothetical protein 0.019 0.1037 1
Brugia malayi hypothetical protein 0.0028 0.0066 0.0074
Echinococcus granulosus smad 0.0026 0.0055 0.0062
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0159 0.0178
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.047 0.272 0.3021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0109 0.0553 0.5189
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.1764 0.1975
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0105
Schistosoma mansoni amine GPCR 0.0028 0.0066 0.0074
Schistosoma mansoni hypothetical protein 0.0049 0.0189 0.0212
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0132 0.0362
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0066 0.0074
Echinococcus multilocularis dihydrofolate reductase 0.0623 0.3641 0.3641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.013 0.0676 0.0725
Schistosoma mansoni hypothetical protein 0.01 0.0496 0.0555
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0028 0.0066 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0066 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0124 0.1195
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0028 0.0066 0.0074
Onchocerca volvulus 0.0028 0.0066 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0734 0.0822
Trypanosoma cruzi ISWI complex protein 0.0049 0.0189 0.0212
Echinococcus multilocularis microtubule associated protein 2 0.1503 0.8935 0.8935
Schistosoma mansoni neuropeptide receptor 0.0028 0.0066 0.0074
Mycobacterium tuberculosis Conserved protein 0.0038 0.0124 0.034
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0 0.5
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.023
Echinococcus granulosus fetal alzheimer antigen falz 0.0073 0.0338 0.0378
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.1764 0.1975
Schistosoma mansoni cpg binding protein 0.0036 0.011 0.0123
Schistosoma mansoni hypothetical protein 0.0066 0.0291 0.0326
Trypanosoma cruzi ISWI complex protein 0.0049 0.0189 0.0212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0734 0.0822
Brugia malayi hypothetical protein 0.0028 0.0066 0.0074
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0099 0.0099
Onchocerca volvulus 0.0028 0.0066 0.0103
Mycobacterium ulcerans hypothetical protein 0.0039 0.0132 0.0362
Brugia malayi G protein-coupled receptor 0.0028 0.0066 0.0074
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0031 0.023
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0195 0.1469
Echinococcus multilocularis short transient receptor potential channel 6 0.007 0.0315 0.0315
Mycobacterium ulcerans hypothetical protein 0.0164 0.088 0.2418
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0066 0.0066
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.019 0.1037 0.116
Schistosoma mansoni hypothetical protein 0.0215 0.1192 0.1334
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Brugia malayi Dopamine receptor 0.0028 0.0066 0.0074
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0124 0.034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus multilocularis serotonin receptor 0.0028 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Entamoeba histolytica hypothetical protein 0.0025 0.0044 0.0136
Loa Loa (eye worm) hypothetical protein 0.0105 0.0529 0.0559
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0031 0.023
Echinococcus granulosus G protein coupled receptor 139 0.0028 0.0066 0.0074
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0055 0.0028
Toxoplasma gondii ABC1 family protein 0.0038 0.0124 0.0933
Schistosoma mansoni amine GPCR 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0105
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0734 0.079
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0192 0.1049 0.1174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0066 0.0066
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0315 0.1791 0.1977
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.088 0.2418
Onchocerca volvulus 0.0038 0.0124 0.3425
Mycobacterium ulcerans integral membrane protein 0.0039 0.0132 0.0362
Plasmodium vivax importin-beta 2, putative 0.003 0.0079 0.0592
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0734 0.0734
Schistosoma mansoni ran 0.0022 0.0031 0.0034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0124 0.0139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0066 0.0074
Onchocerca volvulus 0.0028 0.0066 0.0103
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0124 0.034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus granulosus g-protein coupled receptor 0.0028 0.0066 0.0074
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0124 0.1195
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0044 0.0426
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0066 0.0074
Schistosoma mansoni hypothetical protein 0.0028 0.0066 0.0074
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0099 0.0077
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0028 0.0066 0.0066
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0238 0.1328 0.1487
Echinococcus granulosus sex peptide receptor 0.0028 0.0066 0.0074
Brugia malayi isocitrate dehydrogenase 0.0034 0.0099 0.0111
Entamoeba histolytica CAAX amino terminal protease family 0.0039 0.0132 0.1007
Onchocerca volvulus 0.0028 0.0066 0.0103
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0295
Brugia malayi Thioredoxin reductase 0.005 0.0195 0.0218
Loa Loa (eye worm) hypothetical protein 0.0315 0.1791 0.1977
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0292 0.0802
Trypanosoma brucei C-8 sterol isomerase, putative 0.1503 0.8935 1
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0066 0.0074
Schistosoma mansoni amine GPCR 0.0028 0.0066 0.0074
Schistosoma mansoni smad 0.0026 0.0055 0.0062
Echinococcus multilocularis transient receptor potential gamma protein 0.0105 0.0529 0.0529
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0124 0.034
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0238 0.1328 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0028 0.0066 0.0074
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0292 0.2199
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0124 0.1195
Echinococcus multilocularis sex peptide receptor 0.0028 0.0066 0.0066
Echinococcus multilocularis smad 0.0026 0.0055 0.0055
Schistosoma mansoni tar DNA-binding protein 0.047 0.272 0.3044
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0195 0.0218
Plasmodium falciparum glutathione reductase 0.005 0.0195 0.1469
Loa Loa (eye worm) hypothetical protein 0.0122 0.0631 0.0674
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0028 0.0066 0.0066
Schistosoma mansoni alpha-1 adrenergic receptor 0.0028 0.0066 0.0074
Loa Loa (eye worm) RNA binding protein 0.047 0.272 0.3021
Loa Loa (eye worm) glutathione reductase 0.005 0.0195 0.0185
Echinococcus multilocularis neuropeptide receptor A26 0.0028 0.0066 0.0066
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0238 0.1328 0.1487
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0028 0.0066 0.0074
Mycobacterium tuberculosis Probable integral membrane protein 0.0039 0.0132 0.0362
Loa Loa (eye worm) melatonin receptor type 1A 0.0028 0.0066 0.004
Schistosoma mansoni transient receptor potential channel 0.007 0.0315 0.0352
Onchocerca volvulus 0.0028 0.0066 0.0103
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0578 0.1586
Plasmodium falciparum protease, putative 0.0039 0.0132 0.0992
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.1764 0.1975
Brugia malayi MH1 domain containing protein 0.0026 0.0055 0.0062
Toxoplasma gondii hypothetical protein 0.0039 0.0132 0.0992
Brugia malayi hypothetical protein 0.0109 0.0553 0.0619
Loa Loa (eye worm) Smad1 0.0026 0.0055 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0055 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Brugia malayi MH2 domain containing protein 0.0026 0.0055 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0292 0.0327
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus granulosus peptide allatostatin:somatostatin 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0039 0.0132 0.0114
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0066 0.0066
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0066 0.0066
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0028 0.0066 0.0074
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.01 0.0496 0.0496
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.01 0.0496 0.0496
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.0034
Toxoplasma gondii CAAX amino terminal protease family protein 0.0039 0.0132 0.0992
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0654 0.1506
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0099 0.0111
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0079 0.0088
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Onchocerca volvulus 0.0028 0.0066 0.0103
Loa Loa (eye worm) hypothetical protein 0.01 0.0496 0.0523
Chlamydia trachomatis dihydrofolate reductase 0.0623 0.3641 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0099 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0066 0.0074
Leishmania major importin beta-1 subunit, putative 0.0025 0.0044 0.0049
Schistosoma mansoni opsin-like receptor 0.0028 0.0066 0.0074
Brugia malayi ORL1-like opioid receptor 0.0028 0.0066 0.0074
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0114 0.0584 0.0584
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0099 0.0099
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0055 0.0062
Brugia malayi G-protein coupled receptor 0.0028 0.0066 0.0074
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.184 0.2032
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0039 0.0132 0.0132
Brugia malayi Dopamine receptor protein 2 0.0028 0.0066 0.0074
Schistosoma mansoni tar DNA-binding protein 0.047 0.272 0.3044
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0064 0.0038
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0159 0.0178
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0066 0.004
Schistosoma mansoni transient receptor potential channel 0.007 0.0315 0.0352
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0105
Trichomonas vaginalis esterase, putative 0.0038 0.0124 0.1195
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0066 0.0066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.01 0.0496 0.0555
Brugia malayi Serotonin receptor 0.0028 0.0066 0.0074
Toxoplasma gondii hypothetical protein 0.005 0.0198 0.1489
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0066 0.0074
Schistosoma mansoni methyl-cpg binding protein mbd 0.0054 0.0223 0.0249
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0099 0.0111
Mycobacterium ulcerans hypothetical protein 0.0038 0.0124 0.034
Brugia malayi follicle stimulating hormone receptor 0.0028 0.0066 0.0074
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0066 0.0066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0066 0.0074
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0238 0.1328 1
Echinococcus granulosus TRP transient receptor potential channel 0.0039 0.0132 0.0147
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0066 0.0074
Schistosoma mansoni biogenic amine receptor 0.0028 0.0066 0.0074
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0238 0.1328 0.1487
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Brugia malayi hypothetical protein 0.0028 0.0066 0.0074
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0066 0.0074
Schistosoma mansoni hypothetical protein 0.01 0.0496 0.0555
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0654 0.1795
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0066 0.0066
Echinococcus granulosus neuropeptide receptor 0.0028 0.0066 0.0074
Echinococcus granulosus Smad4 0.0026 0.0055 0.0062
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0028 0.0066 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0124 0.0139
Echinococcus granulosus neuropeptide receptor A26 0.0028 0.0066 0.0074
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0028 0.0066 0.0074
Echinococcus granulosus importin subunit beta 1 0.003 0.0079 0.0088
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0066 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.1503 0.8935 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus granulosus short transient receptor potential channel 6 0.007 0.0315 0.0352
Echinococcus granulosus short transient receptor potential channel 6 0.007 0.0315 0.0352
Loa Loa (eye worm) latrophilin receptor protein 2 0.01 0.0496 0.0523
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0055 0.0227 0.0227
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0079 0.0592
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0124 0.034
Toxoplasma gondii hypothetical protein 0.0039 0.0132 0.0992
Trypanosoma brucei CAAX amino terminal protease, putative 0.019 0.1037 0.116
Loa Loa (eye worm) hypothetical protein 0.0137 0.0722 0.0777
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0066 0.0066
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0039 0.0132 0.0362
Brugia malayi Calcitonin receptor-like protein seb-1 0.0315 0.1791 0.2005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0315 0.1791 0.2005
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0124 0.1195
Brugia malayi beta-lactamase family protein 0.0038 0.0124 0.0139
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0292 0.0327
Loa Loa (eye worm) bromodomain containing protein 0.0056 0.0235 0.0229
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0217 0.0242
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0028 0.0066 0.0066
Onchocerca volvulus 0.0057 0.0238 1
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.019 0.1037 0.116
Echinococcus granulosus transient receptor potential ion channel A 0.0102 0.0508 0.0568
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0066 0.0074
Schistosoma mansoni neuropeptide receptor 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Schistosoma mansoni hypothetical protein 0.0185 0.1008 0.1128
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0066 0.0066
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0124 0.0139
Echinococcus granulosus transient receptor potential gamma protein 0.0105 0.0529 0.0592
Echinococcus multilocularis tumor protein p63 0.0388 0.2233 0.2233
Loa Loa (eye worm) transcription factor SMAD2 0.0387 0.2226 0.2466
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0124 0.0139
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0578 0.1586
Schistosoma mansoni tar DNA-binding protein 0.047 0.272 0.3044
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0099 0.0099
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0028 0.0066 0.0066
Echinococcus granulosus orexin receptor type 2 0.0028 0.0066 0.0074
Entamoeba histolytica hypothetical protein 0.0109 0.0553 0.5189
Echinococcus multilocularis transient receptor potential ion channel A 0.0102 0.0508 0.0508
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0124 0.034
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0044 0.0426
Schistosoma mansoni biogenic amine receptor 0.0028 0.0066 0.0074
Echinococcus granulosus cpg binding protein 0.0036 0.011 0.0123
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0066 0.0074
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0578 0.1586
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0734 0.0822
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0124 0.034
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0073 0.0338 0.0378
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0195 0.0536
Trichomonas vaginalis ran, putative 0.0022 0.0031 0.0295
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0055 0.0062
Schistosoma mansoni tar DNA-binding protein 0.047 0.272 0.3044
Schistosoma mansoni biogenic amine receptor 0.0028 0.0066 0.0074
Plasmodium vivax protease, putative 0.0039 0.0132 0.0992
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Schistosoma mansoni hypothetical protein 0.01 0.0496 0.0555
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0039 0.0132 0.0362
Plasmodium vivax glutathione reductase, putative 0.005 0.0195 0.1469
Brugia malayi Importin beta-1 subunit 0.003 0.0079 0.0088
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0055 0.0062
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0079 0.0088
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Brugia malayi putative neuropeptide receptor NPR1 0.0028 0.0066 0.0074
Schistosoma mansoni neuropeptide receptor 0.0028 0.0066 0.0074
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0114 0.0584 0.0654
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0028 0.0066 0.0074
Schistosoma mansoni hypothetical protein 0.01 0.0496 0.0555
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0623 0.3641 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0031 0.0031
Onchocerca volvulus 0.0038 0.0124 0.3425
Echinococcus granulosus g protein coupled receptor 0.0028 0.0066 0.0074
Echinococcus multilocularis neuropeptide s receptor 0.0028 0.0066 0.0066
Onchocerca volvulus 0.0028 0.0066 0.0103
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0028 0.0066 0.0074
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Schistosoma mansoni smad1 5 8 and 0.0026 0.0055 0.0062
Echinococcus granulosus tar DNA binding protein 0.047 0.272 0.3044
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0195 0.0195
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0031 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.01 0.0496 0.0555
Echinococcus granulosus fmrfamide receptor 0.0028 0.0066 0.0074
Schistosoma mansoni cpg binding protein 0.0036 0.011 0.0123
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0159 0.0178
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0066 0.0074
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0099 0.0099
Echinococcus granulosus g protein coupled receptor 0.0028 0.0066 0.0074
Schistosoma mansoni zinc finger protein 0.0064 0.0281 0.0314
Schistosoma mansoni amine GPCR 0.0028 0.0066 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0124 0.0139
Schistosoma mansoni bromodomain containing protein 0.0203 0.1117 0.125
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0099 0.0111
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Brugia malayi hypothetical protein 0.0028 0.0066 0.0074
Schistosoma mansoni neuropeptide receptor 0.0028 0.0066 0.0074
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0054 0.0223 0.0223
Brugia malayi GnHR receptor homolog 0.0028 0.0066 0.0074
Schistosoma mansoni importin beta-1 0.003 0.0079 0.0088
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0066 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0066 0.0074
Mycobacterium tuberculosis Conserved protein 0.0038 0.0124 0.034
Loa Loa (eye worm) hypothetical protein 0.0768 0.4516 0.5038
Loa Loa (eye worm) hypothetical protein 0.0225 0.125 0.1369
Onchocerca volvulus 0.0028 0.0066 0.0103
Echinococcus multilocularis somatostatin receptor 0.0028 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0105
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0292 0.0327
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0066 0.0074
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0066 0.0074
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0066 0.0074
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0066 0.0066
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.1349 0.3705
Echinococcus multilocularis Smad4 0.0026 0.0055 0.0055
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0066 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0227 0.0254
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0044 0.0049
Leishmania major GTP-binding protein, putative 0.0022 0.0031 0.0034
Brugia malayi PHD-finger family protein 0.0081 0.0383 0.0428
Echinococcus multilocularis G protein coupled receptor 139 0.0028 0.0066 0.0066
Brugia malayi beta-lactamase family protein 0.0038 0.0124 0.0139
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0066 0.0074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0292 0.0802
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0066 0.004
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0028 0.0066 0.0074
Brugia malayi TAR-binding protein 0.047 0.272 0.3044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0066 0.0074
Brugia malayi hypothetical protein 0.0028 0.0066 0.0074
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0238 0.1328 1
Brugia malayi neuropeptide F receptor 0.0028 0.0066 0.0074
Echinococcus granulosus 7tm_1 domain containing protein 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0387 0.2226 0.2466
Schistosoma mansoni hypothetical protein 0.0323 0.184 0.206
Echinococcus multilocularis GPCR, family 2 0.01 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0105
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0028 0.0066 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0124 0.0933
Schistosoma mansoni myosin xvIII 0.0028 0.0066 0.0074
Brugia malayi larval opioid receptor 0.0028 0.0066 0.0074
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0028 0.0066 0.0103
Brugia malayi Tachykinin-like peptides receptor 99D 0.0028 0.0066 0.0074
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0654 0.1795
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus granulosus GPCR family 2 0.01 0.0496 0.0555
Brugia malayi hypothetical protein 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0057 0.0238 0.0234
Echinococcus granulosus zinc finger protein 0.0064 0.0281 0.0314
Brugia malayi sulfakinin receptor protein 0.0028 0.0066 0.0074
Schistosoma mansoni hypothetical protein 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Brugia malayi putative neuropeptide receptor 0.0028 0.0066 0.0074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0292 0.0802
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0124 0.0139
Echinococcus multilocularis cpg binding protein 0.0036 0.011 0.011
Mycobacterium ulcerans short chain dehydrogenase 0.027 0.1523 0.4181
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0066 0.0074
Loa Loa (eye worm) TAR-binding protein 0.047 0.272 0.3021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.004
Echinococcus granulosus allatostatin A receptor 0.0028 0.0066 0.0074
Echinococcus granulosus hypothetical protein 0.0028 0.0066 0.0074
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0055 0.0055
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1503 0.8935 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0066 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0066 0.0074
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.0034

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 55 nM Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPH ChEMBL. 24568657
IC50 (binding) = 1420 nM Inhibition of human dihydrofolate reductase by spectrophotometry ChEMBL. 18834108
IC50 (binding) = 1420 nM Inhibition of human DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPH ChEMBL. 24568657
IC50 (binding) = 0.055 uM Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrate ChEMBL. 19560363
IC50 (binding) = 1.42 uM Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as substrate ChEMBL. 19560363
IC50 (binding) = 17.3 uM Inhibition of wild type Bacillus anthracis recombinant DHFR ChEMBL. 20882962
IC50 (ADMET) = 80 uM Cytotoxicity against human MCF10 cells ChEMBL. 24568657
Ki (binding) = 5.83 uM Inhibition of wild type Bacillus anthracis recombinant DHFR ChEMBL. 20882962
MIC (functional) = 6.25 ug ml-1 Antifungal activity against Candida albicans NCCLS84 after 24 hrs by XTT assay ChEMBL. 24568657
MIC (functional) = 45 ug ml-1 Antifungal activity against Candida albicans by alamar blue assay ChEMBL. 19560363

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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