TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 419.842 | Formula: C17H14ClN5O4S
H donors: 0 H acceptors: 5 LogP: 3.3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)C(=O)N1CCN(CC1)c1nnc(s1)c1ccc(o1)[N+](=O)[O-]
InChi: 1S/C17H14ClN5O4S/c18-12-3-1-2-11(10-12)16(24)21-6-8-22(9-7-21)17-20-19-15(28-17)13-4-5-14(27-13)23(25)26/h1-5,10H,6-9H2
InChiKey: CONKNLVBKVEKDC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	DNA topoisomerase type I	0.992293	0.744776	0.744776
Leishmania major	protein kinase, putative	0.00257145	0.000381647	0.000512432
Mycobacterium ulcerans	DNA topoisomerase I	0.00295095	0.000667077	0.173005
Leishmania major	histone deacetylase, putative	0.0795785	0.0583006	0.0782794
Schistosoma mansoni	brca1-associated protein (brap2)	0.00348956	0.00107218	0.00107218
Treponema pallidum	DNA topoisomerase I (topA)	0.00295095	0.000667077	0.5
Echinococcus multilocularis	histone deacetylase 6	0.0913032	0.0671191	0.0671191
Leishmania major	histone deacetylase, putative	0.0878137	0.0644945	0.0865958
Leishmania major	histone deacetylase, putative	0.0795785	0.0583006	0.0782794
Trypanosoma brucei	membrane transporter protein, putative	0.0189884	0.0127292	0.0170913
Trypanosoma brucei	histone deacetylase 2	0.0389752	0.0277618	0.0372754
Brugia malayi	histone deacetylase 3 (HD3)	0.0795785	0.0583006	0.057672
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0795785	0.0583006	1
Brugia malayi	BRCA1-associated protein 2 containing protein	0.00348956	0.00107218	0.000405373
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.00348956	0.00107218	0.00702893
Mycobacterium ulcerans	putative regulatory protein	0.00719061	0.00385583	1
Echinococcus multilocularis	histone deacetylase 1	0.0795785	0.0583006	0.0583006
Leishmania major	hypothetical protein, conserved	0.0189884	0.0127292	0.0170913
Trypanosoma brucei	membrane transporter protein, putative	0.0189884	0.0127292	0.0170913
Echinococcus multilocularis		0.0509054	0.0367348	0.0367348
Schistosoma mansoni	histone deacetylase hda2	0.0913032	0.0671191	0.0671191
Plasmodium vivax	U4/U6.U5 tri-snRNP-associated protein 2, putative	0.00348956	0.00107218	0.00107218
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.00348956	0.00107218	0.000405373
Trichomonas vaginalis	histone deacetylase, putative	0.0795785	0.0583006	1
Echinococcus granulosus	histone deacetylase 3	0.0795785	0.0583006	0.0583006
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.00697762	0.00369563	0.00369563
Echinococcus multilocularis	BRCA1 associated protein	0.00348956	0.00107218	0.00107218
Plasmodium falciparum	DNA topoisomerase 3, putative	0.00295095	0.000667077	0.000667077
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.00348956	0.00107218	0.000725762
Trypanosoma brucei	histone deacetylase, putative	0.0878137	0.0644945	0.0865958
Loa Loa (eye worm)	hypothetical protein	0.0325948	0.0229629	0.0226241
Trypanosoma cruzi	Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative	0.00348956	0.00107218	0.0014396
Trypanosoma brucei	DNA topoisomerase IA, putative	0.00295095	0.000667077	0.000895675
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.00348956	0.00107218	0.0125187
Schistosoma mansoni	ubiquitin-specific peptidase 44 (C19 family)	0.00348956	0.00107218	0.00107218
Echinococcus granulosus	histone deacetylase 1	0.0795785	0.0583006	0.0583006
Toxoplasma gondii	histone deacetylase HDAC1	0.0878137	0.0644945	0.0644945
Plasmodium vivax	hypothetical protein, conserved	0.00348956	0.00107218	0.00107218
Trichomonas vaginalis	histone deacetylase, putative	0.0795785	0.0583006	1
Brugia malayi	Carboxylesterase family protein	0.00697762	0.00369563	0.00303058
Loa Loa (eye worm)	histone deacetylase 11	0.0389752	0.0277618	0.0274247
Loa Loa (eye worm)	hypothetical protein	0.0795785	0.0583006	0.0579741
Trypanosoma brucei	DNA topoisomerase IB, large subunit	0.992293	0.744776	1
Trypanosoma cruzi	membrane transporter protein, putative	0.0189884	0.0127292	0.0170913
Trypanosoma brucei	histone deacetylase 3	0.0878137	0.0644945	0.0865958
Schistosoma mansoni	aryl hydrocarbon receptor	0.00971556	0.00575491	0.00575491
Echinococcus multilocularis	aryl hydrocarbon receptor	0.00252495	0.000346669	0.000346669
Leishmania major	hypothetical protein, conserved	0.00348956	0.00107218	0.0014396
Plasmodium falciparum	topoisomerase I	1.33163	1	1
Trypanosoma cruzi	Zn-finger in ubiquitin-hydrolases and other protein, putative	0.00348956	0.00107218	0.0014396
Leishmania major	hypothetical protein, conserved	0.0189884	0.0127292	0.0170913
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.00295095	0.000667077	0.000895675
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.00348956	0.00107218	0.0125187
Trypanosoma brucei	histone deacetylase 1	0.0795785	0.0583006	0.0782794
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.00295095	0.000667077	0.00552867
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.00295095	0.000667077	0.000895675
Echinococcus granulosus	acetylcholinesterase	0.00697762	0.00369563	0.00369563
Plasmodium vivax	histone deacetylase, putative	0.0878137	0.0644945	0.0644945
Trypanosoma cruzi	hypothetical protein, conserved	0.0189884	0.0127292	0.0170913
Schistosoma mansoni	DNA topoisomerase type I	0.992293	0.744776	0.744776
Trypanosoma cruzi	DNA topoisomerase type IB small subunit, putative	0.432153	0.323481	0.434333
Echinococcus granulosus	histone deacetylase 6	0.0878137	0.0644945	0.0644945
Loa Loa (eye worm)	hypothetical protein	0.0389752	0.0277618	0.0274247
Echinococcus granulosus	histone deacetylase 8	0.0389752	0.0277618	0.0277618
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.00348956	0.00107218	0.000405373
Echinococcus multilocularis	histone deacetylase 3	0.0795785	0.0583006	0.0583006
Echinococcus granulosus	aryl hydrocarbon receptor	0.00252495	0.000346669	0.000346669
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase 5, putative	0.00348956	0.00107218	0.0183905
Echinococcus granulosus	acetylcholinesterase	0.00697762	0.00369563	0.00369563
Echinococcus multilocularis	carboxylesterase 5A	0.00697762	0.00369563	0.00369563
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.00252495	0.000346669	0.000346669
Echinococcus multilocularis	acetylcholinesterase	0.00697762	0.00369563	0.00369563
Toxoplasma gondii	histone deacetylase HDAC4	0.0389752	0.0277618	0.0277618
Echinococcus multilocularis	rho GTPase activating protein 20	0.00295095	0.000667077	0.000667077
Plasmodium vivax	histone deacetylase 1, putative	0.0795785	0.0583006	0.0583006
Brugia malayi	PAS domain containing protein	0.00971556	0.00575491	0.00509123
Echinococcus multilocularis	DNA topoisomerase 1	1.33163	1	1
Echinococcus multilocularis	Multi antimicrobial extrusion protein MatE	0.0171343	0.0113347	0.0113347
Brugia malayi	hypothetical protein	0.0325948	0.0229629	0.0223107
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.00348956	0.00107218	0.0014396
Schistosoma mansoni	DNA topoisomerase type I	1.33163	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0189884	0.0127292	0.0170913
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.00252495	0.000346669	0.000465467
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.00295095	0.000667077	0.000667077
Trichomonas vaginalis	brca1-associated protein, putative	0.00348956	0.00107218	0.0125187
Trypanosoma cruzi	DNA topoisomerase III, putative	0.00295095	0.000667077	0.000895675
Leishmania major	histone deacetylase, putative	0.0878137	0.0644945	0.0865958
Loa Loa (eye worm)	hypothetical protein	0.00697762	0.00369563	0.00335013
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.00348956	0.00107218	0.000405373
Trypanosoma cruzi	Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative	0.00348956	0.00107218	0.0014396
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0300698	0.0210639	0.0207244
Trypanosoma cruzi	hypothetical protein, conserved	0.0189884	0.0127292	0.0170913
Leishmania major	DNA topoisomerase III, putative	0.00295095	0.000667077	0.000895675
Trypanosoma cruzi	histone deacetylase, putative	0.0389752	0.0277618	0.0372754
Trichomonas vaginalis	histone deacetylase, putative	0.0795785	0.0583006	1
Echinococcus granulosus	DNA topoisomerase 1	1.33163	1	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.00348956	0.00107218	0.0014396
Trypanosoma cruzi	histone deacetylase, putative	0.0878137	0.0644945	0.0865958
Toxoplasma gondii	histone deacetylase HDAC5	0.0389752	0.0277618	0.0277618
Onchocerca volvulus	Uncharacterized RING finger protein homolog	0.00348956	0.00107218	0.0264639
Trypanosoma cruzi	hypothetical protein, conserved	0.0189884	0.0127292	0.0170913
Leishmania major	DNA topoisomerase IB, large subunit	0.992293	0.744776	1
Leishmania major	DNA topoisomerase 1A	0.00295095	0.000667077	0.000895675
Trypanosoma brucei	DNA topoisomerase III, putative	0.00295095	0.000667077	0.000895675
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.00348956	0.00107218	0.0183905
Echinococcus granulosus	histone deacetylase 7	0.0878137	0.0644945	0.0644945
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 22	0.00348956	0.00107218	0.00107218
Schistosoma mansoni	histone deacetylase 4 5	0.0878137	0.0644945	0.0644945
Schistosoma mansoni	histone deacetylase 4 5	0.0878137	0.0644945	0.0644945
Chlamydia trachomatis	DNA topoisomerase I	0.00295095	0.000667077	1
Loa Loa (eye worm)	histone deacetylase 3	0.0795785	0.0583006	0.0579741
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.00348956	0.00107218	0.0014396
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 5	0.00348956	0.00107218	0.00107218
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.00252495	0.000346669	0.000465467
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.00295095	0.000667077	0.00552867
Wolbachia endosymbiont of Brugia malayi	topoisomerase IA, TopA	0.00295095	0.000667077	0.5
Toxoplasma gondii	DNA topoisomerase family protein	0.00295095	0.000667077	0.000667077
Brugia malayi	Histone deacetylase 1	0.0795785	0.0583006	0.057672
Giardia lamblia	Histone deacetylase	0.0795785	0.0583006	1
Toxoplasma gondii	UBA/TS-N domain-containing protein	0.00348956	0.00107218	0.00107218
Entamoeba histolytica	DNA topoisomerase III, putative	0.00295095	0.000667077	0.011442
Echinococcus granulosus	histone deacetylase 6	0.0878137	0.0644945	0.0644945
Toxoplasma gondii	Zn-finger in ubiquitin-hydrolases domain-containing protein	0.00348956	0.00107218	0.00107218
Schistosoma mansoni	serine/threonine protein kinase	0.0223284	0.0152414	0.0152414
Loa Loa (eye worm)	hypothetical protein	0.00697762	0.00369563	0.00335013
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.00348956	0.00107218	0.0183905
Trypanosoma cruzi	DNA topoisomerase IB, large subunit, putative	0.992293	0.744776	1
Echinococcus multilocularis	u4:u6.u5 tri snrnp associated protein 2	0.00348956	0.00107218	0.00107218
Echinococcus multilocularis	histone deacetylase 6	0.0878137	0.0644945	0.0644945
Loa Loa (eye worm)	ubiquitin specific peptidase 39	0.00348956	0.00107218	0.000725762
Plasmodium falciparum	histone deacetylase 1	0.0795785	0.0583006	0.0583006
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0795785	0.0583006	1
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.00252495	0.000346669	0.000346669
Brugia malayi	Histone deacetylase family protein	0.0878137	0.0644945	0.06387
Echinococcus granulosus	u4:u6.u5 tri snrnp associated protein 2	0.00348956	0.00107218	0.00107218
Trypanosoma cruzi	histone deacetylase 1, putative	0.0795785	0.0583006	0.0782794
Echinococcus granulosus	histone deacetylase	0.0878137	0.0644945	0.0644945
Trypanosoma brucei	Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative	0.00348956	0.00107218	0.0014396
Trichomonas vaginalis	histone deacetylase, putative	0.0795785	0.0583006	1
Echinococcus multilocularis	transfer RNA-Lys	0.00719061	0.00385583	0.00385583
Trypanosoma cruzi	histone deacetylase, putative	0.0878137	0.0644945	0.0865958
Brugia malayi	DNA topoisomerase I	1.33163	1	1
Plasmodium falciparum	U4/U6.U5 tri-snRNP-associated protein 2, putative	0.00348956	0.00107218	0.00107218
Schistosoma mansoni	histone deacetylase	0.0795785	0.0583006	0.0583006
Schistosoma mansoni	histone deacetylase	0.0795785	0.0583006	0.0583006
Toxoplasma gondii	DNA topoisomerase I, putative	1.33163	1	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 22	0.00348956	0.00107218	0.00107218
Schistosoma mansoni	ubiquitin-specific peptidase 5 (C19 family)	0.00348956	0.00107218	0.00107218
Schistosoma mansoni	family C19 non-peptidase homologue (C19 family)	0.00348956	0.00107218	0.00107218
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.00252495	0.000346669	0.000465467
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.00348956	0.00107218	0.0125187
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.00348956	0.00107218	0.000725762
Trypanosoma brucei	DNA topoisomerase type IB small subunit	0.432153	0.323481	0.434333
Loa Loa (eye worm)	histone deacetylase 1	0.0795785	0.0583006	0.0579741
Trypanosoma cruzi	hypothetical protein, conserved	0.0189884	0.0127292	0.0170913
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase, putative	0.00348956	0.00107218	0.00107218
Echinococcus granulosus	DNA topoisomerase 3 alpha	0.00295095	0.000667077	0.000667077
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.00348956	0.00107218	0.000725762
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.00257145	0.000381647	0.000512432
Brugia malayi	Protein kinase domain containing protein	0.0223284	0.0152414	0.014584
Giardia lamblia	Hypothetical protein	0.00348956	0.00107218	0.00702893
Loa Loa (eye worm)	histone deacetylase 7A	0.0878137	0.0644945	0.06417
Brugia malayi	hypoxia-induced factor 1	0.0300698	0.0210639	0.0204104
Toxoplasma gondii	histone deacetylase HDAC3	0.0795785	0.0583006	0.0583006
Leishmania major	hypothetical protein, conserved	0.00348956	0.00107218	0.0014396
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0795785	0.0583006	1
Plasmodium vivax	histone deacetylase, putative	0.0389752	0.0277618	0.0277618
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.00257145	0.000381647	0.000512432
Plasmodium vivax	histone deacetylase 2, putative	0.0878137	0.0644945	0.0644945
Brugia malayi	bHLH-PAS transcription factor	0.00719061	0.00385583	0.00319088
Brugia malayi	histone deacetylase 1 (HD1)	0.0795785	0.0583006	0.057672
Loa Loa (eye worm)	acetylcholinesterase 1	0.00697762	0.00369563	0.00335013
Echinococcus multilocularis	histone deacetylase 8	0.0389752	0.0277618	0.0277618
Loa Loa (eye worm)	BRCA1-associated protein 2 containing protein	0.00348956	0.00107218	0.000725762
Trichomonas vaginalis	histone deacetylase, putative	0.0795785	0.0583006	1
Loa Loa (eye worm)	hypothetical protein	0.0488385	0.0351802	0.0348457
Echinococcus multilocularis	histone deacetylase 6	0.0878137	0.0644945	0.0644945
Echinococcus granulosus	single minded 2	0.00719061	0.00385583	0.00385583
Trypanosoma brucei	MATE efflux family protein, putative	0.0189884	0.0127292	0.0170913
Echinococcus granulosus	BRCA1 associated protein	0.00348956	0.00107218	0.00107218
Echinococcus multilocularis	histone deacetylase 7	0.0878137	0.0644945	0.0644945
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase 13, putative	0.00348956	0.00107218	0.00107218
Echinococcus multilocularis	histone deacetylase	0.0878137	0.0644945	0.0644945
Schistosoma mansoni	single-minded	0.00971556	0.00575491	0.00575491
Plasmodium vivax	DNA topoisomerase 3, putative	0.00295095	0.000667077	0.000667077
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0389752	0.0277618	1
Leishmania major	protein kinase, putative	0.00257145	0.000381647	0.000512432
Trypanosoma cruzi	DNA topoisomerase III, putative	0.00295095	0.000667077	0.000895675
Trypanosoma cruzi	histone deacetylase, putative	0.0389752	0.0277618	0.0372754
Echinococcus multilocularis	acetylcholinesterase	0.00697762	0.00369563	0.00369563
Brugia malayi	Histone deacetylase family protein	0.0878137	0.0644945	0.06387
Trypanosoma brucei	membrane transporter protein, putative	0.0189884	0.0127292	0.0170913
Brugia malayi	Carboxylesterase family protein	0.00697762	0.00369563	0.00303058
Echinococcus multilocularis	multidrug and toxin extrusion protein 2	0.0189884	0.0127292	0.0127292
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.00348956	0.00107218	0.0125187
Schistosoma mansoni	histone deacetylase hda2	0.0389752	0.0277618	0.0277618
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.00257145	0.000381647	0.000512432
Loa Loa (eye worm)	DNA topoisomerase I	1.33163	1	1
Loa Loa (eye worm)	DNA topoisomerase III	0.00295095	0.000667077	0.00032052
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.00348956	0.00107218	0.0125187
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.00257145	0.000381647	0.000512432
Plasmodium falciparum	histone deacetylase, putative	0.0878137	0.0644945	0.0644945
Schistosoma mansoni	multidrug resistance protein	0.0189884	0.0127292	0.0127292
Entamoeba histolytica	histone deacetylase, putative	0.0795785	0.0583006	1
Trypanosoma cruzi	histone deacetylase, putative	0.0878137	0.0644945	0.0865958
Loa Loa (eye worm)	histone deacetylase	0.0878137	0.0644945	0.06417
Trichomonas vaginalis	histone deacetylase, putative	0.0795785	0.0583006	1
Mycobacterium leprae	Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (	0.00295095	0.000667077	1
Trypanosoma brucei	Zn-finger in ubiquitin-hydrolases and other protein, putative	0.00348956	0.00107218	0.0014396
Onchocerca volvulus		0.00719061	0.00385583	0.128001
Trypanosoma brucei	histone deacetylase 4	0.0878137	0.0644945	0.0865958
Brugia malayi	histone deacetylase 11	0.0389752	0.0277618	0.0271128
Plasmodium vivax	topoisomerase I, putative	1.33163	1	1
Echinococcus granulosus	carboxylesterase 5A	0.00697762	0.00369563	0.00369563
Trypanosoma cruzi	histone deacetylase 1, putative	0.0795785	0.0583006	0.0782794
Schistosoma mansoni	brca1-associated protein (brap2)	0.00348956	0.00107218	0.00107218
Leishmania major	DNA topoisomerase type IB small subunit	0.432153	0.323481	0.434333
Echinococcus granulosus	multidrug and toxin extrusion protein 2	0.0189884	0.0127292	0.0127292
Trichomonas vaginalis	BRCA1-associated protein, putative	0.00348956	0.00107218	0.0125187
Toxoplasma gondii	ubiquitin specific protease 39 isoform 2, putative	0.00348956	0.00107218	0.00107218
Plasmodium falciparum	histone deacetylase 2	0.0878137	0.0644945	0.0644945
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0223284	0.0152414	0.0148999
Echinococcus granulosus	histone deacetylase 6	0.0913032	0.0671191	0.0671191
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase 13, putative	0.00348956	0.00107218	0.00107218
Loa Loa (eye worm)	carboxylesterase	0.00697762	0.00369563	0.00335013
Schistosoma mansoni	histone deacetylase 1 2 3	0.0389752	0.0277618	0.0277618
Loa Loa (eye worm)	hypothetical protein	0.0523281	0.0378048	0.0374712
Toxoplasma gondii	histone deacetylase HDAC2	0.0795785	0.0583006	0.0583006
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.00348956	0.00107218	0.0014396

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Antileishmanial activity against Leishmania major amastigotes assessed as decrease in infectivity in mouse macrophages after 24 hrs	ChEMBL.	18321711
Activity (functional)		Antileishmanial activity against Leishmania major MRHO/IR/75/ER amastigotes by MTT assay	ChEMBL.	18321711
Activity (functional)		Antileishmanial activity against Leishmania major amastigotes in mouse macrophages assessed as decrease in infectivity index after 24 hrs	ChEMBL.	18321711
IC50 (functional)	= 13.19 uM	Antileishmanial activity against Leishmania major MRHO/IR/75/ER promastigotes by MTT assay	ChEMBL.	18321711

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Leishmania major	ChEMBL23	18321711

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL458527

Bibliographic References

No literature references available for this target.

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Detailed information for compound 960845